Bad reporting does not mean bad methods for randomised trials: observational study of randomised controlled trials performed by the Radiation Therapy Oncology Group.

Abstract:

OBJECTIVE:To determine whether poor reporting of methods in randomised controlled trials reflects on poor methods. DESIGN:Observational study. SETTING:Reports of randomised controlled trials conducted by the Radiation Therapy Oncology Group since its establishment in 1968. PARTICIPANTS:The Radiation Therapy Oncology Group. Outcome measures Content of reports compared with the design features described in the protocols for all randomised controlled trials. RESULTS:The methodological quality of 56 randomised controlled trials was better than reported. Adequate allocation concealment was achieved in all trials but reported in only 42% of papers. An intention to treat analysis was done in 83% of trials but reported in only 69% of papers. The sample size calculation was performed in 76% of the studies, but reported in only 16% of papers. End points were clearly defined and alpha and beta errors were prespecified in 76% and 74% of the trials, respectively, but only reported in 10% of the papers. The one exception was the description of drop outs, where the frequency of reporting was similar to that contained in the original statistical files of the Radiation Therapy Oncology Group. CONCLUSIONS:The reporting of methodological aspects of randomised controlled trials does not necessarily reflect the conduct of the trial. Reviewing research protocols and contacting trialists for more information may improve quality assessment.

journal_name

BMJ

authors

Soares HP,Daniels S,Kumar A,Clarke M,Scott C,Swann S,Djulbegovic B,Radiation Therapy Oncology Group.

doi

10.1136/bmj.328.7430.22

keywords:

subject

Has Abstract

pub_date

2004-01-03 00:00:00

pages

22-4

issue

7430

eissn

0959-8138

issn

1756-1833

pii

328/7430/22

journal_volume

328

pub_type

杂志文章
  • When is it futile for ambulance personnel to initiate cardiopulmonary resuscitation?

    abstract:OBJECTIVE:To determine whether patients with unexpected prehospital cardiac arrest could be identified in whom ambulance resuscitation attempts would be futile. DESIGN:Review of ambulance and hospital records; detailed review of automated external defibrillator rhythm strips of patients in whom no shock was advised. ...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.311.6996.49

    authors: Marsden AK,Ng GA,Dalziel K,Cobbe SM

    更新日期:1995-07-01 00:00:00

  • Outcome of breech delivery at term.

    abstract:OBJECTIVE:To compare neonatal mortality and morbidity in term infants presenting by the breech and delivered vaginally or by caesarean section. DESIGN:Population based comparison of outcomes. Data derived from the St Mary's maternity information system. SETTING:North West Thames Regional Health Authority, 1988-90. S...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.305.6856.746

    authors: Thorpe-Beeston JG,Banfield PJ,Saunders NJ

    更新日期:1992-09-26 00:00:00

  • Consumers' estimation of calorie content at fast food restaurants: cross sectional observational study.

    abstract:OBJECTIVE:To investigate estimation of calorie (energy) content of meals from fast food restaurants in adults, adolescents, and school age children. DESIGN:Cross sectional study of repeated visits to fast food restaurant chains. SETTING:89 fast food restaurants in four cities in New England, United States: McDonald's...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.f2907

    authors: Block JP,Condon SK,Kleinman K,Mullen J,Linakis S,Rifas-Shiman S,Gillman MW

    更新日期:2013-05-23 00:00:00

  • Estimates of burden and consequences of infants born small for gestational age in low and middle income countries with INTERGROWTH-21st standard: analysis of CHERG datasets.

    abstract::Objectives To estimate small for gestational age birth prevalence and attributable neonatal mortality in low and middle income countries with the INTERGROWTH-21st birth weight standard.Design Secondary analysis of data from the Child Health Epidemiology Reference Group (CHERG), including 14 birth cohorts with gestatio...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.j3677

    authors: Lee AC,Kozuki N,Cousens S,Stevens GA,Blencowe H,Silveira MF,Sania A,Rosen HE,Schmiegelow C,Adair LS,Baqui AH,Barros FC,Bhutta ZA,Caulfield LE,Christian P,Clarke SE,Fawzi W,Gonzalez R,Humphrey J,Huybregts L,Kariuki

    更新日期:2017-08-17 00:00:00

  • QT interval and antidepressant use: a cross sectional study of electronic health records.

    abstract:OBJECTIVE:To quantify the impact of citalopram and other selective serotonin reuptake inhibitors on corrected QT interval (QTc), a marker of risk for ventricular arrhythmia, in a large and diverse clinical population. DESIGN:A cross sectional study using electrocardiographic, prescribing, and clinical data from electr...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.f288

    authors: Castro VM,Clements CC,Murphy SN,Gainer VS,Fava M,Weilburg JB,Erb JL,Churchill SE,Kohane IS,Iosifescu DV,Smoller JW,Perlis RH

