Network Models Predict That Pyramidal Neuron Hyperexcitability and Synapse Loss in the dlPFC Lead to Age-Related Spatial Working Memory Impairment in Rhesus Monkeys.

abstract：:Brain computer interfaces allow users to preform various tasks using only the electrical activity of the brain. BCI applications often present the user a set of stimuli and record the corresponding electrical response. The BCI algorithm will then have to decode the acquired brain response and perform the desired task....

journal_title：Frontiers in computational neuroscience

authors： Manor R,Mishali L,Geva AB

更新日期：2016-12-20 00:00:00

abstract：:Deep brain stimulation (DBS) leads with radially distributed electrodes have potential to improve clinical outcomes through more selective targeting of pathways and networks within the brain. However, increasing the number of electrodes on clinical DBS leads by replacing conventional cylindrical shell electrodes with ...

journal_title：Frontiers in computational neuroscience

authors： Teplitzky BA,Zitella LM,Xiao Y,Johnson MD

更新日期：2016-06-10 00:00:00

abstract：:The motor system generates time-varying commands to move our limbs and body. Conventional descriptions of motor control and learning rely on dynamical representations of our body's state (forward and inverse models), and control policies that must be integrated forward to generate feedforward time-varying commands; th...

journal_title：Frontiers in computational neuroscience

authors： Berniker M,Kording KP

更新日期：2015-03-19 00:00:00

abstract：:Statistical models for describing the probability distribution over the states of biological systems are commonly used for dimensional reduction. Among these models, pairwise models are very attractive in part because they can be fit using a reasonable amount of data: knowledge of the mean values and correlations betw...

journal_title：Frontiers in computational neuroscience

authors： Roudi Y,Aurell E,Hertz JA

更新日期：2009-11-17 00:00:00

abstract：:Dopaminergic neurons in the mammalian substantia nigra display characteristic phasic responses to stimuli which reliably predict the receipt of primary rewards. These responses have been suggested to encode reward prediction-errors similar to those used in reinforcement learning. Here, we propose a model of dopaminerg...

journal_title：Frontiers in computational neuroscience

authors： Chorley P,Seth AK

更新日期：2011-05-18 00:00:00

abstract：:Neuronal networks exhibit a wide diversity of structures, which contributes to the diversity of the dynamics therein. The presented work applies an information theoretic framework to simultaneously analyze structure and dynamics in neuronal networks. Information diversity within the structure and dynamics of a neurona...

journal_title：Frontiers in computational neuroscience

authors： Mäki-Marttunen T,Aćimović J,Nykter M,Kesseli J,Ruohonen K,Yli-Harja O,Linne ML

更新日期：2011-06-01 00:00:00

abstract：:Glucose is the brain's principal source of ATP, but the extent to which cerebral glucose consumption (CMRglc) is coupled with its oxygen consumption (CMRO2) remains unclear. Measurements of the brain's oxygen-glucose index OGI = CMRO2/CMRglc suggest that its oxygen uptake largely suffices for oxidative phosphorylation...

journal_title：Frontiers in computational neuroscience

authors： Angleys H,Jespersen SN,Østergaard L

更新日期：2016-10-13 00:00:00

abstract：:We often encounter pairs of variables in the world whose mutual relationship can be described by a function. After training, human responses closely correspond to these functional relationships. Here we study how humans predict unobserved segments of a function that they have been trained on and we compare how human p...

journal_title：Frontiers in computational neuroscience

authors： Narain D,Smeets JB,Mamassian P,Brenner E,van Beers RJ

更新日期：2014-09-30 00:00:00

abstract：:Astrocytes actively shape the dynamics of neurons and neuronal ensembles by affecting several aspects critical to neuronal function, such as regulating synaptic plasticity, modulating neuronal excitability, and maintaining extracellular ion balance. These pathways for astrocyte-neuron interaction can also enhance the ...

journal_title：Frontiers in computational neuroscience

authors： Volman V,Bazhenov M,Sejnowski TJ

更新日期：2012-08-13 00:00:00

abstract：:Neuromodulatory inputs from brainstem systems modulate the normal function of spinal motoneurons by altering the activation properties of persistent inward currents (PICs) in their dendrites. However, the effect of the PIC on firing outputs also depends on its location in the dendritic tree. To investigate the interac...

