DExD/H-Box Helicase 36 Signaling via Myeloid Differentiation Primary Response Gene 88 Contributes to NF-κB Activation to Type 2 Porcine Reproductive and Respiratory Syndrome Virus Infection.

abstract：:PU.1 is an ETS-family transcription factor that plays a broad range of roles in hematopoiesis. A direct regulator of myeloid, dendritic-cell, and B cell functional programs, and a well-known antagonist of terminal erythroid cell differentiation, it is also expressed in the earliest stages of T-cell development of each...

journal_title：Frontiers in immunology

authors： Rothenberg EV,Hosokawa H,Ungerbäck J

更新日期：2019-02-20 00:00:00

abstract：:Vaccination is the most reliable measure to prevent infectious diseases in domestic animals. Development of novel vaccines demands extensive studies with new technologies, such as using novel adjuvants and immunomodulatory molecules. The co-stimulatory molecule 4-1BB provides a key signal that directs the fate of T ce...

journal_title：Frontiers in immunology

authors： Huang G,Liu X,Duszynski DW,Tang X,El-Ashram S,Liu Z,Suo X,Li Q

更新日期：2017-12-18 00:00:00

abstract：:γδ T cells represent an evolutionarily primitive T cell subset characterized by distinct T cell receptors (TCRs) and innate and adaptive immune functions. However, the presence of this T cell subset in ancient vertebrates remains unclear. In this study, γδ T cells from a zebrafish (Danio rerio) model were subjected to...

journal_title：Frontiers in immunology

authors： Wan F,Hu CB,Ma JX,Gao K,Xiang LX,Shao JZ

更新日期：2017-01-09 00:00:00

abstract：:Loss-of-function mutations in the Autoimmune Regulator (AIRE) gene cause a rare inherited form of autoimmune disease, autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy, also known as autoimmune polyglandular syndrome type 1. The patients suffer from multiple endocrine deficiencies, the most common manifes...

journal_title：Frontiers in immunology

authors： Arstila TP,Jarva H

更新日期：2013-10-07 00:00:00

abstract：:Arterial stiffness predicts an increased risk of cardiovascular events. Inflammation plays a major role in large arteries stiffening, related to atherosclerosis, arteriosclerosis, endothelial dysfunction, smooth muscle cell migration, vascular calcification, increased activity of metalloproteinases, extracellular matr...

journal_title：Frontiers in immunology

authors： Mozos I,Malainer C,Horbańczuk J,Gug C,Stoian D,Luca CT,Atanasov AG

更新日期：2017-08-31 00:00:00

abstract：:In gut epithelium, IL-22 transmits signals through STAT3 phosphorylation (pSTAT3) which provides intestinal immunity. Many components in the IL-22-pSTAT3 pathway have been identified as risk factors for inflammatory bowel disease (IBD) and some of them are considered as promising therapeutic targets. However, new pers...

journal_title：Frontiers in immunology

authors： Glal D,Sudhakar JN,Lu HH,Liu MC,Chiang HY,Liu YC,Cheng CF,Shui JW

更新日期：2018-11-05 00:00:00

abstract：Purpose:Obesity is a major modifiable risk factor for cardiovascular disease. Bariatric surgery is considered to be the most effective treatment option for weight reduction in obese patients with and without type 2 diabetes (T2DM). Objective:To evaluate changes in lipoproteins, insulin resistance, mediators of systemi...

journal_title：Frontiers in immunology

authors： Yadav R,Hama S,Liu Y,Siahmansur T,Schofield J,Syed AA,France M,Pemberton P,Adam S,Ho JH,Aghamohammadzadeh R,Dhage S,Donn R,Malik RA,New JP,Jeziorska M,Durrington P,Ammori BA,Soran H

更新日期：2017-11-15 00:00:00

abstract：:TNF-Receptor Associated Factor (TRAF)-3 is a master regulator of B cell homeostasis and function. TRAF3 has been shown to bind and regulate various proteins involved in the control of innate and adaptive immune responses. Previous studies showed that TRAF3 overexpression renders B cells hyper-reactive to antigens and ...

