Abstract:
:Cervical cancer remains an important cause of women morbidity and mortality. The progression of cervical pathology correlates with the HPV integration into the host genome. However, the data on the viral integration status in cervical dysplasias are controversial. The aim of the current study was to evaluate the status of HPV integration in two types of cervical pathology - invasive and non invasive cervical cancer (e.g. carcinoma in situ). 156 women were included in the study: 66 women were diagnosed with invasive cervical cancer (CC) and 90 with non invasive cervical cancer (carcinoma in situ, CIS). 74.2% [95% PI: 63.64÷84.76] of specimens collected from women with diagnosed CC and 85.6% [95% PI: 85.53÷92.85] of CIS specimens were positive for HPV. The most prevalent HPV genotype in both groups was HPV16. To evaluate HPV integration, three selected HPV16 E2 gene fragments were analyzed by PCR. In the majority of CC and CIS specimens the amplification of all three HPV16 E2 gene fragments was observed. The episomal HPV16 form was detected in the majority of CC and CIS specimens. The deletion of all three HPV16 E2 gene fragments was detected in 9.4% of CC specimens and 2.2% of CIS specimens. Finally, integration status could not be used as diagnostical additional test to distinguish between invasive and non invasive cervical cancer.
journal_name
Open Med (Wars)journal_title
Open medicine (Warsaw, Poland)authors
Gudleviciene Z,Kanopiene D,Stumbryte A,Bausyte R,Kirvelaitis E,Simanaviciene V,Zvirbliene Adoi
10.1515/med-2015-0001subject
Has Abstractpub_date
2014-09-25 00:00:00pages
1-7issue
1issn
2391-5463pii
med-2015-0001journal_volume
10pub_type
杂志文章相关文献
Open Medicine文献大全abstract::[This corrects the article on p. 479 in vol. 14, PMID: 31231684.]. ...
journal_title:Open medicine (Warsaw, Poland)
pub_type: 已发布勘误
doi:10.1515/med-2021-0006
更新日期:2020-11-27 00:00:00
abstract:OBJECTIVE:To evaluate the value of individual and combined measurement of human epididymis protein 4 (HE4) and cancer antigen 125 (CA-125) in the diagnosis of ovarian cancer. METHODS:A clinical case-control study was performed in which the levels of serum HE4 and CA-125 of subjects with malignant, borderline, benign o...
journal_title:Open medicine (Warsaw, Poland)
pub_type: 杂志文章
doi:10.1515/med-2016-0024
更新日期:2016-05-06 00:00:00
abstract::We compared the effects of 16-week-training on rest metabolic rate, aerobic power, and body fat, and the post-exercise effects upon rest oxygen uptake and respiratory exchange ratio in overweight middle-aged females. Twenty nine overweight women (BMI 29.9 ± 1.2 kg*m-2) participated in training (3 days a week). The sub...
journal_title:Open medicine (Warsaw, Poland)
pub_type: 杂志文章
doi:10.1515/med-2015-0021
更新日期:2015-02-02 00:00:00
abstract::Lipoma is a benign tumour originating from mature adipose tissue. It can occur in any place in the body where adipose tissue is located. Intraosseous lipoma is a very rare bone tumour. The authors present an infrequent case involving intraosseous lipoma of the mandible in a 32-year old man and provide a review of case...
journal_title:Open medicine (Warsaw, Poland)
pub_type: 杂志文章
doi:10.1515/med-2017-0008
更新日期:2017-03-29 00:00:00
abstract::Recent studies have revealed that microRNAs regulate radiosensitivity of non-small cell lung cancer (NSCLC). The aim of this study was to investigate whether miR-101-3p is correlated with radiosensitivity of NSCLC. According to our results, miR-101-3p was downregulated in NSCLC tissues and cell lines. Moreover, miR-10...
journal_title:Open medicine (Warsaw, Poland)
pub_type: 杂志文章
doi:10.1515/med-2020-0044
更新日期:2020-06-07 00:00:00
abstract::This study evaluates the efficacy and safety of bevacizumab (BEV) in the treatment of non-small cell lung cancer (NSCLC) patients with brain metastases (BM) by performing meta-analyses of response and survival indices. Seventeen studies were included. BEV treatment was associated with a lower new BM incidence (hazard ...
journal_title:Open medicine (Warsaw, Poland)
pub_type: 杂志文章
doi:10.1515/med-2020-0192
更新日期:2020-07-01 00:00:00
abstract:Aim:To compare the clinical effectiveness of the two most commonly used LMWHs, dalteparin (DALT) and enoxaparin (ENOX), in thromboprophylaxis of elective total hip replacement (THR) or total knee replacement (TKR). Material and methods:To the prospective, randomized study were included 66 adult patients qualified to u...
journal_title:Open medicine (Warsaw, Poland)
pub_type: 杂志文章
doi:10.1515/med-2020-0213
更新日期:2020-10-12 00:00:00
abstract::To observe a therapeutic effect of macrolide antibiotics in children with Pseudomonas aeruginosa pneumonia. Fifty-four cases of children with Pseudomonas aeruginosa pneumonia were randomly divided into an observation group (n=30) and a control group (n=24). The observation group was treated with macrolide antibiotics ...
