Single or multiple daily doses of aminoglycosides: a meta-analysis.

abstract：OBJECTIVE:To evaluate the immunogenicity and reactogenicity of a new triple S recombinant hepatitis B vaccine in a cohort of healthy people in whom currently licensed hepatitis B vaccines had persistently not induced an immune response. DESIGN:Single centre, randomised, double blind, dose-response study. SETTING:Rese...

journal_title：BMJ (Clinical research ed.)

authors： Zuckerman JN,Sabin C,Craig FM,Williams A,Zuckerman AJ

更新日期：1997-02-01 00:00:00

abstract：OBJECTIVE:To determine the effects on independence in older people needing rehabilitation in a locality based community hospital compared with care on a ward for elderly people in a district general hospital. DESIGN:Randomised controlled trial. SETTING:Care in a community hospital and district general hospital in Bra...

journal_title：BMJ (Clinical research ed.)

authors： Green J,Young J,Forster A,Mallinder K,Bogle S,Lowson K,Small N

更新日期：2005-08-06 00:00:00

abstract：OBJECTIVE:To determine whether poor reporting of methods in randomised controlled trials reflects on poor methods. DESIGN:Observational study. SETTING:Reports of randomised controlled trials conducted by the Radiation Therapy Oncology Group since its establishment in 1968. PARTICIPANTS:The Radiation Therapy Oncology...

journal_title：BMJ (Clinical research ed.)

authors： Soares HP,Daniels S,Kumar A,Clarke M,Scott C,Swann S,Djulbegovic B,Radiation Therapy Oncology Group.

更新日期：2004-01-03 00:00:00

abstract：OBJECTIVE:To assess the effectiveness of early treatment for amblyopia in children. DESIGN:Follow up of outcomes of treatment for amblyopia in a randomised controlled trial comparing intensive orthoptic screening at 8, 12, 18, 25, 31, and 37 months (intensive group) with orthoptic screening at 37 months only (control ...

journal_title：BMJ (Clinical research ed.)

authors： Williams C,Northstone K,Harrad RA,Sparrow JM,Harvey I,ALSPAC Study Team.

更新日期：2002-06-29 00:00:00

abstract：OBJECTIVE:To examine the associations between neuraxial anaesthesia or general anaesthesia and clinical outcomes, length of hospital stay, and readmission in adults undergoing lower limb revascularisation surgery. DESIGN:Comparative effectiveness study using linked, validated, population based databases. SETTING:Onta...

journal_title：BMJ (Clinical research ed.)

authors： Roberts DJ,Nagpal SK,Kubelik D,Brandys T,Stelfox HT,Lalu MM,Forster AJ,McCartney CJ,McIsaac DI

更新日期：2020-11-25 00:00:00

abstract：OBJECTIVE:To study the dynamic function of hypothalamic 5-hydroxytryptamine receptors in patients with postviral fatigue syndrome. DESIGN:Prospective comparison of patients with postviral fatigue syndrome with two control groups. SETTING:Department of neurology, University of Glasgow, Southern General Hospital; depar...

journal_title：BMJ (Clinical research ed.)

authors： Bakheit AM,Behan PO,Dinan TG,Gray CE,O'Keane V

更新日期：1992-04-18 00:00:00

abstract：OBJECTIVE:To assess the efficacy of high serum cholesterol concentration, raised blood pressure, and smoking as predictors of coronary heart disease. DESIGN:Prospective cohort study of middle aged men conducted over 25 years. SETTING:Finish components of an ongoing international study (seven countries study). PARTIC...

journal_title：BMJ (Clinical research ed.)

authors： Pekkanen J,Nissinen A,Puska P,Punsar S,Karvonen MJ

更新日期：1989-07-08 00:00:00

abstract：OBJECTIVES:To determine prospectively the rates of change in bone mineral density in elderly people and to examine the relation between lifestyle and demographic factors and these rates of change. DESIGN:Longitudinal population based study. SETTING:Dubbo, New South Wales, Australia. SUBJECTS:Representative sample (n...

journal_title：BMJ (Clinical research ed.)

authors： Jones G,Nguyen T,Sambrook P,Kelly PJ,Eisman JA

更新日期：1994-09-17 00:00:00

abstract：:The treatment of renal cell carcinoma (RCC) has changed greatly over the past 15 years. Progress in the surgical management of the primary tumor and increased understanding of the molecular biology and genomics of the disease have led to the development of new therapeutic agents. The management of the primary tumor ha...

journal_title：BMJ (Clinical research ed.)

authors： Jonasch E,Gao J,Rathmell WK

更新日期：2014-11-10 00:00:00

abstract：OBJECTIVES:To compare "hospital at home" and hospital care as an inpatient in acute exacerbations of chronic obstructive pulmonary disease. DESIGN:Prospective randomised controlled trial with three months' follow up. SETTING:University teaching hospital offering secondary care service to 350 000 patients. PATIENTS:S...

journal_title：BMJ (Clinical research ed.)