    更新日期:2013-01-29 00:00:00

  • Simple ultrasound rules to distinguish between benign and malignant adnexal masses before surgery: prospective validation by IOTA group.

    abstract:OBJECTIVES:To prospectively assess the diagnostic performance of simple ultrasound rules to predict benignity/malignancy in an adnexal mass and to test the performance of the risk of malignancy index, two logistic regression models, and subjective assessment of ultrasonic findings by an experienced ultrasound examiner ...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,多中心研究

    doi:10.1136/bmj.c6839

    authors: Timmerman D,Ameye L,Fischerova D,Epstein E,Melis GB,Guerriero S,Van Holsbeke C,Savelli L,Fruscio R,Lissoni AA,Testa AC,Veldman J,Vergote I,Van Huffel S,Bourne T,Valentin L

    更新日期:2010-12-14 00:00:00

  • Effect of a barrier at Bloor Street Viaduct on suicide rates in Toronto: natural experiment.

    abstract:OBJECTIVE:To determine whether rates of suicide changed in Toronto after a barrier was erected at Bloor Street Viaduct, the bridge with the world's second highest annual rate of suicide by jumping after Golden Gate Bridge in San Francisco. DESIGN:Natural experiment. SETTING:City of Toronto and province of Ontario, Ca...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.c2884

    authors: Sinyor M,Levitt AJ

    更新日期:2010-07-06 00:00:00

  • Divorce among physicians and other healthcare professionals in the United States: analysis of census survey data.

    abstract:OBJECTIVES:To estimate the prevalence and incidence of divorce among US physicians compared with other healthcare professionals, lawyers, and non-healthcare professionals, and to analyze factors associated with divorce among physicians. DESIGN:Retrospective analysis of nationally representative surveys conducted by th...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.h706

    authors: Ly DP,Seabury SA,Jena AB

    更新日期:2015-02-18 00:00:00

  • Fruit and vegetable intake and incidence of type 2 diabetes mellitus: systematic review and meta-analysis.

    abstract:OBJECTIVE:To investigate the independent effects of intake of fruit and vegetables on incidence of type 2 diabetes. DESIGN:Systematic review and meta-analysis. DATA SOURCES:Medline, Embase, CINAHL, British Nursing Index (BNI), and the Cochrane library were searched for medical subject headings and keywords on diabete...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,meta分析,评审

    doi:10.1136/bmj.c4229

    authors: Carter P,Gray LJ,Troughton J,Khunti K,Davies MJ

    更新日期:2010-08-18 00:00:00

  • Risk of respiratory morbidity in term infants delivered by elective caesarean section: cohort study.

    abstract:OBJECTIVE:To investigate the association between elective caesarean sections and neonatal respiratory morbidity and the importance of timing of elective caesarean sections. DESIGN:Cohort study with prospectively collected data from the Aarhus birth cohort, Denmark. SETTING:Obstetric department and neonatal department...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.39405.539282.BE

    authors: Hansen AK,Wisborg K,Uldbjerg N,Henriksen TB

    更新日期:2008-01-12 00:00:00

  • Factors affecting early unplanned readmission of elderly patients to hospital.

    abstract::A random sample of 133 elderly patients who had an unplanned readmission to a district general hospital within 28 days of discharge from hospital was studied and compared with a matched control sample of patients who were not readmitted. The total group was drawn from all specialties in the hospital, and by interviewi...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.297.6651.784

    authors: Williams EI,Fitton F

    更新日期:1988-09-24 00:00:00

  • Income distribution and life expectancy: a critical appraisal.

    abstract::In a series of papers published during the past decade Richard Wilkinson has advanced the view that income inequality is the key determinant of variations in average life expectancy at birth among developed countries. Yet a careful examination of the two sources of data on income distribution most often used by Wilkin...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.311.7015.1282

    authors: Judge K

    更新日期:1995-11-11 00:00:00

  • Continuing medical education: experience and opinions of consultants.

    abstract::The right of consultants to study leave and expenses is not binding on trusts and has been eroded in directly managed units. Complaints led to a survey of consultants in North West Thames region. This showed that most consultants use their own time and money to maintain their knowledge by buying and consulting journal...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.306.6889.1398

    authors: Kerr DN,Jones SA,Easmon CS

    更新日期:1993-05-22 00:00:00

  • Trends for prevalence and incidence of resistant hypertension: population based cohort study in the UK 1995-2015.

