Paper-based electrochemiluminescence sensor for highly sensitive detection of amyloid-β oligomerization: Toward potential diagnosis of Alzheimer's disease.

abstract：:Molecular subtyping of breast cancer is of considerable interest owing to its potential for personalized therapy and prognosis. However, current methodologies cannot be used for precise subtyping, thereby posing a challenge in clinical practice. The aim of the present study is to develop a cell-specific single-strande...

journal_title：Theranostics

authors： Liu M,Wang Z,Tan T,Chen Z,Mou X,Yu X,Deng Y,Lu G,He N

更新日期：2018-11-10 00:00:00

abstract：:In advanced atherosclerotic plaques, defective efferocytosis of apoptotic foam cells and decreased cholesterol efflux contribute to lesion progression. In our previous study, we demonstrated that 5-aminolevulinic acid (ALA)-mediated sonodynamic therapy (SDT) could induce foam cells apoptosis via the mitochondrial-casp...

journal_title：Theranostics

authors： Wang H,Yang Y,Sun X,Tian F,Guo S,Wang W,Tian Z,Jin H,Zhang Z,Tian Y

更新日期：2018-09-29 00:00:00

abstract：:Malignant glioma is one of the most untreatable cancers because of the formidable blood-brain barrier (BBB), through which few therapeutics can penetrate and reach the tumors. Biologics have been booming in cancer therapy in the past two decades, but their application in brain tumor has long been ignored due to the im...

journal_title：Theranostics

authors： Chen Y,Zhang M,Jin H,Li D,Xu F,Wu A,Wang J,Huang Y

更新日期：2017-08-15 00:00:00

abstract：:Catalytic nanomaterials with intrinsic enzyme-like activities, called nanozymes, have recently attracted significant research interest due to their unique advantages relative to natural enzymes and conventional artificial enzymes. Among the nanozymes developed, particular interests have been devoted to nanozymes with ...

journal_title：Theranostics

authors： Wang X,Cao W,Qin L,Lin T,Chen W,Lin S,Yao J,Zhao X,Zhou M,Hang C,Wei H

更新日期：2017-06-01 00:00:00

abstract：:Host-guest motifs are likely the most recognizable manifestation of supramolecular chemistry. These complexes are characterized by the organization of small molecules on the basis of preferential association of a guest within the portal of a host. In the context of their therapeutic use, the primary application of the...

journal_title：Theranostics

authors： Braegelman AS,Webber MJ

更新日期：2019-05-15 00:00:00

abstract：:The combination of chemotherapy and RNA interference is a promising approach for efficient cancer therapy. However, the success of such a strategy is hampered by the lack of suitable vectors to coordinate small interfering RNA (siRNA) and chemotherapeutic drug into one single platform. We herein report a novel triple-...

journal_title：Theranostics

authors： Yu H,Guo C,Feng B,Liu J,Chen X,Wang D,Teng L,Li Y,Yin Q,Zhang Z,Li Y

更新日期：2016-01-01 00:00:00

abstract：:MicroRNAs (miRs) are small non-coding RNAs that negatively regulate gene expression by binding to the 3` untranslated regions (3`UTR) of their target mRNAs. MiRs were shown to play pivotal roles in tissue development and function and are also involved in the pathogenesis of various diseases including cancer. MicroRNA-...

journal_title：Theranostics

authors： Novák J,Kružliak P,Bienertová-Vašků J,Slabý O,Novák M

更新日期：2014-01-02 00:00:00

abstract：:Proper selection and effective delivery of combination drugs targeting multiple pathophysiological pathways key to spinal cord injury (SCI) hold promise to address the thus far scarce clinical therapeutics for improving recovery after SCI. In this study, we aim to develop a clinically feasible way for targeted deliver...

journal_title：Theranostics

authors： Wang Q,Zhang H,Xu H,Zhao Y,Li Z,Li J,Wang H,Zhuge D,Guo X,Xu H,Jones S,Li X,Jia X,Xiao J