authors： Davies L,Wilkinson M,Bonner S,Calverley PM,Angus RM

更新日期：2000-11-18 00:00:00

abstract：OBJECTIVE:To independently evaluate the impact of the second phase of the Health Foundation's Safer Patients Initiative (SPI2) on a range of patient safety measures. Design A controlled before and after design. Five substudies: survey of staff attitudes; review of case notes from high risk (respiratory) patients in med...

journal_title：BMJ (Clinical research ed.)

authors： Benning A,Dixon-Woods M,Nwulu U,Ghaleb M,Dawson J,Barber N,Franklin BD,Girling A,Hemming K,Carmalt M,Rudge G,Naicker T,Kotecha A,Derrington MC,Lilford R

更新日期：2011-02-03 00:00:00

abstract：:The UN has reported that five multinational pharmaceutical companies would cut down HIV drug prices in the developing world. One of these drug companies is GlaxoWellcome, which has promised to reduce the price of zidovudine and lamivudine to US$2 in the poorest nations, a fifth of its price in the US. Although Peter ...

journal_title：BMJ (Clinical research ed.)

authors： Yamey G

更新日期：2000-05-20 00:00:00

abstract：:When oxygen concentrators became available on form FP10 in 1985 the Department of Health and Social Security issued clear guidelines for their prescription for long term treatment. Reassessment of those patients prescribed a concentrator in one district showed that 29 out of 61 patients did not fulfil these criteria. ...

journal_title：BMJ (Clinical research ed.)

authors： Walshaw MJ,Lim R,Evans CC,Hind CR

更新日期：1988-10-22 00:00:00

abstract：:A study was carried out analysing the operation of a drug rationalisation programme in a central London teaching district that had evolved from experience over 17 years. Creation of a limited list of about 700 drugs had been achieved by local consensus. Drug selection was based on appraisal of efficacy, safety, and co...

journal_title：BMJ (Clinical research ed.)

authors： Baker JA,Lant AF,Sutters CA

更新日期：1988-08-13 00:00:00

abstract：OBJECTIVE:To examine the effectiveness of post-diagnosis dementia treatment and coordination of care by memory clinics compared with general practitioners. DESIGN:Multicentre randomised controlled trial. SETTING:Nine memory clinics and 159 general practitioners in the Netherlands. PARTICIPANTS:175 patients with a ne...

journal_title：BMJ (Clinical research ed.)

authors： Meeuwsen EJ,Melis RJ,Van Der Aa GC,Golüke-Willemse GA,De Leest BJ,Van Raak FH,Schölzel-Dorenbos CJ,Verheijen DC,Verhey FR,Visser MC,Wolfs CA,Adang EM,Olde Rikkert MG

更新日期：2012-05-15 00:00:00

abstract：OBJECTIVE:To assess whether a raised serum troponin T concentration would be an independent predictor of death in patients with an acute ischaemic stroke. DESIGN:Observational study. SETTING:Auckland Hospital, Auckland, New Zealand. SUBJECTS:All 181 patients with an acute ischaemic stroke admitted over nine months i...

journal_title：BMJ (Clinical research ed.)

authors： James P,Ellis CJ,Whitlock RM,McNeil AR,Henley J,Anderson NE

更新日期：2000-06-03 00:00:00

abstract：OBJECTIVES:To determine the association between ambulance response time and survival from out of hospital cardiopulmonary arrest and to estimate the effect of reducing response times. DESIGN:Cohort study. SETTING:Scottish Ambulance Service. SUBJECTS:All out of hospital cardiopulmonary arrests due to cardiac disease ...

journal_title：BMJ (Clinical research ed.)

authors： Pell JP,Sirel JM,Marsden AK,Ford I,Cobbe SM

更新日期：2001-06-09 00:00:00

abstract：OBJECTIVE:To compare health behaviours during pregnancy (smoking and alcohol consumption) and after birth (initiation and duration of breast feeding) between British/Irish white mothers and mothers from ethnic minority groups; and, in mothers from ethnic minority groups, to examine whether indicators of acculturation (...

journal_title：BMJ (Clinical research ed.)

authors： Hawkins SS,Lamb K,Cole TJ,Law C,Millennium Cohort Study Child Health Group.

更新日期：2008-05-10 00:00:00

abstract：OBJECTIVES:To measure the potential for cadaver organ retrieval in New South Wales and to determine the reasons for potential donors failing to become actual donors. DESIGN:Prospective audit of all patients dying in five hospitals in New South Wales between 1 December 1989 and 30 November 1990; quality assurance of th...

journal_title：BMJ (Clinical research ed.)

authors： Hibberd AD,Pearson IY,McCosker CJ,Chapman JR,Macdonald GJ,Thompson JF,O'Connell DL,Mohacsi PJ,McLoughlin MP,Spratt PM

更新日期：1992-05-23 00:00:00

abstract：OBJECTIVE:To investigate clinical trialists' opinions and experiences of sharing of clinical trial data with investigators who are not directly collaborating with the research team. DESIGN AND SETTING:Cross sectional, web based survey. PARTICIPANTS:Clinical trialists who were corresponding authors of clinical trials ...

journal_title：BMJ (Clinical research ed.)

authors： Rathi V,Dzara K,Gross CP,Hrynaszkiewicz I,Joffe S,Krumholz HM,Strait KM,Ross JS

更新日期：2012-11-20 00:00:00

abstract：OBJECTIVE:To assess the associations between childhood and adulthood social class and insulin resistance. DESIGN:Cross sectional survey. SETTING:23 towns across England, Scotland, and Wales. PARTICIPANTS:4286 women aged 60-79 years. MAIN OUTCOME MEASURES:Insulin resistance and other cardiovascular disease risk fact...

journal_title：BMJ (Clinical research ed.)

authors： Lawlor DA,Ebrahim S,Davey Smith G,British women's heart and health study.

