The Role of Maternal HIV Envelope-Specific Antibodies and Mother-to-Child Transmission Risk.

abstract：:A common feature of many acute and chronic oral diseases is microbial-induced inflammation. Innate immune responses are the first line of defense against pathogenic microorganisms and are initiated by pattern recognition receptors (PRRs) that specifically recognize pathogen-associated molecular patterns and danger-ass...

journal_title：Frontiers in immunology

authors： Wang L,Sun L,Byrd KM,Ko CC,Zhao Z,Fang J

更新日期：2020-08-13 00:00:00

abstract：:Heterogeneous populations of myeloid regulatory cells (MRC), including monocytes, macrophages, dendritic cells, and neutrophils, are found in cancer and infectious diseases. The inflammatory environment in solid tumors as well as infectious foci with persistent pathogens promotes the development and recruitment of MRC...

journal_title：Frontiers in immunology

authors： Dorhoi A,Du Plessis N

更新日期：2018-01-04 00:00:00

abstract：:The mucin gene, MUC5AC, is highly expressed both in chronic respiratory inflammatory diseases and inflammatory bowel disease where mucin secretion is regulated by members of the interleukin IL-20 subfamily. This study was conducted to determine the roles and mechanisms of IL-19, a member of the IL-20 subfamily, in reg...

journal_title：Frontiers in immunology

authors： Lai X,Li X,Chang L,Chen X,Huang Z,Bao H,Huang J,Yang L,Wu X,Wang Z,Bellanti JA,Zheng SG,Zhang G

更新日期：2019-07-17 00:00:00

abstract：:Though promoting remyelination in multiple sclerosis (MS) has emerged as a promising therapeutic strategy, it does not address inflammatory signals that continue to induce neuronal damage and inhibit effectiveness of repair mechanisms. Our lab has previously characterized the immunomodulatory tetrapeptide, tuftsin, wh...

journal_title：Frontiers in immunology

authors： Thompson KK,Nissen JC,Pretory A,Tsirka SE

更新日期：2018-11-28 00:00:00

abstract：:Renal ischemia reperfusion injury (IRI), a common event after renal transplantation, causes acute kidney injury (AKI), increases the risk of delayed graft function (DGF), primes the donor kidney for rejection, and contributes to the long-term risk of graft loss. In the last decade, epidemiological studies have linked ...

journal_title：Frontiers in immunology

authors： Tammaro A,Kers J,Scantlebery AML,Florquin S

更新日期：2020-07-07 00:00:00

abstract：:Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is the most common antibody-mediated encephalitis. There are several studies on B cell repertoire of anti-NMDAR encephalitis in Caucasians. Here, the cerebrospinal fluid (CSF) samples of 12 Chinese patients with first-episode anti-NMDAR encephalitis were collecte...

journal_title：Frontiers in immunology

authors： Feng J,Fan S,Sun Y,Zhang Z,Ren H,Li W,Cui L,Peng B,Ren X,Zhang W,Guan H,Wang J

更新日期：2020-07-29 00:00:00

abstract：:Free heme is an inflammatory molecule capable of inducing migration and activation of neutrophils. Here, we examine the heme-driven oxidative stress-associated cell death mechanisms in human neutrophils infected with Leishmania infantum, an etiologic agent of visceral leishmaniasis (VL). We first performed exploratory...

journal_title：Frontiers in immunology

authors： Quintela-Carvalho G,Luz NF,Celes FS,Zanette DL,Andrade D,Menezes D,Tavares NM,Brodskyn CI,Prates DB,Gonçalves MS,de Oliveira CI,Almeida RP,Bozza MT,Andrade BB,Borges VM

更新日期：2017-11-23 00:00:00

abstract：:The Kallikrein-Kinin System (KKS), comprised of kallikreins (klks), bradykinins (BKs) angiotensin-converting enzyme (ACE), and many other molecules, regulates a number of physiological processes, including inflammation, coagulation, angiogenesis, and control of blood pressure. In this report, we show that KKS regulate...

