Abstract：
:The effects of intravenous administration of iloprost, a prostacyclin analogue, on myocardial energy metabolism and myocardial blood flow (MBF) were examined in anesthetized open-chest dogs subjected to 60 min of myocardial ischemia by coronary ligation. Iloprost administration at levels of 0.1 or 0.2 micrograms/kg/min was started 30 min before the commencement of ischemia and continued throughout the 90 min observation period. Since systolic aortic pressure in the iloprost 0.2 micrograms/kg/min group showed significantly lower values than that in the control group, whereas no clear effect was observed with the lower concentration (0.1 micrograms/kg/min), this latter group was further investigated. This 0.1 microgram/kg/min dose of iloprost lacked influence on MBF in both ischemic and nonischemic areas but did result in a significantly higher value for high energy phosphate contents in the ischemic myocardium. Moreover, myocardial mitochondrial respiratory function in the ischemic area was significantly improved. These results indicate that iloprost brought about preservation of myocardial energy metabolism without alteration of coronary perfusion, suggesting that it may exert a direct cardioprotective effect.
journal_name
Nagoya J Med Scijournal_title
Nagoya journal of medical scienceauthors
Ieda N,Matsubara T,Sakamoto Nsubject
Has Abstractpub_date
1994-03-01 00:00:00pages
25-33issue
1-4eissn
0027-7622issn
2186-3326journal_volume
57pub_type
杂志文章abstract：:Syntrophins are the cytoplasmic peripheral proteins of dystrophin glycoprotein complex, of which five (alpha l, beta 1, beta 2, gamma 1 and gamma 2) isoforms have been identified so far. Respective syntrophin isoforms are encoded by different genes but have similar domain structures. At the sarcolemma of skeletal musc...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：2008-08-01 00:00:00
abstract：:A 67-year-old man underwent posterior cervical decompression surgery for ossification of the posterior longitudinal ligament (OPLL) with fixation using cervical pedicle screws (CPSs) guided by intraoperative 3D image-based navigation. Intraoperatively, while creating the screw hole using the navigation probe, the virt...
journal_title：Nagoya journal of medical science
pub_type：
doi：10.18999/nagjms.82.4.799
更新日期：2020-11-01 00:00:00
abstract：:A total of 483 hips treated by primary total hip arthroplasty (THA) were investigated to evaluate the surgical skill of the performing surgeon. Surgical trainees operated on 259 hips and instructors on 224 hips. The average age of the patients at the time of THA in the trainee and instructor group was 61.9 and 60.8 ye...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：2015-02-01 00:00:00
abstract：:Disorientation responses of animals exposed to microgravity produced by parabolic aircraft flights and also in-space experiments were reviewed. Disoriented postures in floating are largely species-dependent. Reflexive lowered tone of gravity-bearing extensor muscles by labyrinthectomy is not seen in mammals (hamster a...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：1995-12-01 00:00:00
abstract：:Curved intertrochanteric varus osteotomy (CVO) is one of the good surgical procedures for avascular necrosis of the femoral head (ANFH) patients. However, some patients with failed CVO are converted to total hip arthroplasty (THA) as a salvage operation. We compared the clinical and radiographic outcomes of 10 hips co...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：2016-02-01 00:00:00
abstract：:The biological effects of static magnetic fields, and their combined effects with ionizing radiation, were studied using a cultured mammalian cell line (FM3A). The three different modes of magnetic fields evaluated in this report were the 0.3 Tesla (T) field with a gradient of 0.3T/m, the 0.7T field with a gradient of...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：1995-12-01 00:00:00
abstract：:Umbilical metastasis from intra-abdominal or pelvic malignancy, which is called Sister Mary Joseph's nodule (SMJN), is rare, and it has a poor prognosis. Its most common primary sites are the stomach and ovaries. SMJN caused by colon cancer is uncommon. A 42-year-old woman visited local clinics with complaints of an u...