journal_title:Open medicine (Warsaw, Poland)
pub_type: 杂志文章
doi:10.1515/med-2015-0082
更新日期:2015-12-17 00:00:00
abstract:OBJECTIVE:The optimal diagnostics and treatment of acute appendicitis continues to be a challenge. A false positive diagnosis of appendicitis may lead to an unnecessary operation, which has been appropriately termed negative appendectomy. The aim of our study was to identify the effectiveness of preoperative investigat...
journal_title:Open medicine (Warsaw, Poland)
pub_type: 杂志文章
doi:10.1515/med-2016-0045
更新日期:2016-07-22 00:00:00
abstract::Three-dimensional (3D) cell cultures were created with the use of fur keratin associated proteins (F-KAPs) as scaffolds. The procedure of preparation F-KAP involves combinations of chemical activation and enzymatic digestion. The best result in porosity and heterogeneity of F-KAP surface was received during pepsin dig...
journal_title:Open medicine (Warsaw, Poland)
pub_type: 杂志文章
doi:10.1515/med-2020-0031
更新日期:2020-04-03 00:00:00
abstract::The most undesired complication of renal angiomyolipoma (AML) is bleeding. Because of tumor rupture, the bleeding can spread to the retroperitoneal field and can be severe enough to be life threatening. We report a case of retroperitoneal hemorrhage caused by a ruptured AML that was successfully treated with transarte...
journal_title:Open medicine (Warsaw, Poland)
pub_type:
doi:10.1515/med-2015-0035
更新日期:2015-04-02 00:00:00
abstract:Background:Many factors contribute to successful nerve reconstruction. The correct technique of anastomosis is one of the key elements that determine the final result of a surgery. The aim of this study is to examine how useful an electromyography (EMG) can be as an objective intraoperative anastomosis assessment metho...
journal_title:Open medicine (Warsaw, Poland)
pub_type: 杂志文章
doi:10.1515/med-2020-0143
更新日期:2020-06-13 00:00:00
abstract::In this study, an effective means for detecting cancer region through different types of medical image segmentation are presented and explained. We proposed a new method for cancer segmentation on the basis of fuzzy entropy with a level set (FELs) thresholding. The proposed method was successfully utilized to segment ...
journal_title:Open medicine (Warsaw, Poland)
pub_type: 杂志文章
doi:10.1515/med-2018-0056
更新日期:2018-09-08 00:00:00
abstract::Individualized therapies targeting epidermal growth factor receptor (EGFR) mutations show promises for the treatment of non small-cell lung carcinoma (NSCLC). However, disease progression almost invariably occurs 1 year after tyrosine kinase inhibitor (TKI) treatment. The most prominent mechanism of acquired resistanc...
journal_title:Open medicine (Warsaw, Poland)
pub_type: 杂志文章,评审
doi:10.1515/med-2016-0014
更新日期:2016-03-26 00:00:00
abstract::Previous studies indicated that chromosome 9 translocations are involved in reduced male fertility and increased chance of miscarriage in the female partner. The aim of this study was to review the clinical features and genetic counselling requirements of infertile men carrying chromosome 9 translocations. This study ...
journal_title:Open medicine (Warsaw, Poland)
pub_type: 杂志文章
doi:10.1515/med-2019-0100
更新日期:2019-11-10 00:00:00
abstract::Arginine vasopressin can bind to high-affinity vasopressin V1a receptors in human leukocytes. This study aims to investigate the effects of arginine vasopressin on migration and chemotaxis of neutrophils and oxygen free radical release by human leukocytes. Neutrophils and monocytes were obtained from peripheral blood ...
journal_title:Open medicine (Warsaw, Poland)
pub_type: 杂志文章
doi:10.1515/med-2018-0020
更新日期:2018-05-09 00:00:00
abstract::Convolutional neural networks (CNNs) are a branch of deep learning which have been turned into one of the popular methods in different applications, especially medical imaging. One of the significant applications in this category is to help specialists make an early detection of skin cancer in dermoscopy and can reduc...
journal_title:Open medicine (Warsaw, Poland)
pub_type: 杂志文章
doi:10.1515/med-2020-0006
更新日期:2020-01-13 00:00:00
abstract:Background:To analyze the cardio-protective effects of ticagrelor in patients with acute coronary syndrome with S-T segment elevation. Methods:The sample was 200 patients who had been diagnosed with acute coronary syndrome accompanied by diabetes Mellitus type II. Only patients having ST segment elevation before the t...
journal_title:Open medicine (Warsaw, Poland)
pub_type: 杂志文章
doi:10.1515/med-2019-0017
更新日期:2019-02-20 00:00:00
abstract::Triple-negative breast cancer (TNBC) is a particularly aggressive subtype known for its extremely high drug resistance, progression, poor prognosis, and lack of clear therapeutic targets. Researchers are aiming to advance TNBC treatment worldwide. In the past 2-3 years, more positive results have emerged in the clinic...
