VNTR-DAT1 and COMTVal158Met Genotypes Modulate Mental Flexibility and Adaptive Behavior Skills in Down Syndrome.

Abstract:

:Down syndrome (DS) is an aneuploidy syndrome that is caused by trisomy for human chromosome 21 resulting in a characteristic cognitive and behavioral phenotype, which includes executive functioning and adaptive behavior difficulties possibly due to prefrontal cortex (PFC) deficits. DS also present a high risk for early onset of Alzheimer Disease-like dementia. The dopamine (DA) system plays a neuromodulatory role in the activity of the PFC. Several studies have implicated trait differences in DA signaling on executive functioning based on genetic polymorphisms in the genes encoding for the catechol-O-methyltransferase (COMTVal158Met) and the dopamine transporter (VNTR-DAT1). Since it is known that the phenotypic consequences of genetic variants are modulated by the genetic background in which they occur, we here explore whether these polymorphisms variants interact with the trisomic genetic background to influence gene expression, and how this in turn mediates DS phenotype variability regarding PFC cognition. We genotyped 69 young adults of both genders with DS, and found that VNTR-DAT1 was in Hardy-Weinberg equilibrium but COMTVal158Met had a reduced frequency of Met allele homozygotes. In our population, genotypes conferring higher DA availability, such as Met allele carriers and VNTR-DAT1 10-repeat allele homozygotes, resulted in improved performance in executive function tasks that require mental flexibility. Met allele carriers showed worse adaptive social skills and self-direction, and increased scores in the social subscale of the Dementia Questionnaire for People with Intellectual Disabilities than Val allele homozygotes. The VNTR-DAT1 was not involved in adaptive behavior or early dementia symptoms. Our results suggest that genetic variants of COMTVal158Met and VNTR-DAT1 may contribute to PFC-dependent cognition, while only COMTVal158Met is involved in behavioral phenotypes of DS, similar to euploid population.

journal_name

Front Behav Neurosci

authors

Del Hoyo L,Xicota L,Langohr K,Sánchez-Benavides G,de Sola S,Cuenca-Royo A,Rodriguez J,Rodríguez-Morató J,Farré M,Dierssen M,de la Torre R,TESDAD Study Group.

doi

10.3389/fnbeh.2016.00193

subject

Has Abstract

pub_date

2016-10-17 00:00:00

pages

193

issn

1662-5153

journal_volume

10

pub_type

杂志文章
  • Early life environmental and pharmacological stressors result in persistent dysregulations of the serotonergic system.

    abstract::Dysregulations in the brain serotonergic system and exposure to environmental stressors have been implicated in the development of major depressive disorder. Here, we investigate the interactions between the stress and serotonergic systems by characterizing the behavioral and biochemical effects of chronic stress appl...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2015.00094

    authors: Wong P,Sze Y,Gray LJ,Chang CC,Cai S,Zhang X

    更新日期:2015-04-27 00:00:00

  • Functional Alterations in the Posterior Insula and Cerebellum in Migraine Without Aura: A Resting-State MRI Study.

    abstract::Background: Hypothesis-driven functional connectivity (FC) analyses have revealed abnormal functional interaction of regions or networks involved in pain processing in episodic migraine patients. We aimed to investigate the resting-state FC patterns in episodic migraine by combining data-driven voxel-wise degree centr...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2020.567588

    authors: Ke J,Yu Y,Zhang X,Su Y,Wang X,Hu S,Dai H,Hu C,Zhao H,Dai L

    更新日期:2020-10-06 00:00:00

  • Should animals navigating over short distances switch to a magnetic compass sense?

    abstract::Magnetoreception can play a substantial role in long distance navigation by animals. I hypothesize that locomotion guided by a magnetic compass sense could also play a role in short distance navigation. Animals identify mates, prey, or other short distance navigational goals using different sensory modalities (olfacti...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2010.00042

    authors: Wyeth RC

    更新日期:2010-07-30 00:00:00

  • No Evidence for a Relationship Between Hair Testosterone Concentrations and 2D:4D Ratio or Risk Taking.

    abstract::Using a recently developed alternative assay procedure to measure hormone levels from hair samples, we examined the relationships between testosterone, cortisol, 2D:4D ratio, overconfidence and risk taking. A total of 162 (53 male) participants provided a 3 cm sample of hair, a scanned image of their right and left ha...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2018.00030

    authors: Ronay R,van der Meij L,Oostrom JK,Pollet TV

    更新日期:2018-03-05 00:00:00

  • Differences in brain circuitry for appetitive and reactive aggression as revealed by realistic auditory scripts.

