Forced oscillation assessment of respiratory mechanics in ventilated patients.


:The forced oscillation technique (FOT) is a method for non-invasively assessing respiratory mechanics that is applicable both in paralysed and non-paralysed patients. As the FOT requires a minimal modification of the conventional ventilation setting and does not interfere with the ventilation protocol, the technique is potentially useful to monitor patient mechanics during invasive and noninvasive ventilation. FOT allows the assessment of the respiratory system linearity by measuring resistance and reactance at different lung volumes or end-expiratory pressures. Moreover, FOT allows the physician to track the changes in patient mechanics along the ventilation cycle. Applying FOT at different frequencies may allow the physician to interpret patient mechanics in terms of models with pathophysiological interest. The current methodological and technical experience make possible the implementation of portable and compact computerised FOT systems specifically addressed to its application in the mechanical ventilation setting.


Crit Care


Navajas D,Farré R





Has Abstract


2001-01-01 00:00:00












  • Characteristics, practice patterns, and outcomes in patients with acute hypertension: European registry for Studying the Treatment of Acute hyperTension (Euro-STAT).

    abstract:INTRODUCTION:Although effective strategies are available for the management of chronic hypertension, less is known about treating patients with acute, severe elevations in blood pressure. Using data from the European registry for Studying the Treatment of Acute hyperTension (Euro-STAT), we sought to evaluate 'real-life...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Vuylsteke A,Vincent JL,de La Garanderie DP,Anderson FA,Emery L,Wyman A,Rushton-Smith S,Gore JM,Euro-STAT Investigators.

    更新日期:2011-01-01 00:00:00

  • Circulating pro-apoptotic mediators in burn septic acute renal failure.

    abstract::The pathogenesis of septic acute kidney injury (AKI) is not well understood. In the present issue of Critical Care, the combined clinical and experimental study from Mariano's group provides new insight into the disease. The study shows that plasma from septic burn patients with acute renal failure initiated pro-apopt...

    journal_title:Critical care (London, England)

    pub_type: 评论,杂志文章


    authors: Oudemans-van Straaten HM

    更新日期:2008-01-01 00:00:00

  • Isolation of Aspergillus spp. from the respiratory tract in critically ill patients: risk factors, clinical presentation and outcome.

    abstract:INTRODUCTION:Our aims were to assess risk factors, clinical features, management and outcomes in critically ill patients in whom Aspergillus spp. were isolated from respiratory secretions, using a database from a study designed to assess fungal infections. METHODS:A multicentre prospective study was conducted over a 9...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,多中心研究


    authors: Garnacho-Montero J,Amaya-Villar R,Ortiz-Leyba C,León C,Alvarez-Lerma F,Nolla-Salas J,Iruretagoyena JR,Barcenilla F

    更新日期:2005-06-01 00:00:00

  • Duration of red blood cell storage and outcomes in pediatric cardiac surgery: an association found for pump prime blood.

    abstract:INTRODUCTION:Cardiac surgery using cardiopulmonary bypass in newborns, infants and small children often requires intraoperative red blood cell transfusions to prime the circuit and oxygenator and to replace blood lost during surgery. The purpose of this study was to investigate the influence of red blood cell storage t...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Ranucci M,Carlucci C,Isgrò G,Boncilli A,De Benedetti D,De la Torre T,Brozzi S,Frigiola A

    更新日期:2009-01-01 00:00:00

  • The global burden of sepsis: barriers and potential solutions.

    abstract::Sepsis is a major contributor to the global burden of disease. The majority of sepsis cases and deaths are estimated to occur in low and middle-income countries. Barriers to reducing the global burden of sepsis include difficulty quantifying attributable morbidity and mortality, low awareness, poverty and health inequ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审


    authors: Rudd KE,Kissoon N,Limmathurotsakul D,Bory S,Mutahunga B,Seymour CW,Angus DC,West TE

    更新日期:2018-09-23 00:00:00

  • Effects of ventilation strategy on distribution of lung inflammatory cell activity.

    abstract:INTRODUCTION:Leukocyte infiltration is central to the development of acute lung injury, but it is not known how mechanical ventilation strategy alters the distribution or activation of inflammatory cells. We explored how protective (vs. injurious) ventilation alters the magnitude and distribution of lung leukocyte acti...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: de Prost N,Costa EL,Wellman T,Musch G,Tucci MR,Winkler T,Harris R,Venegas JG,Kavanagh BP,Vidal Melo MF

    更新日期:2013-08-15 00:00:00

  • Pre-admission functional status impacts the performance of the APACHE IV model of mortality prediction in critically ill patients.

