Activin A increases phagocytosis of Escherichia coli K1 by primary murine microglial cells activated by toll-like receptor agonists.

abstract：BACKGROUND:Preconditioning is a phenomenon by which tolerance develops to injury by previous exposure to a stressor of mild severity. Previous studies have shown that single or repeated low dose MDMA can attenuate 5-HT transporter loss produced by a subsequent neurotoxic dose of the drug. We have explored the mechanism...

journal_title：Journal of neuroinflammation

authors： Mayado A,Torres E,Gutierrez-Lopez MD,Colado MI,O'Shea E

更新日期：2011-11-24 00:00:00

abstract：BACKGROUND:In the healthy central nervous system (CNS), microglia are found in a homeostatic state and peripheral macrophages are absent from the brain. Microglia play key roles in maintaining CNS homeostasis and acting as first responders to infection and inflammation, and peripheral macrophages infiltrate the CNS dur...

journal_title：Journal of neuroinflammation

authors： DePaula-Silva AB,Gorbea C,Doty DJ,Libbey JE,Sanchez JMS,Hanak TJ,Cazalla D,Fujinami RS

更新日期：2019-07-20 00:00:00

abstract：BACKGROUND:Fenofibrate, a PPAR-α activator, has shown promising results as a neuroprotective therapy, with proposed anti-inflammatory and anti-oxidant effects. However, it displays poor blood-brain barrier permeability leading to some ambiguity over its mechanism of action. Experimentally induced brain injury has been ...

journal_title：Journal of neuroinflammation

authors： Losey P,Ladds E,Laprais M,Guevel B,Burns L,Bordet R,Anthony DC

更新日期：2015-05-22 00:00:00

abstract：AIM:Pre-clinical studies in models of multiple sclerosis and other inflammatory disorders suggest that high-salt diet may induce activation of the immune system and potentiate inflammation. However, high-salt diet constitutes a common non-pharmacological intervention to treat autonomic problems in synucleinopathies suc...

journal_title：Journal of neuroinflammation

authors： Heras-Garvin A,Refolo V,Reindl M,Wenning GK,Stefanova N

更新日期：2020-01-24 00:00:00

abstract：:Interleukin (IL)-18 is a cytokine isolated as an important modulator of immune responses and subsequently shown to be pleiotropic. IL-18 and its receptors are expressed in the central nervous system (CNS) where they participate in neuroinflammatory/neurodegenerative processes but also influence homeostasis and behavio...

journal_title：Journal of neuroinflammation

authors： Alboni S,Cervia D,Sugama S,Conti B

更新日期：2010-01-29 00:00:00

abstract：BACKGROUND:Upregulated levels of 18-kDa translocator proteins (TSPO) and type 2 endocannabinoid receptors (CB2) are considered to reflect different aspects of microglia-related neuroinflammatory responses in the brain. Relative to the increase in the TSPO expression that occurs slightly later during neuroinflammation i...

journal_title：Journal of neuroinflammation

authors： Hosoya T,Fukumoto D,Kakiuchi T,Nishiyama S,Yamamoto S,Ohba H,Tsukada H,Ueki T,Sato K,Ouchi Y

更新日期：2017-03-29 00:00:00

abstract：BACKGROUND:Traumatic brain injury (TBI) is a common pathological condition that presently lacks a specific pharmacological treatment. Adenosine levels rise following TBI, which is thought to be neuroprotective against secondary brain injury. Evidence from stroke and inflammatory disease models suggests that adenosine s...

journal_title：Journal of neuroinflammation

authors： Farr SA,Cuzzocrea S,Esposito E,Campolo M,Niehoff ML,Doyle TM,Salvemini D

更新日期：2020-11-12 00:00:00

abstract：BACKGROUND:Neuroinflammation and demyelination have been suggested as mechanisms causing HIV-1 associated neurocognitive disorder (HAND). This cross-sectional cohort study explores the potential role of antibodies to myelin oligodendrocyte glycoprotein (MOG), a putative autoantigen in multiple sclerosis, in the pathoge...

