Two Behavioral Tests Allow a Better Correlation Between Cognitive Function and Expression of Synaptic Proteins.

abstract：:Studies of the neural mechanisms of navigation and context discrimination have generated a powerful heuristic for understanding how neural codes, circuits, and computations contribute to accurate behavior as animals traverse and learn about spatially extended environments. It is assumed that memories are updated as a ...

journal_title：Frontiers in aging neuroscience

authors： Penner MR,Mizumori SJ

更新日期：2012-08-08 00:00:00

abstract：:[This corrects the article on p. 7 in vol. 7, PMID: 25762930.]. ...

journal_title：Frontiers in aging neuroscience

authors： Sanz L,Murillo-Cuesta S,Cobo P,Cediel R,Contreras J,Rivera T,Varela-Nieto I,Avendaño C

更新日期：2015-05-12 00:00:00

abstract：:Alzheimer disease (AD) has an insidious onset and heterogeneous clinical symptoms. The well-accepted biomarkers for clinical diagnosis of AD include β-amyloid (Aβ) deposition and pathologic tau level within cerebral spinal fluid (CSF) and imaging AD pathology such as positive emission tomography (PET) imaging of the a...

journal_title：Frontiers in aging neuroscience

authors： Jiao F,Yi F,Wang Y,Zhang S,Guo Y,Du W,Gao Y,Ren J,Zhang H,Liu L,Song H,Wang L

更新日期：2020-07-21 00:00:00

abstract：:With promising results in recent treatment trials for Alzheimer's disease (AD), it becomes increasingly important to distinguish AD at early stages from other causes for cognitive impairment. However, existing diagnostic methods are either invasive (lumbar punctures, PET) or inaccurate Magnetic Resonance Imaging (MRI)...

journal_title：Frontiers in aging neuroscience

authors： Gurevich P,Stuke H,Kastrup A,Stuke H,Hildebrandt H

更新日期：2017-04-25 00:00:00

abstract：:Glutamate transporter solute carrier family 1, member 2 (GLT1/EAAT2), a major modulator of glutamate homeostasis in astrocytes, is assessed in post-mortem human brain samples of frontal cortex area 8 in advanced stages of Alzheimer disease (AD) and terminal stages of dementia with Lewy bodies (DLB) in order to gain un...

journal_title：Frontiers in aging neuroscience

authors： Garcia-Esparcia P,Diaz-Lucena D,Ainciburu M,Torrejón-Escribano B,Carmona M,Llorens F,Ferrer I

更新日期：2018-04-26 00:00:00

abstract：:Herpes simplex virus type 1 (HSV1), when present in brain of carriers of the type 4 allele of the apolipoprotein E gene (APOE), has been implicated as a major factor in Alzheimer's disease (AD). It is proposed that virus is normally latent in many elderly brains but reactivates periodically (as in the peripheral nervo...

journal_title：Frontiers in aging neuroscience

authors： Itzhaki RF

更新日期：2014-08-11 00:00:00

abstract：:Exercise may be the most commonly offered yet least consistently followed therapeutic advice for people with Parkinson's disease (PD). Epidemiological studies of prospectively followed cohorts have shown a lower risk for later developing PD in healthy people who report moderate to high levels of physical activity, and...

journal_title：Frontiers in aging neuroscience

authors： Crotty GF,Schwarzschild MA

更新日期：2020-06-19 00:00:00

abstract：:While aging can lead to significant declines in perceptual and cognitive function, the effects of age on multisensory integration, the process in which the brain combines information across the senses, are less clear. Recent reports suggest that older adults are susceptible to the sound-induced flash illusion (Shams e...

journal_title：Frontiers in aging neuroscience

authors： McGovern DP,Roudaia E,Stapleton J,McGinnity TM,Newell FN

更新日期：2014-09-24 00:00:00

abstract：:Despite potential implications for the early detection of impending Alzheimer's disease (AD), very little is known about the differences of large-scale brain networks between amnestic mild cognitive impairment (aMCI) with high cerebral amyloid-beta protein (Aβ) deposition (i.e., aMCI+) and aMCI with no or very little ...

journal_title：Frontiers in aging neuroscience

authors： Yi D,Choe YM,Byun MS,Sohn BK,Seo EH,Han J,Park J,Woo JI,Lee DY

更新日期：2015-02-19 00:00:00

abstract：:Age-related cognitive decline has been linked to a diverse set of neurobiological mechanisms, including bidirectional changes in proteins critical for neuron function. Importantly, these alterations are not uniform across the brain. For example, the hippocampus (HPC) and prefrontal cortex (PFC) show distinct patterns ...

journal_title：Frontiers in aging neuroscience

authors： Hernandez AR,Hernandez CM,Campos K,Truckenbrod L,Federico Q,Moon B,McQuail JA,Maurer AP,Bizon JL,Burke SN

