Mild hypothermia after near drowning in twin toddlers.

abstract：INTRODUCTION:Improved methods to optimize drug dosing in the critically ill are urgently needed. Traditional prescribing culture involves recognition of factors that mandate dose reduction (such as renal impairment), although optimizing drug exposure, through more frequent or augmented dosing, represents an evolving st...

journal_title：Critical care (London, England)

authors： Udy AA,Roberts JA,Shorr AF,Boots RJ,Lipman J

更新日期：2013-02-28 00:00:00

abstract：:Sepsis is characterized by a dysregulated immune response to infection leading to life-threatening organ dysfunction. Sepsis-induced liver injury is recognized as a powerful independent predictor of mortality in the intensive care unit. During systemic infections, the liver regulates immune defenses via bacterial clea...

journal_title：Critical care (London, England)

authors： Sun J,Zhang J,Wang X,Ji F,Ronco C,Tian J,Yin Y

更新日期：2020-10-19 00:00:00

abstract：:The rapid response system concept is one of the first patient-centered and organizational-wide systems aimed at preventing deaths and serious adverse events. It has been strongly argued that we need a benchmark that reflects the care of a deteriorating patient across the organization using a 'score to door time'; that...

journal_title：Critical care (London, England)

authors： Hillman KM

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the global spread of coronavirus disease (COVID-19). Our understanding of the impact this virus has on the nervous system is limited. Our review aims to inform and improve decision-making among the physicians treating COVID-19 ...

journal_title：Critical care (London, England)

authors： Nepal G,Rehrig JH,Shrestha GS,Shing YK,Yadav JK,Ojha R,Pokhrel G,Tu ZL,Huang DY

更新日期：2020-07-13 00:00:00

abstract：BACKGROUND:The safety of perioperative hyperoxia is currently unclear. Previous studies in patients undergoing coronary artery bypass surgery suggest reduced myocardial damage when avoiding extreme perioperative hyperoxia (>400 mmHg). In this study we investigated whether an oxygenation strategy from moderate hyperoxia...

journal_title：Critical care (London, England)

authors： Smit B,Smulders YM,de Waard MC,Boer C,Vonk AB,Veerhoek D,Kamminga S,de Grooth HJ,García-Vallejo JJ,Musters RJ,Girbes AR,Oudemans-van Straaten HM,Spoelstra-de Man AM

更新日期：2016-03-10 00:00:00

abstract：:The forced oscillation technique (FOT) is a method for non-invasively assessing respiratory mechanics that is applicable both in paralysed and non-paralysed patients. As the FOT requires a minimal modification of the conventional ventilation setting and does not interfere with the ventilation protocol, the technique i...

journal_title：Critical care (London, England)

authors： Navajas D,Farré R

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Acute kidney injury and hyperchloremia are commonly present in critically ill septic patients. Our study goal was to evaluate the association of hyperchloremia and acute kidney injury in severe sepsis and septic shock patients. METHODS:In this retrospective cohort study in a provincial tertiary care hospita...

journal_title：Critical care (London, England)

authors： Suetrong B,Pisitsak C,Boyd JH,Russell JA,Walley KR

更新日期：2016-10-06 00:00:00

abstract：INTRODUCTION:Correct bedside measurement of intra-abdominal pressure (IAP) is important. The bladder method is considered as the gold standard for indirect IAP measurement, but the instillation volumes reported in the literature vary substantially. The aim of this study was to evaluate the effect of instillation volume...

journal_title：Critical care (London, England)

authors： Malbrain ML,Deeren DH

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:Dysbiosis of intestinal microbiota likely plays an important role in the development of gut-derived infections, making it a potential therapeutic target against sepsis. However, experience with fecal microbiota transplantation (FMT) in the treatment of sepsis and knowledge of the underlying mechanisms are ...

journal_title：Critical care (London, England)

authors： Li Q,Wang C,Tang C,He Q,Zhao X,Li N,Li J

更新日期：2015-02-09 00:00:00

abstract：BACKGROUND:Several biological markers of lung injury are predictors of morbidity and mortality in patients with acute lung injury (ALI). The low tidal volume lung-protective ventilation strategy is associated with a significant decrease in plasma biomarker levels compared to the high tidal volume ventilation strategy. ...

journal_title：Critical care (London, England)

authors： Cepkova M,Brady S,Sapru A,Matthay MA,Church G

更新日期：2006-01-01 00:00:00

abstract：:Type 2 diabetes has reached epidemic proportions in many parts of the world. The disease is projected to continue to increase and double within the foreseeable future. Dysglycaemia develops in the form of hyperglycaemia, hypoglycaemia and marked glucose variability in critically ill adults whether they are known to ha...