更新日期：2018-08-07 00:00:00

abstract：:Mitochondria in cancer cells maintain a more negative membrane potential than normal cells. Mitochondria are the primary source of cellular reactive oxygen species (ROS), which are necessary for photodynamic therapy. Thus, the strategy of targeting mitochondria can maximize the photodynamic therapeutic efficiency for ...

journal_title：Theranostics

authors： Yue C,Yang Y,Zhang C,Alfranca G,Cheng S,Ma L,Liu Y,Zhi X,Ni J,Jiang W,Song J,de la Fuente JM,Cui D

更新日期：2016-10-01 00:00:00

abstract：:Ferroptosis is a newly discovered form of non-apoptotic cell death in multiple human diseases. However, the epigenetic mechanisms underlying ferroptosis remain poorly defined. First, we demonstrated that lymphoid-specific helicase (LSH), which is a DNA methylation modifier, interacted with WDR76 to inhibit ferroptosis...

journal_title：Theranostics

authors： Jiang Y,Mao C,Yang R,Yan B,Shi Y,Liu X,Lai W,Liu Y,Wang X,Xiao D,Zhou H,Cheng Y,Yu F,Cao Y,Liu S,Yan Q,Tao Y

更新日期：2017-07-23 00:00:00

abstract：:Cerebrospinal fluid (CSF) microRNAs (miRNAs) have emerged as potential biomarkers for minimally invasive diagnosis of central nervous system malignancies. However, despite significant advances in recent years, this field still suffers from poor data reproducibility. This is especially true in cases of infants, conside...

journal_title：Theranostics

authors： Prieto-Fernández E,Aransay AM,Royo F,González E,Lozano JJ,Santos-Zorrozua B,Macias-Camara N,González M,Garay RP,Benito J,Garcia-Orad A,Falcón-Pérez JM

更新日期：2019-06-19 00:00:00

abstract：:Autophagy is a dynamic and complicated catabolic process. Imaging autophagic flux can clearly advance knowledge of its pathophysiology significance. While the most common way autophagy is imaged relies on fluorescent protein-based probes, this method requires substantial genetic manipulation that severely restricts th...

journal_title：Theranostics

authors： Lei Y,Ren W,Wang CK,Tao RR,Xiang HJ,Feng LL,Gao YP,Jiang Q,Li X,Hu Y,Han F

更新日期：2019-08-01 00:00:00

abstract：:Extracellular vesicles, in particular exosomes, have recently gained interest as novel drug delivery vectors due to their biological origin and inherent intercellular biomolecule delivery capability. An in-depth knowledge of their in vivo biodistribution is therefore essential. This work aimed to develop a novel, reli...

journal_title：Theranostics

authors： Faruqu FN,Wang JT,Xu L,McNickle L,Chong EM,Walters A,Gurney M,Clayton A,Smyth LA,Hider R,Sosabowski J,Al-Jamal KT

更新日期：2019-02-28 00:00:00

abstract：:Acute myocardial infarction (AMI) is one of the leading causes of mortality around the world, and the inflammatory response plays a pivotal role in the progress of myocardial necrosis and ventricular remodeling, dysfunction and heart failure after AMI. Therapies aimed at modulating immune response after AMI on a molec...

journal_title：Theranostics

authors： Xiong YY,Gong ZT,Tang RJ,Yang YJ

更新日期：2021-01-01 00:00:00

abstract：:Rationale: Peripheral nerve injury (PNI) is a great challenge for regenerative medicine. Nerve autograft is the gold standard for clinical PNI repair. Due to its significant drawbacks, artificial nerve guidance conduits (NGCs) have drawn much attention as replacement therapies. We developed a combinatorial NGC consist...

