Pacemaker neuron and network oscillations depend on a neuromodulator-regulated linear current.

abstract：:To gain further knowledge on the preclinical phase of Alzheimer's disease (AD), we sought to characterize cognitive performance, neuroimaging and plasma-based AD biomarkers in a cohort of non-demented adults with down syndrome (DS). The goal of the down syndrome biomarker Initiative (DSBI) pilot is to test feasibility...

journal_title：Frontiers in behavioral neuroscience

authors： Rafii MS,Wishnek H,Brewer JB,Donohue MC,Ness S,Mobley WC,Aisen PS,Rissman RA

更新日期：2015-09-14 00:00:00

abstract：:When making decisions, people are typically differently sensitive to gains and losses according to the motivational context in which the choice is performed. As hypothesized by Regulatory Focus Theory (RFT), indeed, goals are supposed to change in relation to the set of possible outcomes. In particular, in a promotion...

journal_title：Frontiers in behavioral neuroscience

authors： Lo Gerfo E,Pisoni A,Ottone S,Ponzano F,Zarri L,Vergallito A,Varoli E,Fedeli D,Romero Lauro LJ

更新日期：2018-04-24 00:00:00

abstract：:First-line treatment of major depression includes administration of a selective serotonin reuptake inhibitor (SSRI), yet studies suggest that remission rates following two trials of an SSRI are <50%. The authors examine the putative biological substrates underlying "treatment resistant depression (TRD)" with the goal ...

journal_title：Frontiers in behavioral neuroscience

authors： Coplan JD,Gopinath S,Abdallah CG,Berry BR

更新日期：2014-05-20 00:00:00

abstract：:Objective: It has been established that reduced vitamin B12 serum levels are associated with cognitive decline and mental illness. The chronic use of methamphetamine (MA), which is a highly addictive drug, can induce cognitive impairment and psychopathological symptoms. There are few studies addressing the association...

journal_title：Frontiers in behavioral neuroscience

authors： Zhai C,Cui M,Cheng X,Ao X,Zhao T,Wu W,Shao Q,Ge D,Song H,Qi F,Ling Q,Ma M,Xu M,Jiao D

更新日期：2018-12-18 00:00:00

abstract：:Inflammatory bowel disease is associated with an increased risk of mental disorders and can be exacerbated by stress. In this study which was performed with male 10-week old C57Bl/6N mice, we used dextran sulfate sodium (DSS)-induced colitis to evaluate behavioral changes caused by intestinal inflammation, to assess t...

journal_title：Frontiers in behavioral neuroscience

authors： Hassan AM,Jain P,Reichmann F,Mayerhofer R,Farzi A,Schuligoi R,Holzer P

更新日期：2014-11-06 00:00:00

abstract：:Reactive and proactive controls of actions are cognitive abilities that allow one to deal with a continuously changing environment by adjusting already programmed actions. They also set forthcoming actions by evaluating the outcome of the previous ones. Earlier studies highlighted sex-related differences in the strate...

journal_title：Frontiers in behavioral neuroscience

authors： Mione V,Canterini S,Brunamonti E,Pani P,Donno F,Fiorenza MT,Ferraina S

更新日期：2015-05-19 00:00:00

abstract：:Instrumental learning and decision-making rely on two parallel systems: a goal-directed and a habitual system. In the past decade, several paradigms have been developed to study these systems in animals and humans by means of e.g., overtraining, devaluation procedures and sequential decision-making. These different pa...

journal_title：Frontiers in behavioral neuroscience

authors： Sjoerds Z,Dietrich A,Deserno L,de Wit S,Villringer A,Heinze HJ,Schlagenhauf F,Horstmann A

更新日期：2016-12-20 00:00:00

abstract：:Adolescent behavior is typified by increased risk-taking, reward- and novelty-seeking, as well as an augmented need for social and environmental stimulation. This behavioral phenotype may result from alterations in outcome valuation or reward learning. In the present set of experiments, we directly compared adult and ...

journal_title：Frontiers in behavioral neuroscience

authors： Stolyarova A,Izquierdo A

更新日期：2015-05-07 00:00:00

abstract：:Anesthetics are often used to characterize the activity of single neurons in vivo for their advantages such as reduction of noise level and convenience in noxious stimulations. Urethane has been a widely used anesthetic in thalamic studies under the assumption that sensory signals are still relayed to the thalamus und...

journal_title：Frontiers in behavioral neuroscience

authors： Huh Y,Cho J

更新日期：2013-10-10 00:00:00

abstract：:Methamphetamine (METH) is a psychomotor stimulant that is reported to enhance sexual desire and behavior in both men and women, leading to increases in unplanned pregnancies, sexually-transmitted infections, and even comorbid psychiatric conditions. Here, we discuss our rodent model of increased sexually-motivated beh...