    abstract::Objective To estimate the incidence and prevalence of resistant hypertension among a UK population treated for hypertension from 1995 to 2015.Design Cohort study.Setting Electronic health records from the UK Clinical Practice Research Datalink in primary care.Participants 1 317 290 users of antihypertensive drugs with...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.j3984

    authors: Sinnott SJ,Smeeth L,Williamson E,Douglas IJ

    更新日期:2017-09-22 00:00:00

  • Diabetic ketoacidosis and hyperosmolar hyperglycemic syndrome: review of acute decompensated diabetes in adult patients.

    abstract::Diabetic ketoacidosis and hyperosmolar hyperglycemic syndrome (HHS) are life threatening complications that occur in patients with diabetes. In addition to timely identification of the precipitating cause, the first step in acute management of these disorders includes aggressive administration of intravenous fluids wi...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,评审

    doi:10.1136/bmj.l1114

    authors: Karslioglu French E,Donihi AC,Korytkowski MT

    更新日期:2019-05-29 00:00:00

  • Associations between macrolide antibiotics prescribing during pregnancy and adverse child outcomes in the UK: population based cohort study.

    abstract:OBJECTIVE:To assess the association between macrolide antibiotics prescribing during pregnancy and major malformations, cerebral palsy, epilepsy, attention deficit hyperactivity disorder, and autism spectrum disorder in children. DESIGN:Population based cohort study. SETTING:The UK Clinical Practice Research Datalink...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.m331

    authors: Fan H,Gilbert R,O'Callaghan F,Li L

    更新日期:2020-02-19 00:00:00

  • Differences in mortality and morbidity in African Caribbean and European people with non-insulin dependent diabetes mellitus: results of 20 year follow up of a London cohort of a multinational study.

    abstract:OBJECTIVE:To examine differences in morbidity and mortality due to non-insulin dependent diabetes in African Caribbeans and Europeans. DESIGN:Cohort study of patients with non-insulin dependent diabetes drawn from diabetes clinics in London. Baseline investigations were performed in 1975-7; follow up continued until 1...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.313.7061.848

    authors: Chaturvedi N,Jarrett J,Morrish N,Keen H,Fuller JH

    更新日期:1996-10-05 00:00:00

  • Physiotherapy intervention late after stroke and mobility.

    abstract:OBJECTIVE:To determine whether the intervention of a physiotherapist improved mobility in patients seen more than one year after stroke. DESIGN:Randomised crossover trial comparing two groups offered intervention by a physiotherapist, one immediately after entry into the trial and the other after a delay of three mont...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/bmj.304.6827.609

    authors: Wade DT,Collen FM,Robb GF,Warlow CP

    更新日期:1992-03-07 00:00:00

  • Computerisation of primary care in Wales.

    abstract:OBJECTIVE:To obtain information about the computerisation of general practice in Wales, and to enable more effective planning of educational provision for doctors and other primary health care workers. DESIGN:Postal questionnaire sent to all general practices in Wales. SUBJECTS:553 general practices, of which 401 (73...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.303.6794.93

    authors: Goves JR,Davies T,Reilly T

    更新日期:1991-07-13 00:00:00

  • Contribution of specific diseases and injuries to changes in health adjusted life expectancy in 187 countries from 1990 to 2013: retrospective observational study.

    abstract:OBJECTIVE:To quantify and compare the contribution of 306 diseases and injuries to the changes in health adjusted life expectancy at birth (HALE0) between 1990 and 2013. DESIGN:Retrospective demographic analysis based on aggregated data and using life table technique, Sullivan method, and decomposition method for diff...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.l969

    authors: Chen H,Chen G,Zheng X,Guo Y

    更新日期:2019-03-27 00:00:00

  • Hysterectomy, endometrial ablation, and levonorgestrel releasing intrauterine system (Mirena) for treatment of heavy menstrual bleeding: cost effectiveness analysis.

    abstract:OBJECTIVE:To undertake a cost effectiveness analysis comparing first and second generation endometrial ablative techniques, hysterectomy, and the levonorgestrel releasing intrauterine system (Mirena) for treating heavy menstrual bleeding. DESIGN:Model based economic evaluation with data from an individual patient data...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,meta分析,评审

    doi:10.1136/bmj.d2202

    authors: Roberts TE,Tsourapas A,Middleton LJ,Champaneria R,Daniels JP,Cooper KG,Bhattacharya S,Barton PM

    更新日期:2011-04-26 00:00:00

  • Setting priorities, can Britain learn from Sweden?

    abstract::The Swedish government recently published a report on priorities in health care. It was written by a cross party group of politicians and drew extensively on the views of the public, health professionals, experience of earlier local exercises in priority setting, and research based evidence. It laid down an ethical fr...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.312.7032.691

    authors: McKee M,Figueras J

    更新日期:1996-03-16 00:00:00

  • Effectiveness of dementia follow-up care by memory clinics or general practitioners: randomised controlled trial.