journal_title：Theranostics

authors： Zheng C,Yang Z,Chen S,Zhang F,Rao Z,Zhao C,Quan D,Bai Y,Shen J

更新日期：2021-01-01 00:00:00

abstract：:Rationale: The ability to treat invalidating neurological diseases is impeded by the presence of the blood-brain barrier (BBB), which inhibits the transport of most blood-borne substances into the brain parenchyma. Targeting the transferrin receptor (TfR) on the surface of brain capillaries has been a popular strategy...

journal_title：Theranostics

authors： Johnsen KB,Bak M,Kempen PJ,Melander F,Burkhart A,Thomsen MS,Nielsen MS,Moos T,Andresen TL

更新日期：2018-05-24 00:00:00

abstract：:The limited clinical efficacy of monotherapies in the clinic has urged the development of novel combination platforms. Taking advantage of light-triggered photodynamic treatment combined together with the controlled release of nanomedicine, it has been possible to treat cancer without eliciting any adverse effects. Ho...

journal_title：Theranostics

authors： Hameed S,Bhattarai P,Liang X,Zhang N,Xu Y,Chen M,Dai Z

更新日期：2018-11-03 00:00:00

abstract：:Background: The dense fibrotic stroma enveloping pancreatic tumors is a major cause of drug resistance. Pancreatic stellate cells (PSCs) in the stroma can be activated to induce intra-tumor fibrosis and worsen patient survival; however, the molecular basics for the regulation of PSC activation remains unclear. Methods...

journal_title：Theranostics

authors： Wang HC,Lin YL,Hsu CC,Chao YJ,Hou YC,Chiu TJ,Huang PH,Tang MJ,Chen LT,Shan YS

更新日期：2019-09-23 00:00:00

abstract：:Cancer theranostics is one of the most important approaches for detecting and treating patients at an early stage. To develop such a technique, accurate detection, specific targeting, and controlled delivery are the key components. Various kinds of nanoparticles have been proposed and demonstrated as potential nanoveh...

journal_title：Theranostics

authors： Ray S,Li Z,Hsu CH,Hwang LP,Lin YC,Chou PT,Lin YY

更新日期：2018-11-29 00:00:00

abstract：:Rationale: Loss of DNA damage repair (DDR) in the tumor is an established hallmark of sensitivity to DNA damaging agents such as chemotherapy. However, there has been scant investigation into gain-of-function alterations of DDR genes in cancer. This study aims to investigate to what extent copy number amplification of...

journal_title：Theranostics

authors： Wu Z,Li S,Tang X,Wang Y,Guo W,Cao G,Chen K,Zhang M,Guan M,Yang D

更新日期：2020-03-04 00:00:00

abstract：:Because of the unparalleled efficiency and universal utility in treating a variety of disease types, siRNA agents have evolved as the future drug-of-choice. Yet, the inability of the polyanionic siRNA macromolecules to cross the cell membrane remains as the bottleneck of possible clinical applications. With the cell p...

journal_title：Theranostics

authors： Ye J,Liu E,Gong J,Wang J,Huang Y,He H,Yang VC

更新日期：2017-06-25 00:00:00

abstract：:Traumatic brain injury (TBI) research has focused on moderate to severe injuries as their outcomes are significantly worse than those of a mild TBI (mTBI). However, recent epidemiological evidence has indicated that a series of even mild TBIs greatly increases the risk of neurodegenerative and psychiatric disorders. N...

journal_title：Theranostics

authors： Adams C,Bazzigaluppi P,Beckett TL,Bishay J,Weisspapir I,Dorr A,Mester JR,Steinman J,Hirschler L,Warnking JM,Barbier EL,McLaurin J,Sled JG,Stefanovic B

更新日期：2018-09-09 00:00:00

abstract：:Aplastic anemia (AA) is characterized as hypoplasia of bone marrow hematopoietic cells and hematopenia of peripheral blood cells. Though the supplement of exogenous erythropoietin (EPO) has been clinically approved for AA treatment, the side-effects hinder its further application. Here a robust treatment for AA induce...