journal_title：Journal of neuroinflammation

authors： Lackner P,Kuenz B,Reindl M,Morandell M,Berger T,Schmutzhard E,Eggers C

更新日期：2010-11-17 00:00:00

abstract：BACKGROUND:Recent evidence suggests that exposure to intrauterine inflammation causes acute fetal brain injury and is linked to a spectrum of neurobehavioral disorders. In a rodent model of intrauterine inflammation induced by lipopolysaccharide (LPS) exposure in utero, activated microglia can be detected in the hippoc...

journal_title：Journal of neuroinflammation

authors： Kelley MH,Wu WW,Lei J,McLane M,Xie H,Hart KD,Pereira L,Burd I,Maylie J

更新日期：2017-09-05 00:00:00

abstract：:Microglia are the primary immunocompetent cells in brain tissue and microglia-mediated inflammation is associated with the pathogenesis of various neuronal disorders. Recently, many studies have shown that mesenchymal stem cells (MSCs) display a remarkable ability to modulate inflammatory and immune responses through ...

journal_title：Journal of neuroinflammation

authors： Liu Y,Zhang R,Yan K,Chen F,Huang W,Lv B,Sun C,Xu L,Li F,Jiang X

更新日期：2014-08-04 00:00:00

abstract：:BACKGROUND: Oligodendrocytes, neurons, astrocytes, microglia, and endothelial cells are capable of synthesizing complement inhibitor proteins. Oligodendrocytes are vulnerable to complement attack, which is particularly observed in multiple sclerosis. This vulnerability may be related to a deficiency in their ability t...

journal_title：Journal of neuroinflammation

authors： Hosokawa M,Klegeris A,McGeer PL

更新日期：2004-08-24 00:00:00

abstract：BACKGROUND:Vascular contributions to cognitive impairment and dementia (VCID) are the second leading cause of dementia behind only Alzheimer's disease (AD); however, VCID is commonly found as a co-morbidity with sporadic AD. We have previously established a mouse model of VCID by inducing hyperhomocysteinemia in both w...

journal_title：Journal of neuroinflammation

authors： Weekman EM,Sudduth TL,Price BR,Woolums AE,Hawthorne D,Seaks CE,Wilcock DM

更新日期：2019-12-30 00:00:00

abstract：BACKGROUND:Rasmussen encephalitis (RE) is a rare neuroinflammatory disease characterized by intractable seizures and progressive atrophy on one side of the cerebrum. Perivascular cuffing and clusters of T cells in the affected cortical hemisphere are indicative of an active cellular immune response. METHODS:Peripheral...

journal_title：Journal of neuroinflammation

authors： Owens GC,Erickson KL,Malone CC,Pan C,Huynh MN,Chang JW,Chirwa T,Vinters HV,Mathern GW,Kruse CA

更新日期：2015-07-19 00:00:00

abstract：BACKGROUND:Repetitive mild traumatic brain injuries (rmTBI) are associated with cognitive deficits, inflammation, and stress-related events. We tested the effect of nutrient intake on the impact of rmTBI in an animal model of chronic traumatic encephalopathy (CTE) to study the pathophysiological mechanisms underlying t...

journal_title：Journal of neuroinflammation

authors： Yu J,Zhu H,Taheri S,Mondy W,Perry S,Kindy MS

更新日期：2018-09-24 00:00:00

abstract：BACKGROUND:DHCR24, involved in the de novo synthesis of cholesterol and protection of neuronal cells against different stress conditions, has been shown to be selectively downregulated in neurons of the affected brain areas in Alzheimer's disease. METHODS:Here, we investigated whether the overexpression of DHCR24 prot...

journal_title：Journal of neuroinflammation

authors： Martiskainen H,Paldanius KMA,Natunen T,Takalo M,Marttinen M,Leskelä S,Huber N,Mäkinen P,Bertling E,Dhungana H,Huuskonen M,Honkakoski P,Hotulainen P,Rilla K,Koistinaho J,Soininen H,Malm T,Haapasalo A,Hiltunen M

