Interleukin-1beta and tumor necrosis factor-alpha are expressed by different subsets of microglia and macrophages after ischemic stroke in mice.

abstract：BACKGROUND:Tick-borne encephalitis virus (TBEV) is one of the most important flaviviruses that targets the central nervous system (CNS) and causes encephalitides in humans. Although neuroinflammatory mechanisms may contribute to brain tissue destruction, the induction pathways and potential roles of specific chemokines...

journal_title：Journal of neuroinflammation

authors： Zhang X,Zheng Z,Liu X,Shu B,Mao P,Bai B,Hu Q,Luo M,Ma X,Cui Z,Wang H

更新日期：2016-08-30 00:00:00

abstract：BACKGROUND:Ischemic stroke is a main cause of mortality. Blood-brain barrier (BBB) breakdown appears to play a critical role in inflammation in patients with ischemic stroke and acceleration of brain injury. The BBB has a protective function and is composed of endothelial cells, pericytes, and astrocytes. In ischemic s...

journal_title：Journal of neuroinflammation

authors： Kim Y,Lee S,Zhang H,Lee S,Kim H,Kim Y,Won MH,Kim YM,Kwon YG

更新日期：2020-02-04 00:00:00

abstract：BACKGROUND:Ureaplasma species (spp.) are commonly regarded as low-virulent commensals but may cause invasive diseases in immunocompromised adults and in neonates, including neonatal meningitis. The interactions of Ureaplasma spp. with host defense mechanisms are poorly understood. This study addressed Ureaplasma-driven...

journal_title：Journal of neuroinflammation

authors： Silwedel C,Haarmann A,Fehrholz M,Claus H,Speer CP,Glaser K

更新日期：2019-02-14 00:00:00

abstract：BACKGROUND:Experimental autoimmune encephalomyelitis (EAE) is the most commonly used and clinically relevant murine model for human multiple sclerosis (MS), a demyelinating autoimmune disease characterized by mononuclear cell infiltration into the central nervous system (CNS). The aim of the present study was to apprai...

journal_title：Journal of neuroinflammation

authors： Teixeira NB,Picolo G,Giardini AC,Boumezbeur F,Pottier G,Kuhnast B,Servent D,Benoit E

更新日期：2020-09-07 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV) continues to be one of the most prevalent global health afflictions to date. The advent and introduction of combined antiretroviral therapy (cART) has made a significant impact on the course of infection. However, as patients are living longer, many HIV-associated illnesses ar...

journal_title：Journal of neuroinflammation

authors： Davidson DC,Jackson JW,Maggirwar SB

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Multiple Sclerosis (MS) is characterized by the pathological trafficking of leukocytes into the central nervous system (CNS). Using the murine MS model, experimental autoimmune encephalomyelitis (EAE), we previously demonstrated that antagonism of the chemokine receptor CXCR7 blocks endothelial cell sequestr...

journal_title：Journal of neuroinflammation

authors： Cruz-Orengo L,Chen YJ,Kim JH,Dorsey D,Song SK,Klein RS

更新日期：2011-12-06 00:00:00

abstract：BACKGROUND:Dengue, one of the most important arboviral diseases of humans, may cause severe systemic disease. Although dengue virus (DENV) has been considered to be a non-neurotropic virus, dengue infection has been associated recently with a series of neurological syndromes, including encephalitis. In this work, we ev...

journal_title：Journal of neuroinflammation

authors： Amaral DC,Rachid MA,Vilela MC,Campos RD,Ferreira GP,Rodrigues DH,Lacerda-Queiroz N,Miranda AS,Costa VV,Campos MA,Kroon EG,Teixeira MM,Teixeira AL

更新日期：2011-03-09 00:00:00

abstract：:Interleukin (IL)-18 is a cytokine isolated as an important modulator of immune responses and subsequently shown to be pleiotropic. IL-18 and its receptors are expressed in the central nervous system (CNS) where they participate in neuroinflammatory/neurodegenerative processes but also influence homeostasis and behavio...