journal_title:Open medicine (Warsaw, Poland)
pub_type: 杂志文章,评审
doi:10.1515/med-2020-0138
更新日期:2020-11-14 00:00:00
abstract::Responsibility means responding to the damaging consequences of technical work and in this binding perspective the general principles of guilt in genetic diagnostics and related activities are not different from any other medical performance. Performing a genetic test however, especially when it has predictive charact...
journal_title:Open medicine (Warsaw, Poland)
pub_type: 杂志文章
doi:10.1515/med-2018-0046
更新日期:2018-08-24 00:00:00
abstract::Aim of the study is to highlight difficulties faced by an inexperienced surgeon in approaching endorectal-ultrasound, trying to define when learning curve can be considered complete. A prospective analysis was conducted on endorectal-ultrasound performed for subperitoneal rectal adenocarcinoma staging in the period fr...
journal_title:Open medicine (Warsaw, Poland)
pub_type: 杂志文章
doi:10.1515/med-2016-0074
更新日期:2016-11-19 00:00:00
abstract:Purpose:We hypothesized that the current criteria may be unsuitable for lacunar pontine infarctions (LPI) diagnosis and that size criteria may indicate different stroke mechanisms. Methods:A total of 102 patients with isolated pontine infarctions were divided into a parent artery disease (PAD) and non-PAD groups accor...
journal_title:Open medicine (Warsaw, Poland)
pub_type: 杂志文章
doi:10.1515/med-2020-0025
更新日期:2020-03-08 00:00:00
abstract::The term vein of Galen aneurysm is related to a group of different vascular anomalies, with one common distinction being the dilatation of the vein of Galen. It represents a rear vascular anomaly, whose incidence is yet unknown, although some authors suggest numbers around 1:25000 deliveries. It accounts for only 1% o...
journal_title:Open medicine (Warsaw, Poland)
pub_type: 杂志文章
doi:10.1515/med-2017-0054
更新日期:2017-12-05 00:00:00
abstract::Not fully maturated immune system in preterm neonates may contribute to the increased susceptibility to infection. The levels of some cytokines can be useful in the prediction and diagnosis of sepsis in premature neonates. In the present study, we evaluated the potential predictive role of IFN-γ and IL-5 in cord and v...
journal_title:Open medicine (Warsaw, Poland)
pub_type: 杂志文章
doi:10.1515/med-2021-0206
更新日期:2021-01-11 00:00:00
abstract:Objective:To observe and analyze the effect of color doppler ultrasonography (CDU) in uterine arterial embolization (UAE). Methods:160 cases of patients with uterine fibroid were selected in this study. CDU were performed on all patients before UAE as well as 5-9 days and 3-6 months after UAE, so as to observe the sha...
journal_title:Open medicine (Warsaw, Poland)
pub_type: 杂志文章
doi:10.1515/med-2017-0069
更新日期:2017-12-29 00:00:00
abstract::Pleiotropic proinflammatory cytokines, interleukin- 1 (IL-1) and tumor necrosis factor-α (TNF-α), involved in the regulations of various immune responses, inflammatory processes and hematopoiesis. In the present study, the expression levels of IL-1 and TNF-α were detected by enzyme-linked immunosorbent assay (ELISA). ...
journal_title:Open medicine (Warsaw, Poland)
pub_type: 杂志文章
doi:10.1515/med-2015-0044
更新日期:2015-06-09 00:00:00
abstract::This study is a case report, which presents a case of severe mitral regurgitation in a 77-year-old man. Two-dimensional transesophageal echocardiography (TEE), regurgitant jets directed anteriorly in early systole and centrally to laterally in late systole were seen, while three-dimensional TEE showed a flail posterio...
journal_title:Open medicine (Warsaw, Poland)
pub_type: 杂志文章
doi:10.1515/med-2018-0047
更新日期:2018-08-11 00:00:00
abstract::The large epidemiological studies demonstrated that atrial fibrillation is correlated with high mortality and adverse events in patients with acute myocardial infarction. The aim of this study was to determinate predictors of atrial fibrillation develop during the hospital period in patients with acute myocardial infa...
journal_title:Open medicine (Warsaw, Poland)
pub_type: 杂志文章
doi:10.1515/med-2017-0018
更新日期:2017-05-02 00:00:00
abstract::To evaluate the clinical value of serum α-L-fucosidase (AFU), 5'-nucleotidase (5'-NT) and alpha fetoprotein (AFP) as biomarkers for primary hepatocellular carcinoma (PHC) diagnosis. METHODS:Thirty six primary hepatocellular carcinoma (PHC) patients and 36 healthy controls were recruited in this study from February 20...
journal_title:Open medicine (Warsaw, Poland)
pub_type: 杂志文章
doi:10.1515/med-2017-0051
更新日期:2017-10-11 00:00:00
abstract::We aimed to investigate the CXCL13 concentration of the serum and cerebral spinal fluid (CSF) in human immunodeficiency virus (HIV)-negative latent syphilis patients with treatment failure and explore the change in CXCL13 after treatment. Sixty-eight latent syphilis patients with treatment failure (failure group), 68 ...
journal_title:Open medicine (Warsaw, Poland)
pub_type: 杂志文章
doi:10.1515/med-2020-0204
更新日期:2020-07-10 00:00:00