更新日期：2017-11-07 00:00:00

abstract：BACKGROUND:Although the acute toxicity of organophosphorus nerve agents is known to result from acetylcholinesterase inhibition, the molecular mechanisms involved in the development of neuropathology following nerve agent-induced seizure are not well understood. To help determine these pathways, we previously used micr...

journal_title：Journal of neuroinflammation

authors： Spradling KD,Lumley LA,Robison CL,Meyerhoff JL,Dillman JF 3rd

更新日期：2011-07-21 00:00:00

abstract：:The complement cascade is a critical effector mechanism of the innate immune system that contributes to the rapid clearance of pathogens and dead or dying cells, as well as contributing to the extent and limit of the inflammatory immune response. In addition, some of the early components of this cascade have been clea...

journal_title：Journal of neuroinflammation

authors： Schartz ND,Tenner AJ

更新日期：2020-11-25 00:00:00

abstract：BACKGROUND:Patients diagnosed with chronic fatigue syndrome (CFS) or fibromyalgia experience chronic pain. Concomitantly, the rat model of CFS exhibits microglial activation in the lumbar spinal cord and pain behavior without peripheral tissue damage and/or inflammation. The present study addressed the mechanism underl...

journal_title：Journal of neuroinflammation

authors： Yasui M,Menjyo Y,Tokizane K,Shiozawa A,Tsuda M,Inoue K,Kiyama H

更新日期：2019-03-30 00:00:00

abstract：BACKGROUND:Neuroinflammation in utero may contribute to brain injury resulting in life-long neurological disabilities. The pivotal role of the efferent cholinergic anti-inflammatory pathway (CAP) in controlling inflammation, e.g., by inhibiting the HMGB1 release, via the macrophages' α7 nicotinic acetylcholine receptor...

journal_title：Journal of neuroinflammation

authors： Frasch MG,Szynkaruk M,Prout AP,Nygard K,Cao M,Veldhuizen R,Hammond R,Richardson BS

更新日期：2016-05-10 00:00:00

abstract：BACKGROUND:Pneumococcal meningitis is the most common and severe form of bacterial meningitis. Fatality rates are substantial, and long-term sequelae develop in about half of survivors. Disease outcome has been related to the severity of the pro-inflammatory response in the subarachnoid space. The complement system, wh...

journal_title：Journal of neuroinflammation

authors： Kasanmoentalib ES,Valls Seron M,Ferwerda B,Tanck MW,Zwinderman AH,Baas F,van der Ende A,Schwaeble WJ,Brouwer MC,van de Beek D

更新日期：2017-01-03 00:00:00

abstract：:We report on a serum autoantibody associated with cerebellar ataxia. Immunohistochemical studies of sera from four patients referred for autoantibody testing revealed binding of high-titer (up to 1:5,000) IgG antibodies, mainly IgG1, to the molecular layer, Purkinje cell layer, and white matter on mouse, rat, porcine,...

journal_title：Journal of neuroinflammation

authors： Jarius S,Scharf M,Begemann N,Stöcker W,Probst C,Serysheva II,Nagel S,Graus F,Psimaras D,Wildemann B,Komorowski L

更新日期：2014-12-11 00:00:00

abstract：BACKGROUND:Aging and neurodegenerative disease predispose to delirium and are both associated with increased activity of the innate immune system resulting in an imbalance between pro- and anti-inflammatory mediators in the brain. We examined whether hip fracture patients who develop postoperative delirium have altered...

journal_title：Journal of neuroinflammation

authors： Westhoff D,Witlox J,Koenderman L,Kalisvaart KJ,de Jonghe JF,van Stijn MF,Houdijk AP,Hoogland IC,Maclullich AM,van Westerloo DJ,van de Beek D,Eikelenboom P,van Gool WA

更新日期：2013-10-07 00:00:00

abstract：BACKGROUND:Mice with pilocarpine-induced temporal lobe epilepsy (TLE) are characterized by intense hippocampal neuroinflammation, a prominent pathological hallmark of TLE that is known to contribute to neuronal hyperexcitability. Recent studies indicate that Adam10, a member of a disintegrin and metalloproteinase domai...

