A prospective trial to evaluate treatment effects of a β-hydroxy-β-methylbutyrate containing nutrient for leakage at the anastomotic site after esophagectomy.

Abstract:

:Anastomotic leakage after esophagectomy is associated with prolonged hospitalization and increased medical cost. Additionally, it sometimes leads to a fatal condition and impaired postoperative quality of life. During the process of wound healing, β-hydroxy-β-methylbutyrate (HMB) is important for collagen biosynthesis. An open-label prospective intervention trial has been designed to evaluate the treatment effect of an enteral nutrient containing HMB with arginine and glutamine (Abound, Abbott Japan Co., Ltd.) for leakage at the anastomotic site after esophagectomy. Patients in whom leakage at the anastomotic site developed within 14 days after esophagectomy are eligible and Abound (24 g) is administered for 14 days through an enteral feeding tube. The target sample size is 10. The primary endpoint is duration between diagnosis and cure of leakage. Surgical procedure, safety, length of fasting, drainage placement and hospital stay, and nutritional status are determined as secondary endpoints. A historical control consisting of 20 patients who had leakage at the anastomotic site after esophagectomy between 2005 and 2018 at Nagoya University Hospital is compared with enrolled patients.

journal_name

Nagoya J Med Sci

authors

Kanda M,Koike M,Fukaya M,Miyata K,Tanaka C,Kobayashi D,Hayashi M,Yamada S,Nakayama G,Murotani K,Fujiwara M,Nagino M,Kodera Y

doi

10.18999/nagjms.82.1.33

subject

Has Abstract

pub_date

2020-02-01 00:00:00

pages

33-37

issue

1

eissn

0027-7622

issn

2186-3326

journal_volume

82

pub_type

杂志文章
  • Prognostic factors for tumor recurrence after gamma knife radiosurgery of partially resected and recurrent craniopharyngiomas.

    abstract::A study was conducted to clarify the prognostic factors related to recurrence of craniopharyngioma and to improve the quality of life of patients by the treatment with intentional partial removal and gamma knife radiosurgery. One hundred cases of craniopharyngioma have been treated at Komaki City Hospital since 1991. ...

    journal_title:Nagoya journal of medical science

    pub_type: 杂志文章

    doi:

    authors: Kobayashi T,Mori Y,Tsugawa T,Hashizume C,Takahashi H

    更新日期:2012-02-01 00:00:00

  • Disorientation of animals in microgravity.

    abstract::Disorientation responses of animals exposed to microgravity produced by parabolic aircraft flights and also in-space experiments were reviewed. Disoriented postures in floating are largely species-dependent. Reflexive lowered tone of gravity-bearing extensor muscles by labyrinthectomy is not seen in mammals (hamster a...

    journal_title:Nagoya journal of medical science

    pub_type: 杂志文章

    doi:

    authors: Mori S

    更新日期:1995-12-01 00:00:00

  • Premature cardiac senescence in DahlS.Z-Lepr(fa)/Lepr(fa) rats as a new animal model of metabolic syndrome.

    abstract::Aging is accelerated by metabolic and cardiovascular diseases, and the risk of these diseases increases with age. Obesity is an important risk factor for many age-related diseases and is linked to reduced telomere length in white blood cells. We investigated whether cardiac senescence might be enhanced in DahlS.Z-Lepr...

    journal_title:Nagoya journal of medical science

    pub_type: 杂志文章

    doi:

    authors: Takahashi K,Takatsu M,Hattori T,Murase T,Ohura S,Takeshita Y,Watanabe S,Murohara T,Nagata K

    更新日期:2014-02-01 00:00:00

  • An overview of ethical review committees in Japan: examining the certification applications of ethical review committees.

    abstract::The survey involves examining the applications from 142 institutions that have consented to make available all certification applications from 2015 and 2016 to a research project for building a certification system for an ethics committee run by the Agency for Medical Research and Development. The number of certified ...

    journal_title:Nagoya journal of medical science

    pub_type: 杂志文章

    doi:10.18999/nagjms.81.3.501

    authors: Iijima Y,Ogasawara K,Toda S,Takano T

    更新日期:2019-08-01 00:00:00

  • The prevalence of homebound individuals in the elderly population: a survey in a city area in Japan.

