Hyaluronate fragments reverse skin atrophy by a CD44-dependent mechanism.

abstract：:Is it ethical for scientists to conduct or to benefit from research in another country if that research would be unlawful, or not generally accepted, in their own country? ...

journal_title：PLoS medicine

authors： Skene L

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:Insecticide-treated nets (ITNs) and indoor residual spraying (IRS) of houses provide effective malaria transmission control. There is conflicting evidence about whether it is more beneficial to provide both interventions in combination. A cluster randomised controlled trial was conducted to investigate wheth...

journal_title：PLoS medicine

authors： West PA,Protopopoff N,Wright A,Kivaju Z,Tigererwa R,Mosha FW,Kisinza W,Rowland M,Kleinschmidt I

更新日期：2014-04-15 00:00:00

abstract：BACKGROUND:Annual influenza vaccination of institutional health care workers (HCWs) is advised in most Western countries, but adherence to this recommendation is generally low. Although protective effects of this intervention for nursing home patients have been demonstrated in some clinical trials, the exact relationsh...

journal_title：PLoS medicine

authors： van den Dool C,Bonten MJ,Hak E,Heijne JC,Wallinga J

更新日期：2008-10-28 00:00:00

abstract：BACKGROUND:With cesarean section rates increasing worldwide, clarity regarding negative effects is essential. This study aimed to investigate the rate of subsequent stillbirth, miscarriage, and ectopic pregnancy following primary cesarean section, controlling for confounding by indication. METHODS AND FINDINGS:We perf...

journal_title：PLoS medicine

authors： O'Neill SM,Agerbo E,Kenny LC,Henriksen TB,Kearney PM,Greene RA,Mortensen PB,Khashan AS

更新日期：2014-07-01 00:00:00

abstract：:In an Editorial, Ligia Kiss and Cathy Zimmerman discuss the need for research on the prevention of human trafficking and mitigation of its effects. ...

journal_title：PLoS medicine

authors： Kiss L,Zimmerman C

更新日期：2019-01-29 00:00:00

abstract：BACKGROUND:Observational epidemiological studies indicate that maternal height is associated with gestational age at birth and fetal growth measures (i.e., shorter mothers deliver infants at earlier gestational ages with lower birth weight and birth length). Different mechanisms have been postulated to explain these as...

journal_title：PLoS medicine

authors： Zhang G,Bacelis J,Lengyel C,Teramo K,Hallman M,Helgeland Ø,Johansson S,Myhre R,Sengpiel V,Njølstad PR,Jacobsson B,Muglia L

更新日期：2015-08-18 00:00:00

abstract：BACKGROUND:The vast majority of medical interventions introduced into clinical development prove unsafe or ineffective. One prominent explanation for the dismal success rate is flawed preclinical research. We conducted a systematic review of preclinical research guidelines and organized recommendations according to the...

journal_title：PLoS medicine

authors： Henderson VC,Kimmelman J,Fergusson D,Grimshaw JM,Hackam DG

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:This paper examines the efforts of consultants affiliated with Philip Morris (PM), the world's leading transnational tobacco corporation, to influence scientific research and training in Thailand via the Chulabhorn Research Institute (CRI). A leading Southeast Asian institute for environmental health science...

journal_title：PLoS medicine

authors： Mackenzie R,Collin J

更新日期：2008-12-23 00:00:00

abstract：BACKGROUND:Undiagnosed and misdiagnosed tuberculosis (TB) drives the epidemic in India. Serological (antibody detection) TB tests are not recommended by any agency, but widely used in many countries, including the Indian private sector. The cost and impact of using serology compared with other diagnostic techniques is ...

journal_title：PLoS medicine

authors： Dowdy DW,Steingart KR,Pai M

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Seven of 15 clinical trial participants treated with a nucleoside analogue (fialuridine [FIAU]) developed acute liver failure. Five treated participants died, and two required a liver transplant. Preclinical toxicology studies in mice, rats, dogs, and primates did not provide any indication that FIAU would b...

journal_title：PLoS medicine

authors： Xu D,Nishimura T,Nishimura S,Zhang H,Zheng M,Guo YY,Masek M,Michie SA,Glenn J,Peltz G

更新日期：2014-04-15 00:00:00

abstract：:Gordon C. Smith discusses the study by Katy Kozhimannil and colleagues that examines variations in cesarean section rates in the US and argues for the need for high-quality routine data collection to better understand the reasons for these variations. Please see later in the article for the Editors' Summary. ...

journal_title：PLoS medicine

authors： Smith GC

更新日期：2014-10-21 00:00:00

abstract：BACKGROUND:Bariatric surgery is becoming a more widespread treatment for obesity. Comprehensive evidence of the long-term effects of contemporary surgery on a broad range of clinical outcomes in large populations treated in routine clinical practice is lacking. The objective of this study was to measure the association...

