Development of epidermal growth factor receptor tyrosine kinase inhibitors against EGFR T790M. Mutation in non small-cell lung carcinoma.

abstract：Background:Cardiac arrest related to nerve blockade using a local anaesthetic is a rare event. We report a case of bupivacaine severe cardiovascular toxicity following cervical paravertebral nerve block. Case presentation:A 44-year-old female was admitted to Republican Vilnius University Hospital, with symptoms of sus...

journal_title：Open medicine (Warsaw, Poland)

authors： Vosylius S,Uvarovas V,Svediene S,Satkauskas I

更新日期：2019-12-17 00:00:00

abstract：:There are many determinants of vancomycin clearance, but these have not been analyzed separately in populations with different levels of renal function, which could be why some important factors have been missed. The aim of our study was to compare the pharmacokinetic parameters and factors that may affect vancomycin ...

journal_title：Open medicine (Warsaw, Poland)

authors： Zaric RZ,Milovanovic J,Rosic N,Milovanovic D,Zecevic DR,Folic M,Jankovic S

更新日期：2018-10-22 00:00:00

abstract：Background and aim:To explore the diagnostic value of recombinant heparin-binding hemagglutinin adhesin (HBHA) protein antigen in spinal tuberculosis. Materials and methods:Forty patients with spinal tuberculosis were included in the experimental group and 40 healthy people were included in the control group. Serum Ig...

journal_title：Open medicine (Warsaw, Poland)

authors： Pu F,Feng J,Niu F,Xia P

更新日期：2020-02-28 00:00:00

abstract：:One of the most dangerous cancers in humans is Melanoma. However, early detection of melanoma can help us to cure it completely. This paper presents a new efficient method to detect malignancy in melanoma via images. At first, the extra scales are eliminated by using edge detection and smoothing. Afterwards, the propo...

journal_title：Open medicine (Warsaw, Poland)

authors： Razmjooy N,Sheykhahmad FR,Ghadimi N

更新日期：2018-03-15 00:00:00

abstract：:To evaluate the clinical value of serum α-L-fucosidase (AFU), 5'-nucleotidase (5'-NT) and alpha fetoprotein (AFP) as biomarkers for primary hepatocellular carcinoma (PHC) diagnosis. METHODS:Thirty six primary hepatocellular carcinoma (PHC) patients and 36 healthy controls were recruited in this study from February 20...

journal_title：Open medicine (Warsaw, Poland)

authors： Junna Z,Gongde C,Jinying X,Xiu Z

更新日期：2017-10-11 00:00:00

abstract：:Regional anaesthesia techniques in ophthalmology are usually utilized for day case surgery. During various procedures, profound akinesia of the eye and anaesthesia of the surgical site are required, both of which are achieved with retrobulbar block. Due to the anatomy of the eye, life-threatening complications are pos...

journal_title：Open medicine (Warsaw, Poland)

authors： Kostadinov I,Hostnik A,Cvenkel B,Potočnik I

更新日期：2019-03-02 00:00:00

abstract：:Our study aimed to find out the views of nurses working in neonatal intensive care units about the limits of professional competencies and to identify situations where the limits are crossed. Methods:The research employed the focus group method. For this research we had three focus groups with nurses working in neona...

journal_title：Open medicine (Warsaw, Poland)

authors： Skorobogatova N,Žemaitienė N,Šmigelskas K,Tamelienė R,Markūnienė E,Stonienė D

更新日期：2018-10-04 00:00:00

abstract：:Arginine vasopressin can bind to high-affinity vasopressin V1a receptors in human leukocytes. This study aims to investigate the effects of arginine vasopressin on migration and chemotaxis of neutrophils and oxygen free radical release by human leukocytes. Neutrophils and monocytes were obtained from peripheral blood ...

journal_title：Open medicine (Warsaw, Poland)

authors： Wiedermann FJ,Watzinger K,Stichlberger M,Joannidis M,Kaehler C,Lederer W

更新日期：2018-05-09 00:00:00

abstract：Background:Many factors contribute to successful nerve reconstruction. The correct technique of anastomosis is one of the key elements that determine the final result of a surgery. The aim of this study is to examine how useful an electromyography (EMG) can be as an objective intraoperative anastomosis assessment metho...

journal_title：Open medicine (Warsaw, Poland)

authors： Czapla N,Bargiel P,Petriczko J,Kotrych D,Krajewski P,Prowans P

更新日期：2020-06-13 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is a particularly aggressive subtype known for its extremely high drug resistance, progression, poor prognosis, and lack of clear therapeutic targets. Researchers are aiming to advance TNBC treatment worldwide. In the past 2-3 years, more positive results have emerged in the clinic...