journal_title：Frontiers in computational neuroscience

authors： Kim H,Heckman CJ

更新日期：2014-09-09 00:00:00

abstract：:Image registration and segmentation are the two most studied problems in medical image analysis. Deep learning algorithms have recently gained a lot of attention due to their success and state-of-the-art results in variety of problems and communities. In this paper, we propose a novel, efficient, and multi-task algori...

journal_title：Frontiers in computational neuroscience

authors： Estienne T,Lerousseau M,Vakalopoulou M,Alvarez Andres E,Battistella E,Carré A,Chandra S,Christodoulidis S,Sahasrabudhe M,Sun R,Robert C,Talbot H,Paragios N,Deutsch E

更新日期：2020-03-20 00:00:00

abstract：:Recent research in neuroscience indicates the importance of tripartite synapses and gliotransmission mediated by astrocytes in neuronal system modulation. Although the astrocyte and neuronal network functions are interrelated, they are fundamentally different in their signaling patterns and, possibly, the time scales ...

journal_title：Frontiers in computational neuroscience

authors： Lenk K,Satuvuori E,Lallouette J,Ladrón-de-Guevara A,Berry H,Hyttinen JAK

更新日期：2020-01-22 00:00:00

abstract：:Although the representation of space is as fundamental to visual processing as the representation of shape, it has received relatively little attention from neurophysiological investigations. In this study we characterize representations of space within visual cortex, and examine how they differ in a first direct comp...

journal_title：Frontiers in computational neuroscience

authors： Sereno AB,Lehky SR

更新日期：2011-02-01 00:00:00

abstract：:We present a high-capacity model for one-shot association learning (hetero-associative memory) in sparse networks. We assume that basic patterns are pre-learned in networks and associations between two patterns are presented only once and have to be learned immediately. The model is a combination of an Amit-Fusi like ...

journal_title：Frontiers in computational neuroscience

authors： Einarsson H,Lengler J,Steger A

更新日期：2014-11-07 00:00:00

abstract：:Over the last decade robotics has attracted a great deal of interest from teachers and researchers as a valuable educational tool from preschool to highschool levels. The implementation of social-support behaviors in robot tutors, in particular in the emotional dimension, can make a significant contribution to learnin...

journal_title：Frontiers in computational neuroscience

authors： Imbernón Cuadrado LE,Manjarrés Riesco Á,De La Paz López F

更新日期：2016-08-03 00:00:00

abstract：:Neuroimaging in combination with graph theory has been successful in analyzing the functional connectome. However almost all analysis are performed based on static graph theory. The derived quantitative graph measures can only describe a snap shot of the disease over time. Neurodegenerative disease evolution is poorly...

journal_title：Frontiers in computational neuroscience

authors： Meyer-Bäse A,Roberts RG,Illan IA,Meyer-Bäse U,Lobbes M,Stadlbauer A,Pinker-Domenig K

更新日期：2017-10-05 00:00:00

abstract：:Probabilistic models of decision making under various forms of uncertainty have been applied in recent years to numerous behavioral and model-based fMRI studies. These studies were highly successful in enabling a better understanding of behavior and delineating the functional properties of brain areas involved in deci...

journal_title：Frontiers in computational neuroscience

authors： Marković D,Kiebel SJ

更新日期：2016-04-20 00:00:00

abstract：:Single-unit measurements have reported many different effects of attention on contrast-response (e.g., contrast-gain, response-gain, additive-offset dependent on visibility), while functional imaging measurements have more uniformly reported increases in response across all contrasts (additive-offset). The normalizati...

journal_title：Frontiers in computational neuroscience

authors： Hara Y,Pestilli F,Gardner JL

更新日期：2014-02-19 00:00:00

abstract：:The accurate automatic segmentation of gliomas and its intra-tumoral structures is important not only for treatment planning but also for follow-up evaluations. Several methods based on 2D and 3D Deep Neural Networks (DNN) have been developed to segment brain tumors and to classify different categories of tumors from ...

journal_title：Frontiers in computational neuroscience

authors： Natekar P,Kori A,Krishnamurthi G

更新日期：2020-02-07 00:00:00

abstract：:Parkinson's disease (PD) is a neurodegenerative disorder which follows from cell loss of dopaminergic neurons in the substantia nigra pars compacta (SNc), a nucleus in the basal ganglia (BG). Deep brain stimulation (DBS) is an electrical therapy that modulates the pathological activity to treat the motor symptoms of P...

