Antibodies to myelin oligodendrocyte glycoprotein in HIV-1 associated neurocognitive disorder: a cross-sectional cohort study.

abstract：BACKGROUND:Although electroconvulsive therapy (ECT) is regarded as one of the efficient treatments for intractable psychiatric disorders, the mechanism of therapeutic action remains unclear. Recently, many studies indicate that ECT affects the immune-related cells, such as microglia, astrocytes, and lymphocytes. Moreov...

journal_title：Journal of neuroinflammation

authors： Limoa E,Hashioka S,Miyaoka T,Tsuchie K,Arauchi R,Azis IA,Wake R,Hayashida M,Araki T,Furuya M,Liaury K,Tanra AJ,Horiguchi J

更新日期：2016-09-02 00:00:00

abstract：BACKGROUND:Ischemic stroke induced matrixmetallo-proteinase-9 (MMP-9) upregulation, which increased blood-brain barrier permeability. Studies demonstrated that mesenchymal stem cell therapy protected blood-brain barrier disruption from several cerebrovascular diseases. However, the underlying mechanism was largely unkn...

journal_title：Journal of neuroinflammation

authors： Cheng Z,Wang L,Qu M,Liang H,Li W,Li Y,Deng L,Zhang Z,Yang GY

更新日期：2018-05-03 00:00:00

abstract：BACKGROUND:Preconditioning is a phenomenon by which tolerance develops to injury by previous exposure to a stressor of mild severity. Previous studies have shown that single or repeated low dose MDMA can attenuate 5-HT transporter loss produced by a subsequent neurotoxic dose of the drug. We have explored the mechanism...

journal_title：Journal of neuroinflammation

authors： Mayado A,Torres E,Gutierrez-Lopez MD,Colado MI,O'Shea E

更新日期：2011-11-24 00:00:00

abstract：BACKGROUND:In neuroinflammatory diseases, macrophages can play a dual role in the process of tissue damage, depending on their activation status (M1 / M2). M1 macrophages are considered to exert damaging effects to neurons, whereas M2 macrophages are reported to aid regeneration and repair of neurons. Their migration w...

journal_title：Journal of neuroinflammation

authors： Vogel DY,Heijnen PD,Breur M,de Vries HE,Tool AT,Amor S,Dijkstra CD

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:The family of 14-3-3 proteins plays an important role in the regulation of cell survival and death. Here, we investigate the role of the 14-3-3 gamma (14-3-3 γ) subunit for glial responses in autoimmune demyelination. METHODS:Expression of 14-3-3 γ in glial cell culture was investigated by reverse transcrip...

journal_title：Journal of neuroinflammation

authors： Lee DH,Steinacker P,Seubert S,Turnescu T,Melms A,Manzel A,Otto M,Linker RA

更新日期：2015-10-06 00:00:00

abstract：BACKGROUND:Leukocytes are believed to be involved in delayed cell death following traumatic brain injury (TBI). However, data demonstrating that blood-borne inflammatory cells are present in the injured brain prior to the onset of secondary brain damage have been inconclusive. We therefore investigated both the interac...

journal_title：Journal of neuroinflammation

authors： Schwarzmaier SM,Zimmermann R,McGarry NB,Trabold R,Kim SW,Plesnila N

更新日期：2013-02-28 00:00:00

abstract：BACKGROUND:Immunoglobulin G (IgG) effector functions are regulated by the composition of glycans attached to a conserved N-glycosylation site in the Fc part. Intrathecal production of IgG, especially IgG1, is a hallmark of multiple sclerosis (MS), but nothing is known about IgG Fc glycosylation in MS and in cerebrospin...

journal_title：Journal of neuroinflammation

authors： Wuhrer M,Selman MH,McDonnell LA,Kümpfel T,Derfuss T,Khademi M,Olsson T,Hohlfeld R,Meinl E,Krumbholz M

更新日期：2015-12-18 00:00:00

abstract：BACKGROUND:Alzheimer's disease (AD) is a multifactorial disorder associated with the accumulation of soluble forms of beta-amyloid (Aβ) and its subsequent deposition into plaques. One of the major contributors to neuronal death is chronic and uncontrolled inflammatory activation of microglial cells around the plaques a...

journal_title：Journal of neuroinflammation

authors： Malm T,Mariani M,Donovan LJ,Neilson L,Landreth GE

更新日期：2015-01-16 00:00:00

abstract：:BACKGROUND: Oligodendrocytes, neurons, astrocytes, microglia, and endothelial cells are capable of synthesizing complement inhibitor proteins. Oligodendrocytes are vulnerable to complement attack, which is particularly observed in multiple sclerosis. This vulnerability may be related to a deficiency in their ability t...

journal_title：Journal of neuroinflammation

authors： Hosokawa M,Klegeris A,McGeer PL

更新日期：2004-08-24 00:00:00

abstract：BACKGROUND:Obesity and its associated disorders are becoming a major health issue in many countries. The resulting low-grade inflammation not only affects the periphery but also the central nervous system. We set out to study, in a time-dependent manner, the effects of a high-fat diet on different regions of the centra...