journal_title：Critical care (London, England)

authors： Smith FG,Sheehy AM,Vincent JL,Coursin DB

更新日期：2010-01-01 00:00:00

abstract：:Acute respiratory distress syndrome (ARDS) has a substantial mortality rate and annually affects more than 140,000 people in the USA alone. Standard management includes lung protective ventilation but this impairs carbon dioxide clearance and may lead to right heart dysfunction or increased intracranial pressure. Extr...

journal_title：Critical care (London, England)

authors： Cove ME,MacLaren G,Federspiel WJ,Kellum JA

更新日期：2012-09-21 00:00:00

abstract：BACKGROUND:The properties of semi-elemental enteral nutrition might theoretically improve gastrointestinal tolerance in brain-injured patients, known to suffer gastroparesis. The purpose of this study was to compare the efficacy and tolerance of a semi-elemental versus a polymeric formula for enteral nutrition (EN) in ...

journal_title：Critical care (London, England)

authors： Carteron L,Samain E,Winiszewski H,Blasco G,Balon AS,Gilli C,Piton G,Capellier G,Pili-Floury S,Besch G

更新日期：2021-01-20 00:00:00

abstract：INTRODUCTION:Ventilation according to the open lung concept (OLC) consists of recruitment maneuvers, followed by low tidal volume and high positive end-expiratory pressure, aiming at minimizing atelectasis. The minimization of atelectasis reduces the right ventricular (RV) afterload, but the increased intrathoracic pre...

journal_title：Critical care (London, England)

authors： Miranda DR,Klompe L,Cademartiri F,Haitsma JJ,Palumbo A,Takkenberg JJ,Lachmann B,Bogers AJ,Gommers D

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:The current shortage of accurate and readily available, validated biomarkers of disease severity in sepsis is an important limitation when attempting to stratify patients into homogeneous groups, in order to study pathogenesis or develop therapeutic interventions. The aim of the present study was to determ...

journal_title：Critical care (London, England)

authors： Bozza FA,Salluh JI,Japiassu AM,Soares M,Assis EF,Gomes RN,Bozza MT,Castro-Faria-Neto HC,Bozza PT

更新日期：2007-01-01 00:00:00

abstract：:Large quantitaties of inflammatory mediators are released during the course of endotoxaemia. These mediators in turn can stimulate the sympathetic nervous system (SNS) to release catecholamines, which ultimately regulate inflammation-associated impairment in tissue perfusion, myocardial impairment and vasodilatation. ...

journal_title：Critical care (London, England)

authors： Beck GCh,Brinkkoetter P,Hanusch C,Schulte J,van Ackern K,van der Woude FJ,Yard BA

更新日期：2004-12-01 00:00:00

abstract：BACKGROUND:Expert systems can help alleviate problems related to the shortage of human resources in critical care, offering expert advice in complex situations. Expert systems use contextual information to provide advice to staff. In mechanical ventilation, it is crucial for an expert system to be able to determine the...

journal_title：Critical care (London, England)

authors： Murias G,Montanyà J,Chacón E,Estruga A,Subirà C,Fernández R,Sales B,de Haro C,López-Aguilar J,Lucangelo U,Villar J,Kacmarek RM,Blanch L

更新日期：2016-08-14 00:00:00

abstract：INTRODUCTION:Refractory status epilepticus (RSE) secondary to traumatic brain injury (TBI) may be under-recognized and is associated with significant morbidity and mortality. METHODS:This case report describes a 20 year old previously healthy woman who suffered a severe TBI as a result of a motor vehicle collision and...

journal_title：Critical care (London, England)

authors： Peets AD,Berthiaume LR,Bagshaw SM,Federico P,Doig CJ,Zygun DA

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Herpes simplex virus (HSV) is frequently detected in the respiratory tract of mechanically ventilated patients. The aim of this study was to assess current evidence to determine whether antiviral therapy is associated with better outcomes in these patients. METHODS:MEDLINE, ISI Web of Science, Cochrane Data...

journal_title：Critical care (London, England)

authors： Hagel S,Scherag A,Schuierer L,Hoffmann R,Luyt CE,Pletz MW,Kesselmeier M,Weis S

更新日期：2020-09-29 00:00:00

abstract：:Since most common diseases have been shown to be influenced by inherited variations in our genes, completion of the Human Genome Project and mapping of the human genome single-nucleotide polymorphisms will have a tremendous impact on our approach to medicine. New developments in genotyping techniques and bioinformatic...

journal_title：Critical care (London, England)

authors： Chiche JD,Cariou A,Mira JP

更新日期：2002-06-01 00:00:00

abstract：INTRODUCTION:An increasing body of evidence from laboratory and clinical studies suggests that vasopressin may represent a promising alternative vasopressor for use during cardiac arrest and resuscitation. Current guidelines for cardiopulmonary resuscitation recommend the use of adrenaline (epinephrine), with vasopress...

