Avoiding the pitfalls of sponsored multicentre research in general practice.

abstract：OBJECTIVE:Although the Polypill concept (proposed in 2003) is promising in terms of benefits for cardiovascular risk management, the potential costs and adverse effects are its main pitfalls. The objective of this study was to identify a tastier and safer alternative to the Polypill: the Polymeal. METHODS:Data on the ...

journal_title：BMJ (Clinical research ed.)

authors： Franco OH,Bonneux L,de Laet C,Peeters A,Steyerberg EW,Mackenbach JP

更新日期：2004-12-18 00:00:00

abstract：OBJECTIVES:To provide a contemporary account of the treatment and outcomes of acute coronary attacks in England and Wales and to identify strategies that might improve the outcome. DESIGN:Two year community and hospital based study in three British health districts. SETTING:Health districts of Brighton (population 28...

journal_title：BMJ (Clinical research ed.)

authors： Norris RM

更新日期：1998-04-04 00:00:00

abstract：OBJECTIVE:To assess whether mini flow meters used to measure peak expiratory flow can track changes in lung function and indicate clinically important changes. DESIGN:Comparison of measurements with a spirometer and different brands of mini flow meter; the meters were allocated to subjects haphazardly. SUBJECTS:12 bo...

journal_title：BMJ (Clinical research ed.)

authors： Sly PD,Cahill P,Willet K,Burton P

更新日期：1994-02-26 00:00:00

abstract：OBJECTIVE:To investigate associations between Apgar scores of 7, 8, and 9 (versus 10) at 1, 5, and 10 minutes, and neonatal mortality and morbidity. DESIGN:Population based cohort study. SETTING:Sweden. PARTICIPANTS:1 551 436 non-malformed live singleton infants, born at term (≥37 weeks' gestation) between 1999 and ...

journal_title：BMJ (Clinical research ed.)

authors： Razaz N,Cnattingius S,Joseph KS

更新日期：2019-05-07 00:00:00

abstract：OBJECTIVE:To investigate the contribution of neuroleptic drugs to cognitive decline in dementia. DESIGN:Two year prospective, longitudinal study consisting of interviews every four months, with necropsy follow up. SETTING:Community settings in Oxfordshire. SUBJECTS:71 subjects with dementia, initially living at home...

journal_title：BMJ (Clinical research ed.)

authors： McShane R,Keene J,Gedling K,Fairburn C,Jacoby R,Hope T

更新日期：1997-01-25 00:00:00

abstract：:The numbers of patients being admitted to hospital with aortic aneurysms have increased recently. A study was carried out to try to find out whether this was a true increase in incidence or whether it could be attributable to more accurate diagnosis and better surgical techniques. From analyses of routine statistics i...

journal_title：BMJ (Clinical research ed.)

authors： Fowkes FG,Macintyre CC,Ruckley CV

更新日期：1989-01-07 00:00:00

abstract：OBJECTIVE:To examine changes in immunisation performance in Grampian region after the introduction of the 1990 contract for general practitioners. DESIGN:Retrospective descriptive study using data held on the Grampian immunisation record system's computer. SETTING:All 95 general practices in Grampian region (313 gene...

journal_title：BMJ (Clinical research ed.)

authors： Ritchie LD,Bisset AF,Russell D,Leslie V,Thomson I

更新日期：1992-03-28 00:00:00

abstract：OBJECTIVE:To assess the direct and indirect effects of being a twin, maternal smoking, birth weight, and mother's height on blood pressure at ages 9 and 18 years. DESIGN:Longitudinal study. SUBJECTS:Cohort born in 1972-3. SETTING:Dunedin, New Zealand. MAIN OUTCOME MEASURE:Blood pressure at ages 9 and 18 years. RES...

journal_title：BMJ (Clinical research ed.)

authors： Williams S,Poulton R

更新日期：1999-04-03 00:00:00

abstract：OBJECTIVES:To identify the need for reproductive health care among a community affected by conflict, and to ascertain the priority given by the community to reproductive health issues. DESIGN:Rapid appraisal. This comprised interviews with key informants, in-depth interviews, and group discussions. Secondary data were...

