Optimizing Clinical Assessments in Parkinson's Disease Through the Use of Wearable Sensors and Data Driven Modeling.

abstract：:In vivo and in vitro experimental studies have found that blocking electrical interactions connecting GABAergic interneurons reduces oscillatory activity in the gamma range in cortex. However, recent theoretical works have shown that the ability of electrical synapses to promote or impede synchrony, when alone, depend...

journal_title：Frontiers in computational neuroscience

authors： Pfeuty B,Golomb D,Mato G,Hansel D

更新日期：2007-11-02 00:00:00

abstract：:Cooperation and competition, as two common and opposite examples of interpersonal dynamics, are thought to be reflected by different cognitive, neural, and behavioral patterns. According to the conventional approach, they have been explored by measuring subjects' reactions during individual performance or turn-based i...

journal_title：Frontiers in computational neuroscience

authors： Balconi M,Vanutelli ME

更新日期：2017-09-29 00:00:00

abstract：:Automatic segmentation of Multiple Sclerosis (MS) lesions from Magnetic Resonance Imaging (MRI) images is essential for clinical assessment and treatment planning of MS. Recent years have seen an increasing use of Convolutional Neural Networks (CNNs) for this task. Although these methods provide accurate segmentation,...

journal_title：Frontiers in computational neuroscience

authors： Ackaouy A,Courty N,Vallée E,Commowick O,Barillot C,Galassi F

更新日期：2020-03-09 00:00:00

abstract：:Brain computer interfaces allow users to preform various tasks using only the electrical activity of the brain. BCI applications often present the user a set of stimuli and record the corresponding electrical response. The BCI algorithm will then have to decode the acquired brain response and perform the desired task....

journal_title：Frontiers in computational neuroscience

authors： Manor R,Mishali L,Geva AB

更新日期：2016-12-20 00:00:00

abstract：:Behavioral studies have shown spatial working memory impairment with aging in several animal species, including humans. Persistent activity of layer 3 pyramidal dorsolateral prefrontal cortex (dlPFC) neurons during delay periods of working memory tasks is important for encoding memory of the stimulus. In vitro studies...

journal_title：Frontiers in computational neuroscience

authors： Ibañez S,Luebke JI,Chang W,Draguljić D,Weaver CM

更新日期：2020-01-17 00:00:00

abstract：:Internal coordination models hold that early nervous systems evolved in the first place to coordinate internal activity at a multicellular level, most notably the use of multicellular contractility as an effector for motility. A recent example of such a model, the skin brain thesis, suggests that excitable epithelia u...

journal_title：Frontiers in computational neuroscience

authors： de Wiljes OO,van Elburg RA,Biehl M,Keijzer FA

更新日期：2015-09-15 00:00:00

abstract：:Burst spike patterns are common in regions of the hippocampal formation such as the subiculum and medial entorhinal cortex (MEC). Neurons in these areas are immersed in extracellular electrical potential fluctuations often recorded as the local field potential (LFP). LFP rhythms within different frequency bands are li...

journal_title：Frontiers in computational neuroscience

authors： Constantinou M,Gonzalo Cogno S,Elijah DH,Kropff E,Gigg J,Samengo I,Montemurro MA

更新日期：2016-12-26 00:00:00

abstract：:A wide range of blind source separation methods have been used in motor control research for the extraction of movement primitives from EMG and kinematic data. Popular examples are principal component analysis (PCA), independent component analysis (ICA), anechoic demixing, and the time-varying synergy model (d'Avella ...

journal_title：Frontiers in computational neuroscience

authors： Endres DM,Chiovetto E,Giese MA

更新日期：2013-12-20 00:00:00

abstract：:The problem of cancer risk analysis is of great importance to health-service providers and medical researchers. In this study, we propose a novel Artificial Neural Network (ANN) algorithm based on the probabilistic framework, which aims to investigate patient patterns associated with their disease development. Compare...

journal_title：Frontiers in computational neuroscience

authors： Yang C,Yang J,Liu Y,Geng X

更新日期：2020-07-21 00:00:00

abstract：:Scaffolds and patterned substrates are among the most successful strategies to dictate the connectivity between neurons in culture. Here, we used numerical simulations to investigate the capacity of physical obstacles placed on a flat substrate to shape structural connectivity, and in turn collective dynamics and effe...