journal_title：Journal of neuroinflammation

authors： Guillemot-Legris O,Masquelier J,Everard A,Cani PD,Alhouayek M,Muccioli GG

更新日期：2016-08-26 00:00:00

abstract：BACKGROUND:Genetic and environmental factors are critical elements influencing the etiology of major depression. It is now accepted that neuroinflammatory processes play a major role in neuropsychological disorders. Neuroinflammation results from the dysregulation of the synthesis and/or release of pro- and anti-inflam...

journal_title：Journal of neuroinflammation

authors： Cazareth J,Guyon A,Heurteaux C,Chabry J,Petit-Paitel A

更新日期：2014-07-28 00:00:00

abstract：BACKGROUND:The NLRP3 inflammasome (NOD-like receptor family, pyrin domain containing 3) is an intracellular protein complex that plays an important role in innate immune sensing. Its activation leads to the maturation of caspase-1 and regulates the cleavage of interleukin (IL)-1β and IL-18. Various studies have shown t...

journal_title：Journal of neuroinflammation

authors： Zhang ZT,Du XM,Ma XJ,Zong Y,Chen JK,Yu CL,Liu YG,Chen YC,Zhao LJ,Lu GC

更新日期：2016-04-05 00:00:00

abstract：BACKGROUND:S100A9 protein (myeloid-related protein MRP14, also referred to as calgranulin B) is a reliable marker of inflammation, an important proinflammatory factor of innate immunity and acts as an additional antimicrobial peptide in the innate immune system. Evidence indicates that S100A9 contributes to Alzheimer's...

journal_title：Journal of neuroinflammation

authors： Lee EO,Yang JH,Chang KA,Suh YH,Chong YH

更新日期：2013-05-30 00:00:00

abstract：:Docosahexaenoic acid (DHA) is an omega-3 (ω-3) long-chain polyunsaturated fatty acid (LCPUFA) relevant for brain function. It has largely been explored as a potential candidate to treat Alzheimer's disease (AD). Clinical evidence favors a role for DHA in the improvement of cognition in very early stages of the AD. In ...

journal_title：Journal of neuroinflammation

authors： Heras-Sandoval D,Pedraza-Chaverri J,Pérez-Rojas JM

更新日期：2016-03-10 00:00:00

abstract：BACKGROUND:Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory disease of the central nervous system that preferentially affects the optic nerves, spinal cord, and area postrema. A series of evidence suggested that B cells play a fundamental role in the pathogenesis of NMOSD. However, there are...

journal_title：Journal of neuroinflammation

authors： Kong BS,Kim Y,Kim GY,Hyun JW,Kim SH,Jeong A,Kim HJ

更新日期：2017-09-25 00:00:00

abstract：BACKGROUND:Inducible nitric oxide synthase (iNOS) makes a great contribution to host defense and inflammation. In many settings, lipopolysaccharide (LPS) induces iNOS expression through activation of the inhibitor of κB-α (IκB-α)-nuclear factor-κB (NF-κB) cascade, whereas interferon-γ (IFN-γ) acts through Janus kinase ...

journal_title：Journal of neuroinflammation

authors： Huang C,Lu X,Tong L,Wang J,Zhang W,Jiang B,Yang R

更新日期：2015-10-14 00:00:00

abstract：BACKGROUND:Glutamate excitotoxicity contributes to oligodendrocyte and tissue damage in multiple sclerosis (MS). Intriguingly, glutamate level in plasma and cerebrospinal fluid of MS patients is elevated, a feature which may be related to the pathophysiology of this disease. In addition to glutamate transporters, level...

journal_title：Journal of neuroinflammation

authors： Pampliega O,Domercq M,Soria FN,Villoslada P,Rodríguez-Antigüedad A,Matute C

更新日期：2011-06-03 00:00:00

abstract：BACKGROUND:Recent evidence has suggested that peripheral inflammatory responses induced by lipopolysaccharides (LPS) play an important role in neuropsychiatric dysfunction in rodents. Interleukin-1β (IL-1β), a pro-inflammatory cytokine, has been proposed to be a key mediator in a variety of behavioral dysfunction induc...

journal_title：Journal of neuroinflammation

authors： Li M,Li C,Yu H,Cai X,Shen X,Sun X,Wang J,Zhang Y,Wang C

更新日期：2017-09-20 00:00:00

abstract：BACKGROUND:Atypical antipsychotic agents, such as clozapine, are used to treat schizophrenia and other psychiatric disorders by a mechanism that is believed to involve modulating the immune system. Multiple sclerosis is an immune-mediated neurological disease, and recently, clozapine was shown to reduce disease severit...

journal_title：Journal of neuroinflammation

authors： Robichon K,Patel V,Connor B,La Flamme AC

更新日期：2020-02-12 00:00:00

abstract：:Multiple lines of evidence support the pathogenic role of neuroinflammation in psychiatric illness. While systemic autoimmune diseases are well-documented causes of neuropsychiatric disorders, synaptic autoimmune encephalitides with psychotic symptoms often go under-recognized. Parallel to the link between psychiatric...