journal_title：BMJ (Clinical research ed.)

authors： Palmer CA

更新日期：1999-09-18 00:00:00

abstract：OBJECTIVE:To characterise the percentage of available outcome data being presented in reports of randomised clinical trials with continuous outcome measures, thereby determining the potential for incomplete reporting bias. DESIGN:Descriptive cross sectional study. DATA SOURCES:A random sample of 200 randomised trials...

journal_title：BMJ (Clinical research ed.)

authors： Schriger DL,Savage DF,Altman DG

更新日期：2012-12-18 00:00:00

abstract：OBJECTIVE:To discover whether the wartime government evacuation of children from London and other population centres to rural districts was associated with any increase in childhood leukaemia. DESIGN:Observational study of mortality from leukaemia among the childhood population of England and Wales in relation to the ...

journal_title：BMJ (Clinical research ed.)

authors： Kinlen LJ,John SM

更新日期：1994-11-05 00:00:00

abstract：OBJECTIVE:To compare the mortality of patients in a palliative care unit on working days with that on weekends and public holidays. DESIGN:Retrospective database study. SETTING:Palliative care unit in Germany. POPULATION:All admissions to palliative care unit between 1 January 1997 and 31 December 2008. MAIN OUTCOM...

journal_title：BMJ (Clinical research ed.)

authors： Voltz R,Kamps R,Greinwald R,Hellmich M,Hamacher S,Becker G,Kuhr K,Gaertner J

更新日期：2014-12-16 00:00:00

abstract：OBJECTIVE:To estimate the risk of breast cancer associated with diagnostic radiation in carriers of BRCA1/2 mutations. DESIGN:Retrospective cohort study (GENE-RAD-RISK). SETTING:Three nationwide studies (GENEPSO, EMBRACE, HEBON) in France, United Kingdom, and the Netherlands, PARTICIPANTS:1993 female carriers of BRC...

journal_title：BMJ (Clinical research ed.)

authors： Pijpe A,Andrieu N,Easton DF,Kesminiene A,Cardis E,Noguès C,Gauthier-Villars M,Lasset C,Fricker JP,Peock S,Frost D,Evans DG,Eeles RA,Paterson J,Manders P,van Asperen CJ,Ausems MG,Meijers-Heijboer H,Thierry-Chef I,Hau

更新日期：2012-09-06 00:00:00

abstract：OBJECTIVE:To evaluate the clinical benefit of lipid lowering drug treatment in patients with and without diabetes mellitus, for primary and secondary prevention. DESIGN:Systematic review and meta-analysis. DATA SOURCES:Cochrane, Medline, Embase, and reference lists up to April 2004. STUDY SELECTION:Randomised, place...

journal_title：BMJ (Clinical research ed.)

authors： Costa J,Borges M,David C,Vaz Carneiro A

更新日期：2006-05-13 00:00:00

abstract：:Objective To examine off-label indications for antidepressants in primary care and determine the level of scientific support for off-label prescribing.Design Descriptive study of antidepressant prescriptions written by primary care physicians using an indication based electronic prescribing system.Setting Primary care...

journal_title：BMJ (Clinical research ed.)

authors： Wong J,Motulsky A,Abrahamowicz M,Eguale T,Buckeridge DL,Tamblyn R

更新日期：2017-02-21 00:00:00

abstract：OBJECTIVES:To measure the prevalence of domestic violence among women attending general practice; test the association between experience of domestic violence and demographic factors; evaluate the extent of recording of domestic violence in records held by general practices; and assess acceptability to women of screeni...

journal_title：BMJ (Clinical research ed.)