更新日期：2018-12-03 00:00:00

abstract：:Parkinson's disease (PD) is the most common progressive neurodegenerative movement disorder, characterized by the selective loss of nigrostriatal dopaminergic neurons, and the presence of intracellular insoluble proteinaceous inclusions, known as Lewy Bodies. Although PD etiopathogenesis remains elusive, the leading h...

journal_title：Frontiers in aging neuroscience

authors： Branco DM,Arduino DM,Esteves AR,Silva DF,Cardoso SM,Oliveira CR

更新日期：2010-05-21 00:00:00

abstract：:The alteration of the functional topological organization in subcortical ischemic vascular cognitive impairment with no dementia (SIVCIND) patients has been illuminated by previous neuroimaging studies. However, in regard to the changes in the structural connectivity of brain networks, little has been reported. In thi...

journal_title：Frontiers in aging neuroscience

authors： Sang L,Liu C,Wang L,Zhang J,Zhang Y,Li P,Qiao L,Li C,Qiu M

更新日期：2020-01-29 00:00:00

abstract：:Characterizing the cognitive declines associated with aging, and differentiating them from the effects of disease in older adults, are important goals for human neuroscience researchers. This is also an issue of public health urgency in countries with rapidly aging populations. Progress toward understanding cognitive ...

journal_title：Frontiers in aging neuroscience

authors： Geldmacher DS,Levin BE,Wright CB

更新日期：2012-09-12 00:00:00

abstract：:[This corrects the article on p. 13 in vol. 8, PMID: 26903857.]. ...

journal_title：Frontiers in aging neuroscience

authors： Hu YB,Li CB,Song N,Zou Y,Chen SD,Ren RJ,Wang G

更新日期：2017-02-23 00:00:00

abstract：:Background: Facial emotion recognition (FER) is impaired in individuals with frontotemporal dementia (FTD) and Alzheimer's disease (AD) when compared to healthy older adults. Since deficits in emotion recognition are closely related to caregiver burden or social interactions, researchers have fundamental interest in F...

journal_title：Frontiers in aging neuroscience

authors： Park S,Kim T,Shin SA,Kim YK,Sohn BK,Park HJ,Youn JH,Lee JY

更新日期：2017-11-30 00:00:00

abstract：:Mitochondrial dysfunction is a common and prominent feature of prion diseases and other neurodegenerative disorders. Mitochondria are dynamic organelles that constantly fuse with one another and subsequently break apart. Defective or superfluous mitochondria are usually eliminated by a form of autophagy, referred to a...

journal_title：Frontiers in aging neuroscience

authors： Zhu T,Chen JL,Wang Q,Shao W,Qi B

更新日期：2018-11-05 00:00:00

abstract：:Previous studies have shown that pupillary response, a physiological measure of cognitive workload, reflects cognitive demand in healthy younger and older adults. However, the relationship between cognitive workload and cognitive demand in Parkinson's disease (PD) remains unclear. The aim of this pilot study was to ex...

journal_title：Frontiers in aging neuroscience

authors： Kahya M,Moon S,Lyons KE,Pahwa R,Akinwuntan AE,Devos H

更新日期：2018-04-10 00:00:00

abstract：:Background and Purpose: Olfactory dysfunction (OD) is a common non-motor symptom of Parkinson disease (PD). However, the relationship between OD and neuropathologic proteins in cerebrospinal fluid (CSF) from PD patients remains unclear. Methods: 166 PD patients were included in the study. Overall olfactory function wa...

journal_title：Frontiers in aging neuroscience

authors： Guo P,Wang RD,Lian TH,Ding DY,Zhang YN,Zhang WJ,Li DN,Li LX,Li JH,Guan HY,Yu SY,Liu L,Hu Y,Zuo LJ,Yu QJ,Wang XM,Zhang W

更新日期：2020-12-11 00:00:00

abstract：:There is a need for rapid and reliable Internet-based screening tools for cognitive assessment in middle-aged and older adults. We report the psychometric properties of an on-line tool designed to screen for cognitive deficits that require further investigation. The tool is composed of measures of memory and executive...

journal_title：Frontiers in aging neuroscience

authors： Troyer AK,Rowe G,Murphy KJ,Levine B,Leach L,Hasher L

更新日期：2014-12-10 00:00:00

abstract：:The recent advent of tau-specific positron emission tomography (PET) has enabled in vivo assessment of tau pathology in Alzheimer's disease (AD). However, because PET scanners have limited spatial resolution, the measured signals of small brain structures or atrophied areas are underestimated by partial volume effects...

journal_title：Frontiers in aging neuroscience

authors： Shigemoto Y,Sone D,Imabayashi E,Maikusa N,Okamura N,Furumoto S,Kudo Y,Ogawa M,Takano H,Yokoi Y,Sakata M,Tsukamoto T,Kato K,Sato N,Matsuda H

更新日期：2018-07-18 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disease, for which aging remains the major risk factor. Aging is under a consistent pressure of increasing brain entropy (BEN) due to the progressive brain deteriorations. Noticeably, the brain constantly consumes a large amount of energy to maintain its func...

journal_title：Frontiers in aging neuroscience

authors： Wang Z,Alzheimer’s Disease Neuroimaging Initiative.

