Neuroinflammation in autism spectrum disorders.

abstract：BACKGROUND:Neurogenic inflammation is orchestrated by a large number of neuropeptides. Tachykinins (substance P, neurokinin A and neurokinin B) are pro-inflammatory neuropeptides that may play an important role in some autoimmune neuroinflammatory diseases. Autoimmunity may have a role in the pathogenesis of autism in ...

journal_title：Journal of neuroinflammation

authors： Mostafa GA,Al-Ayadhi LY

更新日期：2011-12-21 00:00:00

abstract：BACKGROUND:White matter injury (WMI) is the major antecedent of cerebral palsy in premature infants, and is often associated with maternal infection and the fetal inflammatory response. The current study explores the therapeutic potential of glutamate receptor blockade or cyclooxygenase-2 (COX-2) inhibition for inflamm...

journal_title：Journal of neuroinflammation

authors： Weaver-Mikaere L,Gunn AJ,Mitchell MD,Bennet L,Fraser M

更新日期：2013-12-17 00:00:00

abstract：BACKGROUND:Monocyte infiltration is involved in the pathogenesis of many retinal degenerative conditions. This process traditionally depends on local expression of chemokines, though the roles of many of these in the degenerating retina are unclear. Here, we investigate expression and in situ localization of the broad ...

journal_title：Journal of neuroinflammation

authors： Rutar M,Natoli R,Chia RX,Valter K,Provis JM

更新日期：2015-01-17 00:00:00

abstract：BACKGROUND:Neuroinflammation and a systemic inflammatory reaction are important features of perinatal asphyxia. Neuroinflammation may have dual aspects being a hindrance, but also a significant help in the recovery of the CNS. We aimed to assess intracellular cytokine levels of T-lymphocytes and plasma cytokine levels ...

journal_title：Journal of neuroinflammation

authors： Bajnok A,Berta L,Orbán C,Veres G,Zádori D,Barta H,Méder Ü,Vécsei L,Tulassay T,Szabó M,Toldi G

更新日期：2017-12-12 00:00:00

abstract：BACKGROUND:The early dysfunction and subsequent recovery after stroke, characterized by the destruction and remodeling of connective pathways between cortex and subcortical regions, is associated with neuroinflammation. As major components of the inflammatory process, reactive astrocytes have double-edged effects on pa...

journal_title：Journal of neuroinflammation

authors： Hao XZ,Yin LK,Zhang XX,Tian JQ,Li CC,Feng XY,Jiang M,Yang YM

更新日期：2016-06-18 00:00:00

abstract：BACKGROUND:Mitogen-activated protein kinase (MAPK) signaling pathways are implicated in inflammatory and apoptotic processes of cerebral ischemia and reperfusion (I/R) injury. Hence, MAPK pathways represent a promising therapeutic target. Exploring the full potential of inhibitors of MAPK pathways is a useful therapeut...

journal_title：Journal of neuroinflammation

authors： Jiang M,Li J,Peng Q,Liu Y,Liu W,Luo C,Peng J,Li J,Yung KK,Mo Z

更新日期：2014-09-26 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a paralyzing disorder characterized by the progressive degeneration and death of motor neurons and occurs both as a sporadic and familial disease. Mutant SOD1 (mtSOD1) in motor neurons induces vulnerability to the disease through protein misfolding, mitochondrial dysfunction, oxi...

journal_title：Journal of neuroinflammation

authors： Yang EJ,Kim SH,Yang SC,Lee SM,Choi SM

更新日期：2011-06-20 00:00:00

abstract：BACKGROUND:The aim of the research is to study the human leukocyte antigen (HLA) class II allele frequencies in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) associated with anti-neurofascin 155 (NF155) antibodies. METHODS:Thirteen anti-NF155+ and 35 anti-NF155 negative (anti-NF155neg) CIDP patients...

journal_title：Journal of neuroinflammation

authors： Martinez-Martinez L,Lleixà MC,Boera-Carnicero G,Cortese A,Devaux J,Siles A,Rajabally Y,Martinez-Piñeiro A,Carvajal A,Pardo J,Delmont E,Attarian S,Diaz-Manera J,Callegari I,Marchioni E,Franciotta D,Benedetti L,Lauria G,

更新日期：2017-11-16 00:00:00

abstract：BACKGROUND:Ischemic stroke is a leading cause of disability worldwide and characteristically accompanied by downregulation of the Wnt/β-catenin signaling. Activation of Wnt/β-catenin signaling emerges to attenuate neuroinflammation after ischemic stroke; however, its effect on modulating microglial polarization is larg...

journal_title：Journal of neuroinflammation

authors： Song D,Zhang X,Chen J,Liu X,Xue J,Zhang L,Lan X

更新日期：2019-12-06 00:00:00

abstract：BACKGROUND:Obesity can lead to cognitive dysfunction including poor performance in memory tasks. However, poor memory is not seen in all obese humans and takes several months to develop in animal models, indicating the adult brain is relatively resistant to obesity's cognitive effects. We have seen that, in the rat, ov...

journal_title：Journal of neuroinflammation

authors： De Luca SN,Ziko I,Sominsky L,Nguyen JC,Dinan T,Miller AA,Jenkins TA,Spencer SJ