authors： Richardson J,Coid J,Petruckevitch A,Chung WS,Moorey S,Feder G

更新日期：2002-02-02 00:00:00

abstract：OBJECTIVE:To determine whether abnormal results for liver function tests are investigated in primary care and findings on full investigation. DESIGN:Retrospective audit and prospective clinical investigation. SETTING:University hospital and surrounding general practices serving around 330 000 people. SUBJECTS:Adults...

journal_title：BMJ (Clinical research ed.)

authors： Sherwood P,Lyburn I,Brown S,Ryder S

更新日期：2001-02-03 00:00:00

abstract：OBJECTIVE:To determine the risk factors for neonatal encephalopathy among term infants in a developing country. DESIGN:Unmatched case-control study. SETTING:Principal maternity hospital of Kathmandu, Nepal. SUBJECTS:All 131 infants with neonatal encephalopathy from a population of 21 609 infants born over an 18 mont...

journal_title：BMJ (Clinical research ed.)

authors： Ellis M,Manandhar N,Manandhar DS,Costello AM

更新日期：2000-05-06 00:00:00

abstract：OBJECTIVE:To evaluate the effects of a multifaceted empowerment strategy on the actual use of single embryo transfer after in vitro fertilisation. DESIGN:Randomised controlled trial. SETTING:Five in vitro fertilisation clinics in the Netherlands. PARTICIPANTS:308 couples (women aged <40) on the waiting list for a fi...

journal_title：BMJ (Clinical research ed.)

authors： van Peperstraten A,Nelen W,Grol R,Zielhuis G,Adang E,Stalmeier P,Hermens R,Kremer J

更新日期：2010-09-30 00:00:00

abstract：OBJECTIVE:To evaluate the effect of intensive geriatric rehabilitation on demented patients with hip fracture. DESIGN:Preplanned subanalysis of randomised intervention study. Settting: Jyväskylä Central Hospital, Finland. PARTICIPANTS:243 independently living patients aged 65 years or older admitted to hospital with ...

journal_title：BMJ (Clinical research ed.)

authors： Huusko TM,Karppi P,Avikainen V,Kautiainen H,Sulkava R

更新日期：2000-11-04 00:00:00

abstract：OBJECTIVE:To determine whether cognitive therapy is effective in preventing the worsening of emerging psychotic symptoms experienced by help seeking young people deemed to be at risk for serious conditions such as schizophrenia. DESIGN:Multisite single blind randomised controlled trial. SETTING:Diverse services at fi...

journal_title：BMJ (Clinical research ed.)

authors： Morrison AP,French P,Stewart SL,Birchwood M,Fowler D,Gumley AI,Jones PB,Bentall RP,Lewis SW,Murray GK,Patterson P,Brunet K,Conroy J,Parker S,Reilly T,Byrne R,Davies LM,Dunn G

更新日期：2012-04-05 00:00:00

abstract：OBJECTIVE:To investigate the effect of watching different types of video on energy expenditure. DESIGN:Randomised study assessing a "pleasant," an "amusing," an "exciting," and no video film clips. SUBJECTS:12 volunteers who did not know the purpose of the study. MAIN OUTCOME MEASURES:Changes in energy expenditure, ...

journal_title：BMJ (Clinical research ed.)

authors： Cooper BG,Matthews JN,Alberti KG

更新日期：1995-12-23 00:00:00

abstract：OBJECTIVES: To determine whether late mortality after sepsis is driven predominantly by pre-existing comorbid disease or is the result of sepsis itself. DEIGN: Observational cohort study. SETTING: US Health and Retirement Study. PARTICIPANTS: 960 patients aged ≥65 (1998-2010) with fee-for-service Medicare coverage w...

journal_title：BMJ (Clinical research ed.)

authors： Prescott HC,Osterholzer JJ,Langa KM,Angus DC,Iwashyna TJ

更新日期：2016-05-17 00:00:00

abstract：:Objectives To estimate small for gestational age birth prevalence and attributable neonatal mortality in low and middle income countries with the INTERGROWTH-21st birth weight standard.Design Secondary analysis of data from the Child Health Epidemiology Reference Group (CHERG), including 14 birth cohorts with gestatio...

