Abstract:
:Instrumental learning and decision-making rely on two parallel systems: a goal-directed and a habitual system. In the past decade, several paradigms have been developed to study these systems in animals and humans by means of e.g., overtraining, devaluation procedures and sequential decision-making. These different paradigms are thought to measure the same constructs, but cross-validation has rarely been investigated. In this study we compared two widely used paradigms that assess aspects of goal-directed and habitual behavior. We correlated parameters from a two-step sequential decision-making task that assesses model-based (MB) and model-free (MF) learning with a slips-of-action paradigm that assesses the ability to suppress cue-triggered, learnt responses when the outcome has been devalued and is therefore no longer desirable. MB control during the two-step task showed a very moderately positive correlation with goal-directed devaluation sensitivity, whereas MF control did not show any associations. Interestingly, parameter estimates of MB and goal-directed behavior in the two tasks were positively correlated with higher-order cognitive measures (e.g., visual short-term memory). These cognitive measures seemed to (at least partly) mediate the association between MB control during sequential decision-making and goal-directed behavior after instructed devaluation. This study provides moderate support for a common framework to describe the propensity towards goal-directed behavior as measured with two frequently used tasks. However, we have to caution that the amount of shared variance between the goal-directed and MB system in both tasks was rather low, suggesting that each task does also pick up distinct aspects of goal-directed behavior. Further investigation of the commonalities and differences between the MF and habit systems as measured with these, and other, tasks is needed. Also, a follow-up cross-validation on the neural systems driving these constructs across different paradigms would promote the definition and operationalization of measures of instrumental learning and decision-making in humans.
journal_name
Front Behav Neuroscijournal_title
Frontiers in behavioral neuroscienceauthors
Sjoerds Z,Dietrich A,Deserno L,de Wit S,Villringer A,Heinze HJ,Schlagenhauf F,Horstmann Adoi
10.3389/fnbeh.2016.00234subject
Has Abstractpub_date
2016-12-20 00:00:00pages
234issn
1662-5153journal_volume
10pub_type
杂志文章abstract::Subchronic treatment with the psychotomimetic phencyclidine (PCP) has been proposed as a rodent model of the negative and cognitive/executive symptoms of schizophrenia. There has, however, been a paucity of studies on this model in mice, despite the growing use of the mouse as a subject in genetic and molecular studie...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/neuro.08.002.2009
更新日期:2009-02-23 00:00:00
abstract::When making decisions, people are typically differently sensitive to gains and losses according to the motivational context in which the choice is performed. As hypothesized by Regulatory Focus Theory (RFT), indeed, goals are supposed to change in relation to the set of possible outcomes. In particular, in a promotion...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2018.00071
更新日期:2018-04-24 00:00:00
abstract::We performed whole-cell recordings from basal forebrain (BF) cholinergic neurons in transgenic mice expressing enhanced green fluorescent protein (eGFP) under the control of the choline acetyltransferase promoter. BF cholinergic neurons can be differentiated into two electrophysiologically identifiable subtypes: early...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2012.00021
更新日期:2012-05-08 00:00:00
abstract::[This corrects the article DOI: 10.3389/fnbeh.2018.00165.]. ...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章,已发布勘误
doi:10.3389/fnbeh.2019.00029
更新日期:2019-02-19 00:00:00
abstract::Anatomical investigations have revealed connections between the intralaminar thalamic nuclei and areas such as the superior colliculus (SC) that receive short latency input from visual and auditory primary sensory areas. The intralaminar nuclei in turn project to the major input nucleus of the basal ganglia, the stria...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章,评审
doi:10.3389/fnbeh.2014.00115
更新日期:2014-04-02 00:00:00
abstract::Dysregulation of the hypothalamic-pituitary-adrenal (HPA) stress response has been suggested to play a role in vulnerability to stress-related disorders, such as depression. Prenatal alcohol exposure (PAE) may result in HPA dysregulation, which in turn may predispose individuals to the effects of stress exposure throu...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2018.00042
更新日期:2018-03-09 00:00:00
