Immune-Endocrine Links to Gregariousness in Wild House Mice.

Abstract:

:Social interactions are critically important for survival and impact overall-health, but also impose costs on animals, such as exposure to contagious agents. The immune system can play a critical role in modulating social behavior when animals are sick, as has been demonstrated within the context of "sickness behaviors." Can immune molecules affect or be affected by social interactions even when animals are not sick, therefore serving a role in mediating pathogen exposure? We tested whether markers of immune function in both the blood and the brain are associated with gregariousness, quantified as number of animals interacted with per day. To do this, we used remote tracking of social interactions of a wild population of house mice (Mus musculus domesticus) to categorize animals in terms of gregariousness. Blood, hair, brain and other tissue samples from animals with extreme gregariousness phenotypes were collected. We then tested whether the levels of three important cytokines (TNF-α, IFN-γ and IL-1β) in the serum, cortex and hypothalamus of these animals could be explained by the gregariousness phenotype and/or sex of the mice. Using the hair as a long-term quantification of steroid hormones, we also tested whether corticosterone, progesterone and testosterone differed by social phenotype. We found main effects of gregariousness and sex on the serum levels of TNF-α, but not on IFN-γ or IL-1β. Brain gene expression levels were not different between phenotypes. All hair steroids tended to be elevated in animals of high gregariousness phenotype, independent of sex. In sum, elements of the immune system may be associated with gregariousness, even outside of major disease events. These results extend our knowledge of the role that immune signals have in contributing to the regulation of social behaviors outside periods of illness.

journal_name

Front Behav Neurosci

authors

Lopes PC,Carlitz EHD,Kindel M,König B

doi

10.3389/fnbeh.2020.00010

subject

Has Abstract

pub_date

2020-02-05 00:00:00

pages

10

issn

1662-5153

journal_volume

14

pub_type

杂志文章
  • Inducing Physical Inactivity in Mice: Preventing Climbing and Reducing Cage Size Negatively Affect Physical Fitness and Body Composition.

    abstract::Physical inactivity has emerged as an important and risk factor for cardiovascular and metabolic diseases, independent of levels of exercise engagement. Moreover, inactivity is associated with poor brain functioning. However, little data on the effects of physical inactivity on the brain is available and few methods a...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2019.00221

    authors: Roemers P,Hulst Y,van Heijningen S,van Dijk G,van Heuvelen MJG,De Deyn PP,van der Zee EA

    更新日期:2019-10-04 00:00:00

  • Robust training attenuates TBI-induced deficits in reference and working memory on the radial 8-arm maze.

    abstract::Globally, it is estimated that nearly 10 million people sustain severe brain injuries leading to hospitalization and/or death every year. Amongst survivors, traumatic brain injury (TBI) results in a wide variety of physical, emotional and cognitive deficits. The most common cognitive deficit associated with TBI is mem...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2013.00038

    authors: Sebastian V,Diallo A,Ling DS,Serrano PA

    更新日期:2013-05-03 00:00:00

  • Development of brain mechanisms for processing affective touch.

    abstract::Affective tactile stimulation plays a key role in the maturation of neural circuits, but the development of brain mechanisms processing touch is poorly understood. We therefore used functional magnetic resonance imaging (fMRI) to study brain responses to soft brush stroking of both glabrous (palm) and hairy (forearm) ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2014.00024

    authors: Björnsdotter M,Gordon I,Pelphrey KA,Olausson H,Kaiser MD

    更新日期:2014-02-04 00:00:00

  • Glutamate in Salience Network Predicts BOLD Response in Default Mode Network During Salience Processing.

    abstract:Background:Brain investigations identified salience network (SN) comprising the dorsal Anterior Cingulate Cortex (dACC) and the Anterior Insula (AI). Magnetic resonance spectroscopy (MRS) studies revealed the link between the glutamate concentration in the ACC and alterations in attentional scope. Hence, we investigate...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2019.00232

    authors: von Düring F,Ristow I,Li M,Denzel D,Colic L,Demenescu LR,Li S,Borchardt V,Liebe T,Vogel M,Walter M

    更新日期:2019-10-02 00:00:00

  • Functional Alterations in the Posterior Insula and Cerebellum in Migraine Without Aura: A Resting-State MRI Study.

    abstract::Background: Hypothesis-driven functional connectivity (FC) analyses have revealed abnormal functional interaction of regions or networks involved in pain processing in episodic migraine patients. We aimed to investigate the resting-state FC patterns in episodic migraine by combining data-driven voxel-wise degree centr...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2020.567588

    authors: Ke J,Yu Y,Zhang X,Su Y,Wang X,Hu S,Dai H,Hu C,Zhao H,Dai L

    更新日期:2020-10-06 00:00:00

  • Environmental manipulations generate bidirectional shifts in both behavior and gene regulation in a crossbred mouse model of extremes in trait anxiety.