    abstract::Aggressive behavior is thought to divide into two motivational elements: The first being a self-defensively motivated aggression against threat and a second, hedonically motivated "appetitive" aggression. Appetitive aggression is the less understood of the two, often only researched within abnormal psychology. Our app...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2014.00425

    authors: Moran JK,Weierstall R,Elbert T

    更新日期:2014-12-09 00:00:00

  • Boldness in Male and Female Zebrafish (Danio rerio) Is Dependent on Strain and Test.

    abstract::Differences in selection pressure in nature and labs have profound effects on zebrafish strains. The widely used AB strain of zebrafish has been domesticated over several decades. Recently, there has been an upsurge in the availability of genetically modified lines, e.g., the spiegeldanio (spd), which has a mutation i...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2019.00248

    authors: Mustafa A,Roman E,Winberg S

    更新日期:2019-11-19 00:00:00

  • Impairments of working memory in schizophrenia and bipolar disorder: the effect of history of psychotic symptoms and different aspects of cognitive task demands.

    abstract::Comparisons of cognitive impairments between schizophrenia (SZ) and bipolar disorder (BPD) have produced mixed results. We applied different working memory (WM) measures (Digit Span Forward and Backward, Short-delay and Long-delay CPT-AX, N-back) to patients with SZ (n = 23), psychotic BPD (n = 19) and non-psychotic B...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2014.00416

    authors: Frydecka D,Eissa AM,Hewedi DH,Ali M,Drapała J,Misiak B,Kłosińska E,Phillips JR,Moustafa AA

    更新日期:2014-11-28 00:00:00

  • Glucocorticoid-cholinergic interactions in the dorsal striatum in memory consolidation of inhibitory avoidance training.

    abstract::Extensive evidence indicates that glucocorticoid hormones act in a variety of brain regions to enhance the consolidation of memory of emotionally motivated training experiences. We previously reported that corticosterone, the major glucocorticoid in the rat, administered into the dorsal striatum immediately after inhi...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2012.00033

    authors: Sánchez-Resendis O,Medina AC,Serafín N,Prado-Alcalá RA,Roozendaal B,Quirarte GL

    更新日期:2012-06-22 00:00:00

  • Does Experience Enhance Cognitive Flexibility? An Overview of the Evidence Provided by the Environmental Enrichment Studies.

    abstract::Neuroplasticity accounts for the ability of the brain to change in both structure and function in consequence of life experiences. An enhanced stimulation provided by the environment is able to create a form of brain, neural, and cognitive reserve, which allows an individual to cope better with the environmental deman...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2019.00150

    authors: Gelfo F

    更新日期:2019-07-09 00:00:00

  • Stress as a Risk Factor for Substance Use Disorders: A Mini-Review of Molecular Mediators.

    abstract::The extant literature supports the role of stress in enhancing the susceptibility of drug abuse progressing to a substance use disorder diagnosis. However, the molecular mediators by which stress enhances the progression from cocaine abuse to cocaine use disorder via the mesolimbic pathway remain elusive. In this mini...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnbeh.2018.00309

    authors: Mukhara D,Banks ML,Neigh GN

    更新日期:2018-12-21 00:00:00

  • Audiovisual Temporal Processing and Synchrony Perception in the Rat.

    abstract::Extensive research on humans has improved our understanding of how the brain integrates information from our different senses, and has begun to uncover the brain regions and large-scale neural activity that contributes to an observer's ability to perceive the relative timing of auditory and visual stimuli. In the pres...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2016.00246

    authors: Schormans AL,Scott KE,Vo AM,Tyker A,Typlt M,Stolzberg D,Allman BL

    更新日期:2017-01-10 00:00:00

  • Links between Circadian Rhythms and Psychiatric Disease.

    abstract::Determining the cause of psychiatric disorders is a goal of modern neuroscience, and will hopefully lead to the discovery of treatments to either prevent or alleviate the suffering caused by these diseases. One roadblock to attaining this goal is the realization that neuropsychiatric diseases are rarely due to a singl...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnbeh.2014.00162

    authors: Karatsoreos IN

    更新日期:2014-05-06 00:00:00

  • More Than Meets the Eye: The Impact of Materialism on Information Selection During Luxury Choices.