journal_title：Journal of neuroinflammation

authors： Najjar S,Pearlman DM,Alper K,Najjar A,Devinsky O

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Abundant reports indicated that depression was often comorbid with type 2 diabetes and even metabolic syndrome. Considering they might share common biological origins, it was tentatively attributed to the chronic cytokine-mediated inflammatory response which was induced by dysregulation of HPA axis and overa...

journal_title：Journal of neuroinflammation

authors： Su WJ,Peng W,Gong H,Liu YZ,Zhang Y,Lian YJ,Cao ZY,Wu R,Liu LL,Wang B,Wang YX,Jiang CL

更新日期：2017-10-30 00:00:00

abstract：BACKGROUND:There has been a marked increase in the incidence of autoimmune diseases like multiple sclerosis (MS) in the last decades which is most likely driven by a change in environmental factors. Here, growing evidence suggests that ingredients of a Western diet like high intake of sodium chloride (NaCl) or saturate...

journal_title：Journal of neuroinflammation

authors： Hammer A,Schliep A,Jörg S,Haghikia A,Gold R,Kleinewietfeld M,Müller DN,Linker RA

更新日期：2017-09-12 00:00:00

abstract：BACKGROUND:Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disease with no available therapy. Components of the innate immune system are activated in the spinal cord and central nervous system of ALS patients. Studies in the SOD1(G93A) mouse show deposition of C1q and C3/C3b at the motor en...

journal_title：Journal of neuroinflammation

authors： Bahia El Idrissi N,Bosch S,Ramaglia V,Aronica E,Baas F,Troost D

更新日期：2016-04-07 00:00:00

abstract：BACKGROUND:Multiple sclerosis (MS) is an immune-mediated demyelinated disease of the central nervous system. Activation of microglia is involved in the pathogenesis of myelin loss. OBJECTIVE:This study is focused on the role of Hv1 in regulating demyelination and microglial activation through reactive oxygen species (...

journal_title：Journal of neuroinflammation

authors： Chen M,Yang LL,Hu ZW,Qin C,Zhou LQ,Duan YL,Bosco DB,Wu LJ,Zhan KB,Xu SB,Tian DS

更新日期：2020-11-06 00:00:00

abstract：BACKGROUND:A dose-limiting side effect of chemotherapeutic agents such as vincristine (VCR) is neuropathic pain, which is poorly managed at present. Chemokine-mediated immune cell/neuron communication in preclinical VCR-induced pain forms an intriguing basis for the development of analgesics. In a murine VCR model, CX3...

journal_title：Journal of neuroinflammation

authors： Montague K,Simeoli R,Valente J,Malcangio M

更新日期：2018-04-06 00:00:00

abstract：BACKGROUND:Pain is one critical hallmark of inflammatory responses. A large number of studies have demonstrated that stromal cell-derived factor 1 (SDF1, also named as CXCL12) and its cognate receptor C-X-C chemokine receptor type 4 (CXCR4) play an important role in immune reaction and inflammatory processes. However, ...

journal_title：Journal of neuroinflammation

authors： Yang F,Sun W,Yang Y,Wang Y,Li CL,Fu H,Wang XL,Yang F,He T,Chen J

更新日期：2015-11-24 00:00:00

abstract：BACKGROUND:Andrographolide is the major bioactive compound isolated from Andrographis paniculata, a native South Asian herb used medicinally for its anti-inflammatory properties. In this study, we aimed to assess andrographolide's potential utility as an anti-neuroinflammatory therapeutic. METHODS:The effects of andro...

journal_title：Journal of neuroinflammation

authors： Wong SY,Tan MG,Banks WA,Wong WS,Wong PT,Lai MK

更新日期：2016-02-09 00:00:00

abstract：BACKGROUND:Previous studies have suggested that peroxisome proliferator activated receptor-gamma (PPAR-gamma)-mediated neuroprotection involves inhibition of microglial activation and decreased expression and activity of inducible nitric oxide synthase (iNOS); however, the underlying molecular mechanisms have not yet b...

journal_title：Journal of neuroinflammation

authors： Xing B,Xin T,Hunter RL,Bing G

更新日期：2008-01-18 00:00:00

abstract：BACKGROUND:Traumatic brain injury (TBI) is a major cause of death and disability in the USA and the world; it constitutes 30% of injury-related deaths (Taylor et al., MMWR Surveill Summ 66:1-16, 2017). Contact sports athletes often experience repetitive TBI (rTBI), which exerts a cumulative effect later in life. Visual...

journal_title：Journal of neuroinflammation

authors： Das M,Tang X,Han JY,Mayilsamy K,Foran E,Biswal MR,Tzekov R,Mohapatra SS,Mohapatra S

更新日期：2019-05-31 00:00:00

abstract：BACKGROUND:Chungsim-Yeunja-Tang (CYT) has been used as a medicine for cerebral infarction (CI) patients in Korea. The objective of this study was to determine precisely the effect of CYT on CI patients using peripheral blood mononuclear cells (PBMCs). METHODS:For a clinical study, 47 CI patients were identified who ha...

journal_title：Journal of neuroinflammation

authors： Jeong HJ,Choi IY,Kim MH,Kim HM,Moon PD,Hong JW,Kim SH

更新日期：2010-11-25 00:00:00