    abstract:BACKGROUND:Functional status (FS) before intensive care unit (ICU) admission is associated with short-term and long-term outcomes among critically ill patients. However, measures of FS are generally not integrated into ICU-specific mortality prediction models. METHODS:This retrospective cohort study used prospectively...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Krinsley JS,Wasser T,Kang G,Bagshaw SM

    更新日期:2017-05-15 00:00:00

  • Optimization of ventilator setting by flow and pressure waveforms analysis during noninvasive ventilation for acute exacerbations of COPD: a multicentric randomized controlled trial.

    abstract:INTRODUCTION:The analysis of flow and pressure waveforms generated by ventilators can be useful in the optimization of patient-ventilator interactions, notably in chronic obstructive pulmonary disease (COPD) patients. To date, however, a real clinical benefit of this approach has not been proven. METHODS:The aim of th...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,随机对照试验


    authors: Di Marco F,Centanni S,Bellone A,Messinesi G,Pesci A,Scala R,Perren A,Nava S

    更新日期:2011-01-01 00:00:00

  • Bench-to-bedside review: weaning failure--should we rest the respiratory muscles with controlled mechanical ventilation?

    abstract::The use of controlled mechanical ventilation (CMV) in patients who experience weaning failure after a spontaneous breathing trial or after extubation is a strategy based on the premise that respiratory muscle fatigue (requiring rest to recover) is the cause of weaning failure. Recent evidence, however, does not suppor...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审


    authors: Vassilakopoulos T,Zakynthinos S,Roussos C

    更新日期:2006-02-01 00:00:00

  • Clinical review: immunomodulatory effects of dopamine in general inflammation.

    abstract::Large quantitaties of inflammatory mediators are released during the course of endotoxaemia. These mediators in turn can stimulate the sympathetic nervous system (SNS) to release catecholamines, which ultimately regulate inflammation-associated impairment in tissue perfusion, myocardial impairment and vasodilatation. ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审


    authors: Beck GCh,Brinkkoetter P,Hanusch C,Schulte J,van Ackern K,van der Woude FJ,Yard BA

    更新日期:2004-12-01 00:00:00

  • Recombinant human activated protein C resets thrombin generation in patients with severe sepsis - a case control study.

    abstract:INTRODUCTION:Recombinant human activated protein C (rhAPC) is the first drug for which a reduction of mortality in severe sepsis has been demonstrated. However, the mechanism by which this reduction in mortality is achieved is still not clearly defined. The aim of the present study was to evaluate the dynamics of the a...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,多中心研究


    authors: de Pont AC,Bakhtiari K,Hutten BA,de Jonge E,Vroom MB,Meijers JC,Büller HR,Levi M

    更新日期:2005-10-05 00:00:00

  • Enteral nutrition with eicosapentaenoic acid, γ-linolenic acid and antioxidants in the early treatment of sepsis: results from a multicenter, prospective, randomized, double-blinded, controlled study: the INTERSEPT study.

    abstract:INTRODUCTION:Enteral nutrition (EN) with eicosapentaenoic acid (EPA)/γ-linolenic acid (GLA) is recommended for mechanically ventilated patients with severe lung injury. EPA/GLA has anti-inflammatory benefits, as evidenced by its association with reduction in pulmonary inflammation, improvement in oxygenation and improv...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Pontes-Arruda A,Martins LF,de Lima SM,Isola AM,Toledo D,Rezende E,Maia M,Magnan GB,Investigating Nutritional Therapy with EPA, GLA and Antioxidants Role in Sepsis Treatment (INTERSEPT) Study Group.

    更新日期:2011-06-09 00:00:00

  • Excess circulating angiopoietin-2 levels in sepsis: harbinger of death in the intensive care unit?

    abstract::The early recognition and management of sepsis remain the greatest challenges in the field of critical care medicine. Endothelial injury is one of the hallmarks of sepsis, leading to capillary leak, microcirculatory dysfunction, organ failure, and eventual death in many critically ill patients. The angiogenic growth f...

    journal_title:Critical care (London, England)

    pub_type: 评论,杂志文章,评审


    authors: Giuliano JS Jr,Wheeler DS

    更新日期:2009-01-01 00:00:00

  • Neurological manifestations of COVID-19: a systematic review.

    abstract:INTRODUCTION:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the global spread of coronavirus disease (COVID-19). Our understanding of the impact this virus has on the nervous system is limited. Our review aims to inform and improve decision-making among the physicians treating COVID-19 ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Nepal G,Rehrig JH,Shrestha GS,Shing YK,Yadav JK,Ojha R,Pokhrel G,Tu ZL,Huang DY