    abstract::Visual attention is an important condition for consumer decision-making. However, not much is known on individuals' determinants of this visual attention. Using eye tracking, this study investigated how psychological values (i.e., materialism) modulate visual attention to specific sources of information (i.e., product...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2018.00172

    authors: Audrin C,Brosch T,Sander D,Chanal J

    更新日期:2018-08-24 00:00:00

  • Automatic Reappraisal-Based Implementation Intention Produces Early and Sustainable Emotion Regulation Effects: Event-Related Potential Evidence.

    abstract::Implementation intention has proven effective in regulating intense emotions but is found to be difficult when instructed regulation is used. Here, we aim to test whether automatic reappraisal-based implementation intention (RII) downregulates intense negative emotion more efficiently than controlled reappraisal (CR) ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2020.00089

    authors: Chen S,Yu K,Yang J,Yuan J

    更新日期:2020-07-14 00:00:00

  • Neuro-endocrine control of reproduction in hermaphroditic freshwater snails: mechanisms and evolution.

    abstract::Invertebrates are used extensively as model species to investigate neuro-endocrine processes regulating behaviors, and many of these processes may be extrapolated to vertebrates. However, when it comes to reproductive processes, many of these model species differ notably in their mode of reproduction. A point in case ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2010.00167

    authors: Koene JM

    更新日期:2010-10-21 00:00:00

  • Pyriproxyfen Exposure Impairs Cognitive Parameters and Alters Cortisol Levels in Zebrafish.

    abstract::Pyriproxyfen is one of the most used larvicides and insecticides; it acts as an analog of juvenile insect hormone (a growth regulator). It is highly toxic during all stages of mosquito development, suppresses metamorphosis, and interferes in insect reproduction and proliferation. Pyriproxyfen and its main metabolite h...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2020.00103

    authors: Gusso D,Reolon GK,Gonzalez JB,Altenhofen S,Kist LW,Bogo MR,Bonan CD

    更新日期:2020-06-17 00:00:00

  • EEG-microstate dependent emergence of perceptual awareness.

    abstract::We investigated whether the differences in perceptual awareness for stimuli at the threshold of awareness can arise from different global brain states before stimulus onset indexed by the EEG microstate. We used a metacontrast backward masking paradigm in which subjects had to discriminate between two weak stimuli and...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2014.00163

    authors: Britz J,Díaz Hernàndez L,Ro T,Michel CM

    更新日期:2014-05-14 00:00:00

  • Evidence of Rapid Modulation by Social Information of Subjective, Physiological, and Neural Responses to Emotional Expressions.

    abstract::Recent research suggests that conceptual or emotional factors could influence the perceptual processing of stimuli. In this article, we aimed to evaluate the effect of social information (positive, negative, or no information related to the character of the target) on subjective (perceived and felt valence and arousal...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2017.00231

    authors: Mermillod M,Grynberg D,Pio-Lopez L,Rychlowska M,Beffara B,Harquel S,Vermeulen N,Niedenthal PM,Dutheil F,Droit-Volet S

    更新日期:2018-01-09 00:00:00

  • Dorsal periaqueductal gray simultaneously modulates ventral subiculum induced-plasticity in the basolateral amygdala and the nucleus accumbens.

    abstract::The ventral subiculum of the hippocampus projects both to the basolateral amygdala (BLA), which is typically, associated with a response to aversive stimuli, as well as to the nucleus accumbens (NAcc), which is typically associated with a response to appetitive stimuli. Traditionally, studies of the responses to emoti...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2015.00053

    authors: Horovitz O,Richter-Levin G

    更新日期:2015-03-04 00:00:00

  • Enhanced brain susceptibility to negative stimuli in adolescents: ERP evidences.

    abstract:BACKGROUND:Previous studies investigated neural substrates of emotional face processing in adolescents and its comparison with adults. As emotional faces elicit more of emotional expression recognition rather than direct emotional responding, it remains undetermined how adolescents are different from adults in brain su...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2015.00098

    authors: Yuan J,Ju E,Meng X,Chen X,Zhu S,Yang J,Li H

    更新日期:2015-04-28 00:00:00

  • Balancing risks and rewards: the logic of violence.

    abstract::Violence is widespread throughout the natural world, prominent examples being predatory violence between species, seasonal violent competition for mating rights and territories within species and food competition both within and between species. These interactions are generally between unrelated individuals with no so...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/neuro.08.051.2009

    authors: Broom M

    更新日期:2009-11-16 00:00:00

  • The role of dopamine in risk taking: a specific look at Parkinson's disease and gambling.

