IL-13 Signaling in Liver Fibrogenesis.

abstract：Background:A plurality of neurological syndromes is associated with autoantibodies against neural antigens relevant for diagnosis and therapy. Identification of these antigens is crucial to understand the pathogenesis and to develop specific immunoassays. Using an indirect immunofluorescence assay (IFA)-based approach ...

journal_title：Frontiers in immunology

authors： Scharf M,Miske R,Kade S,Hahn S,Denno Y,Begemann N,Rochow N,Radzimski C,Brakopp S,Probst C,Teegen B,Stöcker W,Komorowski L

更新日期：2018-07-09 00:00:00

abstract：:Inflammation is a common characteristic of chronic liver disease (CLD). Inflammasomes are multiprotein complexes that can sense and recognize various exogenous and endogenous danger signals, eventually activating interleukin (IL)-1β and IL-18. The sensor component of the inflammasome system is a nucleotide-binding oli...

journal_title：Frontiers in immunology

authors： Wu X,Dong L,Lin X,Li J

更新日期：2017-12-12 00:00:00

abstract：:The apoptosis of hemocytes plays an essential function in shrimp immune defense against pathogen invasions. In order to further elucidate the differential apoptotic responses of the granulocytes and the hyalinocytes in Fenneropenaeus chinensis post WSSV infection, the characteristics of apoptotic dynamics and viral pr...

journal_title：Frontiers in immunology

authors： Cui C,Liang Q,Tang X,Xing J,Sheng X,Zhan W

更新日期：2020-12-07 00:00:00

abstract：:Vaccine-elicited cytotoxic T lymphocytes (CTL) recognizing conserved fragments of a pathogen's proteome could greatly impact infectious diseases and cancers. Enabling this potential are recent advances in mass spectrometry that identify specific target peptides among the myriad HLA-bound peptides on altered cells. Ult...

journal_title：Frontiers in immunology

authors： Reinherz EL,Keskin DB,Reinhold B

更新日期：2014-09-04 00:00:00

abstract：:The liver has long been known to possess tolerogenic properties. Early experiments in liver transplantation demonstrated that in animal models, hepatic allografts could be accepted across MHC-mismatch without the use of immunosuppression, and that transplantation of livers from the same donor was capable of inducing t...

journal_title：Frontiers in immunology

authors： McCaughan GW,Bowen DG,Bertolino PJ

更新日期：2020-09-11 00:00:00

abstract：:Tuberculosis (TB) remains a leading global health problem that is aggravated by emergence of drug-resistant strains, which account for increasing number of treatment-refractory cases. Thus, eradication of this disease will strongly require better therapeutic strategies. Identification of host factors promoting disease...

journal_title：Frontiers in immunology

authors： Ndlovu H,Marakalala MJ

更新日期：2016-10-24 00:00:00

abstract：:The transfer of maternal immune factors to the newborn is critical for protection from infectious disease in early life. Maternally acquired passive immunity provides protection until the infant is beyond early life's increased susceptibility to severe infections or until active immunity is achieved following infant's...

journal_title：Frontiers in immunology

authors： Abu-Raya B,Smolen KK,Willems F,Kollmann TR,Marchant A

更新日期：2016-08-31 00:00:00

abstract：:Long lasting antibody responses and immunological memory are the desired outcomes of vaccination. In general, multiple vaccine doses result in enhanced immune responses, a notable exception being booster-induced hyporesponsiveness, which has been observed with polysaccharide and glycoconjugate vaccines. In this study,...

journal_title：Frontiers in immunology

authors： Mantile F,Capasso A,De Berardinis P,Prisco A

更新日期：2019-03-19 00:00:00

abstract：:Intestinal dysbiosis associated with immunological deregulation, leaky gut, bacterial translocation, and systemic inflammation has been associated with autoimmune diseases, such as type 1 diabetes (T1D). The aim of this study was to investigate the intestinal dysbiosis in T1D patients and correlate these results with ...

journal_title：Frontiers in immunology

authors： Higuchi BS,Rodrigues N,Gonzaga MI,Paiolo JCC,Stefanutto N,Omori WP,Pinheiro DG,Brisotti JL,Matheucci E Jr,Mariano VS,de Oliveira GLV

更新日期：2018-07-25 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSC) play a crucial role in regulating the intestinal immune response during colitis. We previously revealed an essential role of MDSC in promoting TH17 cell polarization, which was found to be arginase-1 (Arg-1)-dependent; however, the underlying mechanism remains obscure. Here we r...

journal_title：Frontiers in immunology

authors： Ma Z,Zhen Y,Hu C,Yi H

更新日期：2020-04-22 00:00:00

abstract：:Chagas disease, which was once thought to be confined to endemic regions of Latin America, has now gone global becoming a new worldwide challenge. For more than a century since its discovery, it has remained neglected with no effective drugs or vaccines. The mechanisms by which Trypanosoma cruzi regulates and uses the...