journal_title：Frontiers in behavioral neuroscience

authors： Rudzinskas SA,Williams KM,Mong JA,Holder MK

更新日期：2019-09-10 00:00:00

abstract：:The dorsomedial prefrontal cortex (dmPFC) is part of the mentalizing network, a set of brain regions consistently engaged in inferring mental states. However, its precise function in this network remains unclear. It has recently been proposed that the dmPFC is involved in high-level abstract (i.e., categorical) identi...

journal_title：Frontiers in behavioral neuroscience

authors： Baetens KL,Ma N,Van Overwalle F

更新日期：2017-03-14 00:00:00

abstract：:Social interactions are critically important for survival and impact overall-health, but also impose costs on animals, such as exposure to contagious agents. The immune system can play a critical role in modulating social behavior when animals are sick, as has been demonstrated within the context of "sickness behavior...

journal_title：Frontiers in behavioral neuroscience

authors： Lopes PC,Carlitz EHD,Kindel M,König B

更新日期：2020-02-05 00:00:00

abstract：:Down syndrome (DS) is an aneuploidy syndrome that is caused by trisomy for human chromosome 21 resulting in a characteristic cognitive and behavioral phenotype, which includes executive functioning and adaptive behavior difficulties possibly due to prefrontal cortex (PFC) deficits. DS also present a high risk for earl...

journal_title：Frontiers in behavioral neuroscience

authors： Del Hoyo L,Xicota L,Langohr K,Sánchez-Benavides G,de Sola S,Cuenca-Royo A,Rodriguez J,Rodríguez-Morató J,Farré M,Dierssen M,de la Torre R,TESDAD Study Group.

更新日期：2016-10-17 00:00:00

abstract：:The Multiple Arousal Theory (Picard et al., 2016) was proposed to explain retrospective observations of bilateral differences in electrodermal activities occurring in threat-related high-stake situations. The theory proposes different cortical and subcortical structures to be involved in the processing of various face...

journal_title：Frontiers in behavioral neuroscience

authors： Bjørhei A,Pedersen FT,Muhammad S,Tronstad C,Kalvøy H,Wojniusz S,Pabst O,Sütterlin S

更新日期：2019-05-07 00:00:00

abstract：BACKGROUND:Alcohol consumption during pregnancy and lactation induces detrimental consequences, that are not limited to the direct in utero effects of the drug on fetuses, but extend to maternal care. However, the occurrence and severity of alcohol toxicity are related to the drinking pattern and the time of exposure. ...

journal_title：Frontiers in behavioral neuroscience

authors： Brancato A,Plescia F,Lavanco G,Cavallaro A,Cannizzaro C

更新日期：2016-03-03 00:00:00

abstract：:Disgust is a natural defensive emotion that has evolved to protect against potential sources of contamination and has been recently linked to moral judgements in many studies. However, that people often report feelings of disgust when thinking about feces or moral transgressions alike does not necessarily mean that th...

journal_title：Frontiers in behavioral neuroscience

authors： Oaten M,Stevenson RJ,Williams MA,Rich AN,Butko M,Case TI

更新日期：2018-08-22 00:00:00

abstract：:Dysregulations in the brain serotonergic system and exposure to environmental stressors have been implicated in the development of major depressive disorder. Here, we investigate the interactions between the stress and serotonergic systems by characterizing the behavioral and biochemical effects of chronic stress appl...

journal_title：Frontiers in behavioral neuroscience

authors： Wong P,Sze Y,Gray LJ,Chang CC,Cai S,Zhang X

更新日期：2015-04-27 00:00:00

abstract：:It is suggested that striatal cAMP responsive element binding protein (CREB) regulates sensitivity to psychostimulants. To test the cell-specificity of this hypothesis we examined the effects of a dominant-negative CREB protein variant expressed in dopamine receptor D1 (D1R) neurons on cocaine-induced behaviors. A tra...

journal_title：Frontiers in behavioral neuroscience

authors： Bilbao A,Rieker C,Cannella N,Parlato R,Golda S,Piechota M,Korostynski M,Engblom D,Przewlocki R,Schütz G,Spanagel R,Parkitna JR

更新日期：2014-06-11 00:00:00

abstract：:The rat vibrissal system is an important model for the study of somatosensation, but the small size and rapid speed of the vibrissae have precluded measuring precise vibrissal-object contact sequences during behavior. We used a laser light sheet to quantify, with 1 ms resolution, the spatiotemporal structure of whiske...

journal_title：Frontiers in behavioral neuroscience

authors： Hobbs JA,Towal RB,Hartmann MJ

更新日期：2016-01-05 00:00:00

abstract：:Beneficial molecular and neuroplastic changes have been demonstrated in response to environmental enrichment (EE) in laboratory animals across the lifespan. Here, we investigated whether these effects extend to C-type Natriuretic Peptide (CNP), a widely expressed neuropeptide with putative involvement in neuroprotecti...