journal_title：BMJ (Clinical research ed.)

authors： Lee AC,Kozuki N,Cousens S,Stevens GA,Blencowe H,Silveira MF,Sania A,Rosen HE,Schmiegelow C,Adair LS,Baqui AH,Barros FC,Bhutta ZA,Caulfield LE,Christian P,Clarke SE,Fawzi W,Gonzalez R,Humphrey J,Huybregts L,Kariuki

更新日期：2017-08-17 00:00:00

abstract：OBJECTIVES:To determine the impact on teenage pregnancy of interventions that address the social disadvantage associated with early parenthood and to assess the appropriateness of such interventions for young people in the United Kingdom. DESIGN:Systematic review, including a statistical meta-analysis of controlled tr...

journal_title：BMJ (Clinical research ed.)

authors： Harden A,Brunton G,Fletcher A,Oakley A

更新日期：2009-11-12 00:00:00

abstract：:Objective To improve the selection of patients with acute ischaemic stroke for intra-arterial treatment using a clinical decision tool to predict individual treatment benefit.Design Multivariable regression modelling with data from two randomised controlled clinical trials.Setting 16 hospitals in the Netherlands (deri...

journal_title：BMJ (Clinical research ed.)

authors： Venema E,Mulder MJHL,Roozenbeek B,Broderick JP,Yeatts SD,Khatri P,Berkhemer OA,Emmer BJ,Roos YBWEM,Majoie CBLM,van Oostenbrugge RJ,van Zwam WH,van der Lugt A,Steyerberg EW,Dippel DWJ,Lingsma HF

更新日期：2017-05-03 00:00:00

abstract：BACKGROUND:Twenty-four hour ambulatory blood pressure thresholds have been defined for the diagnosis of mild hypertension but not for its treatment or for other blood pressure thresholds used in the diagnosis of moderate to severe hypertension. We aimed to derive age and sex related ambulatory blood pressure equivalent...

journal_title：BMJ (Clinical research ed.)

authors： Head GA,Mihailidou AS,Duggan KA,Beilin LJ,Berry N,Brown MA,Bune AJ,Cowley D,Chalmers JP,Howe PR,Hodgson J,Ludbrook J,Mangoni AA,McGrath BP,Nelson MR,Sharman JE,Stowasser M,Ambulatory Blood Pressure Working Group of the

更新日期：2010-04-14 00:00:00

abstract：OBJECTIVES:To estimate the amount spent on specific hospital care by health agencies in 1993-4 and compare it with the resources allocated to patients registered with fundholding practices for the same type of care. To investigate whether fundholding practices and health agencies pay different amounts for inpatient car...

journal_title：BMJ (Clinical research ed.)

authors： Dixon J,Dinwoodie M,Hodson D,Dodd S,Poltorak T,Garrett C,Rice P,Doncaster I,Williams M

更新日期：1994-07-02 00:00:00

abstract：OBJECTIVES:To determine whether an aid to the diagnosis of pigmented skin lesions reduces the ratio of benign lesions to melanomas excised in general practice. DESIGN:Controlled trial randomised by practice. SETTING:General practices in Perth, Western Australia. PARTICIPANTS:468 general practitioners in 223 practice...

journal_title：BMJ (Clinical research ed.)

authors： English DR,Burton RC,del Mar CB,Donovan RJ,Ireland PD,Emery G

更新日期：2003-08-16 00:00:00

abstract：OBJECTIVE:To estimate the costs of diagnosis and treatment of diabetes in Tanzania. DESIGN:Costs estimated from the reported and recorded experience of patients with newly presenting diabetes in 1989-90 and of diabetic patients first seen in 1981-2. SETTING:Muhimbili Medical Centre, Dar es Salaam. SUBJECTS:464 patie...

journal_title：BMJ (Clinical research ed.)

authors： Chale SS,Swai AB,Mujinja PG,McLarty DG

更新日期：1992-05-09 00:00:00