journal_title：Critical care (London, England)

authors： Grmec S,Mally S

更新日期：2006-02-01 00:00:00

abstract：INTRODUCTION:Respiratory viruses are increasingly recognized as significant etiologies of pneumonia among hospitalized patients. Advanced technologies using multiplex molecular assays and polymerase-chain reaction increase the ability to identify viral pathogens and may ultimately impact antibacterial use. METHOD:This...

journal_title：Critical care (London, England)

authors： Crotty MP,Meyers S,Hampton N,Bledsoe S,Ritchie DJ,Buller RS,Storch GA,Kollef MH,Micek ST

更新日期：2015-11-18 00:00:00

abstract：:Central venous oxygen saturation (ScvO2) >70% or mixed venous oxygen saturation (SvO2) >65% is recommended for both septic and non-septic patients. Although it is the task of experts to suggest clear and simple guidelines, there is a risk of reducing critical care to these simple recommendations. This article reviews ...

journal_title：Critical care (London, England)

authors： Squara P

更新日期：2014-11-10 00:00:00

abstract：OBJECTIVES:We sought to study the association between sedation status, medications (benzodiazepines, opioids, and antipsychotics), and clinical outcomes in a resource-limited setting. DESIGN:A longitudinal study of critically ill participants on mechanical ventilation. SETTING:Five intensive care units (ICUs) in four...

journal_title：Critical care (London, England)

authors： Aragón RE,Proaño A,Mongilardi N,de Ferrari A,Herrera P,Roldan R,Paz E,Jaymez AA,Chirinos E,Portugal J,Quispe R,Brower RG,Checkley W

更新日期：2019-04-17 00:00:00

abstract：BACKGROUND:Post-resuscitation hemodynamic instability following out-of-hospital cardiac arrest (OHCA) may occur from myocardial dysfunction underlying cardiogenic shock and/or inflammation-mediated distributive shock. Distinguishing the predominant shock subtype with widely available clinical metrics may have prognosti...

journal_title：Critical care (London, England)

authors： Anderson RJ,Jinadasa SP,Hsu L,Ghafouri TB,Tyagi S,Joshua J,Mueller A,Talmor D,Sell RE,Beitler JR

更新日期：2018-06-15 00:00:00

abstract：:Severe sepsis and septic shock are among the leading causes of mortality in the intensive care unit. Over a decade ago, early goal-directed therapy (EGDT) emerged as a novel approach for reducing sepsis mortality and was incorporated into guidelines published by the international Surviving Sepsis Campaign. In addition...

journal_title：Critical care (London, England)

authors： Gupta RG,Hartigan SM,Kashiouris MG,Sessler CN,Bearman GM

更新日期：2015-08-28 00:00:00

abstract：BACKGROUND:Augmented renal clearance (ARC) is recognized as a leading cause of β-lactam subexposure when conventional dosing regimens are used. The main objective was to compare the clinical outcome of ARC patients treated by conventional or increased β-lactam dosing regimens for a first episode of hospital or ventilat...

journal_title：Critical care (London, England)

authors： Carrié C,Chadefaux G,Sauvage N,de Courson H,Petit L,Nouette-Gaulain K,Pereira B,Biais M

更新日期：2019-11-27 00:00:00

abstract：INTRODUCTION:Prevalence of iron deficiency (ID) at intensive care (ICU) admission is around 25 to 40%. Blood losses are important during ICU stay, leading to iron losses, but prevalence of ID at ICU discharge is unknown. ID has been associated with fatigue and muscular weakness, and may thus impair post-ICU rehabilitat...

journal_title：Critical care (London, England)

authors： Lasocki S,Chudeau N,Papet T,Tartiere D,Roquilly A,Carlier L,Mimoz O,Seguin P,Malledant Y,Asehnoune K,Hamel JF,AtlanREA group.

更新日期：2014-09-30 00:00:00

abstract：BACKGROUND:Burnout has gained increasing attention worldwide; however, there is a lack of relevant research in China. This study investigated the prevalence and factors associated with burnout in physicians of the intensive care unit (ICU) in mainland China. METHODS:This cross-sectional multicenter study included crit...

journal_title：Critical care (London, England)

authors： Wang J,Hu B,Peng Z,Song H,Cai S,Rao X,Li L,Li J

更新日期：2021-01-05 00:00:00

abstract：BACKGROUND:The purpose of this study was to evaluate the clinical usefulness of open lung biopsy (OLB) in patients undergoing mechanical ventilation for diffuse pulmonary infiltrates of unknown etiology. METHODS:This was a 10-year retrospective study in a 10-bed medical intensive care unit. The medical records of 36 v...

journal_title：Critical care (London, England)

authors： Lim SY,Suh GY,Choi JC,Koh WJ,Lim SY,Han J,Lee KS,Shim YM,Chung MP,Kim H,Kwon OJ

更新日期：2007-01-01 00:00:00