Avoiding the pitfalls of sponsored multicentre research in general practice.

abstract：:Molecular techniques have revolutionised our knowledge of cell and tissue function in both health and disease. We already have new and powerful treatments based on an understanding of communication between cells by messenger molecules called cytokines. Furthermore, there is great therapeutic promise in defining molecu...

journal_title：BMJ (Clinical research ed.)

authors： Savill J

更新日期：1997-01-18 00:00:00

abstract：OBJECTIVES:To calculate socioeconomic and health status measures for the primary care groups in London and to examine the association between these measures and hospital admission rates. DESIGN:Cross sectional study. SETTING:66 primary care groups in London, total list size 8.0 million people. MAIN OUTCOME MEASURES:...

journal_title：BMJ (Clinical research ed.)

authors： Majeed A,Bardsley M,Morgan D,O'Sullivan C,Bindman AB

更新日期：2000-10-28 00:00:00

abstract：OBJECTIVE:To assess the association between mind wandering (thinking unrelated to the task at hand) and the risk of being responsible for a motor vehicle crash. DESIGN:Responsibility case-control study. SETTING:Adult emergency department of a university hospital in France, April 2010 to August 2011. PARTICIPANTS:955...

journal_title：BMJ (Clinical research ed.)

authors： Galéra C,Orriols L,M'Bailara K,Laborey M,Contrand B,Ribéreau-Gayon R,Masson F,Bakiri S,Gabaude C,Fort A,Maury B,Lemercier C,Cours M,Bouvard MP,Lagarde E

更新日期：2012-12-13 00:00:00

abstract：OBJECTIVE:To compare whether differences exist between alternating pressure overlays and alternating pressure mattresses in the development of new pressure ulcers, healing of existing pressure ulcers, and patient acceptability. DESIGN:Pragmatic, open, multicentre, randomised controlled trial. SETTING:11 hospitals in ...

journal_title：BMJ (Clinical research ed.)

authors： Nixon J,Cranny G,Iglesias C,Nelson EA,Hawkins K,Phillips A,Torgerson D,Mason S,Cullum N

更新日期：2006-06-17 00:00:00

abstract：OBJECTIVE:To review and critically appraise published and preprint reports of prediction models for diagnosing coronavirus disease 2019 (covid-19) in patients with suspected infection, for prognosis of patients with covid-19, and for detecting people in the general population at increased risk of becoming infected with...

journal_title：BMJ (Clinical research ed.)

authors： Wynants L,Van Calster B,Collins GS,Riley RD,Heinze G,Schuit E,Bonten MMJ,Damen JAA,Debray TPA,De Vos M,Dhiman P,Haller MC,Harhay MO,Henckaerts L,Kreuzberger N,Lohman A,Luijken K,Ma J,Andaur CL,Reitsma JB,Sergeant

更新日期：2020-04-07 00:00:00

abstract：OBJECTIVES:To describe the menstrual experience of women referred for menstrual problems, in particular menorrhagia (excessive menstrual loss), and to assess associations with reasons for referral given by their general practitioners, the women's understanding of the reasons for their attendance at the hospital clinics...

journal_title：BMJ (Clinical research ed.)

authors： Warner P,Critchley HO,Lumsden MA,Campbell-Brown M,Douglas A,Murray G

更新日期：2001-07-07 00:00:00

abstract：OBJECTIVES:To investigate the consequences of longstanding obesity on left ventricular mass and structure and to examine the effects of weight loss on these variables. DESIGN:Cross sectional survey and controlled intervention study. SETTING:City of Gothenburg and surrounding areas. Sweden. SUBJECTS:41 obese patients...

journal_title：BMJ (Clinical research ed.)

authors： Karason K,Wallentin I,Larsson B,Sjöström L

更新日期：1997-10-11 00:00:00

abstract：OBJECTIVE:To analyse the cost effectiveness of a national programme to screen blood donors for infection with the human T cell leukaemia/lymphoma virus. DESIGN:Three models for calculating the costs and benefits of screening were developed. The first model analysed the cost of continuously testing all donations; the s...

journal_title：BMJ (Clinical research ed.)

authors： Tynell E,Andersson S,Lithander E,Arneborn M,Blomberg J,Hansson HB,Krook A,Nomberg M,Ramstedt K,Shanwell A,Bjorkman A

更新日期：1998-05-09 00:00:00

abstract：OBJECTIVE:To assess the ability of ultrasonography to identify reflux nephropathy in children after urinary tract infection. DESIGN:Ten experienced radiologists performed a total of 240 ultrasonographic examinations of kidneys in a one day study. The examiners were unaware of the results of previous radiological and c...

journal_title：BMJ (Clinical research ed.)

authors： Stokland E,Hellström M,Hansson S,Jodal U,Odén A,Jacobsson B

更新日期：1994-07-23 00:00:00

abstract：OBJECTIVE:To compare the risk of detention under the Mental Health Act 1983 in a representative group of people with psychotic disorders from different ethnic groups. SETTING:Two defined geographical areas in south London. DESIGN:Annual period prevalent cases of psychosis were identified in 1993 in the study areas fr...