更新日期：2016-05-18 00:00:00

abstract：BACKGROUND:Cell-mediated immunity is critical for clearance of central nervous system (CNS) infection with the encephalitic flavivirus, West Nile virus (WNV). Prior studies from our laboratory have shown that WNV-infected neurons express chemoattractants that mediate recruitment of antiviral leukocytes into the CNS. Al...

journal_title：Journal of neuroinflammation

authors： Durrant DM,Daniels BP,Pasieka T,Dorsey D,Klein RS

更新日期：2015-12-15 00:00:00

abstract：:Mesial temporal lobe epilepsy (mTLE) is a chronic and often treatment-refractory brain disorder characterized by recurrent seizures originating from the hippocampus. The pathogenic mechanisms underlying mTLE remain largely unknown. Recent clinical and experimental evidence supports a role of various inflammatory media...

journal_title：Journal of neuroinflammation

authors： Kan AA,de Jager W,de Wit M,Heijnen C,van Zuiden M,Ferrier C,van Rijen P,Gosselaar P,Hessel E,van Nieuwenhuizen O,de Graan PN

更新日期：2012-08-30 00:00:00

abstract：:Multiple sclerosis (MS) is thought to be a CD4+ T cell mediated autoimmune demyelinating disease of the central nervous system (CNS) that is rarely diagnosed during infancy. Cellular and molecular mechanisms that confer disease resistance in this age group are unknown. We tested the hypothesis that a differential comp...

journal_title：Journal of neuroinflammation

authors： Cravens PD,Kieseier BC,Hussain R,Herndon E,Arellano B,Ben LH,Timmons BC,Castro-Rojas C,Hartung HP,Hemmer B,Weber MS,Zamvil SS,Stüve O

更新日期：2013-05-24 00:00:00

abstract：BACKGROUND:Parkinson's disease (PD) is a neurodegenerative disease with characteristics and symptoms that are well defined. Nevertheless, its aetiology remains unknown. PD is characterized by the presence of Lewy bodies inside neurons. α-Synuclein (α-syn) is a soluble protein present in the pre-synaptic terminal of neu...

journal_title：Journal of neuroinflammation

authors： Yshii LM,Denadai-Souza A,Vasconcelos AR,Avellar MC,Scavone C

更新日期：2015-10-26 00:00:00

abstract：BACKGROUND:Atypical antipsychotic agents, such as clozapine, are used to treat schizophrenia and other psychiatric disorders by a mechanism that is believed to involve modulating the immune system. Multiple sclerosis is an immune-mediated neurological disease, and recently, clozapine was shown to reduce disease severit...

journal_title：Journal of neuroinflammation

authors： Robichon K,Patel V,Connor B,La Flamme AC

更新日期：2020-02-12 00:00:00

abstract：BACKGROUND:Brain microvascular pericytes are important constituents of the neurovascular unit. These cells are physically the closest cells to the microvascular endothelial cells in brain capillaries. They significantly contribute to the induction and maintenance of the barrier functions of the blood-brain barrier. How...

journal_title：Journal of neuroinflammation

authors： Kovac A,Erickson MA,Banks WA

更新日期：2011-10-13 00:00:00

abstract：OBJECTIVE:Febrile seizures are the most common form of childhood seizures. Fever is induced by pro-inflammatory cytokines during infection, and pro-inflammatory cytokines may trigger the development of febrile seizures. In order to determine whether active inflammation, including high mobility group box-1 (HMGB1) and p...

journal_title：Journal of neuroinflammation

authors： Choi J,Min HJ,Shin JS

更新日期：2011-10-11 00:00:00

abstract：BACKGROUND:Human gliomas are highly fatal tumors with a significant feature of immune suppression. The association of the immune system in gliomas is gradually revealed, and immunotherapy is expected to improve the survival of glioma patients. In-depth understanding of the immune microenvironment of gliomas and their a...

journal_title：Journal of neuroinflammation

authors： Feng E,Liang T,Wang X,Du J,Tang K,Wang X,Wang F,You G

更新日期：2019-02-12 00:00:00

abstract：BACKGROUND:The CD133(+) stem cell population in recurrent gliomas is associated with clinical features such as therapy resistance, blood-brain barrier disruption and, hence, tumor infiltration. Screening of a large panel of glioma samples increasing histological grade demonstrated frequencies of CD133(+) cells which co...

journal_title：Journal of neuroinflammation

authors： Annabi B,Laflamme C,Sina A,Lachambre MP,Béliveau R

更新日期：2009-03-09 00:00:00

abstract：BACKGROUND:Neuroinflammation and demyelination have been suggested as mechanisms causing HIV-1 associated neurocognitive disorder (HAND). This cross-sectional cohort study explores the potential role of antibodies to myelin oligodendrocyte glycoprotein (MOG), a putative autoantigen in multiple sclerosis, in the pathoge...

