Abstract：
:Although major depressive disorder imposes a serious public health burden and affects nearly one in six individuals in developed countries over their lifetimes, there is still no consensus on its pathophysiology. Inflammation and cytokines have emerged as a promising new avenue in depression research, and, in particular, macrophage migration inhibitory factor (MIF) has been shown to be significant in depression physiology. In this review we summarize current research on MIF and depression. We highlight the arguments for MIF as a pro- and antidepressant species and discuss the potential implications for therapeutics.
journal_name
J Neuroinflammationjournal_title
Journal of neuroinflammationauthors
Bloom J,Al-Abed Ydoi
10.1186/1742-2094-11-11subject
Has Abstractpub_date
2014-01-21 00:00:00pages
11issn
1742-2094pii
1742-2094-11-11journal_volume
11pub_type
杂志文章,评审abstract：BACKGROUND:Interleukin-33 (IL-33) is increasingly being recognized as a key immunomodulatory cytokine in many neurological diseases. METHODS:In the present study, wild-type (WT) and IL-33-/- mice received intracerebroventricular (i.c.v.) injection of lipopolysaccharide (LPS) to induce neuroinflammation. Intravital mic...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-018-1169-6
更新日期：2018-05-04 00:00:00
abstract：BACKGROUND:The neutrophil to lymphocyte ratio (NLR) has been shown to predict short- and long-term outcomes in ischemic stroke patients. We sought to explore the temporal profile of the plasma NLR in stroke patients treated with intravenous thrombolysis (IVT) and its relationship with intracranial bleeding complication...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-016-0680-x
更新日期：2016-08-26 00:00:00
abstract：BACKGROUND:Pro-inflammatory cytokines are known to have deleterious effects on Schwann cells (SCs). Interleukin 17 (IL-17) is a potent pro-inflammatory cytokine that exhibits relevant effects during inflammation in the peripheral nervous system (PNS), and IL-17-secreting cells have been reported within the endoneurium ...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/1742-2094-11-63
更新日期：2014-03-29 00:00:00
abstract：BACKGROUND:The early dysfunction and subsequent recovery after stroke, characterized by the destruction and remodeling of connective pathways between cortex and subcortical regions, is associated with neuroinflammation. As major components of the inflammatory process, reactive astrocytes have double-edged effects on pa...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-016-0622-7
更新日期：2016-06-18 00:00:00
abstract：BACKGROUND:The FDA-approved small-molecule drug ibrutinib is an effective targeted therapy for patients with chronic lymphocytic leukemia (CLL). Ibrutinib inhibits Bruton's tyrosine kinase (BTK), a kinase involved in B cell receptor signaling. However, the potential regulation of neuroinflammatory responses in the brai...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-018-1308-0
更新日期：2018-09-19 00:00:00
abstract：BACKGROUND:Recent evidence has suggested that peripheral inflammatory responses induced by lipopolysaccharides (LPS) play an important role in neuropsychiatric dysfunction in rodents. Interleukin-1β (IL-1β), a pro-inflammatory cytokine, has been proposed to be a key mediator in a variety of behavioral dysfunction induc...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-017-0964-9
更新日期：2017-09-20 00:00:00
abstract：BACKGROUND:Spinal cord ischemia-reperfusion (I/R) involves two-phase injury, including an initial acute ischemic insult and subsequent inflammatory reperfusion injury, resulting in blood-spinal cord barrier (BSCB) dysfunction involving the TLR₄ pathway. However, the correlation between TLR₄/MyD₈₈-dependent and TLR₄/TRI...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/1742-2094-11-62
更新日期：2014-03-28 00:00:00
abstract：BACKGROUND:A dose-limiting side effect of chemotherapeutic agents such as vincristine (VCR) is neuropathic pain, which is poorly managed at present. Chemokine-mediated immune cell/neuron communication in preclinical VCR-induced pain forms an intriguing basis for the development of analgesics. In a murine VCR model, CX3...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-018-1116-6
更新日期：2018-04-06 00:00:00
abstract：BACKGROUND:Microglial activation contributes to the development of chronic migraine (CM). The P2Y12 receptor (P2Y12R), a metabolic purinoceptor that is expressed on microglia in the central nervous system (CNS), has been indicated to play a critical role in the pathogenesis of chronic pain. However, whether it contribu...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-019-1603-4