journal_title：Frontiers in immunology

authors： Perez-Chacon G,Adrados M,Vallejo-Cremades MT,Lefebvre S,Reed JC,Zapata JM

更新日期：2019-01-11 00:00:00

abstract：:The homeostasis of T cell populations depends on migration, division and death of individual cells (1). T cells migrate between spatial compartments (spleen, lymph nodes, lung, liver, etc.), where they may divide or differentiate, and eventually die (2). The kinetics of recirculation influences the speed at which loca...

journal_title：Frontiers in immunology

authors： de la Higuera L,López-García M,Castro M,Abourashchi N,Lythe G,Molina-París C

更新日期：2019-03-06 00:00:00

abstract：:Increasing prevalence in obesity has become a significant public concern. C57BL/6J mice are prone to diet-induced obesity (DIO) when fed high-fat diet (HFD), and develop chronic inflammation and metabolic syndrome, making them a good model to analyze mechanisms whereby obesity elicits pathologies. DIO mice demonstrate...

journal_title：Frontiers in immunology

authors： Lainez NM,Jonak CR,Nair MG,Ethell IM,Wilson EH,Carson MJ,Coss D

更新日期：2018-09-11 00:00:00

abstract：:Hematopoietic stem cell transplantation from a haploidentical donor is increasingly used and has become a standard donor option for patients lacking an appropriately matched sibling or unrelated donor. Historically, prohibitive immunological barriers resulting from the high degree of HLA-mismatch included graft-vs.-ho...

journal_title：Frontiers in immunology

authors： Baumeister SHC,Rambaldi B,Shapiro RM,Romee R

更新日期：2020-02-14 00:00:00

abstract：:GPR84 is a member of the metabolic G protein-coupled receptor family, and its expression has been described predominantly in immune cells. GPR84 activation is involved in the inflammatory response, but the mechanisms by which it modulates inflammation have been incompletely described. In this study, we investigated GP...

journal_title：Frontiers in immunology

authors： Recio C,Lucy D,Purvis GSD,Iveson P,Zeboudj L,Iqbal AJ,Lin D,O'Callaghan C,Davison L,Griesbach E,Russell AJ,Wynne GM,Dib L,Monaco C,Greaves DR

更新日期：2018-06-20 00:00:00

abstract：:The immune system plays a central role in cancer development, showing both anti-tumor and pro-tumor activities depending on the immune cell subsets and the disease context. While CD8 T cells are associated with a favorable outcome in most cancers, only T helper type 1 (Th1) CD4 T cells play a protective role, in contr...

journal_title：Frontiers in immunology

authors： Bohner P,Chevalier MF,Cesson V,Rodrigues-Dias SC,Dartiguenave F,Burruni R,Tawadros T,Valerio M,Lucca I,Nardelli-Haefliger D,Jichlinski P,Derré L

更新日期：2019-03-29 00:00:00

abstract：:Damage associated molecular patterns (DAMPs) are endogenous molecules originate from damaged cells and tissues with the ability to trigger and/or modify innate immune responses. Upon hemolysis hemoglobin (Hb) is released from red blood cells (RBCs) to the circulation and give a rise to the production of different Hb r...

journal_title：Frontiers in immunology

authors： Bozza MT,Jeney V

更新日期：2020-06-30 00:00:00

abstract：:The ubiquitously expressed, monomorphic MHC class Ib molecule MHC class I-related protein 1 (MR1) presents microbial metabolites to mucosal-associated invariant T (MAIT) cells. However, recent work demonstrates that both the ligands bound by MR1 and the T cells restricted by it are more diverse than originally thought...