journal_title：Journal of neuroinflammation

authors： Lackner P,Kuenz B,Reindl M,Morandell M,Berger T,Schmutzhard E,Eggers C

更新日期：2010-11-17 00:00:00

abstract：BACKGROUND:Current evidence suggests a role of neuroinflammation in the pathogenesis of Parkinson's disease (PD) and in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of basal ganglia injury. Reportedly, nonsteroidal anti-inflammatory drugs (NSAIDs) mitigate DAergic neurotoxicity in rodent models of PD. ...

journal_title：Journal of neuroinflammation

authors： L'Episcopo F,Tirolo C,Caniglia S,Testa N,Serra PA,Impagnatiello F,Morale MC,Marchetti B

更新日期：2010-11-23 00:00:00

abstract：BACKGROUND:Multiple sclerosis (MS) is an autoimmune demyelinating disease that affects the central nervous system (CNS), leading to neurodegeneration and chronic disability. Accumulating evidence points to a key role for neuroinflammation, oxidative stress, and excitotoxicity in this degenerative process. System xc- or...

journal_title：Journal of neuroinflammation

authors： Merckx E,Albertini G,Paterka M,Jensen C,Albrecht P,Dietrich M,Van Liefferinge J,Bentea E,Verbruggen L,Demuyser T,Deneyer L,Lewerenz J,van Loo G,De Keyser J,Sato H,Maher P,Methner A,Massie A

更新日期：2017-01-13 00:00:00

abstract：BACKGROUND:Ventral root avulsion is a proximal nerve root lesion in which ventral motor nerve rootlets are torn from surface of the spinal cord, resulting in extensive death of motoneurons. It has been previously shown that if such lesioning is performed in an animal with experimental autoimmune encephalomyelitis (EAE)...

journal_title：Journal of neuroinflammation

authors： Barbizan R,Oliveira AL

更新日期：2010-05-04 00:00:00

abstract：BACKGROUND:Microglial activation contributes to the development of chronic migraine (CM). The P2Y12 receptor (P2Y12R), a metabolic purinoceptor that is expressed on microglia in the central nervous system (CNS), has been indicated to play a critical role in the pathogenesis of chronic pain. However, whether it contribu...

journal_title：Journal of neuroinflammation

authors： Jing F,Zhang Y,Long T,He W,Qin G,Zhang D,Chen L,Zhou J

更新日期：2019-11-13 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via the original article. ...

journal_title：Journal of neuroinflammation

authors： Wang YW,Zhou Q,Zhang X,Qian QQ,Xu JW,Ni PF,Qian YN

更新日期：2020-11-24 00:00:00

abstract：BACKGROUND:Ischemic stroke is a main cause of mortality. Blood-brain barrier (BBB) breakdown appears to play a critical role in inflammation in patients with ischemic stroke and acceleration of brain injury. The BBB has a protective function and is composed of endothelial cells, pericytes, and astrocytes. In ischemic s...

journal_title：Journal of neuroinflammation

authors： Kim Y,Lee S,Zhang H,Lee S,Kim H,Kim Y,Won MH,Kim YM,Kwon YG

更新日期：2020-02-04 00:00:00

abstract：BACKGROUND:Conditions of inflammatory tissue distress are associated with high extracellular levels of adenosine, due to increased adenosine triphosphate (ATP) degradation upon cellular stress or the release of extracellular ATP upon cell death, which can be degraded to adenosine by membrane-bound ecto-enzymes like CD3...

journal_title：Journal of neuroinflammation

authors： Ingwersen J,Wingerath B,Graf J,Lepka K,Hofrichter M,Schröter F,Wedekind F,Bauer A,Schrader J,Hartung HP,Prozorovski T,Aktas O

更新日期：2016-02-26 00:00:00

abstract：BACKGROUND:Neuroinflammation in utero may contribute to brain injury resulting in life-long neurological disabilities. The pivotal role of the efferent cholinergic anti-inflammatory pathway (CAP) in controlling inflammation, e.g., by inhibiting the HMGB1 release, via the macrophages' α7 nicotinic acetylcholine receptor...

journal_title：Journal of neuroinflammation

authors： Frasch MG,Szynkaruk M,Prout AP,Nygard K,Cao M,Veldhuizen R,Hammond R,Richardson BS

更新日期：2016-05-10 00:00:00

abstract：BACKGROUND:Neuroinflammation often develops in sepsis leading to activation of cerebral endothelium, increased permeability of the blood-brain barrier (BBB), and neutrophil infiltration. We have identified protein kinase C-delta (PKCδ) as a critical regulator of the inflammatory response and demonstrated that pharmacol...

journal_title：Journal of neuroinflammation

authors： Tang Y,Soroush F,Sun S,Liverani E,Langston JC,Yang Q,Kilpatrick LE,Kiani MF

更新日期：2018-11-06 00:00:00

abstract：BACKGROUND:S100A9 protein (myeloid-related protein MRP14, also referred to as calgranulin B) is a reliable marker of inflammation, an important proinflammatory factor of innate immunity and acts as an additional antimicrobial peptide in the innate immune system. Evidence indicates that S100A9 contributes to Alzheimer's...

journal_title：Journal of neuroinflammation

authors： Lee EO,Yang JH,Chang KA,Suh YH,Chong YH

更新日期：2013-05-30 00:00:00