    abstract::Being homebound has been reported to be associated with a number of conditions. In the current study, the incidence of homebound individuals was surveyed in an urban city area in Japan. The city office randomly enrolled 5,000 residents of Nagoya City aged 65 and over. A questionnaire was sent to their principal caregi...

    journal_title:Nagoya journal of medical science

    pub_type: 杂志文章

    doi:

    authors: Umegaki H,Yanagawa M,Nakashima H,Makino T,Kuzuya M

    更新日期:2015-08-01 00:00:00

  • Left ventricular dyssynchrony in patients with moderate coronary stenosis and border line fractional flow reserve.

    abstract::The cutoff values of fractional flow reserve (FFR) to detect physiological myocardial ischemia are still controversial. Some studies have reported that left ventricular (LV) dyssynchrony occurs in patients with coronary artery disease (CAD). The purpose of this study was to investigate LV dyssynchrony in patients with...

    journal_title:Nagoya journal of medical science

    pub_type: 杂志文章

    doi:

    authors: Shibata Y,Sone T,Tsuboi H,Isobe S,Ishii H,Suzuki S,Hayashi M,Murohara T

    更新日期:2015-02-01 00:00:00

  • A case of mediastinal embryonal carcinoma successfully treated by integrative therapy.

    abstract::Mediastinal embryonal carcinoma is rare, and the life prognosis of this disease is assumed to be relatively short. We encountered a case of mediastinal embryonal carcinoma for which we could perform radical surgical resection. The patient was male, aged 16 years, and acutely aware of back pain. Because the pain increa...

    journal_title:Nagoya journal of medical science

    pub_type: 杂志文章

    doi:

    authors: Kawanami K,Wakao N,Kamiya M,Takeuchi M,Hirasawa A,Takahashi E,Sato K

    更新日期:2014-02-01 00:00:00

  • Characteristics of assessment of motor and process skills and Rivermead Behavioral Memory Test in elderly women with dementia and community-dwelling women.

    abstract::The purpose of this study was to demonstrate the characteristics of the Instrumental Activities of Daily Living (IADL) ability, evaluated by the Assessment of Motor and Process Skills (AMPS), and everyday memory functions (the memory necessary for daily life), assessed by the Rivermead Behavioral Memory Test (RBMT) in...

    journal_title:Nagoya journal of medical science

    pub_type: 杂志文章

    doi:

    authors: Mori A,Sugimura K

    更新日期:2007-01-01 00:00:00

  • Yokukansankachimpihange increased body weight but not food-incentive motivation in wild-type mice.

    abstract::Yokukansankachimpihange (YKSCH), a traditional Japanese medicine, is widely used for the amelioration of the behavioral and psychological symptoms of dementia with digestive dysfunction. Regardless of its successful use for digestive dysfunction, the effect of YKSCH on body weight was unknown. Furthermore, if YKSCH in...

    journal_title:Nagoya journal of medical science

    pub_type: 杂志文章

    doi:10.18999/nagjms.79.3.351

    authors: Hamaguchi T,Tsutsui-Kimura I,F Tanaka K,Mimura M

    更新日期:2017-08-01 00:00:00

  • DPP4 genetic variants influence baseline prostate-specific antigen levels: the J-MICC study.

    abstract::Prostate specific antigen (PSA) testing plays a major role in prostate cancer screening; however, the low positive predictive value of PSA testing leads to many unnecessary biopsies. Genetic background is one of factors that could cause it. That's why an association between genetic background and PSA levels should be ...

    journal_title:Nagoya journal of medical science

    pub_type: 杂志文章,多中心研究

    doi:

    authors: Higashibata T,Naito M,Mori A,Ozawa N,Furuta M,Tsuchiya R,Koyama E,Morita E,Kawai S,Okada R,Yin G,Wakai K,Hamajima N

    更新日期:2013-02-01 00:00:00

  • Experimental study of coil delivery wire insertion force in intracranial aneurysm embolization: force discrepancy generated inside the microcatheter through that coil delivery wire passes.

    abstract::In endovascular coil embolization for intracranial aneurysms, as coils are filled in the aneurysm and the stage of procedure is advanced, the force to push forward the coil delivery wire (insertion force) increases. However, the coil insertion force that interventionist's felt at his fingertips does not directly refle...