    abstract::Although gene-environment interactions are known to significantly influence psychopathology-related disease states, only few animal models cover both the genetic background and environmental manipulations. Therefore, we have taken advantage of the bidirectionally inbred high (HAB) and low (LAB) anxiety-related behavio...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2014.00087

    authors: Chekmareva NY,Sotnikov SV,Diepold RP,Naik RR,Landgraf R,Czibere L

    更新日期:2014-03-18 00:00:00

  • Slips of Action and Sequential Decisions: A Cross-Validation Study of Tasks Assessing Habitual and Goal-Directed Action Control.

    abstract::Instrumental learning and decision-making rely on two parallel systems: a goal-directed and a habitual system. In the past decade, several paradigms have been developed to study these systems in animals and humans by means of e.g., overtraining, devaluation procedures and sequential decision-making. These different pa...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2016.00234

    authors: Sjoerds Z,Dietrich A,Deserno L,de Wit S,Villringer A,Heinze HJ,Schlagenhauf F,Horstmann A

    更新日期:2016-12-20 00:00:00

  • Learning about time within the spinal cord: evidence that spinal neurons can abstract and store an index of regularity.

    abstract::Prior studies have shown that intermittent noxious stimulation has divergent effects on spinal cord plasticity depending upon whether it occurs in a regular (fixed time, FT) or irregular (variable time, VT) manner: In spinally transected animals, VT stimulation to the tail or hind leg impaired spinal learning whereas ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2015.00274

    authors: Lee KH,Turtle JD,Huang YJ,Strain MM,Baumbauer KM,Grau JW

    更新日期:2015-10-21 00:00:00

  • An Additional Prior Retrieval Alters the Effects of a Retrieval-Extinction Procedure on Recent and Remote Fear Memory.

    abstract::Several studies have shown that the isolated retrieval of a consolidated fear memory can induce a labile phase, during which extinction training can prevent the reinstatement, a form of relapse in which fear response to a fear-provoking context returns when a mild shock is presented. However, fear memory retrieval may...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2017.00259

    authors: An X,Yang P,Chen S,Zhang F,Yu D

    更新日期:2018-01-08 00:00:00

  • Quantifying the Acoustic Startle Response in Mice Using Standard Digital Video.

    abstract::The startle response is an unconditional reflex, characterized by the rapid contraction of facial and skeletal muscles, to a sudden and intense startling stimulus. It is an especially useful tool in translational research for its consistency across species, simple neural circuitry, and sensitivity to a variety of expe...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2020.00083

    authors: Pantoni MM,Herrera GM,Van Alstyne KR,Anagnostaras SG

    更新日期:2020-06-03 00:00:00

  • Corrigendum: The Influence of Chronic Pain and Cognitive Function on Spatial-Numerical Processing.

    abstract::[This corrects the article DOI: 10.3389/fnbeh.2018.00165.]. ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章,已发布勘误

    doi:10.3389/fnbeh.2019.00029

    authors: Spindler M,Koch K,Borisov E,Özyurt J,Sörös P,Thiel C,Bantel C

    更新日期:2019-02-19 00:00:00

  • The bio-distribution of the antidepressant clomipramine is modulated by chronic stress in mice: effects on behavior.

    abstract::Major depression (MD) is one of the most common psychiatric disorders, severely affecting the quality of life of millions of people worldwide. Despite the availability of several classes of antidepressants, treatment efficacy is still very variable and many patients do not respond to the treatment. Clomipramine (CMI),...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2014.00445

    authors: Balsevich G,Namendorf C,Gerlach T,Uhr M,Schmidt MV

    更新日期:2015-01-06 00:00:00

  • Distinct Types of Feeding Related Neurons in Mouse Hypothalamus.

    abstract::The last two decades of research provided evidence for a substantial heterogeneity among feeding-related neurons (FRNs) in the hypothalamus. However, it remains unclear how FRNs differ in their firing patterns during food intake. Here, we investigated the relationship between the activity of neurons in mouse hypothala...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2016.00091

    authors: Tang Y,Benusiglio D,Grinevich V,Lin L

    更新日期:2016-05-18 00:00:00

  • Dynamics of place, boundary and object encoding in rat anterior claustrum.