journal_title：Frontiers in immunology

authors： Seliga A,Lee MH,Fernandes NC,Zuluaga-Ramirez V,Didukh M,Persidsky Y,Potula R,Gallucci S,Sriram U

更新日期：2018-02-02 00:00:00

abstract：:Monoclonal antibodies targeting the regulatory immune "checkpoint" receptors CTLA-4, PD-1, and PD-L1 are now standard therapy for diverse malignancies including melanoma, lung cancer, and renal cell carcinoma. Although effective in many patients and able to induce cures in some, targeting these regulatory pathways has...

journal_title：Frontiers in immunology

authors： Dougan M

更新日期：2017-11-15 00:00:00

abstract：:Glutathione (GSH), a major cellular antioxidant, is considered an inhibitor of the inflammatory response involving reactive oxygen species (ROS). However, evidence is largely based on experiments with exogenously added antioxidants/reducing agents or pro-oxidants. We show that depleting macrophages of 99% of GSH does ...

journal_title：Frontiers in immunology

authors： Diotallevi M,Checconi P,Palamara AT,Celestino I,Coppo L,Holmgren A,Abbas K,Peyrot F,Mengozzi M,Ghezzi P

更新日期：2017-09-29 00:00:00

abstract：:Multiple sclerosis (MS) is an immune-mediated inflammatory demyelinating disease of the central nervous system. It was previously shown that toll-like receptor (TLR)-2 signaling plays a key role in the murine experimental autoimmune encephalomyelitis (EAE) model of MS, and that TLR2-stimulation of regulatory T cells (...

journal_title：Frontiers in immunology

authors： Hossain MJ,Morandi E,Tanasescu R,Frakich N,Caldano M,Onion D,Faraj TA,Erridge C,Gran B

更新日期：2018-03-14 00:00:00

abstract：:Anemia of inflammation (AI) is the second most prevalent anemia after iron deficiency anemia and results in persistent low blood erythrocytes and hemoglobin, fatigue, weakness, and early death. Anemia of inflammation is common in people with chronic inflammation, chronic infections, or sepsis. Although several studies...

journal_title：Frontiers in immunology

authors： Bisht K,Tay J,Wellburn RN,McGirr C,Fleming W,Nowlan B,Barbier V,Winkler IG,Levesque JP

更新日期：2020-10-06 00:00:00

abstract：:In the current quest for a complete cure for HIV/AIDS, highly sensitive HIV-1 latency detection methods are critical to verify full viral eradication. Until now, the in vitro quantitative viral outgrowth assays (qVOA) have been the gold standard for assessing latent HIV-1 viral burden. However, these assays have been ...

journal_title：Frontiers in immunology

authors： Schmitt K,Akkina R

更新日期：2018-03-05 00:00:00

abstract：:Chronic hepatitis C virus (HCV) infection disrupts immune functions, including that of cytotoxic CD8+ T-cells which are important mediators of immune response. While HCV cure aims to eliminate long term sequelae of infection, whether direct-acting antiviral (DAA) treatment results in immune reconstitution remains uncl...

journal_title：Frontiers in immunology

authors： Vranjkovic A,Deonarine F,Kaka S,Angel JB,Cooper CL,Crawley AM

更新日期：2019-08-13 00:00:00

abstract：:Most patients with chronic lymphocytic leukemia (CLL) exhibit an indolent disease course and unresponsive B cell receptors (BCRs) exemplified by an anergic phenotype of their leukemic cells. In up to 5% of patients, CLL transforms from an indolent subtype to an aggressive form of B cell lymphoma (Richter's syndrome), ...

journal_title：Frontiers in immunology

authors： Märklin M,Fuchs AR,Tandler C,Heitmann JS,Salih HR,Kauer J,Quintanilla-Martinez L,Wirths S,Kopp HG,Müller MR