    journal_title:Nagoya journal of medical science

    pub_type: 杂志文章

    doi:10.18999/nagjms.81.2.217

    authors: Shintai K,Matsubara N,Izumi T,Miyachi S,Yamada H,Marui N,Wakabayashi T

    更新日期:2019-05-01 00:00:00

  • Smoking rates and attitudes to smoking among medical students: a 2009 survey at the Nagoya University School of Medicine.

    abstract::Since smoking is implicated in many diseases, medical professionals are expected to contribute to the reduction of smoking rates in their practice. Medical students are also expected to learn the importance of practical measures against smoking. This study surveyed the smoking rates and attitudes to smoking among medi...

    journal_title:Nagoya journal of medical science

    pub_type: 杂志文章

    doi:

    authors: Takeuchi Y,Morita E,Naito M,Hamajima N

    更新日期:2010-08-01 00:00:00

  • Mechanism of dialysis-induced hypotension.

    abstract::Dialysis-induced hypotension, the sharp decrease in blood pressure occurring during hemodialysis, remains one of the most difficult problems associated with hemodialysis even today. However, there is yet no established theory to explain the mechanism triggering dialysis-induced hypotension. This review attempts to off...

    journal_title:Nagoya journal of medical science

    pub_type: 杂志文章,评审

    doi:

    authors: Maeda K,Shinzato T,Nakai S,Takai I,Kobayakawa H

    更新日期:1992-03-01 00:00:00

  • The ethics of blood transfusion refusal in clinical practice among legal and medical professions in Japan.

    abstract::We investigated the differences in Japanese and United States medical and legal professional opinions on ethical support for clinical ethical issues using the refusal of blood transfusions on the grounds of religious principles as an example of a clinical ethical issue. In ethical support systems for medical instituti...

    journal_title:Nagoya journal of medical science

    pub_type: 杂志文章

    doi:10.18999/nagjms.82.2.193

    authors: Iijima Y

    更新日期:2020-05-01 00:00:00

  • Elevated serum interleukin-23 levels in ankylosing spondylitis patients and the relationship with disease activity.

    abstract::This study was aimed to evaluate the relationship between serum interleukin-23 (IL-23) levels and ankylosing spondylitis (AS).Twenty male patients diagnosed with ankylosing spondylitis according to the 1984 modified New York criteria for AS and twenty male healthy controls were included in this study.The demographic c...

    journal_title:Nagoya journal of medical science

    pub_type: 杂志文章

    doi:

    authors: Ugur M,Baygutalp NK,Melikoglu MA,Baygutalp F,Altas EU,Seferoglu B

    更新日期:2015-11-01 00:00:00

  • Hepatic copper accumulation in patients with primary biliary cirrhosis.

    abstract::Liver biopsy specimens from 18 patients with primary biliary cirrhosis were examined histochemically and by energy-dispersive x-ray microanalysis. Using two indices, we classified hepatic copper accumulation into three stages based on the Cu x-ray intensity of cuproproteins that had accumulated in hepatocyte lysosomes...

    journal_title:Nagoya journal of medical science

    pub_type: 杂志文章

    doi:

    authors: Takeshima H,Yagi A,Yano M,Sakamoto N,Kato S,Kuriki J,Arao M,Takikawa T,Hayashi H

    更新日期:1993-03-01 00:00:00

  • Intrawound Vancomycin powder as the prophylaxis of surgical site infection after invasive spine surgery with a high risk of infection.

    abstract::Surgical site infections (SSIs) are one of the most serious complications in spine surgery. We investigated the efficacy of locally administered vancomycin (VCM) powder for prophylaxis on SSI after invasive spine surgery. We retrospectively studied 174 consecutive patients who underwent spine surgery. In patients of t...

    journal_title:Nagoya journal of medical science

    pub_type: 杂志文章

    doi:10.18999/nagjms.79.4.545

    authors: Hida T,Ando K,Kobayashi K,Ito K,Tsushima M,Matsumoto A,Morozumi M,Tanaka S,Machino M,Ota K,Kanbara S,Ito S,Nishida Y,Ishiguro N,Imagama S

    更新日期:2017-11-01 00:00:00

  • An open-label, single-arm study of CRYO2 for tissue removal at the site of central airway obstruction or stenosis: study protocol.