journal_title：PLoS medicine

authors： Douglas IJ,Bhaskaran K,Batterham RL,Smeeth L

更新日期：2015-12-22 00:00:00

abstract：BACKGROUND:Postpartum hemorrhage (PPH) is a leading cause of maternal death in sub-Saharan Africa. Although the World Health Organization recommends use of oxytocin for prevention of PPH, misoprostol use is increasingly common owing to advantages in shelf life and potential for sublingual administration. There is a lac...

journal_title：PLoS medicine

authors： Atukunda EC,Siedner MJ,Obua C,Mugyenyi GR,Twagirumukiza M,Agaba AG

更新日期：2014-11-04 00:00:00

abstract：BACKGROUND:As the number of HIV-infected women initiating lifelong antiretroviral therapy (ART) during pregnancy increases globally, concerns have emerged regarding low levels of retention in HIV services and suboptimal adherence to ART during the postpartum period. We examined the impact of integrating postpartum ART ...

journal_title：PLoS medicine

authors： Myer L,Phillips TK,Zerbe A,Brittain K,Lesosky M,Hsiao NY,Remien RH,Mellins CA,McIntyre JA,Abrams EJ

更新日期：2018-03-30 00:00:00

abstract：BACKGROUND:Many mathematical models have investigated the impact of expanding access to antiretroviral therapy (ART) on new HIV infections. Comparing results and conclusions across models is challenging because models have addressed slightly different questions and have reported different outcome metrics. This study co...

journal_title：PLoS medicine

authors： Eaton JW,Johnson LF,Salomon JA,Bärnighausen T,Bendavid E,Bershteyn A,Bloom DE,Cambiano V,Fraser C,Hontelez JA,Humair S,Klein DJ,Long EF,Phillips AN,Pretorius C,Stover J,Wenger EA,Williams BG,Hallett TB

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Unrecognized myocardial infarction (UMI) is known to constitute a substantial portion of potentially lethal coronary heart disease. However, the diagnosis of UMI is based on the appearance of incidental Q-waves on 12-lead electrocardiography. Thus, the syndrome of non-Q-wave UMI has not been investigated. De...

journal_title：PLoS medicine

authors： Kim HW,Klem I,Shah DJ,Wu E,Meyers SN,Parker MA,Crowley AL,Bonow RO,Judd RM,Kim RJ

更新日期：2009-04-21 00:00:00

abstract：BACKGROUND:The radical cure of Plasmodium vivax and P. ovale requires treatment with primaquine or tafenoquine to clear dormant liver stages. Either drug can induce haemolysis in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency, necessitating screening. The reference diagnostic method for G6PD activ...

journal_title：PLoS medicine

authors： Pfeffer DA,Ley B,Howes RE,Adu P,Alam MS,Bansil P,Boum Y 2nd,Brito M,Charoenkwan P,Clements A,Cui L,Deng Z,Egesie OJ,Espino FE,von Fricken ME,Hamid MMA,He Y,Henriques G,Khan WA,Khim N,Kim S,Lacerda M,Lon C,Me

更新日期：2020-05-14 00:00:00

abstract：:Tom Boyles reflects on differing approaches taken for treating patients with Ebola virus disease in low- and high-resource settings. ...

journal_title：PLoS medicine

authors： Boyles TH

更新日期：2015-07-28 00:00:00

abstract：BACKGROUND:Women with preeclampsia (PEC) and gestational hypertension (GH) exhibit insulin resistance during pregnancy, independent of obesity and glucose intolerance. Our aim was to determine whether women with PEC or GH during pregnancy have an increased risk of developing diabetes after pregnancy, and whether the pr...

journal_title：PLoS medicine

authors： Feig DS,Shah BR,Lipscombe LL,Wu CF,Ray JG,Lowe J,Hwee J,Booth GL

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Four studies previously indicated that the effect of malaria infection during pregnancy on the risk of low birthweight (LBW; <2,500 g) may depend upon maternal nutritional status. We investigated this dependence further using a large, diverse study population. METHODS AND FINDINGS:We evaluated the interacti...

journal_title：PLoS medicine

authors： Cates JE,Unger HW,Briand V,Fievet N,Valea I,Tinto H,D'Alessandro U,Landis SH,Adu-Afarwuah S,Dewey KG,Ter Kuile FO,Desai M,Dellicour S,Ouma P,Gutman J,Oneko M,Slutsker L,Terlouw DJ,Kariuki S,Ayisi J,Madanitsa M,M

更新日期：2017-08-08 00:00:00

abstract：BACKGROUND:Identifying stage II patients with colorectal cancer (CRC) at higher risk of progression is a clinical priority in order to optimize the advantages of adjuvant chemotherapy while avoiding unnecessary toxicity. Recently, the intensity and the quality of the host immune response in the tumor microenvironment h...