    更新日期:2020-07-13 00:00:00

  • Increased β-Lactams dosing regimens improve clinical outcome in critically ill patients with augmented renal clearance treated for a first episode of hospital or ventilator-acquired pneumonia: a before and after study.

    abstract:BACKGROUND:Augmented renal clearance (ARC) is recognized as a leading cause of β-lactam subexposure when conventional dosing regimens are used. The main objective was to compare the clinical outcome of ARC patients treated by conventional or increased β-lactam dosing regimens for a first episode of hospital or ventilat...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Carrié C,Chadefaux G,Sauvage N,de Courson H,Petit L,Nouette-Gaulain K,Pereira B,Biais M

    更新日期:2019-11-27 00:00:00

  • Endothelial dysfunction is a potential contributor to multiple organ failure and mortality in aged mice subjected to septic shock: preclinical studies in a murine model of cecal ligation and puncture.

    abstract:INTRODUCTION:The goal of the current study was to investigate the effect of aging on the development of endothelial dysfunction in a murine model of sepsis, and to compare it with the effect of genetic deficiency of the endothelial isoform of nitric oxide synthase (eNOS). METHODS:Cecal ligation and puncture (CLP) was ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Coletta C,Módis K,Oláh G,Brunyánszki A,Herzig DS,Sherwood ER,Ungvári Z,Szabo C

    更新日期:2014-09-16 00:00:00

  • Long-term quality of life in critically ill patients with acute kidney injury treated with renal replacement therapy: a matched cohort study.

    abstract:INTRODUCTION:Acute kidney injury (AKI) is a common complication in intensive care unit (ICU) patients and is associated with increased morbidity and mortality. We compared long-term outcome and quality of life (QOL) in ICU patients with AKI treated with renal replacement therapy (RRT) with matched non-AKI-RRT patients....

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Oeyen S,De Corte W,Benoit D,Annemans L,Dhondt A,Vanholder R,Decruyenaere J,Hoste E

    更新日期:2015-08-06 00:00:00

  • Mild decrease in heart rate during early phase of targeted temperature management following tachycardia on admission is associated with unfavorable neurological outcomes after severe traumatic brain injury: a post hoc analysis of a multicenter randomized

    abstract:BACKGROUND:The association between isolated admission heart rate (HR) and prognosis has been discussed, but not that between gross HR change and neurological outcome in patients with severe traumatic brain injury (TBI). In the acute phase of severe TBI, HR is influenced by several factors (e.g., pain, sympathetic activ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Inoue A,Hifumi T,Kuroda Y,Nishimoto N,Kawakita K,Yamashita S,Oda Y,Dohi K,Kobata H,Suehiro E,Maekawa T,Brain Hypothermia (B-HYPO) Study Group in Japan.

    更新日期:2018-12-19 00:00:00

  • A meta-analysis of the resuscitative effects of mechanical and manual chest compression in out-of-hospital cardiac arrest patients.

    abstract:OBJECTIVES:To evaluate the resuscitative effects of mechanical and manual chest compression in patients with out-of-hospital cardiac arrest (OHCA). METHODS:All randomized controlled and cohort studies comparing the effects of mechanical compression and manual compression on cardiopulmonary resuscitation in OHCA patien...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,meta分析


    authors: Zhu N,Chen Q,Jiang Z,Liao F,Kou B,Tang H,Zhou M

    更新日期:2019-03-27 00:00:00

  • The race against the "septic shark".

    abstract::Great white sharks are responsible for about 10 cases of death annually worldwide, as compared with millions of deaths caused by sepsis. However, the basic principles of avoiding shark attacks and fighting sepsis seem to be similar: avoidance, attention, and speed, if necessary. The present review discusses the curren...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审


    authors: Westphal M,Kampmeier T

    更新日期:2015-01-01 00:00:00

  • Sepsis is a preventable public health problem.

    abstract::There is a paradigm shift happening for sepsis. Sepsis is no longer solely conceptualized as problem of individual patients treated in emergency departments and intensive care units but also as one that is addressed as public health issue with population- and systems-based solutions. We offer a conceptual framework fo...

    journal_title:Critical care (London, England)

    pub_type: 信件


    authors: Kempker JA,Wang HE,Martin GS

    更新日期:2018-05-06 00:00:00

  • Critically ill patients with Middle East respiratory syndrome coronavirus infection.

