当前位置： SCI文献检索 > Journal of Neuroinflammation期刊下所有文献 > IL-1β suppresses cLTP-induced surface expression of GluA1 and actin polymerization via ceramide-mediated Src activation.

IL-1β suppresses cLTP-induced surface expression of GluA1 and actin polymerization via ceramide-mediated Src activation.

Abstract：

BACKGROUND:Brain inflammation including increases in inflammatory cytokines such as IL-1β is widely believed to contribute to the pathophysiology of Alzheimer's disease. Although IL-1β-induced impairments in long-term potentiation (LTP) in acute hippocampal slices and memory functions in vivo have been well documented, the neuron-specific molecular mechanisms of IL-1β-mediated impairments of LTP and memory remain unclear. METHODS:This study uses an in vitro approach in primary hippocampal neurons to evaluate the effect of IL-1β on chemical LTP (cLTP)-induced structural plasticity and signaling. RESULTS:We found that IL-1β reduces both the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunit GluA1 and the spine growth following cLTP. These effects of IL-1β were mediated by impairing actin polymerization during cLTP, as IL-1β decreased the cLTP-induced formation of F-actin, and the effect of IL-1β on cLTP-induced surface expression of GluA1 can be mimicked by latrunculin, a toxin that disrupts dynamics of actin filaments, and can be prevented by jasplakinolide, a cell-permeable peptide that stabilizes F-actin. Moreover, live-cell imaging demonstrated that IL-1β decreased the stability of the actin cytoskeleton in spines, which is required for LTP consolidation. We further examined the role of sphingolipid signaling in the IL-1β-mediated impairment of spine plasticity and found that both the neutral sphingomyelinase inhibitor GW4869 and the inhibitor of Src kinase PP2 attenuated the IL-1β-mediated suppression of cLTP-induced surface expression of GluA1 and actin polymerization. CONCLUSIONS:These findings support a mechanism by which IL-1β, via the sphingomyelinase/ceramide/Src pathway, impairs structural spine remodeling essential for LTP consolidation and memory.

journal_name

J Neuroinflammation

journal_title

Journal of neuroinflammation

authors

Tong L,Prieto GA,Cotman CW

doi

10.1186/s12974-018-1158-9

subject

Has Abstract

pub_date

2018-04-30 00:00:00

pages

127

issue

1

issn

1742-2094

pii

10.1186/s12974-018-1158-9

journal_volume

15

pub_type

杂志文章

相关文献

Journal of Neuroinflammation文献大全
  • Role of the indoleamine-2,3-dioxygenase/kynurenine pathway of tryptophan metabolism in behavioral alterations in a hepatic encephalopathy rat model.

    abstract：BACKGROUND:This study aims to explore the role of indoleamine-2,3-dioxygenase (IDO)/kynurenine (KYN) pathway of tryptophan (TRY) metabolism in behavioral alterations observed in hepatic encephalopathy (HE) rats. METHODS:Expression levels of proinflammatory cytokines were tested by QT-PCR and ELISA, levels of IDOs were...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-017-1037-9

    authors： Jiang X,Xu L,Tang L,Liu F,Chen Z,Zhang J,Chen L,Pang C,Yu X

    更新日期：2018-01-04 00:00:00

  • Evidence for the activation of pyroptotic and apoptotic pathways in RPE cells associated with NLRP3 inflammasome in the rodent eye.

    abstract：BACKGROUND:Age-related macular degeneration (AMD) is a devastating eye disease causing irreversible vision loss in the elderly. Retinal pigment epithelium (RPE), the primary cell type that is afflicted in AMD, undergoes programmed cell death in the late stages of the disease. However, the exact mechanisms for RPE degen...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-018-1062-3

    authors： Gao J,Cui JZ,To E,Cao S,Matsubara JA

    更新日期：2018-01-12 00:00:00

  • Activation of the NLRP3 inflammasome in lipopolysaccharide-induced mouse fatigue and its relevance to chronic fatigue syndrome.