journal_title：Nagoya journal of medical science
pub_type：
doi：10.18999/nagjms.81.2.325
更新日期：2019-05-01 00:00:00
abstract：:Mediastinal embryonal carcinoma is rare, and the life prognosis of this disease is assumed to be relatively short. We encountered a case of mediastinal embryonal carcinoma for which we could perform radical surgical resection. The patient was male, aged 16 years, and acutely aware of back pain. Because the pain increa...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：2014-02-01 00:00:00
abstract：:Stereotactic radiosurgery for large brain metastases (BM) not amenable to surgical resection is associated with limited local control and neurotoxicity, while hypofractionated stereotactic radiotherapy (HFSRT) has emerged as a promising option. We retrospectively evaluated 61 patients with BM larger than 2 cm in the m...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：10.18999/nagjms.81.3.397
更新日期：2019-08-01 00:00:00
abstract：:A new hypothesis for the origin of metastases is presented. It assumes that a cancer-transformed gene in a primary tumour is incorporated in its identical form via a virus-vector function into biologically potent recipient cells in other organs, such as stem cells, multipotent cells or cells in an early phase of divis...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：2013-02-01 00:00:00
abstract：:Experimental middle ear barotrauma was studied morphologically. White guinea pigs were placed in an experimental hyperbaric chamber, and middle ear barotrauma was created by increasing the pressure in the hyperbaric chamber from 1 atmosphere absolute (ATA) to 2 ATA using pure oxygen, maintaining the pressure at 2 ATA ...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章,评审
doi：
更新日期：1997-11-01 00:00:00
abstract：:Patients with intestinal ischemia associated with acute aortic dissection often require emergent bowel resection, which results in serious complications. We present a case of successful surgical management of extensive bowel necrosis caused by acute aortic dissection. A 42-year-old man underwent emergent subtotal rese...
journal_title：Nagoya journal of medical science
pub_type：
doi：10.18999/nagjms.81.4.711
更新日期：2019-11-01 00:00:00
abstract：:Anastomotic leakage after esophagectomy is associated with prolonged hospitalization and increased medical cost. Additionally, it sometimes leads to a fatal condition and impaired postoperative quality of life. During the process of wound healing, β-hydroxy-β-methylbutyrate (HMB) is important for collagen biosynthesis...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：10.18999/nagjms.82.1.33
更新日期：2020-02-01 00:00:00
abstract：:The aim of this study was to identify the socio-demographic characteristics, knowledge, attitude and accessibility factors related to the utilization of antenatal care (ANC) service among pregnant women in the Kham District, Laos. Data for this cross-sectional study were collected in July 2008, using a two-stage clust...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：2010-02-01 00:00:00
abstract：:The increasing burden of noncommunicable diseases (NCDs) in Bangladesh can be attributable to rapid urbanization and coinciding changes in lifestyle accompanied by nutrition transition. The objective of this study is to explore respondents' lived experiences and perceptions relating to NCDs and nutrition change in an ...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：10.18999/nagjms.80.4.559
更新日期：2018-11-01 00:00:00
abstract：:Hyperperfusion syndrome occurs after treatment of a large or giant cerebral aneurysm. Recently, flow-diverter stent placement has emerged as an effective treatment method for a large cerebral aneurysm, but postoperative ipsilateral delayed intraparenchymal hemorrhage occurs in a minority of cases. The mechanism underl...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：10.18999/nagjms.81.4.629
更新日期：2019-11-01 00:00:00
abstract：:The Japan Agency of Medical Research and Development (AMED) has approved the budget for the 5-year project called Establishment of the JAPAN Brain Bank Network, which commenced in 2016. This project was established with the aim of storing brain tissue samples to enable research on the etiologies and mechanisms of psyc...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章,评审
doi：10.18999/nagjms.80.3.309
更新日期：2018-08-01 00:00:00
abstract：:The purpose of this study was to demonstrate the characteristics of the Instrumental Activities of Daily Living (IADL) ability, evaluated by the Assessment of Motor and Process Skills (AMPS), and everyday memory functions (the memory necessary for daily life), assessed by the Rivermead Behavioral Memory Test (RBMT) in...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：:Respiratory exposure to asbestos fibers has been associated with diffuse malignant mesothelioma (DMM) in humans. Despite advancements in the molecular analyses of human DMM and the development of animal models, the carcinogenic mechanisms of the disease remain unclear. There are basically three hypotheses regarding th...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章,评审