更新日期：2020-09-02 00:00:00

abstract：:Pulmonary hypertension secondary to bronchopulmonary dysplasia (BPD-PH) represents a major complication of BPD in extremely preterm infants for which there are currently no safe and effective interventions. The abundance of interleukin-1 (IL-1) is strongly correlated with the severity and long-term outcome of BPD infa...

journal_title：Frontiers in immunology

authors： Bui CB,Kolodziej M,Lamanna E,Elgass K,Sehgal A,Rudloff I,Schwenke DO,Tsuchimochi H,Kroon MAGM,Cho SX,Maksimenko A,Cholewa M,Berger PJ,Young MJ,Bourke JE,Pearson JT,Nold MF,Nold-Petry CA

更新日期：2019-07-11 00:00:00

abstract：:Thrombocytes, nucleated hemostatic blood cells of non-mammalian vertebrates, are regarded as the functional equivalent of anucleated mammalian platelets. Additional immune functions, including phagocytosis, have also been suggested for thrombocytes, but no conclusive molecular or cellular experimental evidence for the...

journal_title：Frontiers in immunology

authors： Nagasawa T,Nakayasu C,Rieger AM,Barreda DR,Somamoto T,Nakao M

更新日期：2014-09-16 00:00:00

abstract：:Effective prophylactic strategy against the current epidemic of sexually transmitted HIV-1 infection requires understanding of the innate gatekeeping mechanisms at the genital mucosa. Surfactant protein D (SP-D), a member of the collectin family of proteins naturally present in the vaginal tract, is a potential HIV-1 ...

journal_title：Frontiers in immunology

authors： Pandit H,Kale K,Yamamoto H,Thakur G,Rokade S,Chakraborty P,Vasudevan M,Kishore U,Madan T,Fichorova RN

更新日期：2019-03-28 00:00:00

abstract：:[This corrects the article on p. 299 in vol. 6, PMID: 26150816.]. ...

journal_title：Frontiers in immunology

authors： Frontiers Production Office.

更新日期：2016-04-28 00:00:00

abstract：:Objectives: Considering the critical role of microRNAs (miRNAs) in regulation of cell activation, we investigated their role in circulating type-2 conventional dendritic cells (cDC2s) of patients with primary Sjögren's syndrome (pSS) compared to healthy controls (HC). Methods: CD1c-expressing cDC2s were isolated from ...

journal_title：Frontiers in immunology

authors： Lopes AP,van Roon JAG,Blokland SLM,Wang M,Chouri E,Hartgring SAY,van der Wurff-Jacobs KMG,Kruize AA,Burgering BMT,Rossato M,Radstake TRDJ,Hillen MR

更新日期：2019-06-20 00:00:00

abstract：:Genetic modification of mesenchymal stem cells (MSCs) is a promising strategy to improve their therapeutic effects. Granulocyte-colony stimulating factor (G-CSF) is a growth factor widely used in the clinical practice with known regenerative and immunomodulatory actions, including the mobilization of regulatory T cell...

journal_title：Frontiers in immunology

authors： Silva DN,Souza BSF,Vasconcelos JF,Azevedo CM,Valim CXR,Paredes BD,Rocha VPC,Carvalho GB,Daltro PS,Macambira SG,Nonaka CKV,Ribeiro-Dos-Santos R,Soares MBP

更新日期：2018-06-25 00:00:00

abstract：:The heat-labile toxins (LT) produced by enterotoxigenic Escherichia coli display adjuvant effects to coadministered antigens, leading to enhanced production of serum antibodies. Despite extensive knowledge of the adjuvant properties of LT derivatives, including in vitro-generated non-toxic mutant forms, little is know...

journal_title：Frontiers in immunology

authors： Maeda DLNF,Batista MT,Pereira LR,de Jesus Cintra M,Amorim JH,Mathias-Santos C,Pereira SA,Boscardin SB,Silva SDR,Faquim-Mauro EL,Silveira VB,Oliveira DBL,Johnston SA,Ferreira LCS,Rodrigues JF