journal_title：Journal of neuroinflammation

authors： Alboni S,Cervia D,Sugama S,Conti B

更新日期：2010-01-29 00:00:00

abstract：BACKGROUND:The cellular prion protein (PrPC) is an evolutionary conserved protein abundantly expressed not only in the central nervous system but also peripherally including the immune system. A line of Norwegian dairy goats naturally devoid of PrPC (PRNP Ter/Ter) provides a novel model for studying PrPC physiology. M...

journal_title：Journal of neuroinflammation

authors： Salvesen Ø,Reiten MR,Espenes A,Bakkebø MK,Tranulis MA,Ersdal C

更新日期：2017-05-22 00:00:00

abstract：BACKGROUND:Over-activated microglia play a central role during neuroinflammation, leading to neuronal cell death and neurodegeneration. Reversion of over-activated to neuroprotective microglia phenotype could regenerate a healthy CNS-supporting microglia environment. Our aim was to identify a dataset of intracellular m...

journal_title：Journal of neuroinflammation

authors： Neubrand VE,Forte-Lago I,Caro M,Delgado M

更新日期：2018-12-15 00:00:00

abstract：BACKGROUND:Recent work has established that Parkinson's disease (PD) patients have an altered gut microbiome, along with signs of intestinal inflammation. This could help explain the high degree of gastric disturbances in PD patients, as well as potentially be linked to the migration of peripheral inflammatory factors ...

journal_title：Journal of neuroinflammation

authors： Dwyer Z,Chaiquin M,Landrigan J,Ayoub K,Shail P,Rocha J,Childers CL,Storey KB,Philpott DJ,Sun H,Hayley S

更新日期：2021-01-09 00:00:00

abstract：BACKGROUND:Local and systemic inflammatory responses are initiated early after traumatic brain injury (TBI), and may play a key role in the secondary injury processes resulting in neuronal loss and neurological deficits. However, the mechanisms responsible for the rapid expansion of neuroinflammation and its long-term ...

journal_title：Journal of neuroinflammation

authors： Kumar A,Stoica BA,Loane DJ,Yang M,Abulwerdi G,Khan N,Kumar A,Thom SR,Faden AI

更新日期：2017-03-15 00:00:00

abstract：BACKGROUND:Microglial dysfunction is implicated in frontotemporal lobar degeneration (FTLD). Although studies have reported excessive microglial activation or senescence (dystrophy) in Alzheimer's disease (AD), few have explored this in FTLD. We examined regional patterns of microglial burden, activation and dystrophy ...

journal_title：Journal of neuroinflammation

authors： Woollacott IOC,Toomey CE,Strand C,Courtney R,Benson BC,Rohrer JD,Lashley T

更新日期：2020-08-10 00:00:00

abstract：:Increasing evidence suggests that toll-like receptors (TLRs) play an important role in cerebral ischemia-reperfusion injury. The endogenous ligands released from ischemic neurons activate the TLR signaling pathway, resulting in the production of a large number of inflammatory cytokines, thereby causing secondary infla...

journal_title：Journal of neuroinflammation

authors： Wang PF,Xiong XY,Chen J,Wang YC,Duan W,Yang QW

更新日期：2015-04-28 00:00:00

abstract：BACKGROUND:The peripheral immune system is implicated in modulating microglial activation, neurodegeneration and disease progression in amyotrophic lateral sclerosis (ALS). Specifically, there is reduced thymic function and regulatory T cell (Treg) number in ALS patients and mutant superoxide dismutase 1 (SOD1) mice, w...

