Oxidative Stress and Renal Fibrosis: Recent Insights for the Development of Novel Therapeutic Strategies.

abstract：:As opposed to the standard tolerogenic apoptosis, immunogenic cell death (ICD) constitutes a type of cellular demise that elicits an adaptive immune response. ICD has been characterized in malignant cells following cytotoxic interventions, such as chemotherapy or radiotherapy. Briefly, ICD of cancer cells releases som...

journal_title：Frontiers in physiology

authors： Checcoli A,Pol JG,Naldi A,Noel V,Barillot E,Kroemer G,Thieffry D,Calzone L,Stoll G

更新日期：2020-11-12 00:00:00

abstract：:A coronary angiography-derived index of microvascular resistance (caIMR) is proposed for physiological assessment of microvasular diseases in coronary circulation. The aim of the study is to assess diagnostic performance of caIMR, using wire-derived index of microvascular resistance (IMR) as the reference standard. IM...

journal_title：Frontiers in physiology

authors： Ai H,Feng Y,Gong Y,Zheng B,Jin Q,Zhang HP,Sun F,Li J,Chen Y,Huo Y,Huo Y

更新日期：2020-12-16 00:00:00

abstract：:Calcium is an important second messenger required not only for the excitation-contraction coupling of the heart but also critical for the activation of cell signaling pathways involved in the adverse cardiac remodeling and consequently for the heart failure. Sustained neurohumoral activation, pressure-overload, or myo...

journal_title：Frontiers in physiology

authors： Falcón D,Galeano-Otero I,Calderón-Sánchez E,Del Toro R,Martín-Bórnez M,Rosado JA,Hmadcha A,Smani T

更新日期：2019-03-01 00:00:00

abstract：:Mouse Embryonic Stem Cells (ESCs) are pluripotent mammalian cells derived from the Inner Cell Mass (ICM) of mouse blastocysts, which give rise to all three embryonic germ layers both in vivo and in vitro. Mouse ESCs have a distinct epigenetic landscape and a more decondensed chromatin compared to differentiated cells....

journal_title：Frontiers in physiology

authors： Karnavas T,Pintonello L,Agresti A,Bianchi ME

更新日期：2014-08-28 00:00:00

abstract：:Corpus luteum (CL) is a transient endocrine tissue that produces progesterone for maintaining pregnancy in mammals. In addition, the regression of CL is necessary for the initiation of the estrous cycle. Extensive research has shown that the prostaglandin F2α (PGF2α) induces the regression of CL in ruminants. However,...

journal_title：Frontiers in physiology

authors： Wen X,Liu L,Li S,Lin P,Chen H,Zhou D,Tang K,Wang A,Jin Y

更新日期：2020-09-11 00:00:00

abstract：:We tested the hypotheses that prior aerobic (Study 1) or anaerobic (Study 2) exercise attenuates the increase in renal vascular resistance (RVR) during sympathetic stimulation. Ten healthy young adults (5 females) participated in both Study 1 (aerobic exercise) and Study 2 (anaerobic exercise). In Study 1, subjects co...

journal_title：Frontiers in physiology

authors： Schlader ZJ,Chapman CL,Benati JM,Gideon EA,Vargas NT,Lema PC,Johnson BD

更新日期：2019-01-10 00:00:00

abstract：:Hemoglobin (Hb) is a highly conserved molecule present in all life forms and functionally tied to the complexity of aerobic organisms on earth in utilizing oxygen from the atmosphere and delivering to cells and tissues. This primary function sustains the energy requirements of cells and maintains cellular homeostasis....

journal_title：Frontiers in physiology

authors： Quaye IK

更新日期：2015-04-20 00:00:00

abstract：:Before they develop competent endothermy, mammals and birds are sensitive to fluctuating temperature. It follows that early life thermal environment can trigger changes to the ontogeny of thermoregulatory control. At the ecological level, we have incomplete knowledge of how such responses affect temperature tolerance ...

journal_title：Frontiers in physiology

authors： Nord A,Giroud S

更新日期：2020-05-25 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) not only play essential roles in bone development but also are involved in embryonic growth, organogenesis cell proliferation and differentiation. However, the previous studies on the functions of shellfish BMPs genes are still very limited. To better understand its molecular structu...

journal_title：Frontiers in physiology

authors： Zhao J,Cui B,Yao H,Lin Z,Dong Y

更新日期：2020-08-28 00:00:00

abstract：:Head-down bed rest (HDBR) is commonly considered as ground-based analog to spaceflight and simulates the headward fluid shift and cardiovascular deconditioning associated with spaceflight. We investigated in healthy volunteers whether HDBR, with or without countermeasures, affect cerebral autoregulation (CA). Twelve m...

journal_title：Frontiers in physiology

authors： Kermorgant M,Nasr N,Custaud MA,Navasiolava N,Arbeille P,Guinet P,Labrunée M,Besnier F,Arvanitis DN,Czosnyka M,Senard JM,Pavy-Le Traon A