journal_title：Open medicine (Warsaw, Poland)

authors： Shen M,Pan H,Chen Y,Xu YH,Yang W,Wu Z

更新日期：2020-11-14 00:00:00

abstract：:Pleiotropic proinflammatory cytokines, interleukin- 1 (IL-1) and tumor necrosis factor-α (TNF-α), involved in the regulations of various immune responses, inflammatory processes and hematopoiesis. In the present study, the expression levels of IL-1 and TNF-α were detected by enzyme-linked immunosorbent assay (ELISA). ...

journal_title：Open medicine (Warsaw, Poland)

authors： Yuan J,Wang L,Lin Y,Chen J,Hu J

更新日期：2015-06-09 00:00:00

abstract：:During radiotherapy treatment for cervical cancer, up to 84% of patients exhibit some form of acute radiation toxicity (ART). The primary aim of this clinical study is to determine the impact of angiotensin-converting enzyme (ACE) inhibitors, β-blockers and other risk factors such as the patient's anatomical character...

journal_title：Open medicine (Warsaw, Poland)

authors： Radojevic MZ,Tomasevic A,Karapandzic VP,Milosavljevic N,Jankovic S,Folic M

更新日期：2020-09-02 00:00:00

abstract：:Responsibility means responding to the damaging consequences of technical work and in this binding perspective the general principles of guilt in genetic diagnostics and related activities are not different from any other medical performance. Performing a genetic test however, especially when it has predictive charact...

journal_title：Open medicine (Warsaw, Poland)

authors： Bin P,Conti A,Capasso E,Fedeli P,Ceccarelli P,Policino F,Casella C,Delbon P

更新日期：2018-08-24 00:00:00

abstract：:This study evaluates the efficacy and safety of bevacizumab (BEV) in the treatment of non-small cell lung cancer (NSCLC) patients with brain metastases (BM) by performing meta-analyses of response and survival indices. Seventeen studies were included. BEV treatment was associated with a lower new BM incidence (hazard ...

journal_title：Open medicine (Warsaw, Poland)

authors： Liang P,Wang YD,Wei ZM,Deng QJ,Xu T,Liu J,Luo N,Hou J

更新日期：2020-07-01 00:00:00

abstract：:Aim of the study is to highlight difficulties faced by an inexperienced surgeon in approaching endorectal-ultrasound, trying to define when learning curve can be considered complete. A prospective analysis was conducted on endorectal-ultrasound performed for subperitoneal rectal adenocarcinoma staging in the period fr...

journal_title：Open medicine (Warsaw, Poland)

authors： Surace A,Ferrarese A,Gentile V,Bindi M,Cumbo J,Solej M,Enrico S,Martino V

更新日期：2016-11-19 00:00:00

abstract：:An intact hepatic artery is the gateway to successful hepato-biliary surgery. Introduction of laproscopic cholecystectomy (LC) has stimulated a renewed interest in the anatomy of hepatic artery. In this case report we have highlighted importance of variations of right hepatic artery in terms of origin and course We pr...

journal_title：Open medicine (Warsaw, Poland)

authors： Martino V,Ferrarese A,Bindi M,Marola S,Gentile V,Rivelli M,Ferrara Y,Enrico S,Berti S,Solej M

更新日期：2015-12-17 00:00:00

abstract：Background:To analyze the cardio-protective effects of ticagrelor in patients with acute coronary syndrome with S-T segment elevation. Methods:The sample was 200 patients who had been diagnosed with acute coronary syndrome accompanied by diabetes Mellitus type II. Only patients having ST segment elevation before the t...

journal_title：Open medicine (Warsaw, Poland)

authors： Li DT,Li SB,Zheng JY,Tang HH,Qiu YG,Xue N,Cao Y

更新日期：2019-02-20 00:00:00

abstract：:Recent studies have revealed that microRNAs regulate radiosensitivity of non-small cell lung cancer (NSCLC). The aim of this study was to investigate whether miR-101-3p is correlated with radiosensitivity of NSCLC. According to our results, miR-101-3p was downregulated in NSCLC tissues and cell lines. Moreover, miR-10...

journal_title：Open medicine (Warsaw, Poland)

authors： Li Z,Qu Z,Wang Y,Qin M,Zhang H

更新日期：2020-06-07 00:00:00

abstract：INTRODUCTION:In Parkinson's disease (PD), a resting tremor of the thumb may affect the flexor pollicis longus (FPL) and influence hand functions. We investigated the relationship between FPL tendon thickness and hand function in PD patients and compared these characteristics with those in healthy controls. METHODS:The...

journal_title：Open medicine (Warsaw, Poland)

authors： Toktas H,Dundar U,Kusbeci ÖY,Ulasli AM,Toy O,Oruc S

更新日期：2016-02-19 00:00:00

abstract：:The international plastination phenomenon has proved to be immensely popular with audiences world-wide. Never before has the human body been exposed to public gaze in such an accessible manner. The exhibitions have perplexed many, included anatomists, some of whom find the display of human bodies unethical. The object...