journal_title：Frontiers in immunology

authors： Nde PN,Lima MF,Johnson CA,Pratap S,Villalta F

更新日期：2012-11-06 00:00:00

abstract：:Despite the wide availability of antiretroviral therapy (ART) prophylaxis during pregnancy, >150,000 infants become infected through mother-to-child transmission (MTCT) of HIV worldwide. It is likely that additional intervention strategies, such as a maternal HIV vaccine, will be required to eliminate pediatric HIV in...

journal_title：Frontiers in immunology

authors： Douglas AO,Martinez DR,Permar SR

更新日期：2017-09-04 00:00:00

abstract：:Determining whether an asymptomatic individual with Prostate-Specific Antigen (PSA) levels below 20 ng ml-1 has prostate cancer in the absence of definitive, biopsy-based evidence continues to present a significant challenge to clinicians who must decide whether such individuals with low PSA values have prostate cance...

journal_title：Frontiers in immunology

authors： Cosma G,McArdle SE,Reeder S,Foulds GA,Hood S,Khan M,Pockley AG

更新日期：2017-12-18 00:00:00

abstract：:Responsiveness of maturing natural killer (NK) cells to chemotactic molecules directly affect their retention and relocation in selected bone marrow (BM) microenvironment during development, as well as their localization at sites of immune response during inflammatory diseases. BM is the main site of NK cell generatio...

journal_title：Frontiers in immunology

authors： Bernardini G,Sciumè G,Santoni A

更新日期：2013-01-30 00:00:00

abstract：:We characterized five different vaccine candidates and a commercial vaccine in terms of safety, immunogenicity and using a systems vaccinology approach, with the aim to select novel vaccine candidates against Mycoplasma hyopneumoniae. Seven groups of six M. hyopneumoniae-free piglets were primo- and booster vaccinated...

journal_title：Frontiers in immunology

authors： Matthijs AMF,Auray G,Jakob V,García-Nicolás O,Braun RO,Keller I,Bruggman R,Devriendt B,Boyen F,Guzman CA,Michiels A,Haesebrouck F,Collin N,Barnier-Quer C,Maes D,Summerfield A

更新日期：2019-05-24 00:00:00

abstract：:FcγRIIa is an activating FcγR, unique to humans and non-human primates. It induces antibody-dependent proinflammatory responses and exists predominantly as FcγRIIa1. A unique splice variant, we designated FcγRIIa3, has been reported to be associated with anaphylactic reactions to intravenous immunoglobulins (IVIg) the...

journal_title：Frontiers in immunology

authors： Anania JC,Trist HM,Palmer CS,Tan PS,Kouskousis BP,Chenoweth AM,Kent SJ,Mackay GA,Hoi A,Koelmeyer R,Slade C,Bryant VL,Hodgkin PD,Aui PM,van Zelm MC,Wines BD,Hogarth PM

更新日期：2018-08-20 00:00:00

abstract：:While T cell-based immunotherapies are steadily improving, there are still many patients who progress, despite T cell-infiltrated tumors. Emerging evidence suggests that T cells themselves may provoke immune escape of cancer cells. Here, we describe a well-controlled co-culture system for studying the dynamic T cell -...

journal_title：Frontiers in immunology

authors： Neubert NJ,Soneson C,Barras D,Baumgaertner P,Rimoldi D,Delorenzi M,Fuertes Marraco SA,Speiser DE

更新日期：2016-08-30 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) can be divided into prognostically distinct subsets with stereotyped or non-stereotyped, mutated or unmutated B cell receptors (BCRs). Individual subsets vary in antigen specificity and origin, but the impact of antigenic pressure on the CLL BCR repertoire remains unknown. Here, we e...

journal_title：Frontiers in immunology

authors： Pal Singh S,de Bruijn MJW,de Almeida MP,Meijers RWJ,Nitschke L,Langerak AW,Pillai SY,Stadhouders R,Hendriks RW

更新日期：2018-09-13 00:00:00

abstract：:The genome has the ability to respond in a precise and co-ordinated manner to cellular signals. It achieves this through the concerted actions of transcription factors and the chromatin platform, which are targets of the signaling pathways. Our understanding of the molecular mechanisms through which transcription fact...

journal_title：Frontiers in immunology

authors： Brettingham-Moore KH,Taberlay PC,Holloway AF

更新日期：2015-09-29 00:00:00

abstract：:The glycans on the plasma membrane of cells manifest as the glycocalyx, which serves as an information-rich frontier that is directly in contact with its immediate milieu. The glycoconjugates (GCs) that adorn most of the mammalian cells are also abundant in gametes, especially the spermatozoa where they perform unique...