更新日期：2019-08-27 00:00:00

abstract：Purpose:To examine physiological and technical responses to repeated-sprint training in normobaric hypoxia at ∼3,000 m (RSH, n = 11) or in normoxia (RSN, n = 11) compared to a control group (CON, n = 8) in well-trained tennis players. Participants were 28.8 ± 5.9 years old without any previous experience of training in...

journal_title：Frontiers in physiology

authors： Brechbuhl C,Brocherie F,Willis SJ,Blokker T,Montalvan B,Girard O,Millet GP,Schmitt L

更新日期：2020-12-18 00:00:00

abstract：:Advances in high-performance computing are enabling a new generation of software tools that employ computational modeling for surgical planning. Surgical management of laryngeal paralysis is one area where such computational tools could have a significant impact. The current paper describes a comprehensive effort to d...

journal_title：Frontiers in physiology

authors： Mittal R,Zheng X,Bhardwaj R,Seo JH,Xue Q,Bielamowicz S

更新日期：2011-05-02 00:00:00

abstract：UNLABELLED:Since Matrix metalloproteinases (MMPs) have been suggested to contribute to dentin caries progression, the hypothesis that MMP inhibition would affect the progression of dentin caries is clinically relevant. Grape seed extracts (GSE) have been previously reported to be natural inhibitors of MMPs. OBJECTIVE:...

journal_title：Frontiers in physiology

authors： Khaddam M,Salmon B,Le Denmat D,Tjaderhane L,Menashi S,Chaussain C,Rochefort GY,Boukpessi T

更新日期：2014-10-31 00:00:00

abstract：:Carbon monoxide (CO) that is produced in a number of different mammalian tissues is now known to have significant effects on the cardiovascular system. These include: (i) vasodilation, (ii) changes in heart rate and strength of contractions, and (iii) modulation of autonomic nervous system input to both the primary pa...

journal_title：Frontiers in physiology

authors： Trenor B,Cardona K,Saiz J,Rajamani S,Belardinelli L,Giles WR

更新日期：2013-10-17 00:00:00

abstract：:Sensory receptors, including olfactory receptors (ORs), taste receptors (TRs), and opsins (Opns) have recently been found in a variety of non-sensory tissues where they have distinct physiological functions. As G protein-coupled receptors (GPCRs), these proteins can serve as important chemosensors by sensing and inter...

journal_title：Frontiers in physiology

authors： Kurtz R,Steinberg LG,Betcher M,Fowler D,Shepard BD

更新日期：2020-10-06 00:00:00

abstract：:Untreated chronic hypertension causes left ventricular hypertrophy, which is related to the occurrence of atrial fibrillation. Dronedarone is an antiarrhythmic agent recently approved for atrial fibrillation. Our group previously demonstrated that dronedarone produced an early regression of left ventricular hypertroph...

journal_title：Frontiers in physiology

authors： Pazó-Sayós L,González MC,Quintana-Villamandos B

更新日期：2020-08-26 00:00:00

abstract：:The purpose of this study was to examine the effects of a short-term ketogenic diet (KD) on body composition and cardiorespiratory fitness (CRF) in overweight/obese Chinese females. Twenty young females [age: 21.0 ± 3.7 years, weight: 65.5 ± 7.7 kg, body mass index (BMI): 24.9 ± 2.7 kg⋅m-2] consumed 4 weeks of a norma...

journal_title：Frontiers in physiology

authors： Kong Z,Sun S,Shi Q,Zhang H,Tong TK,Nie J

更新日期：2020-07-28 00:00:00

abstract：:Gut-brain signaling controls feeding behavior and energy homeostasis; however, the underlying molecular mechanisms and impact of diet-induced obesity (DIO) on these pathways are poorly defined. We tested the hypothesis that elevated endocannabinoid activity at cannabinoid CB1 receptor (CB1Rs) in the gut of mice render...

journal_title：Frontiers in physiology

authors： Argueta DA,Perez PA,Makriyannis A,DiPatrizio NV

更新日期：2019-06-11 00:00:00

abstract：:The vascular endothelium supplying the brain exhibits very low paracellular and transcellular permeability and is a major constituent of the blood-brain barrier. High-density lipoprotein (HDL) crosses the blood-brain barrier by transcytosis, but technical limitations have made it difficult to elucidate its regulation....

journal_title：Frontiers in physiology

authors： Fung KY,Wang C,Nyegaard S,Heit B,Fairn GD,Lee WL

更新日期：2017-10-30 00:00:00

abstract：:We tested the hypothesis that elastic binding of the abdomen (AB) would enhance neuromuscular efficiency of the human diaphragm during exercise. Twelve healthy non-obese men aged 24.8 ± 1.7 years (mean ± SE) completed a symptom-limited constant-load cycle endurance exercise test at 85% of their peak incremental power ...