journal_title：Journal of neuroinflammation

authors： Zhu X,Li X,Zhu M,Xu K,Yang L,Han B,Huang R,Zhang A,Yao H

更新日期：2018-08-04 00:00:00

abstract：BACKGROUND:Brain microvascular pericytes are important constituents of the neurovascular unit. These cells are physically the closest cells to the microvascular endothelial cells in brain capillaries. They significantly contribute to the induction and maintenance of the barrier functions of the blood-brain barrier. How...

journal_title：Journal of neuroinflammation

authors： Kovac A,Erickson MA,Banks WA

更新日期：2011-10-13 00:00:00

abstract：BACKGROUND:Synucleinopathies comprise a group of neurodegenerative diseases associated with abnormal accumulation of α-synuclein. One of the key factors that contribute to the progression of synucleinopathies is neuroinflammation. However, the role of lymphocytes in synucleinopathies like Parkinson's disease (PD) remai...

journal_title：Journal of neuroinflammation

authors： Sommer A,Fadler T,Dorfmeister E,Hoffmann AC,Xiang W,Winner B,Prots I

更新日期：2016-06-30 00:00:00

abstract：BACKGROUND:Data indicates anti-oxidant, anti-inflammatory and pro-cognitive properties of noradrenaline and analyses of post-mortem brain of Alzheimer's disease (AD) patients reveal major neuronal loss in the noradrenergic locus coeruleus (LC), the main source of CNS noradrenaline (NA). The LC has projections to brain ...

journal_title：Journal of neuroinflammation

authors： Pugh PL,Vidgeon-Hart MP,Ashmeade T,Culbert AA,Seymour Z,Perren MJ,Joyce F,Bate ST,Babin A,Virley DJ,Richardson JC,Upton N,Sunter D

更新日期：2007-02-26 00:00:00

abstract：BACKGROUND:Tick-borne encephalitis virus (TBEV) is one of the most important flaviviruses that targets the central nervous system (CNS) and causes encephalitides in humans. Although neuroinflammatory mechanisms may contribute to brain tissue destruction, the induction pathways and potential roles of specific chemokines...

journal_title：Journal of neuroinflammation

authors： Zhang X,Zheng Z,Liu X,Shu B,Mao P,Bai B,Hu Q,Luo M,Ma X,Cui Z,Wang H

更新日期：2016-08-30 00:00:00

abstract：BACKGROUND:Determining the etiology and possible treatment strategies for numerous diseases requires a comprehensive understanding of compensatory mechanisms in physiological systems. The vagus nerve acts as a key interface between the brain and the peripheral internal organs. We set out to identify mechanisms compensa...

journal_title：Journal of neuroinflammation

authors： Kobrzycka A,Napora P,Pearson BL,Pierzchała-Koziec K,Szewczyk R,Wieczorek M

更新日期：2019-07-19 00:00:00

abstract：BACKGROUND:Oxidative stress plays an important and causal role in the mechanisms by which ischemia/reperfusion (I/R) injury increases brain damage after stroke. Accordingly, reducing oxidative stress has been proposed as a therapeutic strategy for limiting damage in the brain after stroke. Myeloperoxidase (MPO) is a hi...

journal_title：Journal of neuroinflammation

authors： Yu G,Liang Y,Huang Z,Jones DW,Pritchard KA Jr,Zhang H

更新日期：2016-05-24 00:00:00

abstract：BACKGROUND:The loss of locus coeruleus noradrenergic (LC/NE) neurons in the brainstem is reported in multiple neurodegenerative disorders, including Parkinson's disease (PD). However, the mechanisms remain unclear. Strong evidence suggested that microglia-mediated neuroinflammation contributes to neurodegeneration in P...

journal_title：Journal of neuroinflammation

authors： Hou L,Qu X,Qiu X,Huang R,Zhao X,Wang Q

更新日期：2020-05-06 00:00:00