journal_title：Journal of neuroinflammation

authors： Sheean RK,Weston RH,Perera ND,D'Amico A,Nutt SL,Turner BJ

更新日期：2015-02-27 00:00:00

abstract：BACKGROUND:Alzheimer's disease (AD) is characterized by extracellular β-amyloid (Aβ) plaques, neurofibrillary tangles (NFTs), and microglia-dominated neuroinflammation. The Nogo/NgR signal pathway is involved in AD pathological features, but the detailed mechanism needs further investigation. Our previous studies have ...

journal_title：Journal of neuroinflammation

authors： Fang Y,Yao L,Li C,Wang J,Wang J,Chen S,Zhou XF,Liao H

更新日期：2016-03-03 00:00:00

abstract：BACKGROUND:Parkinson's disease (PD) is frequently associated with gastrointestinal (GI) symptoms, including constipation and defecatory dysfunctions. The mechanisms underlying such disorders are still largely unknown, although the occurrence of a bowel inflammatory condition has been hypothesized. This study examined t...

journal_title：Journal of neuroinflammation

authors： Pellegrini C,Fornai M,Colucci R,Tirotta E,Blandini F,Levandis G,Cerri S,Segnani C,Ippolito C,Bernardini N,Cseri K,Blandizzi C,Haskó G,Antonioli L

更新日期：2016-06-13 00:00:00

abstract：BACKGROUND:Determining the etiology and possible treatment strategies for numerous diseases requires a comprehensive understanding of compensatory mechanisms in physiological systems. The vagus nerve acts as a key interface between the brain and the peripheral internal organs. We set out to identify mechanisms compensa...

journal_title：Journal of neuroinflammation

authors： Kobrzycka A,Napora P,Pearson BL,Pierzchała-Koziec K,Szewczyk R,Wieczorek M

更新日期：2019-07-19 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a paralyzing disorder characterized by the progressive degeneration and death of motor neurons and occurs both as a sporadic and familial disease. Mutant SOD1 (mtSOD1) in motor neurons induces vulnerability to the disease through protein misfolding, mitochondrial dysfunction, oxi...

journal_title：Journal of neuroinflammation

authors： Yang EJ,Kim SH,Yang SC,Lee SM,Choi SM

更新日期：2011-06-20 00:00:00

abstract：BACKGROUND:There is a need for clinically useful biomarkers of disease activity in clinically isolated syndrome (CIS) and relapsing remitting MS (RRMS). The aim of this study was to assess the correlation between neurofilament light chain (NFL) in cerebrospinal fluid (CSF) and serum and the relationship between NFL and...

journal_title：Journal of neuroinflammation

authors： Håkansson I,Tisell A,Cassel P,Blennow K,Zetterberg H,Lundberg P,Dahle C,Vrethem M,Ernerudh J

更新日期：2018-07-18 00:00:00

abstract：BACKGROUND:Microglia and astrocytes respond to homeostatic disturbances with profound changes of gene expression. This response, known as glial activation or neuroinflammation, can be detrimental to the surrounding tissue. The transcription factor CCAAT/enhancer binding protein β (C/EBPβ) is an important regulator of g...

journal_title：Journal of neuroinflammation

authors： Straccia M,Gresa-Arribas N,Dentesano G,Ejarque-Ortiz A,Tusell JM,Serratosa J,Solà C,Saura J

更新日期：2011-11-10 00:00:00

abstract：BACKGROUND:Increasing evidence supports a key role for inflammation in the neurodegenerative process of familial amyloidotic polyneuropathy (FAP). While there seems to be an overactivation of the neuronal interleukin-1 signaling pathway, the immune response is apparently compromised in FAP. Accordingly, little immune c...

journal_title：Journal of neuroinflammation

authors： Gonçalves NP,Moreira J,Martins D,Vieira P,Obici L,Merlini G,Saraiva M,Saraiva MJ

更新日期：2017-06-06 00:00:00

abstract：:Stroke is one of the leading causes of death worldwide. A strong inflammatory response characterized by activation and release of cytokines, chemokines, adhesion molecules, and proteolytic enzymes contributes to brain damage following stroke. Stroke outcomes are worse among diabetics, resulting in increased mortality ...

