The pathophysiology of extracellular hemoglobin associated with enhanced oxidative reactions.

abstract：:In the kidney, the stimulation of renin production by the collecting duct (CD-renin) contributes to the development of hypertension. The CD is a major nephron segment for the synthesis of nitric oxide (NO), and low NO bioavailability in the renal medulla is associated with hypertension. However, it is unknown whether ...

journal_title：Frontiers in physiology

authors： Curnow AC,Gonsalez SR,Gogulamudi VR,Visniauskas B,Simon EE,Gonzalez AA,Majid DSA,Lara LS,Prieto MC

更新日期：2020-11-17 00:00:00

abstract：:This work investigates the effect of arterial bifurcation angulation on atherosclerosis development through in-silico simulations of coupled cell dynamics. The computational model presented here combines cellular pathways, fluid dynamics, and physiologically-realistic vessel geometries as observed in the human vascula...

journal_title：Frontiers in physiology

authors： Dowding S,Zakkaroff C,Moore S,David T

更新日期：2018-10-31 00:00:00

abstract：:Defects in mitochondrial ribosomal proteins (MRPs) cause various diseases in humans. Because of the essential role of MRPs in synthesizing the essential subunits of oxidative phosphorylation (OXPHOS) complexes, identifying all of the protein components involved in the mitochondrial translational machinery is critical....

journal_title：Frontiers in physiology

authors： Koc EC,Cimen H,Kumcuoglu B,Abu N,Akpinar G,Haque ME,Spremulli LL,Koc H

更新日期：2013-07-30 00:00:00

abstract：:Untreated chronic hypertension causes left ventricular hypertrophy, which is related to the occurrence of atrial fibrillation. Dronedarone is an antiarrhythmic agent recently approved for atrial fibrillation. Our group previously demonstrated that dronedarone produced an early regression of left ventricular hypertroph...

journal_title：Frontiers in physiology

authors： Pazó-Sayós L,González MC,Quintana-Villamandos B

更新日期：2020-08-26 00:00:00

abstract：:Kir7.1 encoded by the Kcnj13 gene in the mouse is an inwardly rectifying K+ channel present in epithelia where it shares membrane localization with the Na+/K+-pump. Further investigations of the localisation and function of Kir7.1 would benefit from the availability of a knockout mouse, but perinatal mortality attribu...

journal_title：Frontiers in physiology

authors： Cornejo I,Villanueva S,Burgos J,López-Cayuqueo KI,Chambrey R,Julio-Kalajzić F,Buelvas N,Niemeyer MI,Figueiras-Fierro D,Brown PD,Sepúlveda FV,Cid LP

更新日期：2018-04-23 00:00:00

abstract：:Purpose: Aging is associated with changes in muscle energy metabolism. Proton (1H) and phosphorous (31P) magnetic resonance spectroscopy (MRS) has been successfully applied for non-invasive investigation of skeletal muscle metabolism. The aim of this study was to detect differences in adenosine triphosphate (ATP) prod...

journal_title：Frontiers in physiology

authors： Krumpolec P,Klepochová R,Just I,Tušek Jelenc M,Frollo I,Ukropec J,Ukropcová B,Trattnig S,Krššák M,Valkovič L

更新日期：2020-06-29 00:00:00

abstract：:Over the past decade, the excited delirium syndrome (ExDS) has raised continued controversy regarding the cause and manner of death of some highly agitated persons held in police custody, restrained or incapacitated by electrical devices. At autopsy, medical examiners have difficulty in identifying an anatomic cause o...

journal_title：Frontiers in physiology

authors： Mash DC

更新日期：2016-10-13 00:00:00

abstract：:The ingestion of intact protein or essential amino acids (EAA) stimulates mechanistic target of rapamycin complex-1 (mTORC1) signaling and muscle protein synthesis (MPS) following resistance exercise. The purpose of this study was to investigate the response of myofibrillar-MPS to ingestion of branched-chain amino aci...

journal_title：Frontiers in physiology

authors： Jackman SR,Witard OC,Philp A,Wallis GA,Baar K,Tipton KD

更新日期：2017-06-07 00:00:00

abstract：:γ-Aminobutyric Acid (GABA) and its receptors, GABAA,B,C, are expressed in several locations along the gastrointestinal tract. Nevertheless, a role for GABA in enteric synaptic transmission remains elusive. In this study, we characterized the expression and function of GABA in the myenteric plexus of the mouse ileum. A...

journal_title：Frontiers in physiology

authors： Koussoulas K,Swaminathan M,Fung C,Bornstein JC,Foong JPP

更新日期：2018-02-13 00:00:00

abstract：:Skeletal muscle mass reflects a dynamic turnover between net protein synthesis and degradation. In addition, satellite cell inclusion may contribute to increase muscle mass while fiber loss results in a reduction of muscle mass. Since 2010, a few studies looked at the involvement of the newly discovered Hippo pathway ...

