Extracellular hemoglobin: the case of a friend turned foe.

abstract：AIM:The signaling pathways involved in the regulation of cardiac GLUT4 translocation/glucose uptake and CD36 translocation/long-chain fatty acid uptake are not fully understood. We compared in heart/muscle-specific PKC-λ knockout mice the roles of atypical PKCs (PKC-ζ and PKC-λ) in regulating cardiac glucose and fatty ...

journal_title：Frontiers in physiology

authors： Habets DD,Luiken JJ,Ouwens M,Coumans WA,Vergouwe M,Maarbjerg SJ,Leitges M,Bonen A,Richter EA,Glatz JF

更新日期：2012-09-11 00:00:00

abstract：:RNAi is applied as a new and safe method for pest control in agriculture but efficiency and specificity of delivery of dsRNA trigger remains a critical issue. Various agents have been proposed to augment dsRNA delivery, such as engineered micro-organisms and synthetic nanoparticles, but the use of viruses has received...

journal_title：Frontiers in physiology

authors： Kolliopoulou A,Taning CNT,Smagghe G,Swevers L

更新日期：2017-06-14 00:00:00

abstract：:Left ventricular hypertrophy (LVH) is a major contributor to the development of heart failure (HF). Alterations in cyclic adenosine monophosphate (cAMP)-dependent signaling pathways participate in cardiomyocyte hypertrophy and mitochondrial dysfunction occurring in LVH and HF. cAMP signals are received and integrated ...

journal_title：Frontiers in physiology

authors： Schiattarella GG,Boccella N,Paolillo R,Cattaneo F,Trimarco V,Franzone A,D'Apice S,Giugliano G,Rinaldi L,Borzacchiello D,Gentile A,Lombardi A,Feliciello A,Esposito G,Perrino C

更新日期：2018-05-28 00:00:00

abstract：:Muscle strain is one of the most frequent sports injuries, having the rectus femoris (RF) muscle as the reported preferred site of quadriceps muscle strain. The decrease muscle stiffness could be an effective RF muscle strain prevention. In recent studies, a high-intensity static stretching intervention decreased pass...

journal_title：Frontiers in physiology

authors： Nakamura M,Sato S,Murakami Y,Kiyono R,Yahata K,Sanuki F,Yoshida R,Fukaya T,Takeuchi K

更新日期：2021-01-13 00:00:00

abstract：:Over the last decades, various measures have been introduced to assess stability during walking. All of these measures assume that gait stability may be equated with exponential stability, where dynamic stability is quantified by a Floquet multiplier or Lyapunov exponent. These specific constructs of dynamic stability...

journal_title：Frontiers in physiology

authors： Ihlen EAF,van Schooten KS,Bruijn SM,Pijnappels M,van Dieën JH

更新日期：2017-08-29 00:00:00

abstract：:Prior peripheral hypoxia induced via remote ischemic preconditioning (IPC) can improve physical performance in male athletes through improved O2 delivery and utilization. Since females may have an innate protective mechanism against ischemia-reperfusion injury, and since muscle metabolism during contraction differs be...

journal_title：Frontiers in physiology

authors： Paradis-Deschênes P,Joanisse DR,Billaut F

更新日期：2017-01-05 00:00:00

abstract：:Background: Periodontitis is a chronic inflammatory disease with a possible infectious component. Anemia of inflammation (AI) occurring in various chronic diseases alters the hemoglobin (Hb) concentration and iron status. Currently, the association between periodontitis and AI is still controversial. The aim of this s...

journal_title：Frontiers in physiology

authors： Wu D,Lin Z,Zhang S,Cao F,Liang D,Zhou X

更新日期：2020-01-31 00:00:00

abstract：:Much effort has gone into elucidating control of the body by the brain, less so the role of the body in controlling the brain. This essay develops the idea that the brain does a great deal of work in the service of behavior that is controlled by the body, a blue-collar role compared to the white-collar control exercis...

journal_title：Frontiers in physiology

authors： Van Orden G,Hollis G,Wallot S

更新日期：2012-06-18 00:00:00

abstract：:This study examined the selective influences of one-repetition maximum (1RM) values [assessed in the half-squat (HS)] and bar-power production [assessed in both HS and jump squat (JS) exercises] on the physical performance of male and female team sport athletes from four different sports. Three-hundred and three elite...

journal_title：Frontiers in physiology

authors： Loturco I,Suchomel T,James LP,Bishop C,Abad CCC,Pereira LA,McGuigan MR

更新日期：2018-12-17 00:00:00

abstract：:Rapamycin, also known as sirolimus, is an antifungal agent and immunosuppressant drug used to prevent organ rejection in transplantation. However, little is known about the role of rapamycin in cardiac hypertrophy and the signaling pathways involved. Here, the effect of rapamycin was examined using phenylephrine (PE) ...