更新日期：2019-11-13 00:00:00
abstract：BACKGROUND:Ischemic stroke is a devastating disease without a cure. The available treatments for ischemic stroke, thrombolysis by tissue plasminogen activator, and thrombectomy are suitable only to a fraction of patients and thus novel therapeutic approaches are urgently needed. The neuroinflammatory responses elicited...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-020-01870-w
更新日期：2020-06-19 00:00:00
abstract：BACKGROUND:Discoveries that microglia-mediated neuroinflammation is involved in the pathological process of depression provided a new strategy for novel antidepressant therapy. Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor regulating inflammation and microglial polarization and, therefore, ...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-016-0728-y
更新日期：2016-10-04 00:00:00
abstract：BACKGROUND:Over-activated microglia play a central role during neuroinflammation, leading to neuronal cell death and neurodegeneration. Reversion of over-activated to neuroprotective microglia phenotype could regenerate a healthy CNS-supporting microglia environment. Our aim was to identify a dataset of intracellular m...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-018-1386-z
更新日期：2018-12-15 00:00:00
abstract：BACKGROUND:Therapeutic modalities effective in patients with progressive forms of multiple sclerosis (MS) are limited. In a murine model of progressive MS, the sustained disability during the chronic phase of experimental autoimmune encephalomyelitis (EAE) correlated with elevated expression of interleukin (IL)-6, a cy...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-015-0293-9
更新日期：2015-04-22 00:00:00
abstract：BACKGROUND:Parkinson's disease (PD) is a neurodegenerative disease with characteristics and symptoms that are well defined. Nevertheless, its aetiology remains unknown. PD is characterized by the presence of Lewy bodies inside neurons. α-Synuclein (α-syn) is a soluble protein present in the pre-synaptic terminal of neu...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-015-0412-7
更新日期：2015-10-26 00:00:00
abstract：BACKGROUND:Noradrenaline (NA) is known to limit neuroinflammation. However, the previously described induction by NA of a chemokine involved in the progression of immune/inflammatory processes, such as chemokine (C-C motif) ligand 2 (CCL2)/monocyte chemotactic protein-1 (MCP-1), apparently contradicts NA anti-inflammat...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/1742-2094-10-81
更新日期：2013-07-09 00:00:00
abstract：BACKGROUND:Several lines of evidence suggest that CCL2 could initiate the hyperalgesia of neuropathic pain by causing central sensitization of spinal dorsal horn neurons and facilitating nociceptive transmission in the spinal dorsal horn. The cellular and molecular mechanisms by which CCL2 enhances spinal pain transmis...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/1742-2094-11-7
更新日期：2014-01-10 00:00:00
abstract：BACKGROUND:Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive loss of cognitive abilities and memory leading to dementia. Electroacupuncture (EA) is a complementary alternative medicine approach, applying an electrical current to acupuncture points. In clinical and animal studies, EA ...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-019-1665-3
更新日期：2019-12-13 00:00:00
abstract：BACKGROUND:Rasmussen encephalitis (RE) is a rare neuroinflammatory disease characterized by intractable seizures and progressive atrophy on one side of the cerebrum. Perivascular cuffing and clusters of T cells in the affected cortical hemisphere are indicative of an active cellular immune response. METHODS:Peripheral...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-015-0352-2
更新日期：2015-07-19 00:00:00
abstract：BACKGROUND:Although evidence suggests that the prevalence of Parkinson's disease (PD) is lower in smokers than in non-smokers, the mechanisms of nicotine-induced neuroprotection remain unclear. Stimulation of the α7 nicotinic acetylcholine receptor (α7-nAChR) seems to be a crucial mechanism underlying the anti-inflamma...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/1742-2094-9-98
更新日期：2012-05-24 00:00:00