journal_title：BMJ (Clinical research ed.)

authors： Davies S,Thornicroft G,Leese M,Higgingbotham A,Phelan M

更新日期：1996-03-02 00:00:00

abstract：:There is currently much debate about how to improve undergraduate medical education, and in particular on how best to prepare students for clinical responsibility. For 20 years a period of trainee internship has formed part of New Zealand medical students' undergraduate training, and the model could have much to offer...

journal_title：BMJ (Clinical research ed.)

authors： Allen PI,Colls BM

更新日期：1994-02-05 00:00:00

abstract：OBJECTIVE:To establish whether there is evidence of the efficacy of homoeopathy from controlled trials in humans. DESIGN:Criteria based meta-analysis. Assessment of the methodological quality of 107 controlled trials in 96 published reports found after an extensive search. Trials were scored using a list of predefined...

journal_title：BMJ (Clinical research ed.)

authors： Kleijnen J,Knipschild P,ter Riet G

更新日期：1991-02-09 00:00:00

abstract：OBJECTIVE:To confirm the findings of pilot studies that interferon alfa is an effective treatment of Europid men with chronic hepatitis B virus infection. DESIGN:Randomised controlled trial of three months treatment with interferon alfa followed by 12 months of observation. SETTING:Outpatient clinic of a tertiary ref...

journal_title：BMJ (Clinical research ed.)

authors： Brook MG,Chan G,Yap I,Karayiannis P,Lever AM,Jacyna M,Main J,Thomas HC

更新日期：1989-09-09 00:00:00

abstract：:The development of a molecular genetics diagnostic service over a three year period was studied in a National Health Service region with a population of three million. Starting from a time when few diagnostic applications were possible, the number of disorders and the overall demand had grown rapidly. Conditions for w...

journal_title：BMJ (Clinical research ed.)

authors： Meredith AL,Upadhyaya M,Harper PS

更新日期：1988-10-01 00:00:00

abstract：OBJECTIVE:To identify additional factors, such as maternal age or factors related to previous reproductive outcome or family history, and the corresponding probability of carrying a chromosome abnormality in couples with two or more miscarriages. DESIGN:Nested case-control study. SETTING:Six centres for clinical gene...

journal_title：BMJ (Clinical research ed.)

authors： Franssen MT,Korevaar JC,Leschot NJ,Bossuyt PM,Knegt AC,Gerssen-Schoorl KB,Wouters CH,Hansson KB,Hochstenbach R,Madan K,van der Veen F,Goddijn M

更新日期：2005-07-16 00:00:00

abstract：OBJECTIVES:To assess aspects of the internal validity of recently published cluster randomised trials and explore the reporting of information useful in assessing the external validity of these trials. DESIGN:Review of 34 cluster randomised trials in primary care published in 2004 and 2005 in seven journals (British M...

journal_title：BMJ (Clinical research ed.)

authors： Eldridge S,Ashby D,Bennett C,Wakelin M,Feder G

更新日期：2008-04-19 00:00:00

abstract：OBJECTIVE:To determine the prevalence of HIV among pregnant women, in particular those whose behaviour or that of their partners put them at "low risk" of infection. DESIGN:Voluntary named or anonymous HIV testing of pregnant women during 21 months (November 1988 to July 1990). SUBJECTS AND SETTING:All women who plan...

journal_title：BMJ (Clinical research ed.)

authors： Goldberg DJ,MacKinnon H,Smith R,Patel NB,Scrimgeour JB,Inglis JM,Peutherer JF,Urquhart GE,Emslie JA,Covell RG

更新日期：1992-04-25 00:00:00

abstract：OBJECTIVE:To investigate associations between Apgar scores of 7, 8, and 9 (versus 10) at 1, 5, and 10 minutes, and neonatal mortality and morbidity. DESIGN:Population based cohort study. SETTING:Sweden. PARTICIPANTS:1 551 436 non-malformed live singleton infants, born at term (≥37 weeks' gestation) between 1999 and ...

journal_title：BMJ (Clinical research ed.)

authors： Razaz N,Cnattingius S,Joseph KS

更新日期：2019-05-07 00:00:00

abstract：OBJECTIVE:To evaluate the effect of intensive geriatric rehabilitation on demented patients with hip fracture. DESIGN:Preplanned subanalysis of randomised intervention study. Settting: Jyväskylä Central Hospital, Finland. PARTICIPANTS:243 independently living patients aged 65 years or older admitted to hospital with ...

journal_title：BMJ (Clinical research ed.)

authors： Huusko TM,Karppi P,Avikainen V,Kautiainen H,Sulkava R

更新日期：2000-11-04 00:00:00

abstract：OBJECTIVE:To assess the effects of social deprivation on survival after cardiac surgery and to examine the influence of potentially modifiable risk factors. DESIGN:Analysis of prospectively collected data. Prognostic models used to examine the additional effect of social deprivation on the end points. SETTING:Birming...

journal_title：BMJ (Clinical research ed.)