更新日期：2002-10-12 00:00:00

abstract：:To study a range of possible risk factors for HIV among injecting drug user patients attending a clinic in London were interviewed from November 1986 to November 1987. Serum samples were tested for viral markers. Of 116 patients, 101 had shared injecting equipment, 75 on the first occasion of injecting and 76 during t...

journal_title：BMJ (Clinical research ed.)

authors： Hart GJ,Sonnex C,Petherick A,Johnson AM,Feinmann C,Adler MW

更新日期：1989-04-22 00:00:00

abstract：OBJECTIVE:To determine the prevalence of asthma in cohorts of Finnish young men in the period 1926-89. DESIGN:A retrospective analysis using reports and statistics of Finnish defence forces. SETTING:Call up examinations of candidates for military conscription and examination of conscripts discharged because of poor h...

journal_title：BMJ (Clinical research ed.)

authors： Haahtela T,Lindholm H,Björkstén F,Koskenvuo K,Laitinen LA

更新日期：1990-08-04 00:00:00

abstract：OBJECTIVE:To study the effects on children of humanitarian aid agencies restricting help to refugee families (internally displaced people). DESIGN:Follow up study of 3 months. SETTING:Prabis peninsular outside Bissau, the capital of Guinea-Bissau, which has functioned as a refugee area for internally displaced people...

journal_title：BMJ (Clinical research ed.)

authors： Aaby P,Gomes J,Fernandes M,Djana Q,Lisse I,Jensen H

更新日期：1999-10-02 00:00:00

abstract：:The right of consultants to study leave and expenses is not binding on trusts and has been eroded in directly managed units. Complaints led to a survey of consultants in North West Thames region. This showed that most consultants use their own time and money to maintain their knowledge by buying and consulting journal...

journal_title：BMJ (Clinical research ed.)

authors： Kerr DN,Jones SA,Easmon CS

更新日期：1993-05-22 00:00:00

abstract：OBJECTIVE:To evaluate the impact and cost effectiveness of a programme to transform adult critical care throughout England initiated in late 2000. DESIGN:Evaluation of trends in inputs, processes, and outcomes during 1998-2000 compared with last quarter of 2000-6. SETTING:96 critical care units in England. PARTICIPA...

journal_title：BMJ (Clinical research ed.)

authors： Hutchings A,Durand MA,Grieve R,Harrison D,Rowan K,Green J,Cairns J,Black N

更新日期：2009-11-11 00:00:00

abstract：:The benefits to medical practitioners of using the Internet are growing rapidly as the Internet becomes easier to use and ever more biomedical resources become available on line. The Internet is the largest computer network in the world; it is also a virtual community, larger than many nation states, with its own rule...

journal_title：BMJ (Clinical research ed.)

authors： Pallen M

更新日期：1995-11-25 00:00:00

abstract：OBJECTIVE:To investigate whether work related stress, measured and defined as job strain, is associated with the overall risk of cancer and the risk of colorectal, lung, breast, or prostate cancers. DESIGN:Meta-analysis of pooled prospective individual participant data from 12 European cohort studies including 116,056...

journal_title：BMJ (Clinical research ed.)

authors： Heikkilä K,Nyberg ST,Theorell T,Fransson EI,Alfredsson L,Bjorner JB,Bonenfant S,Borritz M,Bouillon K,Burr H,Dragano N,Geuskens GA,Goldberg M,Hamer M,Hooftman WE,Houtman IL,Joensuu M,Knutsson A,Koskenvuo M,Koskinen A

更新日期：2013-02-07 00:00:00

abstract：OBJECTIVE:To evaluate the effectiveness and costs of a multifaceted flexible educational programme aimed at reducing antibiotic dispensing at the practice level in primary care. DESIGN:Randomised controlled trial with general practices as the unit of randomisation and analysis. Clinicians and researchers were blinded ...

journal_title：BMJ (Clinical research ed.)

authors： Butler CC,Simpson SA,Dunstan F,Rollnick S,Cohen D,Gillespie D,Evans MR,Alam MF,Bekkers MJ,Evans J,Moore L,Howe R,Hayes J,Hare M,Hood K

更新日期：2012-02-02 00:00:00

abstract：OBJECTIVE:To describe the mechanism established by Richmond, Twickenham, and Roehampton Health Authority to manage extracontractual referral requests made on behalf of its resident population and to examine its working in the first three months of the new arrangements. DESIGN:Description of the procedures for managing...

journal_title：BMJ (Clinical research ed.)

authors： Williamson JD

更新日期：1991-08-31 00:00:00