    abstract::Discrete populations of brain cells signal differing types of spatial information. These "spatial cells" are largely confined to a closely-connected network of sites. We describe here, for the first time, cells in the anterior claustrum of the freely-moving rat encoding place, boundary and object information. This nov...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2015.00250

    authors: Jankowski MM,O'Mara SM

    更新日期:2015-10-14 00:00:00

  • Common Recruitment of Angular Gyrus in Episodic Autobiographical Memory and Bodily Self-Consciousness.

    abstract::Parietal cortex and adjacent parts of the temporal cortex have recently been associated with bodily self-consciousness (BSC). Similarly, growing evidence suggests that the lateral parietal cortex is crucial for the subjective aspects of episodic autobiographical memory (EAM), which is based on the conscious experience...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2018.00270

    authors: Bréchet L,Grivaz P,Gauthier B,Blanke O

    更新日期:2018-11-14 00:00:00

  • Chronic Nicotine Exposure Initiated in Adolescence and Unpaired to Behavioral Context Fails to Enhance Sweetened Ethanol Seeking.

    abstract::Nicotine use in adolescence is pervasive in the United States and, according to the Gateway Hypothesis, may lead to progression towards other addictive substances. Given the prevalence of nicotine and ethanol comorbidity, it is difficult to ascertain if nicotine is a gateway drug for ethanol. Our study investigated th...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2017.00153

    authors: Madayag AC,Czarnecki KS,Wangler LM,Robinson DL

    更新日期:2017-08-17 00:00:00

  • Distributed circuits underlying anxiety.

    abstract::Anxiety is of paramount importance for animals, as it allows assessment of the environment while minimizing exposure to potential threats. Furthermore, anxiety disorders are highly prevalent. Consequently, the neural circuitry underlying anxiety has been a topic of great interest. In this mini review, we will discuss ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnbeh.2014.00112

    authors: Adhikari A

    更新日期:2014-04-01 00:00:00

  • Optogenetic silencing of locus coeruleus activity in mice impairs cognitive flexibility in an attentional set-shifting task.

    abstract::The locus coeruleus (LC) is the sole source of noradrenergic projections to the cortex and essential for attention-dependent cognitive processes. In this study we used unilateral optogenetic silencing of the LC in an attentional set-shifting task (ASST) to evaluate the influence of the LC on prefrontal cortex-dependen...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2015.00286

    authors: Janitzky K,Lippert MT,Engelhorn A,Tegtmeier J,Goldschmidt J,Heinze HJ,Ohl FW

    更新日期:2015-11-04 00:00:00

  • Neuroanatomical Basis of Individuality in Muscle Tuning Function: Neural Correlates of Muscle Tuning.

    abstract::In a conventional view of motor control, the human brain might employ an optimization principle that leads a stereotypical motor behavior which we observe as an averaged behavioral data over subjects. In this scenario, the inter-individual motor variability is considered as an observation noise. Here, we challenged th...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2019.00028

    authors: Kita K,Osu R,Hosoda C,Honda M,Hanakawa T,Izawa J

    更新日期:2019-03-06 00:00:00

  • Avoidance expression in rats as a function of signal-shock interval: strain and sex differences.

    abstract::Inbred Wistar Kyoto (WKY) rats express inhibited temperament, increased sensitivity to stress, and exaggerated expressions of avoidance. A long-standing observation for lever press escape/avoidance learning in rats is the duration of the warning signal (WS) determines whether avoidance is expressed over escape. Outbre...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2015.00168

    authors: Servatius RJ,Avcu P,Ko N,Jiao X,Beck KD,Minor TR,Pang KC

    更新日期:2015-07-06 00:00:00

  • Influence of Pre-reproductive Maternal Enrichment on Coping Response to Stress and Expression of c-Fos and Glucocorticoid Receptors in Adolescent Offspring.

    abstract::Environmental enrichment (EE) is an experimental setting broadly used for investigating the effects of complex social, cognitive, and sensorimotor stimulations on brain structure and function. Recent studies point out that parental EE experience, even occurring in the pre-reproductive phase, affects neural development...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2017.00073

    authors: Cutuli D,Berretta E,Pasqualini G,De Bartolo P,Caporali P,Laricchiuta D,Sampedro-Piquero P,Gelfo F,Pesoli M,Foti F,Begega A,Petrosini L

    更新日期:2017-05-09 00:00:00

  • Allopregnanolone in the bed nucleus of the stria terminalis modulates contextual fear in rats.

