The Polymeal: a more natural, safer, and probably tastier (than the Polypill) strategy to reduce cardiovascular disease by more than 75%.

Abstract:

OBJECTIVE:Although the Polypill concept (proposed in 2003) is promising in terms of benefits for cardiovascular risk management, the potential costs and adverse effects are its main pitfalls. The objective of this study was to identify a tastier and safer alternative to the Polypill: the Polymeal. METHODS:Data on the ingredients of the Polymeal were taken from the literature. The evidence based recipe included wine, fish, dark chocolate, fruits, vegetables, garlic, and almonds. Data from the Framingham heart study and the Framingham offspring study were used to build life tables to model the benefits of the Polymeal in the general population from age 50, assuming multiplicative correlations. RESULTS:Combining the ingredients of the Polymeal would reduce cardiovascular disease events by 76%. For men, taking the Polymeal daily represented an increase in total life expectancy of 6.6 years, an increase in life expectancy free from cardiovascular disease of 9.0 years, and a decrease in life expectancy with cardiovascular disease of 2.4 years. The corresponding differences for women were 4.8, 8.1, and 3.3 years. CONCLUSION:The Polymeal promises to be an effective, non-pharmacological, safe, cheap, and tasty alternative to reduce cardiovascular morbidity and increase life expectancy in the general population.

journal_name

BMJ

authors

Franco OH,Bonneux L,de Laet C,Peeters A,Steyerberg EW,Mackenbach JP

doi

10.1136/bmj.329.7480.1447

keywords:

subject

Has Abstract

pub_date

2004-12-18 00:00:00

pages

1447-50

issue

7480

eissn

0959-8138

issn

1756-1833

pii

329/7480/1447

journal_volume

329

pub_type

杂志文章,评审
  • "Catastrophic" pathways to smoking cessation: findings from national survey.

    abstract:OBJECTIVE:To assess the extent to which the prevailing model of smoking cessation (that smokers typically prepare their attempts to stop smoking in advance and that doing so increases their chances of success) is correct. DESIGN:Cross sectional household survey. SETTING:England. PARTICIPANTS:918 smokers who reported...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.38723.573866.AE

    authors: West R,Sohal T

    更新日期:2006-02-25 00:00:00

  • Weighting in the dark: resource allocation in the new NHS.

    abstract::National allocation of resources to regional health authorities and by them to districts is now determined by a weighted capitation formula. The national formula was derived from regression analysis, with hospital utilisation as an index of need for health care--a method which has fundamental limitations. This paper a...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.306.6881.835

    authors: Sheldon TA,Smith GD,Bevan G

    更新日期:1993-03-27 00:00:00

  • Probiotics for treatment of acute diarrhoea in children: randomised clinical trial of five different preparations.

    abstract:OBJECTIVE:To compare the efficacy of five probiotic preparations recommended to parents in the treatment of acute diarrhoea in children. Design Randomised controlled clinical trial in collaboration with family paediatricians over 12 months. SETTING:Primary care. PARTICIPANTS:Children aged 3-36 months visiting a famil...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,随机对照试验

    doi:10.1136/bmj.39272.581736.55

    authors: Canani RB,Cirillo P,Terrin G,Cesarano L,Spagnuolo MI,De Vincenzo A,Albano F,Passariello A,De Marco G,Manguso F,Guarino A

    更新日期:2007-08-18 00:00:00

  • Association between contemporary hormonal contraception and ovarian cancer in women of reproductive age in Denmark: prospective, nationwide cohort study.

    abstract:OBJECTIVES:To investigate the association between contemporary combined hormonal contraceptives (including progestogen types in combined preparations and all progestogen-only products) and overall and specific types of ovarian cancer. DESIGN:Prospective, nationwide cohort study. SETTING:Denmark, 1995-2014. PARTICIPA...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.k3609

    authors: Iversen L,Fielding S,Lidegaard Ø,Mørch LS,Skovlund CW,Hannaford PC

    更新日期:2018-09-26 00:00:00

  • Lichen planus and liver diseases: a multicentre case-control study. Gruppo Italiano Studi Epidemiologici in Dermatologia (GISED).

    abstract:OBJECTIVE:To assess the association of lichen planus with liver complaints and with known aetiological factors of liver diseases. DESIGN:Multicentre case-control study. Interviews were conducted by trained medical investigators on the basis of a structured questionnaire. At the interview patients and controls were ask...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1136/bmj.300.6719.227

    authors:

    更新日期:1990-01-27 00:00:00

  • Misdiagnosis of the vegetative state: retrospective study in a rehabilitation unit.