authors： Pagano D,Freemantle N,Bridgewater B,Howell N,Ray D,Jackson M,Fabri BM,Au J,Keenan D,Kirkup B,Keogh BE,Quality and Outcomes Research Unit (QuORU) UHB Birmingham.,North West Quality Improvement Programme in Cardiac Interventions (U

更新日期：2009-04-02 00:00:00

abstract：OBJECTIVES:To compile a register of diabetic patients within the catchment area of a district general hospital and evaluate the characteristics of the population using aggregated data from a general practice audit. DESIGN:Cross sectional study. Practices identified all known diabetics and completed a questionnaire fro...

journal_title：BMJ (Clinical research ed.)

authors： Howitt AJ,Cheales NA

更新日期：1993-10-23 00:00:00

abstract：OBJECTIVE:To evaluate the association between body mass index and mortality from overall cardiovascular disease and specific subtypes of cardiovascular disease in east and south Asians. DESIGN:Pooled analyses of 20 prospective cohorts in Asia, including data from 835,082 east Asians and 289,815 south Asians. Cohorts w...

journal_title：BMJ (Clinical research ed.)

authors： Chen Y,Copeland WK,Vedanthan R,Grant E,Lee JE,Gu D,Gupta PC,Ramadas K,Inoue M,Tsugane S,Tamakoshi A,Gao YT,Yuan JM,Shu XO,Ozasa K,Tsuji I,Kakizaki M,Tanaka H,Nishino Y,Chen CJ,Wang R,Yoo KY,Ahn YO,Ahsan H,

更新日期：2013-10-01 00:00:00

abstract：OBJECTIVES:To assess, as part of wider inspections by HM Inspectorate of Prisons, the extent and quality of health care in prisons in England and Wales. DESIGN:Inspections based on a set of "expectations" derived mainly from existing healthcare quality standards published by the prison service and existing ethical gui...

journal_title：BMJ (Clinical research ed.)

authors： Reed J,Lyne M

更新日期：1997-11-29 00:00:00

abstract：OBJECTIVE:To examine whether, according to the conclusions of a 2000 systematic review with meta-analysis on interventions to prevent pain from propofol injection that provided a research agenda to guide further research on the topic, subsequently published trials were more often optimally blinded, reported on children...

journal_title：BMJ (Clinical research ed.)

authors： Habre C,Tramèr MR,Pöpping DM,Elia N

更新日期：2014-08-26 00:00:00

abstract：:In most European countries health has been shown to be linked to social circumstances--gradients in health status have persisted for decades, despite major changes in the principal causes of death. In central and eastern Europe life expectancy has stagnated since the mid-60s, whereas in the West it has increased; but ...

journal_title：BMJ (Clinical research ed.)

authors： Power C

更新日期：1994-04-30 00:00:00

abstract：OBJECTIVE:To examine changes in primary care in London in the 11 years since the Acheson report on primary health care in inner London. DESIGN:Analysis of key data from the family health services authority performance indicators and from the Department of Health; study of trends since the time of the Acheson report; e...

journal_title：BMJ (Clinical research ed.)

authors： Jarman B,Bosanquet N

更新日期：1992-11-07 00:00:00

abstract：OBJECTIVE:To assess whether occupational exposure among commercial airline cabin attendants are associated with risk of cancer. DESIGN:Record linkage study. SETTING:Finland. SUBJECTS-1577 female and 187 male cabin attendants who had worked for the Finnish airline companies. MAIN OUTCOME MEASURE:Standardised incidenc...

journal_title：BMJ (Clinical research ed.)

authors： Pukkala E,Auvinen A,Wahlberg G

更新日期：1995-09-09 00:00:00

abstract：:The studyTaylor RS, Walker S, Ciani O, et al. Exercise-based cardiac rehabilitation for chronic heart failure: the EXTRAMATCH II individual participant data meta-analysis. Health Technol Assess 2019;23:1-98.This project was funded by the NIHR Health Technology Assessment Programme (project number 15/80/30).To read the...

journal_title：BMJ (Clinical research ed.)

authors： Cook R,Davidson P,Martin R,NIHR Dissemination Centre.

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVES:To explore general practitioners' reasons for recent changes in their prescribing behaviour. DESIGN:Qualitative analysis of semistructured interviews. SETTING:General practice in south east London. SUBJECTS:A heterogeneous sample of 18 general practitioners. RESULTS:Interviewees were able to identify bet...

journal_title：BMJ (Clinical research ed.)

authors： Armstrong D,Reyburn H,Jones R

更新日期：1996-04-13 00:00:00

abstract：OBJECTIVE:To study the processes involved in and impact of mergers between NHS trusts, including the effect on management costs. DESIGN:Cross sectional study involving in depth interviews and documentary analysis; case study to compare savings in management costs between case trusts and control trusts. SETTING:Nine t...

journal_title：BMJ (Clinical research ed.)

authors： Fulop N,Protopsaltis G,Hutchings A,King A,Allen P,Normand C,Walters R

更新日期：2002-08-03 00:00:00