    abstract：BACKGROUND:The NLRP3 inflammasome (NOD-like receptor family, pyrin domain containing 3) is an intracellular protein complex that plays an important role in innate immune sensing. Its activation leads to the maturation of caspase-1 and regulates the cleavage of interleukin (IL)-1β and IL-18. Various studies have shown t...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-016-0539-1

    authors： Zhang ZT,Du XM,Ma XJ,Zong Y,Chen JK,Yu CL,Liu YG,Chen YC,Zhao LJ,Lu GC

    更新日期：2016-04-05 00:00:00

  • The antidepressant-like effects of pioglitazone in a chronic mild stress mouse model are associated with PPARγ-mediated alteration of microglial activation phenotypes.

    abstract：BACKGROUND:Discoveries that microglia-mediated neuroinflammation is involved in the pathological process of depression provided a new strategy for novel antidepressant therapy. Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor regulating inflammation and microglial polarization and, therefore, ...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-016-0728-y

    authors： Zhao Q,Wu X,Yan S,Xie X,Fan Y,Zhang J,Peng C,You Z

    更新日期：2016-10-04 00:00:00

  • CX3CR1 deficiency suppresses activation and neurotoxicity of microglia/macrophage in experimental ischemic stroke.

    abstract：BACKGROUND:Chemokine (C-X3-C motif) ligand 1 (CX3CL1)/ CX3C chemokine receptor 1 (CX3CR1) signaling is important in modulating the communication between neurons and resident microglia/migrated macrophages in the central nervous system (CNS). Although CX3CR1 deficiency is associated with an improved outcome following is...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/1742-2094-11-26

    authors： Tang Z,Gan Y,Liu Q,Yin JX,Liu Q,Shi J,Shi FD

    更新日期：2014-02-03 00:00:00

  • Regional microglia are transcriptionally distinct but similarly exacerbate neurodegeneration in a culture model of Parkinson's disease.

    abstract：BACKGROUND:Parkinson's disease (PD) is characterized by selective degeneration of dopaminergic (DA) neurons of the substantia nigra pars compacta (SN) while neighboring ventral tegmental area (VTA) DA neurons are relatively spared. Mechanisms underlying the selective protection of the VTA and susceptibility of the SN a...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-018-1181-x

    authors： Kostuk EW,Cai J,Iacovitti L

    更新日期：2018-05-11 00:00:00

  • Urate inhibits microglia activation to protect neurons in an LPS-induced model of Parkinson's disease.

    abstract：BACKGROUND:Multiple risk factors contribute to the progression of Parkinson's disease, including oxidative stress and neuroinflammation. Epidemiological studies have revealed a link between higher urate level and a lower risk of developing PD. However, the mechanistic basis for this association remains unclear. Urate p...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-018-1175-8

    authors： Bao LH,Zhang YN,Zhang JN,Gu L,Yang HM,Huang YY,Xia N,Zhang H

    更新日期：2018-05-02 00:00:00

  • Benzo(a)pyrene exposure induced neuronal loss, plaque deposition, and cognitive decline in APP/PS1 mice.

    abstract：BACKGROUND:Exposure to benzo(a)pyrene (BaP) was associated with cognitive impairments and some Alzheimer's disease (AD)-like pathological changes. However, it is largely unknown whether BaP exposure participates in the disease progression of AD. OBJECTIVES:To investigate the effect of BaP exposure on AD progression an...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-020-01925-y

    authors： Liu D,Zhao Y,Qi Y,Gao Y,Tu D,Wang Y,Gao HM,Zhou H

    更新日期：2020-08-31 00:00:00

  • Dynamic response of microglia/macrophage polarization following demyelination in mice.

    abstract：BACKGROUND:The glial response in multiple sclerosis (MS), especially for recruitment and differentiation of oligodendrocyte progenitor cells (OPCs), predicts the success of remyelination of MS plaques and return of function. As a central player in neuroinflammation, activation and polarization of microglia/macrophages ...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-019-1586-1

    authors： Chu T,Zhang YP,Tian Z,Ye C,Zhu M,Shields LBE,Kong M,Barnes GN,Shields CB,Cai J

    更新日期：2019-10-17 00:00:00

  • Maternal high-fat diet induces sex-specific changes to glucocorticoid and inflammatory signaling in response to corticosterone and lipopolysaccharide challenge in adult rat offspring.