journal_title：Frontiers in physiology

authors： Gu J,Hu W,Song ZP,Chen YG,Zhang DD,Wang CQ

更新日期：2016-03-18 00:00:00

abstract：:Many cell division processes have been conserved throughout evolution and are being revealed by studies on model organisms such as bacteria, yeasts, and protozoa. Cellular membrane constriction is one of these processes, observed almost universally during cell division. It happens similarly in all organisms through a ...

journal_title：Frontiers in physiology

authors： Beltrán-Heredia E,Almendro-Vedia VG,Monroy F,Cao FJ

更新日期：2017-05-19 00:00:00

abstract：:In the mammalian ear, transduction of sound stimuli is initiated by K+ entry through mechano-sensitive channels into inner hair cells. K+ entry is driven by a positive endocochlear potential that is maintained by the marginal cell layer of the stria vascularis. This process requires basolateral K+ import by NKCC1 Na+-...

journal_title：Frontiers in physiology

authors： Tan H,Bungert-Plümke S,Fahlke C,Stölting G

更新日期：2017-05-15 00:00:00

abstract：:The non-selective mechanosensitive ion channel PIEZO1 controls erythrocyte volume homeostasis. Different missense gain-of-function mutations in PIEZO1 gene have been identified that cause Hereditary Xerocytosis (HX), a rare autosomal dominant haemolytic anemia. PIEZO1 expression is not limited to erythrocytes and expr...

journal_title：Frontiers in physiology

authors： Aglialoro F,Hofsink N,Hofman M,Brandhorst N,van den Akker E

更新日期：2020-07-31 00:00:00

abstract：:Remote focussing microscopy allows sharp, in-focus images to be acquired at high speed from outside of the focal plane of an objective lens without any agitation of the specimen. However, without careful optical alignment, the advantages of remote focussing microscopy could be compromised by the introduction of depth-...

journal_title：Frontiers in physiology

authors： Corbett AD,Burton RA,Bub G,Salter PS,Tuohy S,Booth MJ,Wilson T

更新日期：2014-10-08 00:00:00

abstract：:Children with Developmental Coordination Disorder (DCD) and children at risk for DCD (r-DCD) present motor impairments interfering in their school, leisure and daily activities. In addition, these children may have abnormalities in their cardiac autonomic control, which together with their motor impairments, restrict ...

journal_title：Frontiers in physiology

authors： Cavalcante Neto JL,Zamunér AR,Moreno BC,Silva E,Tudella E

更新日期：2018-03-22 00:00:00

abstract：:A primary goal of enamel research is to understand and potentially treat or prevent enamel defects related to amelogenesis imperfecta (AI). Rodents are ideal models to assist our understanding of how enamel is formed because they are easily genetically modified, and their continuously erupting incisors display all sta...

journal_title：Frontiers in physiology

authors： Pugach MK,Gibson CW

更新日期：2014-09-17 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fphys.2019.00313.]. ...

journal_title：Frontiers in physiology

authors： Naro F,Venturelli M,Monaco L,Toniolo L,Muti E,Milanese C,Zhao J,Richardson RS,Schena F,Reggiani C

更新日期：2020-02-25 00:00:00

abstract：:The spawning migration of the European eel is an extensive journey over 5000 to 7000 km from the European coast to the Sargasso Sea. Eels do not feed during this journey and on-board fuels must be sufficient to support the journey of 3.5 to 6 month, as well as sexual maturation and the spawning activity. Swimming of e...

journal_title：Frontiers in physiology

authors： Pelster B

更新日期：2015-01-05 00:00:00

abstract：:The Subolesin/Akirin constitutes a good model for the study of functional evolution because these proteins have been conserved throughout the metazoan and play a role in the regulation of different biological processes. Here, we investigated the evolutionary history of Subolesin/Akirin with recent results on their str...

journal_title：Frontiers in physiology

authors： Artigas-Jerónimo S,Villar M,Cabezas-Cruz A,Valdés JJ,Estrada-Peña A,Alberdi P,de la Fuente J

更新日期：2018-11-13 00:00:00

abstract：OBJECTIVES:The dynamic interaction between blood pressure (BP) and cerebral blood flow velocity (CBFV) is not fully understood, especially for CBFV changes lasting longer than 50 s. The interaction between BP and CBFV is relatively well characterized for periods <50 s using transfer function (TF) estimations of phase, ...