journal_title：Frontiers in immunology

authors： Kulicke C,Karamooz E,Lewinsohn D,Harriff M

更新日期：2020-09-02 00:00:00

abstract：:Inflammation plays vital roles in protective responses against pathogens and tissue repair, however, improper resolution of inflammatory networks is centrally involved in the pathogenesis of many acute and chronic diseases. Extensive advances have been made in recent years to define the inflammatory processes that are...

journal_title：Frontiers in immunology

authors： Lukens JR,Gross JM,Kanneganti TD

更新日期：2012-10-09 00:00:00

abstract：:Differentiation of Natural Killer (NK) cells is a stepwise process having its origin in the bone marrow and proceeding in the periphery, where these cells follow organ specific trajectories. Several soluble factors and cytokines regulate the distinct stages of NK cell differentiation, and ultimately, their functional ...

journal_title：Frontiers in immunology

authors： Scarno G,Pietropaolo G,Di Censo C,Gadina M,Santoni A,Sciumè G

更新日期：2019-10-17 00:00:00

abstract：:Immunoglobulin superfamily member (IgSF) proteins play a significant role in regulating immune responses with surface expression on all immune cell subsets, making the IgSF an attractive family of proteins for therapeutic targeting in human diseases. We have developed a directed evolution platform capable of engineeri...

journal_title：Frontiers in immunology

authors： Levin SD,Evans LS,Bort S,Rickel E,Lewis KE,Wu RP,Hoover J,MacNeil S,La D,Wolfson MF,Rixon MW,Dillon SR,Kornacker MG,Swanson R,Peng SL

更新日期：2020-01-21 00:00:00

abstract：:Cervical cancer remains a global health burden despite the introduction of highly effective vaccines for the prophylaxis of causative human papillomavirus infection (HPV). Current efforts to eradicate cervical cancer focus on the development of broadly protective, cost-effective approaches. HPV minor capsid protein L2...

journal_title：Frontiers in immunology

authors： Yang F,Mariz FC,Zhao X,Spagnoli G,Ottonello S,Müller M

更新日期：2020-12-04 00:00:00

abstract：:The protein kinase C-θ (PKCθ), which is essential for T cell function and survival, is also required for efficient anti-tumor immune surveillance. Natural killer (NK) cells, which express PKCθ, play a prominent role in this process, mainly by elimination of tumor cells with reduced or absent major histocompatibility c...

journal_title：Frontiers in immunology

authors： Anel A,Aguiló JI,Catalán E,Garaude J,Rathore MG,Pardo J,Villalba M

更新日期：2012-07-05 00:00:00

abstract：:Guava Psidium guajava L (Pg) and bhumi amla Phyllanthus amarus Schum. et Thonn (Pa) are well-known plants in traditional medicine. However, the capacity of these plants for improving the immune system of aquatic species has received less attention so far. This study aimed to investigate the effects of single supply or...

journal_title：Frontiers in immunology

authors： Nhu TQ,Bich Hang BT,Cornet V,Oger M,Bach LT,Anh Dao NL,Thanh Huong DT,Quetin-Leclercq J,Scippo ML,Phuong NT,Kestemont P

更新日期：2020-05-05 00:00:00

abstract：:In dairy herds, mastitis caused by Staphylococcus aureus is difficult to completely cure on the account that S. aureus can invade bovine mammary epithelial cells (BMECs) and result in persistent infection in the mammary gland. Recent studies have demonstrated that autophagy can participate in cell homeostasis by elimi...

journal_title：Frontiers in immunology

authors： Geng N,Wang X,Yu X,Wang R,Zhu Y,Zhang M,Liu J,Liu Y

更新日期：2020-05-05 00:00:00

abstract：:Despite advances, identification and formulation of safe and effective vaccine for long-lasting protection against leishmaniasis is still inadequate. In this study, we have identified a novel antigen, leishmanial elongation factor-1α (EF1-α), as an immunodominant component of solubilized leishmanial membrane antigens ...

journal_title：Frontiers in immunology

authors： Sabur A,Bhowmick S,Chhajer R,Ejazi SA,Didwania N,Asad M,Bhattacharyya A,Sinha U,Ali N