    abstract::Argon-plasma coagulation, high-frequency electrosurgical snare, laser therapy, and microwave treatment are therapeutic options to reduce tumor-related stenosis of the central airway. These treatments may cause airway fire under a high concentration of oxygen, so FiO2 levels must be ≤40%. This restriction may be danger...

    journal_title:Nagoya journal of medical science

    pub_type: 杂志文章

    doi:10.18999/nagjms.80.3.411

    authors: Saka H,Kada A

    更新日期:2018-08-01 00:00:00

  • Characterization of the human DNA polymerase delta catalytic subunit expressed by a recombinant baculovirus.

    abstract::The catalytic subunit of human DNA polymerase (pol) delta, p125, was expressed in recombinant baculovirus-infected insect cells, separated from a baculovirus-encoded DNA polymerase, and was purified to homogeneity by affinity trapping with a histidine-octapeptide at the C-terminus of p125 as the ligand. Purified p125 ...

    journal_title:Nagoya journal of medical science

    pub_type: 杂志文章

    doi:

    authors: Suzuki S,Suzuki M,Yoshida S

    更新日期:2000-11-01 00:00:00

  • Preoperative embolization of meningiomas with low-concentration n-butyl cyanoacrylate.

    abstract::The aim of this study was to determine the clinical safety and efficacy of preoperative embolization of meningiomas with low-concentration n-butyl cyanoacrylate (NBCA). Nineteen cases of hypervascular intracranial meningiomas were treated by preoperative embolization with 14% NBCA, using a wedged superselective cathet...

    journal_title:Nagoya journal of medical science

    pub_type: 杂志文章

    doi:

    authors: Yamamoto T,Ohshima T,Nishihori M,Goto S,Nishizawa T,Shimato S,Kato K

    更新日期:2015-08-01 00:00:00

  • Surgical skills training for primary total hip arthroplasty.

    abstract::A total of 483 hips treated by primary total hip arthroplasty (THA) were investigated to evaluate the surgical skill of the performing surgeon. Surgical trainees operated on 259 hips and instructors on 224 hips. The average age of the patients at the time of THA in the trainee and instructor group was 61.9 and 60.8 ye...

    journal_title:Nagoya journal of medical science

    pub_type: 杂志文章

    doi:

    authors: Hasegawa Y,Amano T

    更新日期:2015-02-01 00:00:00

  • Biochemical staging of the chronic hepatic lesions of Wilson disease.

    abstract:BACKGROUND:Copper toxicity steadily affects the livers of patients with Wilson disease. However, the toxic effect of copper on serum aspartate and alanine aminotransferase levels remains to be clarified as a prerequisite for diagnostic tests. The clinical records of 33 cases were analyzed to clarify the natural history...

    journal_title:Nagoya journal of medical science

    pub_type: 杂志文章

    doi:

    authors: Katano Y,Hayashi K,Hattori A,Tatsumi Y,Ueyama J,Wakusawa S,Yano M,Toyoda H,Kumada T,Mizutani N,Hayashi H,Goto H

    更新日期:2014-02-01 00:00:00

  • Comparing surgical outcomes of complete thoracoscopic lobectomy for congenital cystic lung disease between neonatal and infantile patients.

    abstract::Thoracoscopic lobectomy has recently become a widely used surgical treatment for congenital cystic lung disease, but significant issues can arise in some cases, such as a limited working space in neonates, a limited view in cases involving large cystic lesions. We reviewed the treatment outcomes of neonates that under...

    journal_title:Nagoya journal of medical science

    pub_type: 杂志文章

    doi:10.18999/nagjms.78.4.447

    authors: Tainaka T,Uchida H,Tanaka Y,Shirota C,Yokota K,Murase N,Oshima K,Shirotsuki R,Chiba K,Hinoki A

    更新日期:2016-12-01 00:00:00

  • Retrospective analysis of hypofractionated stereotactic radiotherapy for tumors larger than 2 cm.

    abstract::Stereotactic radiosurgery for large brain metastases (BM) not amenable to surgical resection is associated with limited local control and neurotoxicity, while hypofractionated stereotactic radiotherapy (HFSRT) has emerged as a promising option. We retrospectively evaluated 61 patients with BM larger than 2 cm in the m...