journal_title：Frontiers in physiology

authors： Gnimassou O,Francaux M,Deldicque L

更新日期：2017-03-29 00:00:00

abstract：:Current cardiac drug safety assessments focus on hERG channel block and QT prolongation for evaluating arrhythmic risks, whereas the optogenetic approach focuses on the action potential (AP) waveform generated by a monolayer of human cardiomyocytes beating synchronously, thus assessing the contribution of several ion ...

journal_title：Frontiers in physiology

authors： Björk S,Ojala EA,Nordström T,Ahola A,Liljeström M,Hyttinen J,Kankuri E,Mervaala E

更新日期：2017-11-02 00:00:00

abstract：:Eryptosis is the suicidal destruction-process of erythrocytes, much like apoptosis of nucleated cells, in the course of which the stressed red cell undergoes cell-shrinkage, vesiculation and externalization of membrane phosphatidylserine. Currently, there exist numerous methods to detect eryptosis, both morphometrical...

journal_title：Frontiers in physiology

authors： Jacob SS,Prasad K,Rao P,Kamath A,Hegde RB,Baby PM,Rao RK

更新日期：2019-09-24 00:00:00

abstract：:We tested the hypothesis that elastic binding of the abdomen (AB) would enhance neuromuscular efficiency of the human diaphragm during exercise. Twelve healthy non-obese men aged 24.8 ± 1.7 years (mean ± SE) completed a symptom-limited constant-load cycle endurance exercise test at 85% of their peak incremental power ...

journal_title：Frontiers in physiology

authors： Abdallah SJ,Chan DS,Glicksman R,Mendonca CT,Luo Y,Bourbeau J,Smith BM,Jensen D

更新日期：2017-05-31 00:00:00

abstract：:Giant clams live in symbiosis with extracellular zooxanthellae and display high rates of growth and shell formation (calcification) in light. Light-enhanced calcification requires an increase in the supply of Ca2+ to, and simultaneously an augmented removal of H+ from, the extrapallial fluid where shell formation occu...

journal_title：Frontiers in physiology

authors： Ip YK,Hiong KC,Goh EJK,Boo MV,Choo CYL,Ching B,Wong WP,Chew SF

更新日期：2017-10-10 00:00:00

abstract：:Temporal computations are important in the acoustic communication of anurans. In many cases, calls between closely related species are nearly identical spectrally but differ markedly in temporal structure. Depending on the species, calls can differ in pulse duration, shape and/or rate (i.e., amplitude modulation), dir...

journal_title：Frontiers in physiology

authors： Rose GJ

更新日期：2014-05-30 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is a devastating and fatal chronic lung disease. While current pharmacotherapies have improved patient quality of life, PAH drugs suffer from limitations in the form of short-term pharmacokinetics, instability, and poor organ specificity. Traditionally, nanotechnology-based delive...

journal_title：Frontiers in physiology

authors： Segura-Ibarra V,Wu S,Hassan N,Moran-Guerrero JA,Ferrari M,Guha A,Karmouty-Quintana H,Blanco E

更新日期：2018-07-13 00:00:00

abstract：:The appearance of oxygen in the terrestrial atmosphere represented an important selective pressure for ancestral living organisms and contributed toward setting up the pace of evolutionary changes in structural and functional systems. The evolution of using oxygen for efficient energy production served as a driving fo...

journal_title：Frontiers in physiology

authors： Naudí A,Jové M,Ayala V,Portero-Otín M,Barja G,Pamplona R

更新日期：2013-12-17 00:00:00

abstract：Objective:Varicose veins are a common problem worldwide and can cause significant impairments in health-related quality of life, but the etiology and pathogenesis remain not well defined. This study aims to elucidate transcriptomic regulations of varicose veins by detecting differentially expressed genes, pathways and ...

journal_title：Frontiers in physiology

authors： Zhang J,Nie Q,Si C,Wang C,Chen Y,Sun W,Pan L,Guo J,Kong J,Cui Y,Wang F,Fan X,Ye Z,Wen J,Liu P

更新日期：2019-03-19 00:00:00

abstract：:The capacity of the human brain to interpret and respond to multiple temporal scales in its surroundings suggests that its internal interactions must also be able to operate over a broad temporal range. In this paper, we utilize a recently introduced method for characterizing the rate of change of the phase difference...

journal_title：Frontiers in physiology

authors： Botcharova M,Berthouze L,Brookes MJ,Barnes GR,Farmer SF

更新日期：2015-06-17 00:00:00

abstract：:Skeletal muscles are the largest cells in the body and are one of the few syncytial ones. There is a longstanding belief that a given nucleus controls a defined volume of cytoplasm, so when a muscle grows (hypertrophy) or shrinks (atrophy), the number of myonuclei change accordingly. This phenomenon is known as the "m...

journal_title：Frontiers in physiology

authors： Schwartz LM

更新日期：2019-01-25 00:00:00

abstract：:An early event in atherogenesis is the recruitment and infiltration of circulating monocytes and macrophage activation in the subendothelial space. Atherosclerosis subsequently progresses as a unresolved inflammatory disease, particularly in hypercholesterolemic conditions. Although physical exercise training has been...