journal_title：Frontiers in physiology

authors： Abdallah SJ,Chan DS,Glicksman R,Mendonca CT,Luo Y,Bourbeau J,Smith BM,Jensen D

更新日期：2017-05-31 00:00:00

abstract：:Heart failure with preserved ejection fraction (HFpEF) is an increasingly studied entity accounting for 50% of all diagnosed heart failure and that has claimed its own dignity being markedly different from heart failure with reduced EF in terms of etiology and natural history (Graziani et al., 2018). Recently, a growi...

journal_title：Frontiers in physiology

authors： D'Amario D,Migliaro S,Borovac JA,Restivo A,Vergallo R,Galli M,Leone AM,Montone RA,Niccoli G,Aspromonte N,Crea F

更新日期：2019-11-05 00:00:00

abstract：:Tubular aggregates (TAs) in skeletal muscle fibers are unusual accumulation of sarcoplasmic reticulum (SR) tubes that are found in different disorders including TA myopathy (TAM). TAM is a muscular disease characterized by muscle pain, cramping, and weakness that has been recently linked to mutations in STIM1 and ORAI...

journal_title：Frontiers in physiology

authors： Boncompagni S,Pecorai C,Michelucci A,Pietrangelo L,Protasi F

更新日期：2021-01-05 00:00:00

abstract：:Cycling test such Wingate anaerobic test (WAnT) is used to measure anaerobic power (AP), but not anaerobic capacity (AC, i.e., the metabolic energy demand). However, in sports that do not involve cycling movements (Karate), the continuous jump for 30 s (vertical jumps for 30 s) has been extensively used to measure ana...

journal_title：Frontiers in physiology

authors： Čular D,Ivančev V,Zagatto AM,Milić M,Beslija T,Sellami M,Padulo J

更新日期：2018-05-15 00:00:00

abstract：BACKGROUND:Human labor is a complex series of cellular and molecular events that occur at the materno-fetal and uterine levels. Many hypotheses have been proposed for the initiation of human labor, one hypothesis suggests that maturation of the fetus releases a signal in the amniotic fluid that will be transmitted to m...

journal_title：Frontiers in physiology

authors： Alzamil HA,Pawade J,Fortier MA,Bernal AL

更新日期：2014-07-30 00:00:00

abstract：:Left ventricular (LV) myocardial dysfunction occurs after myocardial infarction (MI) is associated with the location, infarct size, and transmurality degrees of MI. The myocardial strain is a sensitive index used for the quantification of myocardium dysfunction. This study used Tissue-Tracking to evaluate whether the ...

journal_title：Frontiers in physiology

authors： Li S,Zhao L,Lu A,Tian J,Gong L,Ma X

更新日期：2020-12-10 00:00:00

abstract：:To excrete body nitrogen waste and regulate electrolyte and fluid balance, the kidney has developed into an energy factory with only second to the heart in mitochondrial content in the body to meet the high-energy demand and regulate homeostasis. Energy supply from the renal mitochondria majorly depends on lipid metab...

journal_title：Frontiers in physiology

authors： Lin PH,Duann P

更新日期：2020-09-03 00:00:00

abstract：:Ontologies and standards are very important parts of today's bioscience research. With the rapid increase of biological knowledge, they provide mechanisms to better store and represent data in a controlled and structured way, so that scientists can share the data, and utilize a wide variety of software and tools to ma...

journal_title：Frontiers in physiology

authors： Mi H,Thomas PD

更新日期：2011-02-21 00:00:00

abstract：:Background: Subthalamic Nucleus Deep Brain Stimulation (STN-DBS) is highly effective in alleviating motor symptoms of Parkinson's disease (PD) which are not optimally controlled by dopamine replacement therapy. Clinical studies and reports suggest that STN-DBS may result in increased impulsivity and de novo impulse co...

journal_title：Frontiers in physiology

authors： Mandali A,Chakravarthy VS,Rajan R,Sarma S,Kishore A

更新日期：2016-11-29 00:00:00

abstract：:This review details the manner in which the central nervous system regulates metabolic homeostasis in normal weight and obese rodents and humans. It includes a review of the homeostatic contributions of neurons located in the hypothalamus, the midbrain and limbic structures, the pons and the medullary area postrema, n...

journal_title：Frontiers in physiology

authors： Smith JK

更新日期：2018-05-17 00:00:00

abstract：:Nedd4-2 is a ubiquitin ligase previously demonstrated to regulate endocytosis and lysosomal degradation of the epithelial Na(+) channel (ENaC) and other ion channels and transporters. Recent studies using Nedd4-2 knockout mice specifically in kidney or lung epithelia has revealed a critical role for this E3 ubiquitin ...

journal_title：Frontiers in physiology

authors： Rotin D,Staub O

更新日期：2012-06-21 00:00:00