    abstract::This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency medicine 2016. Other selected articles can be found online at Further information about the Annual Update in Intensive Care and Emergency Medicine is available f...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审


    authors: Al-Dorzi HM,Alsolamy S,Arabi YM

    更新日期:2016-03-16 00:00:00

  • Role of selective V2-receptor-antagonism in septic shock: a randomized, controlled, experimental study.

    abstract:INTRODUCTION:V(2)-receptor (V(2)R) stimulation potentially aggravates sepsis-induced vasodilation, fluid accumulation and microvascular thrombosis. Therefore, the present study was performed to determine the effects of a first-line therapy with the selective V(2)R-antagonist (Propionyl(1)-D-Tyr(Et)(2)-Val(4)-Abu(6)-Arg...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,随机对照试验


    authors: Rehberg S,Ertmer C,Lange M,Morelli A,Whorton E,Dünser M,Strohhäcker AK,Lipke E,Kampmeier TG,Van Aken H,Traber DL,Westphal M

    更新日期:2010-01-01 00:00:00

  • Anaemia is not a risk factor for progression of acute kidney injury: a retrospective analysis.

    abstract:BACKGROUND:In hospitalised patients, anaemia increases the risk of developing acute kidney injury (AKI). Our aim was to determine whether anaemia also has an impact on the risk of progression from early AKI to more severe AKI in critically ill patients. METHODS:We retrospectively analysed the data of patients admitted...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Powell-Tuck J,Crichton S,Raimundo M,Camporota L,Wyncoll D,Ostermann M

    更新日期:2016-03-08 00:00:00

  • Ethyl pyruvate reduces liver injury at early phase but impairs regeneration at late phase in acetaminophen overdose.

    abstract:INTRODUCTION:Inflammation may critically affect mechanisms of liver injury in acetaminophen (APAP) hepatotoxicity. Kupffer cells (KC) play important roles in inflammation, and KC depletion confers protection at early time points after APAP treatment but can lead to more severe injury at a later time point. It is possib...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Yang R,Zou X,Koskinen ML,Tenhunen J

    更新日期:2012-01-16 00:00:00

  • Sleeping with the enemy: Clostridium difficile infection in the intensive care unit.

    abstract::Over the last years, there was an increase in the number and severity of Clostridium difficile infections (CDI) in all medical settings, including the intensive care unit (ICU). The current prevalence of CDI among ICU patients is estimated at 0.4-4% and has severe impact on morbidity and mortality. An estimated 10-20%...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审


    authors: Prechter F,Katzer K,Bauer M,Stallmach A

    更新日期:2017-10-22 00:00:00

  • Year in review 2013: Critical Care--sepsis.

    abstract::This review presents key publications from the research field of sepsis published in Critical Care and other relevant journals during 2013. The results of these experimental studies and clinical trials are discussed in the context of current scientific and clinical background. The discussion highlights and summarises ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审


    authors: de Montmollin E,Annane D

    更新日期:2014-10-15 00:00:00

  • Ventilator-associated pneumonia using a heated humidifier or a heat and moisture exchanger: a randomized controlled trial [ISRCTN88724583].

    abstract:INTRODUCTION:Some guidelines to prevent ventilator-associated pneumonia (VAP) do not establish a recommendation for the preferential use of either heat and moisture exchangers (HMEs) or heated humidifiers (HHs), while other guidelines clearly advocate the use of HMEs. The aim of this study was to determine the incidenc...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,随机对照试验


    authors: Lorente L,Lecuona M,Jiménez A,Mora ML,Sierra A

    更新日期:2006-01-01 00:00:00

  • Activated protein C in septic shock: a propensity-matched analysis.

    abstract:INTRODUCTION:The use of human recombinant activated protein C (rhAPC) for the treatment of severe sepsis remains controversial despite multiple reported trials. The efficacy of rhAPC remains a matter of dispute. We hypothesized that patients with septic shock who were treated with rhAPC had an improved in-hospital mort...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Sadaka F,O'Brien J,Migneron M,Stortz J,Vanston A,Taylor RW

    更新日期:2011-01-01 00:00:00

  • Thrombomodulin phenotype of a distinct monocyte subtype is an independent prognostic marker for disseminated intravascular coagulation.

    abstract:INTRODUCTION:Thrombomodulin, which is expressed solely on monocytes, along with tissue factor (TF), takes part in coagulation and inflammation. Circulating blood monocytes can be divided into 3 major subtypes on the basis of their receptor phenotype: classical (CD14brightCD16negative, CMs), inflammatory (CD14brightCD16...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Hwang SM,Kim JE,Han KS,Kim HK

    更新日期:2011-01-01 00:00:00