journal_title：Frontiers in physiology

authors： Rentz T,Wanschel ACBA,de Carvalho Moi L,Lorza-Gil E,de Souza JC,Dos Santos RR,Oliveira HCF

更新日期：2020-11-23 00:00:00

abstract：:The multifunctional CD36 scavenger receptor facilitates fatty acid (FA) uptake and oxidation and it has been involved in the pathophysiology related to dysfunctional FA metabolism. The common variant in the CD36 gene, rs1761667 (A/G), whose allele A is characterized by a reduced protein expression, has been associated...

journal_title：Frontiers in physiology

authors： Melis M,Carta G,Pintus S,Pintus P,Piras CA,Murru E,Manca C,Di Marzo V,Banni S,Tomassini Barbarossa I

更新日期：2017-12-06 00:00:00

abstract：:Muscle wasting in cancer cachexia can be alleviated by blocking activin receptor type 2 (ACVR2) ligands through changes in protein synthesis/degradation. These changes in cellular and protein metabolism may alter protein homeostasis. First, we elucidated the acute (1-2 days) and 2-week effects of blocking ACVR2 ligand...

journal_title：Frontiers in physiology

authors： Hentilä J,Nissinen TA,Korkmaz A,Lensu S,Silvennoinen M,Pasternack A,Ritvos O,Atalay M,Hulmi JJ

更新日期：2019-01-18 00:00:00

abstract：:Inflammation is a process whose main function is to fight against invading pathogens or foreign agents. Nonetheless, it is widely accepted that inflammation takes part in multiple processes in a physiological or pathophysiological context. Among these processes the inflammation has been closely related to bone metabol...

journal_title：Frontiers in physiology

authors： Alonso-Pérez A,Franco-Trepat E,Guillán-Fresco M,Jorge-Mora A,López V,Pino J,Gualillo O,Gómez R

更新日期：2018-05-08 00:00:00

abstract：:The Pacific white shrimp (Litopenaeus vannamei), a euryhaline penaeid species, can tolerate a wide range of salinities, but little is known on its strategies to cope with low salinity fluctuations from the aspect of lipidomics. Thus, in this study, L. vannamei were grown in two different salinities [3 and 30‰ (control...

journal_title：Frontiers in physiology

authors： Huang M,Dong Y,Zhang Y,Chen Q,Xie J,Xu C,Zhao Q,Li E

更新日期：2019-08-23 00:00:00

abstract：:Background: Dental aberrations have been mentioned in relation to non-surgical hypoparathyroidism (Ns-HypoPT) and pseudohypoparathyroidism (PHP). However, a systematic review of dental characteristics have not been performed. The present systematic review describes the dental findings in patients with Ns-HypoPT and PH...

journal_title：Frontiers in physiology

authors： Hejlesen J,Underbjerg L,Gjørup H,Bloch-Zupan A,Sikjaer T,Rejnmark L,Haubek D

更新日期：2018-06-19 00:00:00

abstract：:The spawning migration of the European eel is an extensive journey over 5000 to 7000 km from the European coast to the Sargasso Sea. Eels do not feed during this journey and on-board fuels must be sufficient to support the journey of 3.5 to 6 month, as well as sexual maturation and the spawning activity. Swimming of e...

journal_title：Frontiers in physiology

authors： Pelster B

更新日期：2015-01-05 00:00:00

abstract：Objective:Polycystin-1 (PC-1) is a protein encoded by the gene of polycystic kidney disease-1 (PKD-1). This study was designed to investigate the regulatory mechanisms of PC-1 on phenotypes of aortic vascular smooth muscle cells (VSMCs) and functions of extracellular matrix (ECM) in thoracic aortic dissection (TAD). M...

journal_title：Frontiers in physiology

authors： Zhang J,Liu F,He YB,Zhang W,Ma WR,Xing J,Wang LX

更新日期：2020-09-24 00:00:00

abstract：:The analysis of neural systems leverages tools from many different fields. Drawing on techniques from the study of critical phenomena in statistical mechanics, several studies have reported signatures of criticality in neural systems, including power-law distributions, shape collapses, and optimized quantities under t...

journal_title：Frontiers in physiology

authors： Timme NM,Marshall NJ,Bennett N,Ripp M,Lautzenhiser E,Beggs JM

更新日期：2016-09-27 00:00:00

abstract：:We previously demonstrated that ureteral obstruction is associated with a urinary concentrating defect and reduced expression of renal aquaporins (AQPs), in which the renin-angiotensin system (RAS) may play an important role. The aims of the present study were to examine whether the renin inhibitor aliskiren could pre...

journal_title：Frontiers in physiology

authors： Hu S,Xie H,Luo R,Feng P,Liu Q,Han M,Kong Y,Zou X,Wang W,Li C

更新日期：2019-09-13 00:00:00