abstract::Parkinson's disease is a neurodegenerative disorder characterized by motor and non-motor disturbances. Various pathogenic pathways drive disease progression including oxidative stress, mitochondrial dysfunction, α-synuclein aggregation and impairment of protein degradation systems. Dysfunction of the ubiquitin-proteas...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2015.00068
更新日期:2015-03-31 00:00:00
abstract::Cooperation among unrelated humans is frequently regarded as a defining feature in the evolutionary success of our species. Whereas, much research has addressed the strategic and cognitive mechanisms that underlie cooperation, investigations into chemosensory processes have received very limited research attention. To...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2017.00079
更新日期:2017-05-02 00:00:00
abstract::Rationale: Given datasets with a large or diverse set of predictors of aggression, machine learning (ML) provides efficient tools for identifying the most salient variables and building a parsimonious statistical model. ML techniques permit efficient exploration of data, have not been widely used in aggression researc...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2018.00089
更新日期:2018-05-07 00:00:00
abstract::In previous study, we demonstrated that ethanol preexposure may increase ethanol consumption in both adolescent and adult mice, in a two-bottle choice model. We now questioned if ethanol exposure during adolescence results in changes of consumption pattern using a three-bottle choice procedure, considering drinking-in...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2017.00046
更新日期:2017-03-23 00:00:00
abstract::Visual-to-auditory sensory substitution is used to convey visual information through audition, and it was initially created to compensate for blindness; it consists of software converting the visual images captured by a video-camera into the equivalent auditory images, or "soundscapes". Here, it was used by blindfolde...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2016.00079
更新日期:2016-04-21 00:00:00
abstract::We investigated whether the differences in perceptual awareness for stimuli at the threshold of awareness can arise from different global brain states before stimulus onset indexed by the EEG microstate. We used a metacontrast backward masking paradigm in which subjects had to discriminate between two weak stimuli and...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2014.00163
更新日期:2014-05-14 00:00:00
abstract::We come to understand other people's physical and mental states by re-mapping their bodily states onto our sensorimotor system. This process, also called somatosensory resonance, is an essential ability for social cognition and is stronger when observing ingroup than outgroup members. Here we investigated, first, whet...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2013.00165
更新日期:2013-11-18 00:00:00
abstract::Acquisition of social dominance is important for social species including mice, for preferential access to foods and mates. Male mice establish social rank through agonistic behaviors, which are regulated by gonadal steroid hormone, testosterone, as its original form and aromatized form. It is well known that estrogen...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2018.00245
更新日期:2018-10-22 00:00:00
abstract::Sleep has been related to emotional functioning. However, the extent to which emotional salience is processed during sleep is unknown. To address this concern, we investigated night sleep in healthy adults regarding brain reactivity to the emotionally (happily, fearfully) spoken meaningless syllables dada, along with ...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2016.00117
更新日期:2016-06-14 00:00:00
abstract::The ability to accurately integrate or bind stimuli from more than one sensory modality is highly dependent on the features of the stimuli, such as their intensity and relative timing. Previous studies have demonstrated that the ability to perceptually bind stimuli is impaired in various clinical conditions such as au...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2018.00256
更新日期:2018-10-31 00:00:00
abstract::The locus coeruleus (LC) is the sole source of noradrenergic projections to the cortex and essential for attention-dependent cognitive processes. In this study we used unilateral optogenetic silencing of the LC in an attentional set-shifting task (ASST) to evaluate the influence of the LC on prefrontal cortex-dependen...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2015.00286
更新日期:2015-11-04 00:00:00
abstract::The increased understanding that neuropathology begins decades before symptom onset, has led to the conceptualization and widespread utilization of Mild Cognitive Impairment (MCI) as an important transitional state between healthy aging and dementia. Further subcategorization to MCI subtype has led to more distinct pr...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2019.00259
更新日期:2019-11-21 00:00:00