更新日期：2018-01-30 00:00:00

abstract：:Central memory T cell (Tcm) and polyfunctional CD4 T cell responses contribute to vaccine-elicited protection with both human and bovine tuberculosis (TB); however, their combined role in protective immunity to TB is unclear. To address this question, we evaluated polyfunctional cytokine responses by CD4 T cell effect...

journal_title：Frontiers in immunology

authors： Maggioli MF,Palmer MV,Thacker TC,Vordermeier HM,McGill JL,Whelan AO,Larsen MH,Jacobs WR Jr,Waters WR

更新日期：2016-10-17 00:00:00

abstract：:Mycobacteria display pro- and anti-inflammatory effects in human and experimental pathology. We show here that both effects are mediated by Toll-like receptor 2 (Tlr2), by exploiting a previously characterized Tlr2 variant (Met82Ile). Tlr2 82ile promoted self-specific proinflammatory polarization as well as expansion ...

journal_title：Frontiers in immunology

authors： Piermattei A,Migliara G,Di Sante G,Foti M,Hayrabedyan SB,Papagna A,Geloso MC,Corbi M,Valentini M,Sgambato A,Delogu G,Constantin G,Ria F

更新日期：2016-05-24 00:00:00

abstract：:During the course of Chagas disease, infectious forms of Trypanosoma cruzi are occasionally liberated from parasitized heart cells. Studies performed with tissue culture trypomastigotes (TCTs, Dm28c strain) demonstrated that these parasites evoke neutrophil/CXCR2-dependent microvascular leakage by activating innate se...

journal_title：Frontiers in immunology

authors： Nascimento CR,Andrade D,Carvalho-Pinto CE,Serra RR,Vellasco L,Brasil G,Ramos-Junior ES,da Mota JB,Almeida LN,Andrade MV,Correia Soeiro MN,Juliano L,Alvarenga PH,Oliveira AC,Sicuro FL,de Carvalho ACC,Svensjö E,Scharfstei

更新日期：2017-08-02 00:00:00

abstract：:Tuberculosis (TB) is a major health issue globally. Although typically the disease can be cured by chemotherapy in all age groups, and prevented in part in newborn by vaccination, general consensus exists that development of novel intervention measures requires better understanding of disease mechanisms. Human TB is c...

journal_title：Frontiers in immunology

authors： Dorhoi A,Iannaccone M,Maertzdorf J,Nouailles G,Weiner J 3rd,Kaufmann SH

更新日期：2014-02-05 00:00:00

abstract：:Allergies and asthma are a major cause of chronic disease whose prevalence has been on the rise. Allergic disease including seasonal rhinitis, atopic dermatitis, urticaria, anaphylaxis, and asthma, are associated with activation of tissue-resident mast cells and circulating basophils. Although these cells can be activ...

journal_title：Frontiers in immunology

authors： Gomez G

更新日期：2019-02-07 00:00:00

abstract：:The microenvironment of a developing tumor is composed of proliferating cancer cells, blood vessels, stromal cells, infiltrating inflammatory cells, and a variety of associated tissue cells. The crosstalk between stromal cells and malignant cells within this environment crucially determines the fate of tumor progressi...

journal_title：Frontiers in immunology

authors： Terry S,Buart S,Chouaib S

更新日期：2017-11-24 00:00:00

abstract：:Rationale: Caspase-1 is a zymogen whose activation predominantly depends upon the assembly of ASC monomers into insoluble prion-like polymers (specks). ASC polymers support caspase-1 dimer formation inducing a proximity mediated auto-activation of caspase-1. Therefore, the amount and nature of ASC monomers and polymer...

journal_title：Frontiers in immunology

authors： Gavrilin MA,McAndrew CC,Prather ER,Tsai M,Spitzer CR,Song MA,Mitra S,Sarkar A,Shields PG,Diaz PT,Wewers MD

更新日期：2020-03-19 00:00:00