    abstract:OBJECTIVE:To identify the number of patients who were misdiagnosed as being in the vegetative state and their characteristics. DESIGN:Retrospective study of the clinical records of the medical, occupational therapy, and clinical psychology departments. SETTING:20 bed unit specialising in the rehabilitation of patient...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.313.7048.13

    authors: Andrews K,Murphy L,Munday R,Littlewood C

    更新日期:1996-07-06 00:00:00

  • Appraisal of a new scheme for prenatal screening for Down's syndrome.

    abstract:OBJECTIVE:To appraise a new method of prenatal screening for Down's syndrome based on maternal serum concentrations of alpha fetoprotein, unconjugated oestriol, and human chorionic gonadotrophin combined with maternal age--the "triple test." DESIGN:Examination of the cost effectiveness of the triple test relative to s...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.302.6785.1133

    authors: Sheldon TA,Simpson J

    更新日期:1991-05-11 00:00:00

  • Childhood leukaemia and poliomyelitis in relation to military encampments in England and Wales in the period of national military service, 1950-63.

    abstract:OBJECTIVE:To determine if any excess of childhood leukaemia was associated with the large and increasing numbers of national military servicemen in 1949 and 1950, particularly in rural districts. This would be a further test of the hypothesis that childhood leukaemia can originate in an infection, the transmission of w...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.303.6814.1357

    authors: Kinlen LJ,Hudson C

    更新日期:1991-11-30 00:00:00

  • Increase in incidence of disease due to diagnostic drift: primary liver cancer in Denmark, 1943-85.

    abstract:OBJECTIVE:To examine the extent to which changes in diagnostic methods and classification are responsible for the striking increase in incidence of primary liver cancer in Denmark since 1943. DESIGN:Analysis of the time trends in sex specific, age standardised incidence of primary liver cancer and unspecified liver ca...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.302.6774.437

    authors: Anderson IB,Sørensen TI,Prener A

    更新日期:1991-02-23 00:00:00

  • How good is general practice developmental screening?

    abstract::All developmental screening in Somerset is performed by general practitioners and health visitors. A retrospective review of a cohort of 1504 7 year old children living in semirural Somerset found that the development assessment by a health visitor at age 3 1/2 years had a sensitivity of 45% for identifying the 103 ch...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.300.6733.1177

    authors: Dearlove J,Kearney D

    更新日期:1990-05-05 00:00:00

  • Advances in the management of chronic insomnia.

    abstract::Chronic insomnia is a common condition that affects people worldwide and has negative effects on patients' health and wellbeing. The treatment of insomnia can be complex and time consuming for patients and providers. Although behavioral interventions are the first line therapy, there are barriers to access for these t...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,评审

    doi:10.1136/bmj.i2123

    authors: Kay-Stacey M,Attarian H

    更新日期:2016-07-06 00:00:00

  • Research priorities in environmental health.

    abstract::Environmental issues tend to greater political attention than do environmental health aspects. Therefore, when conflicts of interest occur with other environmental concerns, negative consequences for public health may result. For example, a strategy to substantially reduce indoor ventilation in many dwellings in Sca...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 社论

    doi:10.1136/bmj.318.7199.1636

    authors: Pershagen G

    更新日期:1999-06-19 00:00:00

  • Influenza A/H1N1 MF59 adjuvanted vaccine in pregnant women and adverse perinatal outcomes: multicentre study.

    abstract:OBJECTIVE:To assess the risk of adverse perinatal events of vaccination of pregnant women with an MF59 adjuvanted vaccine. DESIGN:Cross sectional multicentre study. SETTING:49 public hospitals in major cities in Argentina, from September 2010 to May 2011. PARTICIPANTS:30,448 mothers (7293 vaccinated) and their 30,76...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,多中心研究

    doi:10.1136/bmj.f393

    authors: Rubinstein F,Micone P,Bonotti A,Wainer V,Schwarcz A,Augustovski F,Pichon Riviere A,Karolinski A,EVA Study Research Group Estudio Embarazo y Vacuna Antigripal.