journal_title：Theranostics

authors： Jia W,Zhen M,Li L,Zhou C,Sun Z,Liu S,Zhao Z,Li J,Wang C,Bai C

更新日期：2020-05-23 00:00:00

abstract：:Tumor hypoxia is an important reason for the limited therapeutic efficacy of photodynamic therapy (PDT) because of the oxygen requirement of the therapeutic process. PDT consumes tissue oxygen and destroys tumor vasculature, further hampering its own efficacy in promoting tumor deterioration. Therefore, overcoming the...

journal_title：Theranostics

authors： Yang Z,Wang J,Ai S,Sun J,Mai X,Guan W

更新日期：2019-09-20 00:00:00

abstract：:Triple-modal imaging magnetic nanocapsules, encapsulating hydrophobic superparamagnetic iron oxide nanoparticles, are formulated and used to magnetically target solid tumours after intravenous administration in tumour-bearing mice. The engineered magnetic polymeric nanocapsules m-NCs are ~200 nm in size with negative ...

journal_title：Theranostics

authors： Bai J,Wang JT,Rubio N,Protti A,Heidari H,Elgogary R,Southern P,Al-Jamal WT,Sosabowski J,Shah AM,Bals S,Pankhurst QA,Al-Jamal KT

更新日期：2016-01-01 00:00:00

abstract：:Compared with other diagnostic methods, ultrasound is proven to be a safe, simple, non-invasive and cost-effective imaging technique, but the resolution is not comparable to that of magnetic resonance imaging (MRI). Contrast-enhanced ultrasound employing microbubbles can gain a better resolution and is now widely used...

journal_title：Theranostics

authors： Cai X,Yang F,Gu N

更新日期：2012-01-01 00:00:00

abstract：:Background: Lysophosphatidic acid (LPA) is a small glycerophospholipid that acts as a potent extracellular signal in various biological processes and diseases. Our previous work demonstrated that the expression of the LPA receptors LPA1 and LPA3 is elevated in the early postnatal heart. However, the role of this stage...

journal_title：Theranostics

authors： Wang F,Liu S,Pei J,Cai L,Liu N,Liang T,Dong X,Cong X,Chun J,Chen J,Hu S,Chen X

更新日期：2020-08-29 00:00:00

abstract：:Cerebrospinal fluid (CSF) leakage can lead to brain and spine pathologies and there is an urgent need for a rapid diagnostic method for determining CSF leakage. Beta-2 transferrin (β2TF), asialotransferrin, is a specific CSF glycoprotein biomarker used to determine CSF leakage when distinguished from serum sialotransf...

journal_title：Theranostics

authors： Oh J,Kwon SJ,Dordick JS,Sonstein WJ,Linhardt RJ,Kim MG

更新日期：2019-05-31 00:00:00

abstract：:Rationale: Colitis-associated colorectal cancer (CAC) usually exhibits an accelerated disease progression, an increased resistance to therapeutic drugs and a higher mortality rate than sporadic colorectal cancer (CRC). PIAS3 is a member of the protein inhibitor of activated STAT (PIAS) family; however, little is known...

journal_title：Theranostics

authors： Ma J,Yang Y,Fu Y,Guo F,Zhang X,Xiao S,Zhu W,Huang Z,Zhang J,Chen J

更新日期：2018-04-30 00:00:00

abstract：:A recent study revealed that quantitative hepatitis B core antibody (qAnti-HBc) level could serve as a novel marker for predicting treatment response. In the present study, we further investigated the predictive value of qAnti-HBc level in HBeAg-positive patients undergoing PEG-IFN therapy. A total of 140 HBeAg-positi...

journal_title：Theranostics

authors： Hou FQ,Song LW,Yuan Q,Fang LL,Ge SX,Zhang J,Sheng JF,Xie DY,Shang J,Wu SH,Sun YT,Wei SF,Wang MR,Wan MB,Jia JD,Luo GH,Tang H,Li SC,Niu JQ,Zhou WD,Sun L,Xia NS,Wang GQ

更新日期：2015-01-01 00:00:00