journal_title：Frontiers in behavioral neuroscience

authors： Rapley SA,Prickett TCR,Dalrymple-Alford JC,Espiner EA

更新日期：2018-07-19 00:00:00

abstract：:We have recently shown that upregulation of glutamate transporter 1 (GLT1) in the brain is associated in part with reduction in ethanol intake in alcohol-preferring (P) male rats. In this study, we investigated the effects of a synthetic compound, (R)-(-)-5-methyl-1-nicotinoyl-2-pyrazoline (MS-153), known to activate ...

journal_title：Frontiers in behavioral neuroscience

authors： Alhaddad H,Kim NT,Aal-Aaboda M,Althobaiti YS,Leighton J,Boddu SH,Wei Y,Sari Y

更新日期：2014-10-30 00:00:00

abstract：:Epilepsy is a chronic neurological disease which is usually associated with psychiatric comorbidities. Depsression and cognition impairment are considered to be the most common psychiatric comorbidities in epilepsy patients. However, the specific contribution of epilepsy made to these psychiatric comorbidities remains...

journal_title：Frontiers in behavioral neuroscience

authors： Zhu X,Dong J,Han B,Huang R,Zhang A,Xia Z,Chang H,Chao J,Yao H

更新日期：2017-10-18 00:00:00

abstract：:Reduction of mu activity within the EEG is an indicator of cognitive empathy and can be generated in response to visual depictions of others in pain. The current study tested whether this brain response can be modulated by an auditory and a chemosensory context. Participants observed pictures of painful and non-painfu...

journal_title：Frontiers in behavioral neuroscience

authors： Hoenen M,Lübke KT,Pause BM

更新日期：2018-10-16 00:00:00

abstract：:This study investigated the effects of early institutional care on memory and executive functioning. Subjects were participants in the Bucharest Early Intervention Project (BEIP) and included institutionalized children, children with a history of institutionalization who were assigned to a foster care intervention, an...

journal_title：Frontiers in behavioral neuroscience

authors： Bos KJ,Fox N,Zeanah CH,Nelson Iii CA

更新日期：2009-09-01 00:00:00

abstract：PURPOSE:The present study assessed the influence of L-DOPA administration on neostriatal dopamine (DA) transporter (DAT) binding in relation to motor and exploratory behaviors in the rat. METHODS:Rats received injections of 5 mg/kg L-DOPA, 10 mg/kg L-DOPA or vehicle. Motor and exploratory behaviors were assessed for 3...

journal_title：Frontiers in behavioral neuroscience

authors： Nikolaus S,Beu M,De Souza Silva AM,Huston JP,Hautzel H,Chao OY,Antke C,Müller HW

更新日期：2014-12-17 00:00:00

abstract：:Endogenous and exogenous cannabinoids bind to central cannabinoid receptors to control a multitude of behavioral functions, including aggression. The first main objective of this review is to dissect components of the endocannabinoid system, including cannabinoid 1 and cannabinoid 2 receptors; the endogenous cannabino...

journal_title：Frontiers in behavioral neuroscience

authors： Kolla NJ,Mishra A

更新日期：2018-03-27 00:00:00

abstract：:Dopaminergic medication for motor symptoms in Parkinson's disease (PD) recently has been linked with impulse control disorders, including pathological gambling (PG), which affects up to 8% of patients. PG often is considered a behavioral addiction associated with disinhibition, risky decision-making, and altered stria...

journal_title：Frontiers in behavioral neuroscience

authors： Callesen MB,Hansen KV,Gjedde A,Linnet J,Møller A

更新日期：2013-07-29 00:00:00

abstract：:Moral behavior has been a key topic of debate for philosophy and psychology for a long time. In recent years, thanks to the development of novel methodologies in cognitive sciences, the question of how we make moral choices has expanded to the study of neurobiological correlates that subtend the mental processes invol...

journal_title：Frontiers in behavioral neuroscience

authors： Pellegrini S,Palumbo S,Iofrida C,Melissari E,Rota G,Mariotti V,Anastasio T,Manfrinati A,Rumiati R,Lotto L,Sarlo M,Pietrini P

更新日期：2017-08-29 00:00:00

abstract：:Decision-making is an ethologically adaptive construct that is impaired in multiple psychiatric disorders. Activity within the mesocorticolimbic dopamine system has been traditionally associated with decision-making. The endocannabinoid system through its actions on inhibitory and excitatory synapses modulates dopamin...

journal_title：Frontiers in behavioral neuroscience

authors： Hernandez G,Cheer JF

更新日期：2015-12-17 00:00:00

abstract：:Corticosteroid hormones, released after stress, are known to influence neuronal activity and produce a wide range of effects upon the brain. They affect cognitive tasks including decision-making. Recently it was shown that systemic injections of corticosterone (CORT) disrupt reward-based decision-making in rats when t...

journal_title：Frontiers in behavioral neuroscience

authors： Koot S,Koukou M,Baars A,Hesseling P,van 't Klooster J,Joëls M,van den Bos R

更新日期：2014-04-21 00:00:00