Abstract:
OBJECTIVE:To assess the effectiveness of early treatment for amblyopia in children. DESIGN:Follow up of outcomes of treatment for amblyopia in a randomised controlled trial comparing intensive orthoptic screening at 8, 12, 18, 25, 31, and 37 months (intensive group) with orthoptic screening at 37 months only (control group). SETTING:Avon, southwest England. PARTICIPANTS:3490 children who were part of a birth cohort study. MAIN OUTCOME MEASURES:Prevalence of amblyopia and visual acuity of the worse seeing eye at 7.5 years of age. RESULTS:Amblyopia at 7.5 years was less prevalent in the intensive group than in the control group (0.6% v 1.8%; P=0.02). Mean visual acuities in the worse seeing eye were better for children who had been treated for amblyopia in the intensive group than for similar children in the control group (0.15 v 0.26 LogMAR units; P<0.001). A higher proportion of the children who were treated for amblyopia had been seen in a hospital eye clinic before 3 years of age in the intensive group than in the control group (48% v 13%; P=0.0002). CONCLUSIONS:The intensive screening protocol was associated with better acuity in the amblyopic eye and a lower prevalence of amblyopia at 7.5 years of age, in comparison with screening at 37 months only. These data support the hypothesis that early treatment for amblyopia leads to a better outcome than later treatment and may act as a stimulus for research into feasible screening programmes.
journal_name
BMJjournal_title
BMJ (Clinical research ed.)authors
Williams C,Northstone K,Harrad RA,Sparrow JM,Harvey I,ALSPAC Study Team.doi
10.1136/bmj.324.7353.1549keywords:
subject
Has Abstractpub_date
2002-06-29 00:00:00pages
1549issue
7353eissn
0959-8138issn
1756-1833journal_volume
324pub_type
临床试验,杂志文章,随机对照试验abstract:OBJECTIVE:To determine whether women with atrial fibrillation have a higher risk of stroke than men. DESIGN:Nationwide retrospective cohort study. SETTING:Patients with a diagnosis of atrial fibrillation in the Swedish hospital discharge register between 1 July 2005 and 31 December 2008. Information about drug treatm...
journal_title:BMJ (Clinical research ed.)
pub_type: 杂志文章
doi:10.1136/bmj.e3522
更新日期:2012-05-30 00:00:00
abstract::The studyEveritt H, Landau G, Little P. Therapist telephone-delivered CBT and web-based CBT compared with treatment as usual in refractory irritable bowel syndrome: the ACTIB three-arm RCT. Health Technol Assess 2019;23:1-154.This project was funded by the NIHR Health Technology Assessment Programme (project number 11...
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pub_type: 评论,杂志文章
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更新日期:2019-11-04 00:00:00
abstract:OBJECTIVE:To investigate the contribution of neuroleptic drugs to cognitive decline in dementia. DESIGN:Two year prospective, longitudinal study consisting of interviews every four months, with necropsy follow up. SETTING:Community settings in Oxfordshire. SUBJECTS:71 subjects with dementia, initially living at home...
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pub_type: 杂志文章,评审
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更新日期:2002-01-26 00:00:00
abstract:OBJECTIVE:To assess the incidence and severity of physical and psychosexual symptoms in young women due to ovarian failure caused by total body irradiation for leukaemia and the women's response to hormone treatment. DESIGN:Postal questionnaire and interview. SETTING:Leukaemia unit of oncology hospital. PATIENTS:Con...
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doi:10.1136/bmj.307.6909.891
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abstract:OBJECTIVES:To determine the prevalence of drug and alcohol use among newly remanded prisoners, assess the effectiveness of prison reception screening, and examine the clinical management of substance misusers among remand prisoners. DESIGN:A consecutive case study of remand prisoners screened at reception for substanc...
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更新日期:1997-07-05 00:00:00
abstract:OBJECTIVE:To assess whether a raised serum troponin T concentration would be an independent predictor of death in patients with an acute ischaemic stroke. DESIGN:Observational study. SETTING:Auckland Hospital, Auckland, New Zealand. SUBJECTS:All 181 patients with an acute ischaemic stroke admitted over nine months i...
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doi:10.1136/bmj.320.7248.1502
更新日期:2000-06-03 00:00:00
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更新日期:1996-03-02 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2010-12-14 00:00:00
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pub_type: 杂志文章
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更新日期:1995-09-30 00:00:00
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更新日期:2012-12-04 00:00:00
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pub_type: 杂志文章,meta分析
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更新日期:2019-03-27 00:00:00
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pub_type: 杂志文章
doi:10.1136/bmj.301.6756.835
更新日期:1990-10-13 00:00:00
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pub_type: 杂志文章
doi:10.1136/bmj.312.7029.501
更新日期:1996-02-24 00:00:00
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pub_type: 杂志文章
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更新日期:1996-11-16 00:00:00
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更新日期:2016-03-29 00:00:00
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doi:
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2005-06-18 00:00:00
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pub_type: 杂志文章
doi:10.1136/bmj.308.6930.681
更新日期:1994-03-12 00:00:00
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pub_type: 杂志文章
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更新日期:2013-02-14 00:00:00
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journal_title:BMJ (Clinical research ed.)
pub_type: 社论
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journal_title:BMJ (Clinical research ed.)
pub_type: 临床试验,杂志文章
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更新日期:1989-04-22 00:00:00