journal_title：Frontiers in computational neuroscience

authors： Ludl AA,Soriano J

更新日期：2020-08-31 00:00:00

abstract：:A major puzzle in the field of computational neuroscience is how to relate system-level learning in higher organisms to synaptic plasticity. Recently, plasticity rules depending not only on pre- and post-synaptic activity but also on a third, non-local neuromodulatory signal have emerged as key candidates to bridge th...

journal_title：Frontiers in computational neuroscience

authors： Potjans W,Morrison A,Diesmann M

更新日期：2010-11-23 00:00:00

abstract：:Calcium concentrations as well as time courses have been used to model the signaling cascades leading to changes in the strength of synaptic connections. Previous models consider the dendritic spines as uniform compartments regarding calcium signaling. However, calcium concentrations can vary drastically on distances ...

journal_title：Frontiers in computational neuroscience

authors： Mihalas S

更新日期：2011-01-13 00:00:00

abstract：:In order to be able to examine the extracellular potential's influence on network activity and to better understand dipole properties of the extracellular potential, we present and analyze a three-dimensional formulation of the cable equation which facilitates numeric simulations. When the neuron's intra- and extracel...

journal_title：Frontiers in computational neuroscience

authors： Xylouris K,Wittum G

更新日期：2015-07-17 00:00:00

abstract：:We do not claim that the brain is completely deterministic, and we agree that noise may be beneficial in some cases. But we suggest that neuronal variability may be often overestimated, due to uncontrolled internal variables, and/or the use of inappropriate reference times. These ideas are not new, but should be re-ex...

journal_title：Frontiers in computational neuroscience

authors： Masquelier T

更新日期：2013-02-25 00:00:00

abstract：:The cerebellum is known to play a critical role in learning relevant patterns of activity for adaptive motor control, but the underlying network mechanisms are only partly understood. The classical long-term synaptic plasticity between parallel fibers (PFs) and Purkinje cells (PCs), which is driven by the inferior oli...

journal_title：Frontiers in computational neuroscience

authors： Luque NR,Garrido JA,Carrillo RR,D'Angelo E,Ros E

更新日期：2014-08-15 00:00:00

abstract：:Abnormal neuronal synchrony plays an important role in a number of brain diseases. To specifically counteract abnormal neuronal synchrony by desynchronization, Coordinated Reset (CR) stimulation, a spatiotemporally patterned stimulation technique, was designed with computational means. In neuronal networks with spike ...

journal_title：Frontiers in computational neuroscience

authors： Zeitler M,Tass PA

更新日期：2016-05-17 00:00:00

abstract：:Previous studies have shown that the auditory cortex can enhance the perception of behaviorally important sounds in the presence of background noise, but the mechanisms by which it does this are not yet elucidated. Rapid plasticity of spectrotemporal receptive fields (STRFs) in the primary (A1) cortical neurons is obs...

journal_title：Frontiers in computational neuroscience

authors： Chambers JD,Elgueda D,Fritz JB,Shamma SA,Burkitt AN,Grayden DB

更新日期：2019-05-24 00:00:00

abstract：:This paper proposed a new method to determine the neuronal tuning curves for maximum information efficiency by computing the optimum firing rate distribution. Firstly, we proposed a general definition for the information efficiency, which is relevant to mutual information and neuronal energy consumption. The energy co...

journal_title：Frontiers in computational neuroscience

authors： Han F,Wang Z,Fan H

更新日期：2017-02-21 00:00:00

abstract：:Although the representation of space is as fundamental to visual processing as the representation of shape, it has received relatively little attention from neurophysiological investigations. In this study we characterize representations of space within visual cortex, and examine how they differ in a first direct comp...

journal_title：Frontiers in computational neuroscience

authors： Sereno AB,Lehky SR

更新日期：2011-02-01 00:00:00

abstract：:The histograms of response times of optimal YES/NO decisions that are computed from a single sensory Poisson neuron are highly structured. In particular, response times in NO decisions are quantized to a small set of times, while response times in YES decisions have a multimodal structure. Both the times of NO decisio...

journal_title：Frontiers in computational neuroscience

authors： Perona P

更新日期：2014-04-11 00:00:00

abstract：:The generation of pain signals from primary afferent neurons is explained by a labeled-line code. However, this notion cannot apply in a simple way to cutaneous C-fibers, which carry signals from a variety of receptors that respond to various stimuli including agonist chemicals. To represent the discharge patterns of ...