    abstract：BACKGROUND:Maternal obesity as a result of high levels of saturated fat (HFD) consumption leads to significant negative health outcomes in both mother and exposed offspring. Offspring exposed to maternal HFD show sex-specific alterations in metabolic, behavioral, and endocrine function, as well as increased levels of b...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-020-01798-1

    authors： Wijenayake S,Rahman MF,Lum CMW,De Vega WC,Sasaki A,McGowan PO

    更新日期：2020-04-15 00:00:00

  • The role of the complement system in traumatic brain injury: a review.

    abstract：:Traumatic brain injury (TBI) is an important cause of disability and mortality in the western world. While the initial injury sustained results in damage, it is the subsequent secondary cascade that is thought to be the significant determinant of subsequent outcomes. The changes associated with the secondary injury do...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章,评审

    doi：10.1186/s12974-018-1066-z

    authors： Hammad A,Westacott L,Zaben M

    更新日期：2018-01-22 00:00:00

  • Chronic morphine and HIV-1 Tat promote differential central nervous system trafficking of CD3+ and Ly6C+ immune cells in a murine Streptococcus pneumoniae infection model.

    abstract：BACKGROUND:Persistent systemic infection results in excessive trafficking of peripheral immune cells into the central nervous system (CNS), thereby contributing to sustained neuroinflammation that leads to neurocognitive deficits. In this study, we explored the role of opportunistic systemic infection with Streptococcu...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-015-0341-5

    authors： Dutta R,Roy S

    更新日期：2015-06-20 00:00:00

  • Activin A increases phagocytosis of Escherichia coli K1 by primary murine microglial cells activated by toll-like receptor agonists.

    abstract：BACKGROUND:Bacterial meningitis is associated with high mortality and long-term neurological sequelae. Increasing the phagocytic activity of microglia could improve the resistance of the CNS against infections. We studied the influence of activin A, a member of the TGF-β family with known immunoregulatory and neuroprot...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-018-1209-2

    authors： Diesselberg C,Ribes S,Seele J,Kaufmann A,Redlich S,Bunkowski S,Hanisch UK,Michel U,Nau R,Schütze S

    更新日期：2018-06-07 00:00:00

  • Antibodies to myelin oligodendrocyte glycoprotein in HIV-1 associated neurocognitive disorder: a cross-sectional cohort study.

    abstract：BACKGROUND:Neuroinflammation and demyelination have been suggested as mechanisms causing HIV-1 associated neurocognitive disorder (HAND). This cross-sectional cohort study explores the potential role of antibodies to myelin oligodendrocyte glycoprotein (MOG), a putative autoantigen in multiple sclerosis, in the pathoge...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/1742-2094-7-79

    authors： Lackner P,Kuenz B,Reindl M,Morandell M,Berger T,Schmutzhard E,Eggers C

    更新日期：2010-11-17 00:00:00

  • Oligodendrocyte-specific ATF4 inactivation does not influence the development of EAE.

    abstract：BACKGROUND:Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are inflammatory demyelinating and neurodegenerative diseases of the CNS. Although recent studies suggest the neuroprotective effects of oligodendrocytes in neurodegenerative diseases, it remains unknown whether ol...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-019-1415-6

    authors： Yue Y,Stanojlovic M,Lin Y,Karsenty G,Lin W

    更新日期：2019-02-01 00:00:00

  • Electroconvulsive shock attenuated microgliosis and astrogliosis in the hippocampus and ameliorated schizophrenia-like behavior of Gunn rat.

    abstract：BACKGROUND:Although electroconvulsive therapy (ECT) is regarded as one of the efficient treatments for intractable psychiatric disorders, the mechanism of therapeutic action remains unclear. Recently, many studies indicate that ECT affects the immune-related cells, such as microglia, astrocytes, and lymphocytes. Moreov...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-016-0688-2

    authors： Limoa E,Hashioka S,Miyaoka T,Tsuchie K,Arauchi R,Azis IA,Wake R,Hayashida M,Araki T,Furuya M,Liaury K,Tanra AJ,Horiguchi J

    更新日期：2016-09-02 00:00:00

  • Immunological classification of gliomas based on immunogenomic profiling.

    abstract：BACKGROUND:Gliomas are heterogeneous in the tumor immune microenvironment (TIM). However, a classification of gliomas based on immunogenomic profiling remains lacking. METHODS:We hierarchically clustered gliomas based on the enrichment levels of 28 immune cells in the TIM in five datasets and obtained three clusters: ...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-020-02030-w

    authors： Feng Q,Li L,Li M,Wang X

    更新日期：2020-11-27 00:00:00

  • Influence of type I IFN signaling on anti-MOG antibody-mediated demyelination.