journal_title：Frontiers in computational neuroscience

authors： Summerson SR,Aazhang B,Kemere C

更新日期：2015-06-26 00:00:00

abstract：:The muscle synergy hypothesis assumes that individual muscle synergies are independent of each other and voluntarily controllable. However, this assumption has not been empirically tested. This study tested if human subjects can voluntarily activate individual muscle synergies extracted by non-negative matrix factoriz...

journal_title：Frontiers in computational neuroscience

authors： Togo S,Imamizu H

更新日期：2017-09-06 00:00:00

abstract：:The inverse problem for estimating model parameters from brain spike data is an ill-posed problem because of a huge mismatch in the system complexity between the model and the brain as well as its non-stationary dynamics, and needs a stochastic approach that finds the most likely solution among many possible solutions...

journal_title：Frontiers in computational neuroscience

authors： Hoang H,Yamashita O,Tokuda IT,Sato MA,Kawato M,Toyama K

更新日期：2015-05-21 00:00:00

abstract：:We describe a model for cortical development that resolves long-standing difficulties of earlier models. It is proposed that, during embryonic development, synchronous firing of neurons and their competition for limited metabolic resources leads to selection of an array of neurons with ultra-small-world characteristic...

journal_title：Frontiers in computational neuroscience

authors： Wright JJ,Bourke PD

更新日期：2013-02-15 00:00:00

abstract：:In this article, we describe and analyze the chaotic behavior of a conductance-based neuronal bursting model. This is a model with a reduced number of variables, yet it retains biophysical plausibility. Inspired by the activity of cold thermoreceptors, the model contains a persistent Sodium current, a Calcium-activate...

journal_title：Frontiers in computational neuroscience

authors： Xu K,Maidana JP,Caviedes M,Quero D,Aguirre P,Orio P

更新日期：2017-03-10 00:00:00

abstract：:Synchronization of neural activity across brain regions is critical to processes that include perception, learning, and memory. After traumatic brain injury (TBI), neuronal degeneration is one possible effect and can alter communication between neural circuits. Consequently, synchronization between neurons may change ...

journal_title：Frontiers in computational neuroscience

authors： Schumm SN,Gabrieli D,Meaney DF

更新日期：2020-03-03 00:00:00

abstract：:Recently, biologically inspired models are gradually proposed to solve the problem in text analysis. Convolutional neural networks (CNN) are hierarchical artificial neural networks, which include a various of multilayer perceptrons. According to biological research, CNN can be improved by bringing in the attention mod...

journal_title：Frontiers in computational neuroscience

authors： Fu H,Niu Z,Zhang C,Ma J,Chen J

更新日期：2016-07-14 00:00:00

abstract：:Head direction cells fire to signal the direction in which an animal's head is pointing. They are able to track head direction using only internally-derived information (path integration)In this simulation study we investigate the factors that affect path integration accuracy. Specifically, two major limiting factors ...

journal_title：Frontiers in computational neuroscience

authors： Page HJ,Walters D,Stringer SM

更新日期：2015-02-06 00:00:00

abstract：:Synchrony and asynchrony are essential aspects of the functioning of interconnected neuronal cells and networks. New information on neuronal synchronization can be expected to aid in understanding these systems. Synchronization provides insight in the functional connectivity and the spatial distribution of the informa...

journal_title：Frontiers in computational neuroscience

authors： Kapucu FE,Välkki I,Mikkonen JE,Leone C,Lenk K,Tanskanen JM,Hyttinen JA

更新日期：2016-10-18 00:00:00

abstract：:Neurons innervate space by extending axonal and dendritic arborizations. When axons and dendrites come in close proximity of each other, synapses between neurons can be formed. Neurons vary greatly in their morphologies and synaptic connections with other neurons. The size and shape of the arborizations determine the ...

journal_title：Frontiers in computational neuroscience

authors： van Pelt J,van Ooyen A

更新日期：2013-11-25 00:00:00

abstract：:Sensitivity analysis can provide useful information when one is interested in identifying the parameter θ of a system since it measures the variations of the output u when θ changes. In the literature two different sensitivity functions are frequently used: the traditional sensitivity functions (TSF) and the generaliz...

journal_title：Frontiers in computational neuroscience

authors： Troparevsky MI,Rubio D,Saintier N

更新日期：2010-09-30 00:00:00