更新日期：2017-09-25 00:00:00

abstract：:Human pathogen Campylobacter jejuni is a significant risk factor for the development of long-term intestinal dysfunction although the cellular and molecular mechanisms remain scantily defined. IL-23 is an emerging therapeutic target for the treatment of inflammatory intestinal diseases, however its role in C. jejuni-d...

journal_title：Frontiers in immunology

authors： Jing X,Korchagina AA,Shein SA,Muraoka WT,Koroleva E,Tumanov AV

更新日期：2021-01-06 00:00:00

abstract：:Experimental evidence indicates that mesenchymal stromal cells (MSCs) may regulate tumor microenvironment (TME). It is conceivable that the interaction with MSC can influence neoplastic cell functional behavior, remodeling TME and generating a tumor cell niche that supports tissue neovascularization, tumor invasion an...

journal_title：Frontiers in immunology

authors： Poggi A,Varesano S,Zocchi MR

更新日期：2018-02-19 00:00:00

abstract：:The generation of antibodies against protein antigens (such as donor-specific HLA molecules) requires that T follicular helper cells (Tfh) provide help to B cells. Immunosuppressive (IS) armamentarium prevents T cell activation, yet a significant proportion of renal transplant patients develop donor-specific antibodie...

journal_title：Frontiers in immunology

authors： Dahdal S,Saison C,Valette M,Bachy E,Pallet N,Lina B,Koenig A,Monneret G,Defrance T,Morelon E,Thaunat O

更新日期：2019-02-05 00:00:00

abstract：:Inflammasome activation can trigger an inflammatory and innate immune response through the release of cytokines and induction of pyroptosis. A dysfunctional inflammasome has been implicated in the development of human pathologies, including sepsis and septic shock. Here, we show that advanced glycosylation end-product...

journal_title：Frontiers in immunology

authors： Chen R,Zhu S,Zeng L,Wang Q,Sheng Y,Zhou B,Tang D,Kang R

更新日期：2019-08-08 00:00:00

abstract：:Loss-of-function mutations in the Autoimmune Regulator (AIRE) gene cause a rare inherited form of autoimmune disease, autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy, also known as autoimmune polyglandular syndrome type 1. The patients suffer from multiple endocrine deficiencies, the most common manifes...

journal_title：Frontiers in immunology

authors： Arstila TP,Jarva H

更新日期：2013-10-07 00:00:00

abstract：:Antibody production and function represent an essential part of the immune response, particularly in fighting bacterial and viral infections. Multiple immunological phenotypes can result in dysregulation of the immune system humoral compartment, including class-switch recombination (CSR) defects associated with hyper-...

journal_title：Frontiers in immunology

authors： Jhamnani RD,Nunes-Santos CJ,Bergerson J,Rosenzweig SD

更新日期：2018-09-26 00:00:00

abstract：:Recent events have made it clear that potentially pandemic strains of influenza regularly pose a threat to human populations. Therefore, it is essential that we develop better strategies to enhance vaccine design and evaluation to predict those that will be poor responders to vaccination and to identify those that are...

journal_title：Frontiers in immunology

authors： DiPiazza A,Richards KA,Knowlden ZA,Nayak JL,Sant AJ

更新日期：2016-01-25 00:00:00

abstract：:In addition to physical barriers, neutrophils are considered a part of the first line of immune defense. They can be found in the bloodstream, with a lifespan of 6-8 h, and in tissue, where they can last up to 7 days. The mechanisms that neutrophils utilize for host defense are phagocytosis, degranulation, cytokine pr...

journal_title：Frontiers in immunology

authors： Delgado-Rizo V,Martínez-Guzmán MA,Iñiguez-Gutierrez L,García-Orozco A,Alvarado-Navarro A,Fafutis-Morris M

更新日期：2017-02-06 00:00:00