    更新日期:2013-02-04 00:00:00

  • Retrospective analysis of census data on general practitioners who qualified in South Asia: who will replace them as they retire?

    abstract:OBJECTIVES:To determine the number and geographical distribution of general practitioners in the NHS who qualified medically in South Asia and to project their numbers as they retire. DESIGN:Retrospective analysis of yearly data and projection of future trends. SETTING:England and Wales. SUBJECTS:General practitione...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.318.7179.306

    authors: Taylor DH Jr,Esmail A

    更新日期:1999-01-30 00:00:00

  • Patient characteristics and clinical caseload of short stay independent hospitals in England and Wales, 1992-3.

    abstract:OBJECTIVE:To describe and quantify the patients and clinical activities of independent short stay hospitals. DESIGN:Retrospective survey of hospital records for sampled periods of one financial year and comparison with data from 1981 to 1986. SETTING:217 independent hospitals in England and Wales, 1992-3. MAIN OUTCO...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.308.6945.1699

    authors: Williams BT,Nicholl JP

    更新日期:1994-06-25 00:00:00

  • Referral letters and replies from orthopaedic departments: opportunities missed.

    abstract:OBJECTIVE:To study delays between sending referral letters and the outpatient appointment and to assess the content of referral and reply letters, their educational value, and the extent to which questions asked are answered by reply letters. DESIGN:Retrospective review of referrals to 16 consultant orthopaedic surgeo...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.301.6750.470

    authors: Jacobs LG,Pringle MA

    更新日期:1990-09-08 00:00:00

  • The demand for neonatal intensive care.

    abstract::In a one year prospective study within the Trent Regional Health Authority the demand for neonatal intensive care was estimated to be 1.1 cots per 1000 births. Intensive care level 1 (as defined by the British Paediatric Association and British Association for Perinatal Paediatrics) was determined by two separate tech...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.299.6711.1305

    authors: Field DJ,Hodges S,Mason E,Burton P,Yates J,Wale S

    更新日期:1989-11-25 00:00:00

  • Attendance at cultural events, reading books or periodicals, and making music or singing in a choir as determinants for survival: Swedish interview survey of living conditions.

    abstract:OBJECTIVES:To investigate the possible influence of attendance at cultural events, reading books or periodicals, making music or singing in a choir as determinants for survival. DESIGN:A simple random sample was drawn of 15,198 individuals aged 16-74 years. Of these, 85% (12,982) were interviewed by trained non-medica...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.313.7072.1577

    authors: Bygren LO,Konlaan BB,Johansson SE

    更新日期:1996-12-21 00:00:00

  • Amblyopia treatment outcomes after screening before or at age 3 years: follow up from randomised trial.

    abstract:OBJECTIVE:To assess the effectiveness of early treatment for amblyopia in children. DESIGN:Follow up of outcomes of treatment for amblyopia in a randomised controlled trial comparing intensive orthoptic screening at 8, 12, 18, 25, 31, and 37 months (intensive group) with orthoptic screening at 37 months only (control ...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/bmj.324.7353.1549

    authors: Williams C,Northstone K,Harrad RA,Sparrow JM,Harvey I,ALSPAC Study Team.

    更新日期:2002-06-29 00:00:00

  • Must diabetes be a fatal disease in Africa? Study of costs of treatment.

    abstract:OBJECTIVE:To estimate the costs of diagnosis and treatment of diabetes in Tanzania. DESIGN:Costs estimated from the reported and recorded experience of patients with newly presenting diabetes in 1989-90 and of diabetic patients first seen in 1981-2. SETTING:Muhimbili Medical Centre, Dar es Salaam. SUBJECTS:464 patie...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.304.6836.1215

    authors: Chale SS,Swai AB,Mujinja PG,McLarty DG

    更新日期:1992-05-09 00:00:00

  • Postapproval studies of drugs initially approved by the FDA on the basis of limited evidence: systematic review.

    abstract::Objective To characterize the prospective controlled clinical studies for all novel drugs that were initially approved by the Food and Drug Administration on the basis of limited evidence.Design Systematic review.Data sources Drugs@FDA database and PubMed.Study inclusion All prospective controlled clinical studies pub...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,评审

    doi:10.1136/bmj.j1680

    authors: Pease AM,Krumholz HM,Downing NS,Aminawung JA,Shah ND,Ross JS

    更新日期:2017-05-03 00:00:00

  • Evaluation of aid to diagnosis of pigmented skin lesions in general practice: controlled trial randomised by practice.

    abstract:OBJECTIVES:To determine whether an aid to the diagnosis of pigmented skin lesions reduces the ratio of benign lesions to melanomas excised in general practice. DESIGN:Controlled trial randomised by practice. SETTING:General practices in Perth, Western Australia. PARTICIPANTS:468 general practitioners in 223 practice...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1136/bmj.327.7411.375

    authors: English DR,Burton RC,del Mar CB,Donovan RJ,Ireland PD,Emery G

    更新日期:2003-08-16 00:00:00

  • Progressive loss of bone in the femoral neck in elderly people: longitudinal findings from the Dubbo osteoporosis epidemiology study.