abstract::Recent studies have used conditional knockout mice to selectively delete the D2 autoreceptor; however, these approaches result in global deletion of D2 autoreceptors early in development. The present study takes a different approach using RNA interference (RNAi) to knockdown the expression of the D2 receptors (D2R) in...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2016.00248
更新日期:2017-01-19 00:00:00
abstract::The Supplementary Eye Field (SEF) and the Frontal Eye Field (FEF) have been described as participating in gaze shift control. Recent evidence suggests, however, that other areas of the dorsomedial prefrontal cortex also influence gaze shift. Herein, we have investigated electrically evoked ear- and eye movements from ...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2014.00454
更新日期:2015-01-30 00:00:00
abstract::Very preterm (VPT) infants need long-lasting hospitalization in the Neonatal Intensive Care Unit (NICU) during which they are daily exposed to pain-related stress. Alterations of DNA methylation at the promoter region of the SLC6A4 have been associated with early adverse experiences in infants. The main aim of the pre...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2015.00099
更新日期:2015-04-21 00:00:00
abstract::Increasing evidence focuses on acetaldehyde (ACD) as the mediator of the rewarding and motivational properties of ethanol. Indeed, ACD stimulates dopamine release in the nucleus accumbens and it is self-administered under different conditions. Besides the dopaminergic transmission, the endocannabinoid system has been ...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2013.00064
更新日期:2013-06-11 00:00:00
abstract::Exergames are increasingly used to train both physical and cognitive functioning, but direct evidence whether and how exergames affect cortical activity is lacking. Although portable electroencephalography (EEG) can be used while exergaming, it is unknown whether brain activity will be obscured by movement artifacts. ...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2018.00102
更新日期:2018-05-18 00:00:00
abstract::Cannabinoid compounds may influence both emotional and cognitive processes depending on the level of environmental aversiveness at the time of drug administration. However, the mechanisms responsible for these responses remain to be elucidated. The present experiments investigated the effects induced by the endocannab...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2012.00011
更新日期:2012-03-20 00:00:00
abstract::Background: The intermittent access 2-bottle choice (IA2BC) and drinking in the dark (DID) models were developed for studying rodent binge-like consumption. Traditionally, IA2BC was used with rats and DID with mice. Recently, IA2BC was adapted to study mouse ethanol consumption. However, it is unknown whether DID is s...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2017.00029
更新日期:2017-02-22 00:00:00
abstract::Decision-making is an ethologically adaptive construct that is impaired in multiple psychiatric disorders. Activity within the mesocorticolimbic dopamine system has been traditionally associated with decision-making. The endocannabinoid system through its actions on inhibitory and excitatory synapses modulates dopamin...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章,评审
doi:10.3389/fnbeh.2015.00336
更新日期:2015-12-17 00:00:00
abstract::"Schizotypy" is a latent organization of personality related to the genetic risk for schizophrenia. Some evidence suggests that schizophrenia and schizotypy share some biological features, including a link to dopaminergic D2 receptor signaling. A polymorphism in the D2 gene (DRD2 rs1076560, guanine > thymine (G > T)) ...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2014.00235
更新日期:2014-07-09 00:00:00
abstract::Over the past 25 years, visual processing has been discussed in the context of the dual stream hypothesis consisting of a ventral ("what") and a dorsal ("where") visual information processing pathway. Patients with brain damage of the ventral pathway typically present with signs of visual agnosia, the inability to ide...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2012.00056
更新日期:2012-08-28 00:00:00
abstract::According to recent WHO reports, alcohol remains the number one substance used and abused by adolescents, despite public health efforts to curb its use. Adolescence is a critical period of biological maturation where brain development, particularly the mesocorticolimbic dopamine system, undergoes substantial remodelin...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2017.00134
更新日期:2017-07-25 00:00:00
abstract::Opioid use is a widespread epidemic, and traumatic stress exposure is a critical risk factor in opioid use and relapse. There is a significant gap in our understanding of how stress contributes to heroin use, and there are limited studies investigating individual differences underlying stress reactivity and subsequent...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2019.00134
更新日期:2019-06-25 00:00:00