Abstract:
OBJECTIVES:Although novel early breast cancer prognostic factors are being continuously discovered, only rare factors predicting survival in metastatic breast cancer have been validated. The prognostic role of early breast cancer prognostic factors in metastatic disease also remains mostly unclear. DESIGN AND SETTING:Prospective cohort study in a Finnish University Hospital. PARTICIPANTS AND OUTCOMES:594 women with early breast cancer were originally followed. Sixty-one of these patients developed distant metastases during the follow-up, and their primary breast cancer properties, such as tumour size, nodal status, oestrogen receptor (ER) and progesterone receptor expression, grade, proliferation rate, histopathological subtype and breast cancer subtype were analysed as potential prognostic factors for metastatic disease. RESULTS:In multivariate analysis, the presence of lymph node metastases at the time of early breast cancer surgery (HR, 2.17; 95% CI, 1.09-4.31; p=0.027) and ER status (negative vs positive, HR, 2.16; 95% CI, 1.14-4.10; p=0.018) were significant predictors of survival in metastatic disease. CONCLUSIONS:These results confirm ER status as a primary prognostic factor in metastatic breast cancer. Furthermore, it also suggests that the presence of initial lymph node metastases could serve as a prognostic factor in recurrent breast cancer.
journal_name
BMJ Openjournal_title
BMJ openauthors
Karihtala P,Jääskeläinen A,Roininen N,Jukkola Adoi
10.1136/bmjopen-2020-038798subject
Has Abstractpub_date
2020-10-12 00:00:00pages
e038798issue
10issn
2044-6055pii
bmjopen-2020-038798journal_volume
10pub_type
杂志文章相关文献
BMJ Open文献大全abstract:INTRODUCTION:Internet-based and mobile-based interventions (IMIs) provide an innovative and efficient self-management tool for mental health problems. This systematic review aims to summarise and critically evaluate studies addressing the effectiveness and feasibility of IMIs for normal and complicated grief in bereave...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-036034
更新日期:2020-04-22 00:00:00
abstract:INTRODUCTION:Type 2 diabetes mellitus (T2DM) is a highly prevalent chronic disease in the Spanish population. Typically, T2DM is associated with other chronic conditions. Intensive medication at the time of diagnosis has proven effective in reducing cardiovascular risk, improving glycaemic control and preventing T2DM c...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-033725
更新日期:2020-06-23 00:00:00
abstract:OBJECTIVE:This study determined the prevalence and factors associated with sexual dysfunction in breastfeeding women. DESIGN:Cross-sectional analytical study. SETTING:Population-based study of individuals living in the northeast region of São Paulo state, Brazil. PARTICIPANTS:From May to August 2017, 372 women aged ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-025833
更新日期:2019-04-25 00:00:00
abstract:INTRODUCTION:Emergency admission risk prediction models are increasingly used to identify patients, typically with one or more chronic conditions, for proactive management in primary care to avoid admissions, save costs and improve patient experience. AIM:To identify and review the published evidence on the costs, eff...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2015-009653
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVES:To analyse free-text responses from the first Scottish Cancer Patient Experience Survey (SCPES) to understand patients' experiences of care, identify valued aspects and areas for improvement. DESIGN:Inductive thematic analysis of seven free-text comment boxes covering all stages of the cancer experience, fr...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-015726
更新日期:2017-06-15 00:00:00
abstract:INTRODUCTION:The ongoing opioid epidemic has necessitated increasing prescriptions of buprenorphine, which is an evidence-based treatment for opioid use disorder, and also shown to reduce harms associated with unsafe opioid administration. A systematic review of perioperative management strategies for patients taking b...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-027374
更新日期:2019-05-22 00:00:00
abstract:INTRODUCTION:Financial toxicity (FT) is a well-recognised problem in oncology. US-based studies have shown that: (a) cancer patients have a 2.7 times risk of bankruptcy; (b) patients who declare bankruptcy have a 79% greater hazard of death; (c) financial burden significantly impairs quality of life (QoL) and (d) reduc...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究
doi:10.1136/bmjopen-2019-031485
更新日期:2019-09-09 00:00:00
abstract:INTRODUCTION:Person-centredness is a philosophy for organising and delivering healthcare based on patients' needs, preferences and experiences. Although widely endorsed, the concept suffers from a lack of detail and clarification, in turn accounting for ambiguous implementation and outcomes. While a conceptual framewor...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-011959
更新日期:2016-07-19 00:00:00
abstract:OBJECTIVE:To clarify prognostic factors for idiopathic inflammatory myopathy (IIM)-associated interstitial lung disease (ILD). DESIGN:Systematic review and meta-analysis using the Grades of Recommendation, Assessment, Development and Evaluation system. DATA SOURCES:Medline, EMBASE and Science Citation Index Expanded ...