更新日期：2020-11-10 00:00:00

abstract：OBJECTIVE:Temporo-parietal cortex thinning is associated to mild cognitive impairment (MCI) due to Alzheimer disease (AD). The increase of EEG upper/low alpha power ratio has been associated with AD-converter MCI subjects. We investigated the association of alpha3/alpha2 ratio with patterns of cortical thickness in MCI...

journal_title：Frontiers in aging neuroscience

authors： Moretti DV,Paternicò D,Binetti G,Zanetti O,Frisoni GB

更新日期：2013-10-25 00:00:00

abstract：:Cognitive Reserve is the capital of knowledge and experiences that an individual acquires over their life-span. Cognitive Reserve is strictly related to Brain Reserve, which is the ability of the brain to cope with damage. These two concepts could explain many phenomena such as the modality of onset in dementia or the...

journal_title：Frontiers in aging neuroscience

authors： Arcara G,Mondini S,Bisso A,Palmer K,Meneghello F,Semenza C

更新日期：2017-12-22 00:00:00

abstract：:Background: Parkinson's disease (PD) is one of the most common neurodegenerative diseases. Variants in the LRRK2 gene have been shown to be associated with PD. However, the clinical characteristics of LRRK2-related PD are heterogeneous. In our study, we performed a comprehensive pooled analysis of the association betw...

journal_title：Frontiers in aging neuroscience

authors： Shu L,Zhang Y,Pan H,Xu Q,Guo J,Tang B,Sun Q

更新日期：2018-09-19 00:00:00

abstract：:Background and Purpose: Previous studies of voxel-based morphometry (VBM) have found that patients with type 2 diabetes mellitus (T2DM) exhibit gray matter alterations, but these findings are inconsistent and have not been quantitatively reviewed. Therefore, the aim of this study was to conduct a quantitative meta-ana...

journal_title：Frontiers in aging neuroscience

authors： Liu J,Liu T,Wang W,Ma L,Ma X,Shi S,Gong Q,Wang M

更新日期：2017-05-22 00:00:00

abstract：:Despite varied etiologies and symptoms, several neurodegenerative diseases-specifically, Alzheimer's (AD), Parkinson's (PD), and Huntington's diseases (HDs)-share the common feature of abnormal circadian rhythms, such as those in behavior (e.g., disrupted sleep/wake cycles), physiological processes (e.g., diminished h...

journal_title：Frontiers in aging neuroscience

authors： Hood S,Amir S

更新日期：2017-05-30 00:00:00

abstract：:Stroke is a major public health problem worldwide with a high burden of neurological disability and mortality. Long noncoding RNAs (lncRNAs) have attracted much attention in the past decades because of their newly discovered roles in pathophysiological processes in many diseases. The abundance of lncRNAs in the nervou...

journal_title：Frontiers in aging neuroscience

authors： Fan J,Saft M,Sadanandan N,Gonzales-Portillo B,Park YJ,Sanberg PR,Borlongan CV,Luo Y

更新日期：2020-10-19 00:00:00

abstract：:Objectives: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common hereditary small vessel disease, with reported frequencies of 2-5/100,000 individuals. Recently, it has been reported that some patients with NOTCH3 gene mutations show atypical clinical ...

journal_title：Frontiers in aging neuroscience

authors： Okada T,Washida K,Irie K,Saito S,Noguchi M,Tomita T,Koga M,Toyoda K,Okazaki S,Koizumi T,Mizuta I,Mizuno T,Ihara M

更新日期：2020-05-14 00:00:00

abstract：:Alzheimer's disease (AD) and treatment of the brain in aging require the development of new biologic drugs, such as recombinant proteins or gene therapies. Biologics are large molecule therapeutics that do not cross the blood-brain barrier (BBB). BBB drug delivery is the limiting factor in the future development of ne...

journal_title：Frontiers in aging neuroscience

authors： Pardridge WM

更新日期：2020-01-10 00:00:00

abstract：:Background: Leisure-time physical activity (PA) has been proposed as a protective factor against dementia, whereas psychological distress is associated with an increased risk of dementia. We investigated the associations of leisure-time PA and psychological distress with dementia-related mortality, and whether the ass...

journal_title：Frontiers in aging neuroscience

authors： Zotcheva E,Selbæk G,Bjertness E,Ernstsen L,Strand BH

更新日期：2018-05-25 00:00:00