    journal_title:Nagoya journal of medical science

    pub_type: 杂志文章

    doi:10.18999/nagjms.81.3.397

    authors: Koide Y,Tomita N,Adachi S,Tanaka H,Tachibana H,Kodaira T

    更新日期:2019-08-01 00:00:00

  • Beneficial effects of iloprost on acute myocardial ischemia in dogs.

    abstract::The effects of intravenous administration of iloprost, a prostacyclin analogue, on myocardial energy metabolism and myocardial blood flow (MBF) were examined in anesthetized open-chest dogs subjected to 60 min of myocardial ischemia by coronary ligation. Iloprost administration at levels of 0.1 or 0.2 micrograms/kg/mi...

    journal_title:Nagoya journal of medical science

    pub_type: 杂志文章

    doi:

    authors: Ieda N,Matsubara T,Sakamoto N

    更新日期:1994-03-01 00:00:00

  • Central diabetes insipidus.

    abstract::Central diabetes insipidus (CDI), characterized by polyuria and polydipsia, is caused by deficiency of arginine vasopressin (AVP), an antidiuretic hormone which acts on V2 receptors in kidney to promote reabsorption of free water. CDI is classified into three subtypes; idiopathic, secondary and familial. A previous st...

    journal_title:Nagoya journal of medical science

    pub_type: 杂志文章,评审

    doi:10.18999/nagjms.78.4.349

    authors: Arima H,Azuma Y,Morishita Y,Hagiwara D

    更新日期:2016-12-01 00:00:00

  • Social correlates of female infertility in Uzbekistan.

    abstract::The purpose of this matched case-control study was to investigate the social correlates of primary infertility among females aged 35 years or less. The study was conducted in the Clinics of Samarkand Medical Institute, Uzbekistan, among 120 infertile and 120 healthy women matched by age, residential area, and occupati...

    journal_title:Nagoya journal of medical science

    pub_type: 杂志文章

    doi:

    authors: Jumayev I,Harun-Or-Rashid M,Rustamov O,Zakirova N,Kasuya H,Sakamoto J

    更新日期:2012-08-01 00:00:00

  • Evaluation of the association between locomotive syndrome and depressive states: a cross-sectional study.

    abstract::The Japanese Orthopaedic Association has proposed the term "locomotive syndrome" to designate a condition that places a person at high risk for long-term care. However, in daily clinical practice, even when a diagnosis of locomotive syndrome is made, exercise therapy often cannot be successfully performed in some pati...

    journal_title:Nagoya journal of medical science

    pub_type: 杂志文章

    doi:10.18999/nagjms.79.1.43

    authors: Saito T,Watanabe H,Kikkawa I,Takeshita K

    更新日期:2017-02-01 00:00:00

  • Clinical outcomes of neoadjuvant chemotherapy for patients with breast cancer: Tri-weekly nanoparticle albumin-bound paclitaxel followed by 5-fluorouracil, epirubicin, and cyclophosphamide: a retrospective observational study.

    abstract::Neoadjuvant chemotherapy (NAC) using the combination of anthracycline and taxanes is the standard regimen for patients with primary breast cancer. Among the taxanes, conventional paclitaxel (PTX) and docetaxel have usually been adopted in the neoadjuvant or adjuvant setting. Nanoparticle albumin-bound paclitaxel (nab-...

    journal_title:Nagoya journal of medical science

    pub_type: 杂志文章

    doi:10.18999/nagjms.82.3.457

    authors: Shizuku M,Shibata M,Shimizu Y,Takeuchi D,Mizuno Y

    更新日期:2020-08-01 00:00:00

  • Application of subsecond rotation scan to helical CT for lung cancer screening.

    abstract:PURPOSE:To clarify whether the benefit of a reduced effective scan width obtained using a smaller pitch outweighs the disadvantage of increased noise in the application of a subsecond helical CT to mass screenings for lung cancer. MATERIALS AND METHODS:Twenty-two helical CT scans of the lung were obtained in 11 health...

    journal_title:Nagoya journal of medical science

    pub_type: 杂志文章

    doi:

    authors: Mori Y,Itoh S,Ikeda M,Sawaki A,Suzuki K,Iwano S,Satake H,Arahata S,Ota T,Ishigaki T

    更新日期:2006-06-01 00:00:00