journal_title：Frontiers in physiology

authors： Müller MW,Osterreich M

更新日期：2014-08-26 00:00:00

abstract：:Forced sustained swimming exercise at optimal speed enhances growth in many fish species, particularly through hypertrophy of the white skeletal muscle. The exact mechanism of this effect has not been resolved yet. To explore the role of cortisol, we first subjected wild-type zebrafish to an exercise protocol validate...

journal_title：Frontiers in physiology

authors： Palstra AP,Mendez S,Dirks RP,Schaaf MJM

更新日期：2019-01-14 00:00:00

abstract：Introduction:Obstructive sleep apnea (OSA) has been associated with non-dipping blood pressure (BP). The precise mechanism is still under investigation, but repetitive oxygen desaturation and arousal induced sleep fragmentation are considered the main contributors. Methods:We analyzed beat-to-beat measurements of hemo...

journal_title：Frontiers in physiology

authors： Staats R,Barros I,Fernandes D,Grencho D,Reis C,Matos F,Valença J,Marôco J,de Almeida AB,Bárbara C

更新日期：2020-03-13 00:00:00

abstract：:Although motor output of the postural function clearly influences postural performance in young and older subjects, no relationship has been formally established between them. However, the relationship between lower-extremity muscle strength/power and postural performance is often pointed out, especially in older subj...

journal_title：Frontiers in physiology

authors： Paillard T

更新日期：2017-08-15 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is a devastating and fatal chronic lung disease. While current pharmacotherapies have improved patient quality of life, PAH drugs suffer from limitations in the form of short-term pharmacokinetics, instability, and poor organ specificity. Traditionally, nanotechnology-based delive...

journal_title：Frontiers in physiology

authors： Segura-Ibarra V,Wu S,Hassan N,Moran-Guerrero JA,Ferrari M,Guha A,Karmouty-Quintana H,Blanco E

更新日期：2018-07-13 00:00:00

abstract：:Xinnao shutong (XNST) capsules have been clinically used in China to treat cerebrovascular diseases. Previous studies have demonstrated that XNST has significant neuroprotective effects against acute cerebral ischemic stroke. The present study investigated the effects and mechanisms of XNST treatment following chronic...

journal_title：Frontiers in physiology

authors： Wang L,Wang R,Chen Z,Zhao H,Luo Y

更新日期：2018-05-15 00:00:00

abstract：:The aim of this study was to investigate the effects of two consecutive Crossfit® training sessions (24 h apart) designed to enhance work-capacity that involved both cardiovascular and muscular exercises on cytokines, muscle power, blood lactate and glucose. Nine male members of the CrossFit® community (age 26.7 ± 6.6...

journal_title：Frontiers in physiology

authors： Tibana RA,de Almeida LM,Frade de Sousa NM,Nascimento Dda C,Neto IV,de Almeida JA,de Souza VC,Lopes Mde F,Nobrega Ode T,Vieira DC,Navalta JW,Prestes J

更新日期：2016-06-28 00:00:00

abstract：:In this paper, we computationally generate hypotheses for dose-finding studies in the context of desynchronizing neuromodulation techniques. Abnormally strong neuronal synchronization is a hallmark of several brain disorders. Coordinated Reset (CR) stimulation is a spatio-temporally patterned stimulation technique tha...

journal_title：Frontiers in physiology

authors： Manos T,Zeitler M,Tass PA

更新日期：2018-04-12 00:00:00

abstract：:Preterm birth complications are the leading cause of child death worldwide and a top global health priority. Among the survivors, the risk of life-long disabilities is high, including cerebral palsy and impairment of movement, cognition, and behavior. Understanding the molecular mechanisms of preterm brain injuries is...

journal_title：Frontiers in physiology

authors： Pregnolato S,Chakkarapani E,Isles AR,Luyt K

更新日期：2019-04-24 00:00:00

abstract：:Oxidative modification of proteins in photosystem II (PSII) exposed to high light has been studied for a few decades, but the characterization of protein radicals formed by protein oxidation is largely unknown. Protein oxidation is induced by the direct reaction of proteins with reactive oxygen species known to form h...

journal_title：Frontiers in physiology

authors： Kumar A,Prasad A,Sedlářová M,Pospíšil P

更新日期：2019-08-13 00:00:00

abstract：:Several studies have highlighted the interplay between metabolism, immunity and inflammation. Both tissue resident and infiltrating immune cells play a major role in the inflammatory process of rheumatoid arthritis (RA) via the production of cytokines, adipo-cytokines and metabolic intermediates. These functions are m...

journal_title：Frontiers in physiology

authors： Pucino V,Certo M,Varricchi G,Marone G,Ursini F,Rossi FW,De Paulis A,Mauro C,Raza K,Buckley CD

更新日期：2020-04-17 00:00:00