journal_title:BMJ open
pub_type: 杂志文章,meta分析
doi:10.1136/bmjopen-2018-023998
更新日期:2018-12-16 00:00:00
abstract:OBJECTIVES:This study aimed to identify intrauterine growth differences according to infertility treatment compared with spontaneous conception and to describe intrauterine growth trajectories. DESIGN:Retrospective cohort study. SETTING:A single primary and tertiary medical centre in Japan. PARTICIPANTS:This study i...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-033675
更新日期:2020-04-28 00:00:00
abstract:OBJECTIVE:Severe infections are a major cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE). Our primary objective was to use data from a large Spanish cohort to develop a risk score for severe infection in SLE, the SLE Severe Infection Score (SLESIS) and to validate SLESIS in a separat...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-028697
更新日期:2019-06-14 00:00:00
abstract:INTRODUCTION:A cancer diagnose, for example, colorectal cancer, not only affects the cancer-person stricken, but also the surrounding family. Thus, this scoping review intends to identify appropriate models of support that will guide the development of a model of support to family members during the trajectory of color...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-037633
更新日期:2020-09-03 00:00:00
abstract:OBJECTIVE:Financial incentives may encourage private for-profit providers to perform more caesarean section (CS) than non-profit hospitals. We therefore sought to determine the association of for-profit status of hospital and odds of CS. DESIGN:Systematic review and meta-analysis. DATA SOURCES:MEDLINE, EMBASE and the...
journal_title:BMJ open
pub_type: 杂志文章,meta分析,评审
doi:10.1136/bmjopen-2016-013670
更新日期:2017-02-17 00:00:00
abstract:INTRODUCTION:Sciatica is a lower spine condition characterised by radiating leg pain below the knee. It may be accompanied by motor and sensory loss in the distribution of a spinal nerve. There are few effective treatments for sciatica. Orally administered glucocorticoids have shown some promise, however, any beneficia...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-040559
更新日期:2020-06-23 00:00:00
abstract:INTRODUCTION:Despite the significant disease burden of bronchiectasis in Korea, no large-scale, representative prospective cohort studies have been conducted to evaluate the clinical characteristics of Korean patients with bronchiectasis, indicating an urgent need for cohort studies on bronchiectasis. METHODS AND ANAL...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-034090
更新日期:2020-01-19 00:00:00
abstract:OBJECTIVE:Danish medical registries are widely used for cardiovascular research, but little is known about the data quality of cardiac interventions. We computed positive predictive values (PPVs) of codes for cardiac examinations, procedures and surgeries registered in the Danish National Patient Registry during 2010-2...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-012817
更新日期:2016-12-09 00:00:00
abstract:OBJECTIVES:The difference between income quintiles in health is relatively well accepted by the general public as a measure of health inequality. However, the slope index of inequality (SII) in health reflects the patterns of all social groups, including the middle 60%, and it could therefore be considered more academi...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-028687
更新日期:2019-06-27 00:00:00
abstract:OBJECTIVES:Medical image analysis practices face challenges that can potentially be addressed with algorithm-based segmentation tools. In this study, we map the field of automatic MR brain lesion segmentation to understand the clinical applicability of prevalent methods and study designs, as well as challenges and limi...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-042660
更新日期:2021-01-29 00:00:00
abstract:OBJECTIVES:Scientific literacy is assumed necessary for appraising the reliability of health claims. Using a national science achievement test, we explored whether students located at the lower quartile on the latent trait (scientific literacy) scale were likely to identify a health claim in a fictitious brief news rep...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-028781
更新日期:2019-10-18 00:00:00
