Abstract:
:HNF1A-antisense 1 (HNF1A-AS1), a long non-coding RNA (lncRNA), is associated with metastasis and is an independent prognostic factor for lung cancer. Recent studies demonstrated that HNF1A-AS1 play important roles in cacinogenesis. However, the exact effects and molecular mechanisms of HNF1A-AS1 in osteosarcoma (OS) progression is still unclear. In the present study, we found that HNF1A-AS1 was markedly up-regulated in OS tissues compared to their adjacent non-tumor tissues. HNF1A-AS1 expression levels were positively associated with the clinical stage, distant metastasis, and reduced overall survival of OS patients. In addition, knockdown HNF1A-AS1 expression inhibited cell proliferation, metastasis and influences the activity of the Wnt/β-catenin pathway in OS cells. Wnt/β-catenin pathway activator (LiCl) rescued the anticancer effect of knockdown HNF1A-AS1 expression in OS cells. In conclusion, our study demonstrated that HNF1A-AS1 promoted the progression of OS via regulating the activity of the Wnt/β-catenin pathway, indicating that HNF1A-AS1 might be a potential target for the treatment of OS.
journal_name
Am J Transl Resjournal_title
American journal of translational researchauthors
Zhao H,Hou W,Tao J,Zhao Y,Wan G,Ma C,Xu Hsubject
Has Abstractpub_date
2016-08-15 00:00:00pages
3503-12issue
8issn
1943-8141journal_volume
8pub_type
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journal_title:American journal of translational research
pub_type: 杂志文章
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journal_title:American journal of translational research
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journal_title:American journal of translational research
pub_type: 杂志文章
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journal_title:American journal of translational research
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journal_title:American journal of translational research
pub_type: 杂志文章,评审
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journal_title:American journal of translational research
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journal_title:American journal of translational research
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journal_title:American journal of translational research
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journal_title:American journal of translational research
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journal_title:American journal of translational research
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更新日期:2018-05-15 00:00:00
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journal_title:American journal of translational research
pub_type: 杂志文章
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journal_title:American journal of translational research
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journal_title:American journal of translational research
pub_type: 杂志文章,收录出版
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journal_title:American journal of translational research
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journal_title:American journal of translational research
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更新日期:2018-03-15 00:00:00
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journal_title:American journal of translational research
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journal_title:American journal of translational research
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更新日期:2019-11-15 00:00:00
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journal_title:American journal of translational research
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journal_title:American journal of translational research
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journal_title:American journal of translational research
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journal_title:American journal of translational research
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journal_title:American journal of translational research
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journal_title:American journal of translational research
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