doi：
更新日期：2009-02-01 00:00:00
abstract：:Argon-plasma coagulation, high-frequency electrosurgical snare, laser therapy, and microwave treatment are therapeutic options to reduce tumor-related stenosis of the central airway. These treatments may cause airway fire under a high concentration of oxygen, so FiO2 levels must be ≤40%. This restriction may be danger...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：10.18999/nagjms.80.3.411
更新日期：2018-08-01 00:00:00
abstract：:We retrospectively reviewed 12 patients (3 men and 9 women, with a mean age of 72 years) who were surgically treated for carpal tunnel syndrome associated with Kienböck disease. All patients except 1 were incidentally diagnosed with Kienböck disease and had little or no wrist pain. Radiographic tests revealed advanced...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：2016-08-01 00:00:00
abstract：:Surgical intervention for the treatment of acetabular fracture non-union is often challenging. Here, we present a case of acetabular fracture non-union with pelvic discontinuity in a patient who underwent cemented total hip arthroplasty (THA) after intra- and extra-articular plate fixation. The case was a 70-year-old ...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：10.18999/nagjms.81.1.113
更新日期：2019-02-01 00:00:00
abstract：:The distribution of nerve fibers containing either calcitonin gene-related peptide (CGRP) and substance P (SP) was investigated in rat skin with special reference to their relationship to the lymphatic vessels. These nerve fibers exhibited a similar distribution pattern but the former were more numerous than the latte...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：1996-12-01 00:00:00
abstract：:Since smoking is implicated in many diseases, medical professionals are expected to contribute to the reduction of smoking rates in their practice. Medical students are also expected to learn the importance of practical measures against smoking. This study surveyed the smoking rates and attitudes to smoking among medi...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：2010-08-01 00:00:00
abstract：:This study aimed to evaluate the efficacy of interventions to reduce patient misidentification incidents classified as level 2 and over (adverse events occurred for patients) with the step-by-step problem-solving method. All incidents related to patient misidentification were selected, and relevant information was col...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：10.18999/nagjms.82.2.315
更新日期：2020-05-01 00:00:00
abstract：:The survey involves examining the applications from 142 institutions that have consented to make available all certification applications from 2015 and 2016 to a research project for building a certification system for an ethics committee run by the Agency for Medical Research and Development. The number of certified ...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：10.18999/nagjms.81.3.501
更新日期：2019-08-01 00:00:00
abstract：:The number of pollinosis patients in Japan has significantly increased over the past 20 years. The majority of genome-wide association studies (GWAS) on pollinosis have been conducted in subjects of European descent, with few studies in Japanese populations. The aim of our GWAS was to identify genetic loci associated ...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：10.18999/nagjms.80.1.109
更新日期：2018-02-01 00:00:00
abstract：:Surgical site infections (SSIs) are one of the most serious complications in spine surgery. We investigated the efficacy of locally administered vancomycin (VCM) powder for prophylaxis on SSI after invasive spine surgery. We retrospectively studied 174 consecutive patients who underwent spine surgery. In patients of t...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：10.18999/nagjms.79.4.545
更新日期：2017-11-01 00:00:00
abstract：:Liver biopsy specimens from 18 patients with primary biliary cirrhosis were examined histochemically and by energy-dispersive x-ray microanalysis. Using two indices, we classified hepatic copper accumulation into three stages based on the Cu x-ray intensity of cuproproteins that had accumulated in hepatocyte lysosomes...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：1993-03-01 00:00:00
abstract：:Neoadjuvant chemotherapy (NAC) using the combination of anthracycline and taxanes is the standard regimen for patients with primary breast cancer. Among the taxanes, conventional paclitaxel (PTX) and docetaxel have usually been adopted in the neoadjuvant or adjuvant setting. Nanoparticle albumin-bound paclitaxel (nab-...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：10.18999/nagjms.82.3.457
更新日期：2020-08-01 00:00:00