abstract：BACKGROUND:Pain is one critical hallmark of inflammatory responses. A large number of studies have demonstrated that stromal cell-derived factor 1 (SDF1, also named as CXCL12) and its cognate receptor C-X-C chemokine receptor type 4 (CXCR4) play an important role in immune reaction and inflammatory processes. However, ...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-015-0441-2
更新日期：2015-11-24 00:00:00
abstract：BACKGROUND:Neuroinflammation and demyelination have been suggested as mechanisms causing HIV-1 associated neurocognitive disorder (HAND). This cross-sectional cohort study explores the potential role of antibodies to myelin oligodendrocyte glycoprotein (MOG), a putative autoantigen in multiple sclerosis, in the pathoge...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/1742-2094-7-79
更新日期：2010-11-17 00:00:00
abstract：BACKGROUND:Subarachnoid hemorrhage (SAH) is a neurological emergency with limited pharmacological treatment options. Inflammation is increasingly recognized as a key pathogenic contributor to brain injury in this condition. In the present study, we examined the neuroprotective effects of the immunomodulatory agent, fin...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-015-0234-7
更新日期：2015-01-27 00:00:00
abstract：BACKGROUND:Ischemic stroke is a main cause of mortality. Blood-brain barrier (BBB) breakdown appears to play a critical role in inflammation in patients with ischemic stroke and acceleration of brain injury. The BBB has a protective function and is composed of endothelial cells, pericytes, and astrocytes. In ischemic s...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-020-1727-6
更新日期：2020-02-04 00:00:00
abstract：BACKGROUND:Interleukin-17A (IL-17A) is the founding member of a novel family of inflammatory cytokines that plays a critical role in the pathogenesis of many autoimmune diseases, including multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). IL-17A signals through its receptor,...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/1742-2094-6-14
更新日期：2009-04-28 00:00:00
abstract：:Stroke is one of the leading causes of death worldwide. A strong inflammatory response characterized by activation and release of cytokines, chemokines, adhesion molecules, and proteolytic enzymes contributes to brain damage following stroke. Stroke outcomes are worse among diabetics, resulting in increased mortality ...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章,评审
doi：10.1186/s12974-016-0774-5
更新日期：2017-01-23 00:00:00
abstract：BACKGROUND:Necrotizing enterocolitis (NEC) is an acute gut inflammatory disorder that occurs in preterm infants in the first weeks after birth. Infants surviving NEC often show impaired neurodevelopment. The mechanisms linking NEC lesions with later neurodevelopment are poorly understood but may include proinflammatory...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-018-1201-x
更新日期：2018-06-09 00:00:00
abstract：BACKGROUND:Synucleinopathies comprise a group of neurodegenerative diseases associated with abnormal accumulation of α-synuclein. One of the key factors that contribute to the progression of synucleinopathies is neuroinflammation. However, the role of lymphocytes in synucleinopathies like Parkinson's disease (PD) remai...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-016-0632-5
更新日期：2016-06-30 00:00:00
abstract：BACKGROUND:Extracellular matrix metalloproteinase inducer (EMMPRIN; CD147, basigin) is an inducer of the expression of several matrix metalloproteinases (MMPs). We reported previously that blocking EMMPRIN activity reduced neuroinflammation and severity of disease in an animal model of multiple sclerosis (MS), experime...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/1742-2094-9-64
更新日期：2012-04-05 00:00:00
abstract：BACKGROUND:Since HIV-associated neurocognitive disorders (HANDs) occur in up to half of HIV-positive individuals, even with combined antiretroviral therapy (cART), adjunctive therapies are needed. Chronic CNS inflammation contributes to HAND and HIV encephalitis (HIVE). Baricitinib is a JAK 1/2 inhibitor approved in th...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-019-1565-6
更新日期：2019-09-27 00:00:00
abstract：:Major depressive disorder (MDD) is a leading cause of disability worldwide. After the first episode, patients with remitted MDD have a 60% chance of experiencing a second episode. Consideration of therapy continuation should be viewed in terms of the balance between the adverse effects of medication and the need to pr...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章,评审
doi：10.1186/s12974-019-1475-7
更新日期：2019-04-17 00:00:00