journal_title：Journal of neuroinflammation

authors： Shukla V,Shakya AK,Perez-Pinzon MA,Dave KR

更新日期：2017-01-23 00:00:00

abstract：BACKGROUND:Inflammation is a critical process for the progression of neuronal death in neurodegenerative disorders. Microglia play a central role in neuroinflammation and may affect neuron vulnerability. Next generation sequencing has shown the molecular heterogeneity of microglial cells; however, the variability in th...

journal_title：Journal of neuroinflammation

authors： Abellanas MA,Zamarbide M,Basurco L,Luquin E,Garcia-Granero M,Clavero P,San Martin-Uriz P,Vilas A,Mengual E,Hervas-Stubbs S,Aymerich MS

更新日期：2019-11-22 00:00:00

abstract：BACKGROUND:Social deficit is one of the core symptoms of neuropsychiatric diseases, in which immune genes play an important role. Although a few immune genes have been shown to regulate social and emotional behaviors, how immune gene network(s) may jointly regulate sociability has not been investigated so far. METHODS...

journal_title：Journal of neuroinflammation

authors： Ma L,Piirainen S,Kulesskaya N,Rauvala H,Tian L

更新日期：2015-04-18 00:00:00

abstract：BACKGROUND:Immune activation, specifically activation of macrophages and resident microglia, leading to inflammation is a key component in the progression of spinal cord injury (SCI). Macrophages/microglia exist in two states-the classically activated M1 phenotype that confers pro-inflammatory effects or the alternativ...

journal_title：Journal of neuroinflammation

authors： Xu S,Zhu W,Shao M,Zhang F,Guo J,Xu H,Jiang J,Ma X,Xia X,Zhi X,Zhou P,Lu F

更新日期：2018-05-22 00:00:00

abstract：BACKGROUND:Chemokine (C-X3-C motif) ligand 1 (CX3CL1)/ CX3C chemokine receptor 1 (CX3CR1) signaling is important in modulating the communication between neurons and resident microglia/migrated macrophages in the central nervous system (CNS). Although CX3CR1 deficiency is associated with an improved outcome following is...

journal_title：Journal of neuroinflammation

authors： Tang Z,Gan Y,Liu Q,Yin JX,Liu Q,Shi J,Shi FD

更新日期：2014-02-03 00:00:00

abstract：BACKGROUND:Persistent and/or recurrent inflammatory processes are the main factor leading to multiple sclerosis (MS) lesions. The composite ultramicronized palmitoylethanolamide, an endogenous N-acylethanolamine, combined with the flavonoid luteolin, PEALut, have been found to exert neuroprotective activities in experi...

journal_title：Journal of neuroinflammation

authors： Contarini G,Franceschini D,Facci L,Barbierato M,Giusti P,Zusso M

更新日期：2019-06-20 00:00:00

abstract：BACKGROUND:Pain is one critical hallmark of inflammatory responses. A large number of studies have demonstrated that stromal cell-derived factor 1 (SDF1, also named as CXCL12) and its cognate receptor C-X-C chemokine receptor type 4 (CXCR4) play an important role in immune reaction and inflammatory processes. However, ...

journal_title：Journal of neuroinflammation

authors： Yang F,Sun W,Yang Y,Wang Y,Li CL,Fu H,Wang XL,Yang F,He T,Chen J

更新日期：2015-11-24 00:00:00

abstract：BACKGROUND:It is well known that methamphetamine (METH) is neurotoxic and recent studies have suggested the involvement of neuroinflammatory processes in brain dysfunction induced by misuse of this drug. Indeed, glial cells seem to be activated in response to METH, but its effects on microglial cells are not fully unde...

journal_title：Journal of neuroinflammation

authors： Coelho-Santos V,Gonçalves J,Fontes-Ribeiro C,Silva AP

更新日期：2012-07-06 00:00:00