abstract:INTRODUCTION:Although many effective treatment options exist, depression is still undertreated indicating gaps in the healthcare system. The complementary provision of mental healthcare through technologies (eg, computer, smartphone) has the potential to fill treatment gaps and to overcome access barriers to mental hea...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-028042
更新日期:2019-03-27 00:00:00
abstract:OBJECTIVES:To assess the quantity and evaluate the quality of policies and curricula focusing on conflicts of interests (COI) at medical schools across Germany. DESIGN:Cross-sectional study, survey of medical schools, standardised web search. SETTING:Medical schools, Germany. PARTICIPANTS:38 German medical schools. ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-039782
更新日期:2020-09-30 00:00:00
abstract:OBJECTIVE:To examine whether confidence in primary healthcare (PHC) differs among ethnic-linguistic groups and which PHC experiences are associated with confidence. DESIGN:A cross-sectional study where patient surveys were administered using random digit dialling. Regression models identify whether ethnic-linguistic g...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2013-003884
更新日期:2014-02-25 00:00:00
abstract:INTRODUCTION:The role of adjuvant chemotherapy after radical radiotherapy (RT) or chemoradiotherapy (CRT) in cervical cancer awaits further confirmation. Evidences have shown that persistent human papilloma virus (HPV) DNA in exfoliated cell post-RT is a potential biomarker of subclinical residual disease and thus incr...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-028171
更新日期:2019-10-07 00:00:00
abstract:OBJECTIVE:To explore the optimal content and design of a clinical trial of an end-of-life intervention for advanced heart disease with patients, carers and healthcare professionals. DESIGN:Qualitative interview and focus group study. SETTING:Community and hospital-based focus groups and interviews. PARTICIPANTS:Stab...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-005021
更新日期:2014-07-14 00:00:00
abstract:OBJECTIVES:Injury is an important issue in public health. Spinal curvature disorders are deformities characterised by excessive curves of the spine. The prevalence of spinal curvature disorders is not low, but its relationship with injury has not been studied. The aim of this study is to investigate whether spinal curv...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-023604
更新日期:2019-01-17 00:00:00
abstract:INTRODUCTION:There has been a growing awareness of the need for rigorously and transparent reported health research, to ensure the reproducibility of studies by future researchers. Health economic evaluations, the comparative analysis of alternative interventions in terms of their costs and consequences, have been prom...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-034463
更新日期:2020-02-13 00:00:00
abstract:INTRODUCTION:Chemotherapy-induced peripheral neuropathy (CIPN) is a prevalent and clinically meaningful side effect of cancer treatment. CIPN is induced by neurotoxic agents, causing severe sensory and/or motor deficits, resulting in disability and poor recovery, reducing patients' quality of life and limiting medical ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-024467
更新日期:2019-04-24 00:00:00
abstract:BACKGROUND:Atrial fibrillation (AF) is associated with a high risk of stroke and may often be asymptomatic. AF is commonly undiagnosed until patients present with sequelae, such as heart failure and stroke. Stroke secondary to AF is highly preventable with the use of appropriate thromboprophylaxis. Therefore, early ide...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2012-001355
更新日期:2012-06-25 00:00:00
abstract:OBJECTIVES:Inaccurate antibiotic dosing can lead to treatment failure, fuel antimicrobial resistance and increase side effects. The British National Formulary for Children (BNFC) guidance recommends oral antibiotic dosing according to age bands as a proxy for weight. Recommended doses of amoxicillin for children were i...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-016363
更新日期:2017-09-27 00:00:00
abstract:INTRODUCTION:Multimorbidity is a major challenge for current healthcare systems and professionals. From the different approaches that have been proposed to analyse this issue, the hypothesis of the existence of association patterns of different chronic conditions is gaining visibility. In addition, multimorbidity can b...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究
doi:10.1136/bmjopen-2019-033322
更新日期:2020-01-26 00:00:00