    abstract::Trauma- and stress-related disorders are among the most common types of mental illness affecting the U.S. population. For many of these disorders, there is a striking sex difference in lifetime prevalence; for instance, women are twice as likely as men to be affected by posttraumatic stress disorder (PTSD). Gonadal st...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2015.00205

    authors: Nagaya N,Acca GM,Maren S

    更新日期:2015-08-04 00:00:00

  • Sex-Specific Relationships Between Interoceptive Accuracy and Emotion Regulation.

    abstract::Over the last years, there has been a resurge in the interest to study the relationship between interoception and emotion. By now, it is well established that interoception contributes to the experience of emotions. However, it may also be possible that interoception contributes to the regulation of emotions. To test ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2020.00067

    authors: Lischke A,Pahnke R,Mau-Moeller A,Jacksteit R,Weippert M

    更新日期:2020-06-23 00:00:00

  • Neuro-endocrine control of reproduction in hermaphroditic freshwater snails: mechanisms and evolution.

    abstract::Invertebrates are used extensively as model species to investigate neuro-endocrine processes regulating behaviors, and many of these processes may be extrapolated to vertebrates. However, when it comes to reproductive processes, many of these model species differ notably in their mode of reproduction. A point in case ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2010.00167

    authors: Koene JM

    更新日期:2010-10-21 00:00:00

  • Long-Term Effects of Chronic Buspirone during Adolescence Reduce the Adverse Influences of Neonatal Inflammatory Pain and Stress on Adaptive Behavior in Adult Male Rats.

    abstract::Neonatal pain and stress induce long-term changes in pain sensitivity and behavior. Previously we found alterations in pain sensitivity in adolescent rats exposed to early-life adverse events. We tested whether these alterations have long-lasting effects and if those effects can be improved by the 5-hydroxytryptamine ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2017.00011

    authors: Butkevich IP,Mikhailenko VA,Vershinina EA,Aloisi AM,Barr GA

    更新日期:2017-01-26 00:00:00

  • Dscam2 affects visual perception in Drosophila melanogaster.

    abstract::Dscam2, a cell surface protein that mediates cellular repulsion, plays a crucial role in the development of the Drosophila melanogaster visual system. Dscam2 generates boundaries between neighboring modules in the fly optic lobe; in Dscam2 mutants this visual system modularity is compromised. Although developmental wi...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2015.00149

    authors: Bosch DS,van Swinderen B,Millard SS

    更新日期:2015-06-09 00:00:00

  • Texture dependence of motion sensing and free flight behavior in blowflies.

    abstract::MANY FLYING INSECTS EXHIBIT AN ACTIVE FLIGHT AND GAZE STRATEGY: purely translational flight segments alternate with quick turns called saccades. To generate such a saccadic flight pattern, the animals decide the timing, direction, and amplitude of the next saccade during the previous translatory intersaccadic interval...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2012.00092

    authors: Lindemann JP,Egelhaaf M

    更新日期:2013-01-11 00:00:00

  • Repeated, Intermittent Social Defeat across the Entire Juvenile Period Resulted in Behavioral, Physiological, Hormonal, Immunological, and Neurochemical Alterations in Young Adult Male Golden Hamsters.

    abstract::The developing brain is vulnerable to social defeat during the juvenile period. As complements of human studies, animal models of social defeat provide a straightforward approach to investigating the functional and neurobiological consequences of social defeats. Taking advantage of agonist behavior and social defeat i...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2016.00110

    authors: Yu WC,Liu CY,Lai WS

    更新日期:2016-06-10 00:00:00

  • Vasopressin Differentially Affects Handgrip Force of Expectant Fathers in Reaction to Own and Unknown Infant Faces.

    abstract::The underlying mechanisms of paternal responses to infant signals are poorly understood. Vasopressin has previously been proposed to affect these responses. Using a double-blind, placebo-controlled, within-subject design (N = 25 expectant fathers), we examined the effect of vasopressin administration on the use of exc...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2019.00105

    authors: Alyousefi-van Dijk K,van 't Veer AE,Meijer WM,Lotz AM,Rijlaarsdam J,Witteman J,Bakermans-Kranenburg MJ

    更新日期:2019-05-21 00:00:00

  • Continuous and Intermittent Alcohol Free-Choice from Pre-gestational Time to Lactation: Focus on Drinking Trajectories and Maternal Behavior.

    abstract:BACKGROUND:Alcohol consumption during pregnancy and lactation induces detrimental consequences, that are not limited to the direct in utero effects of the drug on fetuses, but extend to maternal care. However, the occurrence and severity of alcohol toxicity are related to the drinking pattern and the time of exposure. ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2016.00031

    authors: Brancato A,Plescia F,Lavanco G,Cavallaro A,Cannizzaro C

    更新日期:2016-03-03 00:00:00