journal_title：Frontiers in immunology

authors： Batra V,Dagar K,Nayak S,Kumaresan A,Kumar R,Datta TK

更新日期：2020-08-28 00:00:00

abstract：:Recent years have seen an unprecedented rise in the incidence of multidrug-resistant (MDR) Gram-negative bacteria (GNBs) such as Acinetobacter and Klebsiella species. In view of the shortage of novel drugs in the pipeline, alternative strategies to prevent, and treat infections by GNBs are urgently needed. Previously,...

journal_title：Frontiers in immunology

authors： Youssef EG,Zhang L,Alkhazraji S,Gebremariam T,Singh S,Yount NY,Yeaman MR,Uppuluri P,Ibrahim AS

更新日期：2020-02-18 00:00:00

abstract：:Current pain therapeutics offer inadequate relief to patients with chronic pain. A growing literature supports that pro-inflammatory cytokine signaling between immune, glial, and neural cells is integral to the development of pathological pain. Modulation of these communications may hold the key to improved pain manag...

journal_title：Frontiers in immunology

authors： Vanderwall AG,Milligan ED

更新日期：2019-12-23 00:00:00

abstract：:Mycobacterium tuberculosis continues to be one of the most successful pathogens on earth. Upon inhalation of M. tuberculosis by a healthy individual, the host immune system will attempt to eliminate these pathogens using a combination of immune defense strategies. These include the recruitment of macrophages and other...

journal_title：Frontiers in immunology

authors： BoseDasgupta S,Pieters J

更新日期：2014-10-08 00:00:00

abstract：:Re-directing T cells via chimeric antigen receptors (CARs) was first tested in HIV-infected individuals with limited success, but these pioneering studies laid the groundwork for the clinically successful CD19 CARs that were recently FDA approved. Now there is great interest in revisiting the concept of using CAR-expr...

journal_title：Frontiers in immunology

authors： Kim GB,Hege K,Riley JL

更新日期：2019-09-27 00:00:00

abstract：:Immunological aging remodels the immune system at several levels. This has been documented in particular for the T-cell receptor (TCR)αβ+ T-cell compartment, showing reduced naive T-cell outputs and an accumulation of terminally differentiated clonally expanding effector T-cells, leading to increased proneness to auto...

journal_title：Frontiers in immunology

authors： Kallemeijn MJ,Kavelaars FG,van der Klift MY,Wolvers-Tettero ILM,Valk PJM,van Dongen JJM,Langerak AW

更新日期：2018-03-06 00:00:00

abstract：:NK cells play an important role in the innate defenses against tumor growth and metastases. Human NK cell activation and function are regulated by an array of HLA class I-specific inhibitory receptors and activating receptors recognizing ligands expressed de novo on tumor or virus-infected cells. NK cells have been ex...

journal_title：Frontiers in immunology

authors： Vacca P,Pietra G,Tumino N,Munari E,Mingari MC,Moretta L

更新日期：2020-01-17 00:00:00

abstract：:This study aimed to investigate the adipokine and cytokine profiles of adipocytes from epicardial and subcutaneous adipose tissues in interconnection with the visceral adipose tissue area and the biochemical and clinical characteristics of patients with coronary artery disease. We assessed 84 patients with coronary ar...

journal_title：Frontiers in immunology

authors： Gruzdeva O,Uchasova E,Dyleva Y,Borodkina D,Akbasheva O,Antonova L,Matveeva V,Belik E,Ivanov S,Sotnikov A,Kozyrin K,Brel N,Sinitsky M,Karetnikova V,Kokov A,Bychkova E,Pecherina T,Barbarash O

更新日期：2019-09-19 00:00:00

abstract：:The follicular helper T (Tfh) cells help is critical for activation of B cells, antibody class switching, and germinal center (GC) formation. The Tfh cells are characterized by the expression of CXC chemokine receptor 5 (CXCR5), ICOS, programed death 1 (PD-1), B cell lymphoma 6 (BCL-6), and IL-21. They are involved in...

journal_title：Frontiers in immunology

authors： Jogdand GM,Mohanty S,Devadas S

更新日期：2016-11-23 00:00:00

abstract：:Damage associated molecular patterns (DAMPs) are endogenous molecules originate from damaged cells and tissues with the ability to trigger and/or modify innate immune responses. Upon hemolysis hemoglobin (Hb) is released from red blood cells (RBCs) to the circulation and give a rise to the production of different Hb r...

journal_title：Frontiers in immunology

authors： Bozza MT,Jeney V

更新日期：2020-06-30 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by erosive polyarthritis. Beyond joint pathology, RA is associated with neuropsychiatric comorbidity including depression, anxiety, and an increased risk to develop neurodegenerative diseases in later life. Studies investigating the central nerv...

journal_title：Frontiers in immunology

authors： Süß P,Rothe T,Hoffmann A,Schlachetzki JCM,Winkler J

更新日期：2020-12-10 00:00:00