    abstract：BACKGROUND:Antibodies with specificity for myelin oligodendrocyte glycoprotein (MOG) are implicated in multiple sclerosis and related diseases. The pathogenic importance of anti-MOG antibody in primary demyelinating pathology remains poorly characterized. OBJECTIVE:The objective of this study is to investigate whether...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-017-0899-1

    authors： Berg CT,Khorooshi R,Asgari N,Owens T

    更新日期：2017-06-24 00:00:00

  • Interleukin-1beta and tumor necrosis factor-alpha are expressed by different subsets of microglia and macrophages after ischemic stroke in mice.

    abstract：BACKGROUND:Interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) are expressed by microglia and infiltrating macrophages following ischemic stroke. Whereas IL-1beta is primarily neurotoxic in ischemic stroke, TNF-alpha may have neurotoxic and/or neuroprotective effects. We investigated whether IL-1be...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/1742-2094-5-46

    authors： Clausen BH,Lambertsen KL,Babcock AA,Holm TH,Dagnaes-Hansen F,Finsen B

    更新日期：2008-10-23 00:00:00

  • CCAAT/enhancer-binding protein delta regulates the stemness of glioma stem-like cells through activating PDGFA expression upon inflammatory stimulation.

    abstract：BACKGROUND:The small population of glioma stem-like cells (GSCs) contributes to tumor initiation, malignancy, and recurrence in glioblastoma. However, the maintenance of GSC properties in the tumor microenvironment remains unclear. In glioma, non-neoplastic cells create an inflammatory environment and subsequently medi...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-019-1535-z

    authors： Wang SM,Lin HY,Chen YL,Hsu TI,Chuang JY,Kao TJ,Ko CY

    更新日期：2019-07-12 00:00:00

  • Human mesenchymal stem/stromal cells suppress spinal inflammation in mice with contribution of pituitary adenylate cyclase-activating polypeptide (PACAP).

    abstract：BACKGROUND:Adult human mesenchymal stem/stromal cells (hMSCs) from bone marrow have been reported to exhibit beneficial effects on spinal cord injury (SCI). A neuropeptide, pituitary adenylate cyclase-activating polypeptide (PACAP) is known to decrease neuronal cell death and inflammatory response after ischemia, SCI, ...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-015-0252-5

    authors： Tsumuraya T,Ohtaki H,Song D,Sato A,Watanabe J,Hiraizumi Y,Nakamachi T,Xu Z,Dohi K,Hashimoto H,Atsumi T,Shioda S

    更新日期：2015-02-22 00:00:00

  • Antibodies to the inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) in cerebellar ataxia.

    abstract：:We report on a serum autoantibody associated with cerebellar ataxia. Immunohistochemical studies of sera from four patients referred for autoantibody testing revealed binding of high-titer (up to 1:5,000) IgG antibodies, mainly IgG1, to the molecular layer, Purkinje cell layer, and white matter on mouse, rat, porcine,...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-014-0206-3

    authors： Jarius S,Scharf M,Begemann N,Stöcker W,Probst C,Serysheva II,Nagel S,Graus F,Psimaras D,Wildemann B,Komorowski L

    更新日期：2014-12-11 00:00:00

  • Mu-opioid receptor and delta-opioid receptor differentially regulate microglial inflammatory response to control proopiomelanocortin neuronal apoptosis in the hypothalamus: effects of neonatal alcohol.

    abstract：BACKGROUND:Opioid receptors are known to control neurotransmission of various peptidergic neurons, but their potential role in regulation of microglia and neuronal cell communications is unknown. We investigated the role of mu-opioid receptors (MOR) and delta-opioid receptors (DOR) on microglia in the regulation of apo...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-017-0844-3

    authors： Shrivastava P,Cabrera MA,Chastain LG,Boyadjieva NI,Jabbar S,Franklin T,Sarkar DK

    更新日期：2017-04-14 00:00:00

  • LPS-induced systemic inflammation reveals an immunomodulatory role for the prion protein at the blood-brain interface.