journal_title：PLoS medicine

authors： Sanz-Pamplona R,Melas M,Maoz A,Schmit SL,Rennert H,Lejbkowicz F,Greenson JK,Sanjuan X,Lopez-Zambrano M,Alonso MH,Qu C,McDonnell KJ,Idos GE,Vignali M,Emerson R,Fields P,Guinó E,Santos C,Salazar R,Robins HS,Rennert

更新日期：2020-09-24 00:00:00

abstract：BACKGROUND:Only about half the studies that have collected information on the relevance of women's height and body mass index to their risk of developing ovarian cancer have published their results, and findings are inconsistent. Here, we bring together the worldwide evidence, published and unpublished, and describe th...

journal_title：PLoS medicine

authors： Collaborative Group on Epidemiological Studies of Ovarian Cancer.

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Spurred by the creation of potential modified risk tobacco products, the US Food and Drug Administration (FDA) commissioned the Institute of Medicine (IOM) to assess the science base for tobacco "harm reduction," leading to the 2001 IOM report Clearing the Smoke. The objective of this study was to determine ...

journal_title：PLoS medicine

authors： Tan CE,Kyriss T,Glantz SA

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Development of noninvasive molecular assays to improve disease diagnosis and patient monitoring is a critical need. In renal transplantation, acute rejection (AR) increases the risk for chronic graft injury and failure. Noninvasive diagnostic assays to improve current late and nonspecific diagnosis of reject...

journal_title：PLoS medicine

authors： Roedder S,Sigdel T,Salomonis N,Hsieh S,Dai H,Bestard O,Metes D,Zeevi A,Gritsch A,Cheeseman J,Macedo C,Peddy R,Medeiros M,Vincenti F,Asher N,Salvatierra O,Shapiro R,Kirk A,Reed EF,Sarwal MM

更新日期：2014-11-11 00:00:00

abstract：BACKGROUND:Lifetime glycemic exposure and its relationship with age at diagnosis in type 2 diabetes (T2D) are unknown. Pharmacologic glycemic management strategies for young-onset T2D (age at diagnosis <40 years) are poorly defined. We studied how age at diagnosis affects glycemic exposure, glycemic deterioration, and ...

journal_title：PLoS medicine

authors： Ke C,Stukel TA,Shah BR,Lau E,Ma RC,So WY,Kong AP,Chow E,Chan JCN,Luk A

更新日期：2020-09-18 00:00:00

abstract：BACKGROUND:Research needs to be reported transparently so readers can critically assess the strengths and weaknesses of the design, conduct, and analysis of studies. Reporting guidelines have been developed to inform reporting for a variety of study designs. The objective of this study was to identify whether there is ...

journal_title：PLoS medicine

authors： Bennett C,Khangura S,Brehaut JC,Graham ID,Moher D,Potter BK,Grimshaw JM

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Psychosis is a severe mental condition that is characterized by a loss of contact with reality and is typically associated with hallucinations and delusional beliefs. There are numerous psychiatric conditions that present with psychotic symptoms, most importantly schizophrenia, bipolar affective disorder, an...

journal_title：PLoS medicine

authors： Huang JT,Leweke FM,Oxley D,Wang L,Harris N,Koethe D,Gerth CW,Nolden BM,Gross S,Schreiber D,Reed B,Bahn S

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:The risk of perinatal death and severe neonatal morbidity increases gradually after 41 weeks of pregnancy. Several randomised controlled trials (RCTs) have assessed if induction of labour (IOL) in uncomplicated pregnancies at 41 weeks will improve perinatal outcomes. We performed an individual participant da...

journal_title：PLoS medicine

authors： Alkmark M,Keulen JKJ,Kortekaas JC,Bergh C,van Dillen J,Duijnhoven RG,Hagberg H,Mol BW,Molin M,van der Post JAM,Saltvedt S,Wikström AK,Wennerholm UB,de Miranda E

更新日期：2020-12-08 00:00:00

abstract：:David Studdert and colleagues explore how to balance public health, individual freedom, and good government when it comes to sugar-sweetened drinks. ...

journal_title：PLoS medicine

authors： Studdert DM,Flanders J,Mello MM

更新日期：2015-07-07 00:00:00

abstract：BACKGROUND:Although it has long been appreciated that ovarian carcinoma subtypes (serous, clear cell, endometrioid, and mucinous) are associated with different natural histories, most ovarian carcinoma biomarker studies and current treatment protocols for women with this disease are not subtype specific. With the emerg...

journal_title：PLoS medicine

authors： Köbel M,Kalloger SE,Boyd N,McKinney S,Mehl E,Palmer C,Leung S,Bowen NJ,Ionescu DN,Rajput A,Prentice LM,Miller D,Santos J,Swenerton K,Gilks CB,Huntsman D

更新日期：2008-12-02 00:00:00