    abstract:OBJECTIVE:To examine the effectiveness of post-diagnosis dementia treatment and coordination of care by memory clinics compared with general practitioners. DESIGN:Multicentre randomised controlled trial. SETTING:Nine memory clinics and 159 general practitioners in the Netherlands. PARTICIPANTS:175 patients with a ne...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1136/bmj.e3086

    authors: Meeuwsen EJ,Melis RJ,Van Der Aa GC,Golüke-Willemse GA,De Leest BJ,Van Raak FH,Schölzel-Dorenbos CJ,Verheijen DC,Verhey FR,Visser MC,Wolfs CA,Adang EM,Olde Rikkert MG

    更新日期:2012-05-15 00:00:00

  • Right-left discrimination among medical students: questionnaire and psychometric study.

    abstract:OBJECTIVE:To determine medical students' self awareness and ability to discriminate right from left; to identify characteristics associated with this ability; and to identify any techniques used to aid discrimination. DESIGN:Questionnaire and psychometric study. SETTING:Undergraduate medical school, Northern Ireland....

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.a2826

    authors: Gormley GJ,Dempster M,Best R

    更新日期:2008-12-16 00:00:00

  • Contribution of dihydrotestosterone to male sexual behaviour.

    abstract:OBJECTIVE:To document the relative importance of endogenous sex steroids in modulating the frequency of orgasms, the dominant aspect of sexual behaviour in healthy eugonadal men. DESIGN:Measurement of adrenal and testicular sex steroids in a sample of army recruits and study of their relation to frequency of orgasms a...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.310.6990.1289

    authors: Mantzoros CS,Georgiadis EI,Trichopoulos D

    更新日期:1995-05-20 00:00:00

  • Implications of childhood obesity for adult health: findings from thousand families cohort study.

    abstract:OBJECTIVE:To determine whether being overweight in childhood increases adult obesity and risk of disease. DESIGN:Prospective cohort study. SETTING:City of Newcastle upon Tyne. PARTICIPANTS:932 members of thousand families 1947 birth cohort, of whom 412 attended for clinical examination age 50. MAIN OUTCOME MEASURES...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.323.7324.1280

    authors: Wright CM,Parker L,Lamont D,Craft AW

    更新日期:2001-12-01 00:00:00

  • Must diabetes be a fatal disease in Africa? Study of costs of treatment.

    abstract:OBJECTIVE:To estimate the costs of diagnosis and treatment of diabetes in Tanzania. DESIGN:Costs estimated from the reported and recorded experience of patients with newly presenting diabetes in 1989-90 and of diabetic patients first seen in 1981-2. SETTING:Muhimbili Medical Centre, Dar es Salaam. SUBJECTS:464 patie...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.304.6836.1215

    authors: Chale SS,Swai AB,Mujinja PG,McLarty DG

    更新日期:1992-05-09 00:00:00

  • A feasibility study of signed consent for the collection of patient identifiable information for a national paediatric clinical audit database.

    abstract:OBJECTIVES:To investigate the feasibility of obtaining signed consent for submission of patient identifiable data to a national clinical audit database and to identify factors influencing the consent process and its success. DESIGN:Feasibility study. SETTING:Seven paediatric intensive care units in England. PARTICIP...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,多中心研究

    doi:10.1136/bmj.38404.650208.AE

    authors: McKinney PA,Jones S,Parslow R,Davey N,Darowski M,Chaudhry B,Stack C,Parry G,Draper ES,PICANet Consent Study Group.

    更新日期:2005-04-16 00:00:00

  • Children on hunger strike: child abuse or legitimate protest?

    abstract::The issue of children on hunger strike (voluntary total fasting) has not been reported before. The World Medical Association Declaration of Tokyo 1975 and the Declaration of Malta 1991 (revised 1992) provide clinicians with guidelines for the management of adult patients on hunger strike but do not mention children. W...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.312.7029.501

    authors: Mok A,Nelson EA,Murphy J,Hampson A,Hendriks JH

    更新日期:1996-02-24 00:00:00

  • Risk of moderate to advanced kidney disease in patients with psoriasis: population based cohort study.

    abstract:OBJECTIVE:To determine the risk of chronic kidney disease in patients with psoriasis. DESIGN:Population based cohort study and nested cross sectional study. SETTING:Electronic medical records database based in United Kingdom. PARTICIPANTS:Cohort study: patients with psoriasis aged 18-90 each matched to up to five pa...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.f5961

    authors: Wan J,Wang S,Haynes K,Denburg MR,Shin DB,Gelfand JM

    更新日期:2013-10-15 00:00:00