    abstract：BACKGROUND:The cellular prion protein (PrPC) is an evolutionary conserved protein abundantly expressed not only in the central nervous system but also peripherally including the immune system. A line of Norwegian dairy goats naturally devoid of PrPC (PRNP Ter/Ter) provides a novel model for studying PrPC physiology. M...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-017-0879-5

    authors： Salvesen Ø,Reiten MR,Espenes A,Bakkebø MK,Tranulis MA,Ersdal C

    更新日期：2017-05-22 00:00:00

  • Virus-mediated EpoR76E gene therapy preserves vision in a glaucoma model by modulating neuroinflammation and decreasing oxidative stress.

    abstract：BACKGROUND:Glaucoma is a complex neurodegeneration and a leading cause of blindness worldwide. Current therapeutic strategies, which are all directed towards lowering the intraocular pressure (IOP), do not stop progression of the disease. We have demonstrated that recombinant adeno-associated virus (rAAV) gene delivery...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-016-0499-5

    authors： Hines-Beard J,Bond WS,Backstrom JR,Rex TS

    更新日期：2016-02-15 00:00:00

  • Astrocyte response to IFN-γ limits IL-6-mediated microglia activation and progressive autoimmune encephalomyelitis.

    abstract：BACKGROUND:Therapeutic modalities effective in patients with progressive forms of multiple sclerosis (MS) are limited. In a murine model of progressive MS, the sustained disability during the chronic phase of experimental autoimmune encephalomyelitis (EAE) correlated with elevated expression of interleukin (IL)-6, a cy...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-015-0293-9

    authors： Savarin C,Hinton DR,Valentin-Torres A,Chen Z,Trapp BD,Bergmann CC,Stohlman SA

    更新日期：2015-04-22 00:00:00

  • Repeated administration of the noradrenergic neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) modulates neuroinflammation and amyloid plaque load in mice bearing amyloid precursor protein and presenilin-1 mutant transgenes.

    abstract：BACKGROUND:Data indicates anti-oxidant, anti-inflammatory and pro-cognitive properties of noradrenaline and analyses of post-mortem brain of Alzheimer's disease (AD) patients reveal major neuronal loss in the noradrenergic locus coeruleus (LC), the main source of CNS noradrenaline (NA). The LC has projections to brain ...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/1742-2094-4-8

    authors： Pugh PL,Vidgeon-Hart MP,Ashmeade T,Culbert AA,Seymour Z,Perren MJ,Joyce F,Bate ST,Babin A,Virley DJ,Richardson JC,Upton N,Sunter D

    更新日期：2007-02-26 00:00:00

  • Pioglitazone inhibition of lipopolysaccharide-induced nitric oxide synthase is associated with altered activity of p38 MAP kinase and PI3K/Akt.

    abstract：BACKGROUND:Previous studies have suggested that peroxisome proliferator activated receptor-gamma (PPAR-gamma)-mediated neuroprotection involves inhibition of microglial activation and decreased expression and activity of inducible nitric oxide synthase (iNOS); however, the underlying molecular mechanisms have not yet b...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/1742-2094-5-4

    authors： Xing B,Xin T,Hunter RL,Bing G

    更新日期：2008-01-18 00:00:00

  • Suppression of MyD88-dependent signaling alleviates neuropathic pain induced by peripheral nerve injury in the rat.

    abstract：BACKGROUND:MyD88 is the adaptor protein of MyD88-dependent signaling pathway of TLRs and IL-1 receptor and regulates innate immune response. However, it was not clear whether and how MyD88 and related signaling pathways in the dorsal root ganglion (DRG) and spinal dorsal horn (SDH) are involved in neuropathic pain. ME...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-017-0822-9

    authors： Liu F,Wang Z,Qiu Y,Wei M,Li C,Xie Y,Shen L,Huang Y,Ma C

    更新日期：2017-03-31 00:00:00

  • Neuroinflammation in autism spectrum disorders.

    abstract：OBJECTIVES:The neurobiological basis for autism remains poorly understood. However, research suggests that environmentalfactors and neuroinflammation, as well as genetic factors, are contributors. This study aims to test the role that might be played by heat shock protein (HSP)70, transforming growth factor (TGF)-β2, C...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/1742-2094-9-265

    authors： El-Ansary A,Al-Ayadhi L

    更新日期：2012-12-11 00:00:00