    abstract:OBJECTIVES:To determine prospectively the rates of change in bone mineral density in elderly people and to examine the relation between lifestyle and demographic factors and these rates of change. DESIGN:Longitudinal population based study. SETTING:Dubbo, New South Wales, Australia. SUBJECTS:Representative sample (n...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:

    authors: Jones G,Nguyen T,Sambrook P,Kelly PJ,Eisman JA

    更新日期:1994-09-17 00:00:00

  • Examination of instruments used to rate quality of health information on the internet: chronicle of a voyage with an unclear destination.

    abstract:OBJECTIVE:This study updates work published in 1998, which found that of 47 rating instruments appearing on websites offering health information, 14 described how they were developed, five provided instructions for use, and none reported the interobserver reliability and construct validity of the measurements. DESIGN:...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,评审

    doi:10.1136/bmj.324.7337.569

    authors: Gagliardi A,Jadad AR

    更新日期:2002-03-09 00:00:00

  • Antiretroviral treatment can reduce the risk of HIV transmission between male partners to 'zero'.

    abstract::The studyA Rodger, V Cambiano, T Bruun, et al. Risk of HIV transmission through condomless sex in serodifferent gay couples with the HIV-positive partner taking suppressive antiretroviral therapy (PARTNER): final results of a multicentre, prospective, observational study. Lancet 2019;393:2428-38.This project was funde...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 评论,杂志文章

    doi:10.1136/bmj.l4915

    authors: Cook R,Davidson P,clinical adviser,.,Martin R,NIHR Dissemination Centre.

    更新日期:2019-08-27 00:00:00

  • Why Rudolph's nose is red: observational study.

    abstract:OBJECTIVE:To characterise the functional morphology of the nasal microcirculation in humans in comparison with reindeer as a means of testing the hypothesis that the luminous red nose of Rudolph, one of the most well known reindeer pulling Santa Claus's sleigh, is due to the presence of a highly dense and rich nasal mi...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.e8311

    authors: Ince C,van Kuijen AM,Milstein DM,Yürük K,Folkow LP,Fokkens WJ,Blix AS

    更新日期:2012-12-14 00:00:00

  • Randomised study of effect of different doses of vitamin A on childhood morbidity and mortality.

    abstract:OBJECTIVES:To determine whether the dose of vitamin A currently recommended by the World Health Organization or half this dose gives better protection against childhood morbidity and mortality. DESIGN:Randomised study. SETTING:A combined oral polio vaccine and vitamin A supplementation campaign in Guinea-Bissau, Afri...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,随机对照试验

    doi:10.1136/bmj.38670.639340.55

    authors: Benn CS,Martins C,Rodrigues A,Jensen H,Lisse IM,Aaby P

    更新日期:2005-12-17 00:00:00

  • Assessing the risk of venous thromboembolic events in women taking progestin-only contraception: a meta-analysis.

    abstract:OBJECTIVES:To evaluate the risk of venous thromboembolic events associated with the use of progestin-only contraception and whether that risk differs with the mode of drug delivery (oral, intrauterine, or depot injection). DESIGN:Systematic review and meta-analysis of randomised controlled trials and observational stu...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,meta分析,评审

    doi:10.1136/bmj.e4944

    authors: Mantha S,Karp R,Raghavan V,Terrin N,Bauer KA,Zwicker JI

    更新日期:2012-08-07 00:00:00

  • Associations between macrolide antibiotics prescribing during pregnancy and adverse child outcomes in the UK: population based cohort study.

    abstract:OBJECTIVE:To assess the association between macrolide antibiotics prescribing during pregnancy and major malformations, cerebral palsy, epilepsy, attention deficit hyperactivity disorder, and autism spectrum disorder in children. DESIGN:Population based cohort study. SETTING:The UK Clinical Practice Research Datalink...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.m331

    authors: Fan H,Gilbert R,O'Callaghan F,Li L

    更新日期:2020-02-19 00:00:00

  • Country of training and ethnic origin of UK doctors: database and survey studies.

    abstract:OBJECTIVES:To report on the country of training and ethnicity of consultants in different specialties in the NHS, on trends in intake to UK medical schools by ethnicity, and on the specialty choices made by UK medical graduates in different ethnic groups. DESIGN:Analysis of official databases of consultants and of stu...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.38202.364271.BE

    authors: Goldacre MJ,Davidson JM,Lambert TW

    更新日期:2004-09-11 00:00:00