journal_title：Open medicine (Warsaw, Poland)

authors： Bin P,Conti A,Buccelli C,Addeo G,Capasso E,Piras M

更新日期：2016-12-16 00:00:00

abstract：Background:Numbers of the elderly have been on a steady increase both in Poland and other countries of the world. As they age, their health declines and they need help with their housekeeping. This, coupled with the transformation of intergenerational into single-generation or nuclear family structures, causes a marked...

journal_title：Open medicine (Warsaw, Poland)

authors： Trybusińska D,Saracen A

更新日期：2019-04-24 00:00:00

abstract：Objective:To explore the clinical significance and mechanisms of altered miRNAs in squamous cell carcinoma of head and neck (SCCHN) and provide references for SCCHN diagnosis and prognosis. Method:Differential expressed miRNAs (DEMs) in SCCHN were screened through gene expression omnibus (GEO) DataSets and verified by...

journal_title：Open medicine (Warsaw, Poland)

authors： Zhao L,Tian C,Xiao E,Du J,Liang J,Chen X,Chi W

更新日期：2020-08-03 00:00:00

abstract：:To investigate the safety and efficacy of laparoscopic splenectomy and portaazygous devascularization, we studied laparoscopic splenectomy and porto-azygos devascularization patients within the peri-operative period. Clinical data and curative effect are detailed alongside statistical analysis. The laparoscopic splene...

journal_title：Open medicine (Warsaw, Poland)

authors： Fengyong W,Yuanshui S,Zhangbing,Yuewu W,Weihua Z,Jianfeng S,Qi W,Jinming L,Ji X,Zaiyuan Y

更新日期：2015-12-17 00:00:00

abstract：:The purpose of this study was to examine the efficacy rendered with a single dose of live attenuated measles, rubella, mumps, and varicella containing vaccine. We inoculated healthcare workers (HCWs) with a single dose of vaccine to a disease lacking in antibody titer for those not meeting the criteria of our hospital...

journal_title：Open medicine (Warsaw, Poland)

authors： Ogawa T,Uchiyama-Nakamura F,Sugata-Tsubaki A,Yamada Y,Uno K,Kasahara K,Maeda K,Konishi M,Mikasa K

更新日期：2016-11-26 00:00:00

abstract：:[This corrects the article on p. 479 in vol. 14, PMID: 31231684.]. ...

journal_title：Open medicine (Warsaw, Poland)

authors： Tb M,G T,A G,D A

更新日期：2020-11-27 00:00:00

abstract：:In this study, an effective means for detecting cancer region through different types of medical image segmentation are presented and explained. We proposed a new method for cancer segmentation on the basis of fuzzy entropy with a level set (FELs) thresholding. The proposed method was successfully utilized to segment ...

journal_title：Open medicine (Warsaw, Poland)

authors： Maolood IY,Al-Salhi YEA,Lu S

更新日期：2018-09-08 00:00:00

abstract：OBJECTIVE:To evaluate the expression and correlations of liver X receptor alpha (LXRa) and its target gene sterol regulatory element-binding protein-1c (SREBP-1c) in placentas of preeclampsia (PE) and their significance in PE. METHODS:Pregnancies were divided into two groups, 60 cases (29 cases of mild and 31 cases of...

journal_title：Open medicine (Warsaw, Poland)

authors： Jianhua L,Xueqin M,Jifen H

更新日期：2016-08-13 00:00:00

abstract：:An 85-year-old female suffered pelvic fracture, multiple rib fractures, right hemopneumothorax, and blunt abdominal aortic injury in a traffic accident. After transfer to our hospital, transcatheter arterial embolization (TAE) was performed immediately for hemorrhage from the bilateral internal iliac arteries. Enhance...

journal_title：Open medicine (Warsaw, Poland)

authors： Murata M,Aoki M,Hagiwara S,Sekihara M,Kohri T,Shibuya K,Koike N,Miyazaki D,Oshima K

更新日期：2018-05-24 00:00:00

abstract：:Pulmonary Langerhans Cell Histiocytosis (PLCH) is a rare disease. From the insidious onset and nonspecific manifestations, it is difficult to diagnose PLCH. To help improve the diagnosis and therapy options of adult PLCH, we present this case report and literature review about a confusing case of PLCH. In this report,...

journal_title：Open medicine (Warsaw, Poland)

authors： Li Y,Zhen W,Costable U,Jun X,Zhe R,YuPing M

更新日期：2016-06-15 00:00:00

abstract：:This study is a case report, which presents a case of severe mitral regurgitation in a 77-year-old man. Two-dimensional transesophageal echocardiography (TEE), regurgitant jets directed anteriorly in early systole and centrally to laterally in late systole were seen, while three-dimensional TEE showed a flail posterio...

journal_title：Open medicine (Warsaw, Poland)

authors： Iida R,Aono M,Choy J

更新日期：2018-08-11 00:00:00