journal_title：Frontiers in computational neuroscience

authors： Cho K,Jang JH,Kim SP,Lee SH,Chung SC,Kim IY,Jang DP,Jung SJ

更新日期：2016-11-18 00:00:00

abstract：:The motor system generates time-varying commands to move our limbs and body. Conventional descriptions of motor control and learning rely on dynamical representations of our body's state (forward and inverse models), and control policies that must be integrated forward to generate feedforward time-varying commands; th...

journal_title：Frontiers in computational neuroscience

authors： Berniker M,Kording KP

更新日期：2015-03-19 00:00:00

abstract：:A primary objective for cognitive neuroscience is to identify how features of the sensory environment are encoded in neural activity. Current auditory models of loudness perception can be used to make detailed predictions about the neural activity of the cortex as an individual listens to speech. We used two such mode...

journal_title：Frontiers in computational neuroscience

authors： Thwaites A,Nimmo-Smith I,Fonteneau E,Patterson RD,Buttery P,Marslen-Wilson WD

更新日期：2015-02-10 00:00:00

abstract：:Scientific research produces new knowledge, technologies, and clinical treatments that can lead to enormous returns. Often, the path from basic research to new paradigms and direct impact on society takes time. Precise quantification of scientific output in the short-term is not an easy task but is critical for evalua...

journal_title：Frontiers in computational neuroscience

authors： Kreiman G,Maunsell JH

更新日期：2011-11-10 00:00:00

abstract：:Spatio-temporal brain activities with variable delay detectable in resting-state functional magnetic resonance imaging (rs-fMRI) give rise to highly reproducible structures, termed cortical lag threads, that propagate from one brain region to another. Using a computational topology of data approach, we found that pers...

journal_title：Frontiers in computational neuroscience

authors： Don APH,Peters JF,Ramanna S,Tozzi A

更新日期：2020-04-22 00:00:00

abstract：:Image registration and segmentation are the two most studied problems in medical image analysis. Deep learning algorithms have recently gained a lot of attention due to their success and state-of-the-art results in variety of problems and communities. In this paper, we propose a novel, efficient, and multi-task algori...

journal_title：Frontiers in computational neuroscience

authors： Estienne T,Lerousseau M,Vakalopoulou M,Alvarez Andres E,Battistella E,Carré A,Chandra S,Christodoulidis S,Sahasrabudhe M,Sun R,Robert C,Talbot H,Paragios N,Deutsch E

更新日期：2020-03-20 00:00:00

abstract：:Synchrony and asynchrony are essential aspects of the functioning of interconnected neuronal cells and networks. New information on neuronal synchronization can be expected to aid in understanding these systems. Synchronization provides insight in the functional connectivity and the spatial distribution of the informa...

journal_title：Frontiers in computational neuroscience

authors： Kapucu FE,Välkki I,Mikkonen JE,Leone C,Lenk K,Tanskanen JM,Hyttinen JA

更新日期：2016-10-18 00:00:00

abstract：:To understand the function of the neocortex, which is a hierarchical distributed network, it is useful giving meaning to the signals transmitted between these areas from the computational viewpoint. The overall anatomical structure or organs related to this network, including the neocortex, thalamus, and basal ganglia...

journal_title：Frontiers in computational neuroscience

authors： Yamakawa H

更新日期：2020-08-18 00:00:00

abstract：:This paper presents a new model-based method to define muscle synergies. Unlike the conventional factorization approach, which extracts synergies from electromyographic data, the proposed method employs a biomechanical model and formally defines the synergies as the solution of an optimal control problem. As a result,...

journal_title：Frontiers in computational neuroscience

authors： Sharif Razavian R,Mehrabi N,McPhee J

更新日期：2015-10-06 00:00:00

abstract：:Pitch is a perceptual correlate of periodicity. Sounds with distinct spectra can elicit the same pitch. Despite the importance of pitch perception, understanding the cellular mechanism of pitch perception is still a major challenge and a mechanistic model of pitch is lacking. A multi-stage neuronal network model is de...

journal_title：Frontiers in computational neuroscience

authors： Huang C,Rinzel J

更新日期：2016-06-16 00:00:00