Late mortality after sepsis: propensity matched cohort study.

Abstract:

OBJECTIVES: To determine whether late mortality after sepsis is driven predominantly by pre-existing comorbid disease or is the result of sepsis itself. DEIGN: Observational cohort study. SETTING: US Health and Retirement Study. PARTICIPANTS: 960 patients aged ≥65 (1998-2010) with fee-for-service Medicare coverage who were admitted to hospital with sepsis. Patients were matched to 777 adults not currently in hospital, 788 patients admitted with non-sepsis infection, and 504 patients admitted with acute sterile inflammatory conditions. MAIN OUTCOME MEASURES: Late (31 days to two years) mortality and odds of death at various intervals. RESULTS: Sepsis was associated with a 22.1% (95% confidence interval 17.5% to 26.7%) absolute increase in late mortality relative to adults not in hospital, a 10.4% (5.4% to 15.4%) absolute increase relative to patients admitted with non-sepsis infection, and a 16.2% (10.2% to 22.2%) absolute increase relative to patients admitted with sterile inflammatory conditions (P<0.001 for each comparison). Mortality remained higher for at least two years relative to adults not in hospital. CONCLUSIONS: More than one in five patients who survives sepsis has a late death not explained by health status before sepsis.

journal_name

BMJ

authors

Prescott HC,Osterholzer JJ,Langa KM,Angus DC,Iwashyna TJ

doi

10.1136/bmj.i2375

subject

Has Abstract

pub_date

2016-05-17 00:00:00

pages

i2375

eissn

0959-8138

issn

1756-1833

journal_volume

353

pub_type

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