    abstract::An influential model suggests that dopamine signals the difference between predicted and experienced reward. In this way, dopamine can act as a learning signal that can shape behaviors to maximize rewards and avoid punishments. Dopamine is also thought to invigorate reward seeking behavior. Loss of dopamine signaling ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnbeh.2014.00196

    authors: Clark CA,Dagher A

    更新日期:2014-05-30 00:00:00

  • Assessing the construct validity of aberrant salience.

    abstract::We sought to validate the psychometric properties of a recently developed paradigm that aims to measure salience attribution processes proposed to contribute to positive psychotic symptoms, the Salience Attribution Test (SAT). The "aberrant salience" measure from the SAT showed good face validity in previous results, ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/neuro.08.058.2009

    authors: Schmidt K,Roiser JP

    更新日期:2009-12-23 00:00:00

  • The Endocannabinoid System, Aggression, and the Violence of Synthetic Cannabinoid Use, Borderline Personality Disorder, Antisocial Personality Disorder, and Other Psychiatric Disorders.

    abstract::Endogenous and exogenous cannabinoids bind to central cannabinoid receptors to control a multitude of behavioral functions, including aggression. The first main objective of this review is to dissect components of the endocannabinoid system, including cannabinoid 1 and cannabinoid 2 receptors; the endogenous cannabino...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnbeh.2018.00041

    authors: Kolla NJ,Mishra A

    更新日期:2018-03-27 00:00:00

  • The bio-distribution of the antidepressant clomipramine is modulated by chronic stress in mice: effects on behavior.

    abstract::Major depression (MD) is one of the most common psychiatric disorders, severely affecting the quality of life of millions of people worldwide. Despite the availability of several classes of antidepressants, treatment efficacy is still very variable and many patients do not respond to the treatment. Clomipramine (CMI),...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2014.00445

    authors: Balsevich G,Namendorf C,Gerlach T,Uhr M,Schmidt MV

    更新日期:2015-01-06 00:00:00

  • Effects of optimism on motivation in rats.

    abstract::In humans, optimism is a cognitive construct related to motivation; optimists exert effort, whereas pessimists disengage from effort. In this study, using a recently developed ambiguous-cue interpretation (ACI) paradigm we took the unique opportunity to investigate whether "optimism" as a trait is correlated with moti...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2015.00032

    authors: Rygula R,Golebiowska J,Kregiel J,Kubik J,Popik P

    更新日期:2015-02-25 00:00:00

  • Behavioral and Neural Dysregulation to Social Rewards and Links to Internalizing Symptoms in Adolescents.

    abstract::Adolescence is a time of unique sensitivity to socially salient stimuli such as social rewards. This period overlaps with the onset of psychopathology such as internalizing and externalizing symptoms. In the current studies, we examined behavioral and neural patterns of dysregulation to social rewards and threats, and...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2019.00158

    authors: Kwon SJ,Ivory SL,McCormick EM,Telzer EH

    更新日期:2019-07-23 00:00:00

  • Early adversity disrupts the adult use of aversive prediction errors to reduce fear in uncertainty.

    abstract::Early life adversity increases anxiety in adult rodents and primates, and increases the risk for developing post-traumatic disorder (PTSD) in humans. We hypothesized that early adversity impairs the use of learning signals -negative, aversive prediction errors-to reduce fear in uncertainty. To test this hypothesis, we...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2015.00227

    authors: Wright KM,DiLeo A,McDannald MA

    更新日期:2015-08-27 00:00:00

  • Aberrant neural synchrony in the maternal immune activation model: using translatable measures to explore targeted interventions.

    abstract::Maternal exposure to infection occurring mid-gestation produces a three-fold increase in the risk of schizophrenia in the offspring. The critical initiating factor appears to be the maternal immune activation (MIA) that follows infection. This process can be induced in rodents by exposure of pregnant dams to the viral...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnbeh.2013.00217

    authors: Dickerson DD,Bilkey DK

    更新日期:2013-12-27 00:00:00

  • Chronic Stress Alters Behavior in the Forced Swim Test and Underlying Neural Activity in Animals Exposed to Alcohol Prenatally: Sex- and Time-Dependent Effects.

    abstract::Dysregulation of the hypothalamic-pituitary-adrenal (HPA) stress response has been suggested to play a role in vulnerability to stress-related disorders, such as depression. Prenatal alcohol exposure (PAE) may result in HPA dysregulation, which in turn may predispose individuals to the effects of stress exposure throu...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2018.00042

    authors: Lam VYY,Raineki C,Takeuchi LE,Ellis L,Woodward TS,Weinberg J

    更新日期:2018-03-09 00:00:00