Multicentre, randomised controlled trial of adjuvant chemotherapy in cervical cancer with residual human papilloma virus DNA following primary radiotherapy or chemoradiotherapy: a study protocol.

abstract：INTRODUCTION:Inflammatory bowel diseases (IBD) are among the most common chronic illnesses diagnosed in childhood. Transition from paediatric to adult care is a crucial phase. The implementation of joint visits during the transition period in IBD is widely recommended, however, strong evidence supporting their benefit ...

journal_title：BMJ open

authors： Erős A,Dohos D,Veres G,Tárnok A,Vincze Á,Tészás A,Zádori N,Gede N,Hegyi P,Sarlós P

更新日期：2020-10-06 00:00:00

abstract：OBJECTIVE:To assess whether the obesity paradox persists in the long term and to study the effect of optimal medical treatment on this phenomenon. DESIGN:A retrospective cohort study. SETTING:A tertiary care centre in Rotterdam. PARTICIPANTS:From January 2000 to December 2005, 6332 patients undergoing percutaneous c...

journal_title：BMJ open

authors： Schenkeveld L,Magro M,Oemrawsingh RM,Lenzen M,de Jaegere P,van Geuns RJ,Serruys PW,van Domburg RT

更新日期：2012-02-09 00:00:00

abstract：OBJECTIVE:To estimate the costs and outcomes associated with treating non-asthmatic adults (nor suffering from other lung-disease) presenting to primary care with acute lower respiratory tract infection (ALRTI) with oral corticosteroids compared with placebo. DESIGN:Cost-consequence analysis alongside a randomised con...

journal_title：BMJ open

authors： Moure-Fernandez A,Hollinghurst S,Carroll FE,Downing H,Young G,Brookes S,May M,El-Gohary M,Harnden A,Kendrick D,Lafond N,Little P,Moore M,Orton E,Thompson M,Timmins D,Wang K,Hay AD

更新日期：2020-02-18 00:00:00

abstract：OBJECTIVES:We examined the patterns of total and domain-specific physical activity (PA) by sex, socioeconomic status and maternal education level in adolescents from Sao Paulo city, Brazil. DESIGN:Cross-sectional study. PARTICIPANTS:We included a representative sample of 2682 (52.2% boys) adolescents aged 14-15 years...

journal_title：BMJ open

authors： Ferrari G,Rezende LFM,Wagner GA,Florindo AA,Peres MFT

更新日期：2020-09-02 00:00:00

abstract：OBJECTIVES:With accurate molecular tests now available for diagnosis of chlamydia and gonorrhoea (Chlamydia trachomatis (CT)/Neisseria gonorrhoeae (NG)) at the point-of-care (POC), we aimed to explore the public health implications (benefits and barriers) of their integration into remote primary care in Australia. MET...

journal_title：BMJ open

authors： Natoli L,Guy RJ,Shephard M,Whiley D,Tabrizi SN,Ward J,Regan DG,Badman SG,Anderson DA,Kaldor J,Maher L,TTANGO investigator group.

更新日期：2015-04-28 00:00:00

abstract：OBJECTIVES:Intercountry comparability between studies on medication use in pregnancy is difficult due to dissimilarities in study design and methodology. This study aimed to examine patterns and factors associated with medications use in pregnancy from a multinational perspective, with emphasis on type of medication ut...

journal_title：BMJ open

authors： Lupattelli A,Spigset O,Twigg MJ,Zagorodnikova K,Mårdby AC,Moretti ME,Drozd M,Panchaud A,Hämeen-Anttila K,Rieutord A,Gjergja Juraski R,Odalovic M,Kennedy D,Rudolf G,Juch H,Passier A,Björnsdóttir I,Nordeng H

更新日期：2014-02-17 00:00:00

abstract：INTRODUCTION:Age-related loss of muscle mass and strength, sarcopaenia, burdens many older adults. The process is accelerated with bed rest, protein intakes below requirements and the catabolic effect of certain illnesses. Thus, acutely ill, hospitalised older adults are particularly vulnerable. Protein supplementation...

journal_title：BMJ open

authors： Gade J,Beck AM,Bitz C,Christensen B,Klausen TW,Vinther A,Astrup A

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVE:Olanzapine is an atypical antipsychotic drug commonly used for the treatment of schizophrenia. However, there are still many complications associated with the use of olanzapine, and researchers continually strive to improve the handling of data from regular therapeutic drug monitoring (TDM). The objective of ...

journal_title：BMJ open

authors： Li A,Ji S,Yue W,Yan H,Dong F,Ruan C,Li W,Lu W,Zhang D,Wang C

更新日期：2018-08-17 00:00:00

abstract：OBJECTIVES:To define the core competencies essential for specialist training in neurocritical care in China. DESIGN:Modified Delphi method and nominal group (NG) technique. SETTING:National. PARTICIPANTS:A total of 1094 respondents from 33 provinces in China participated in the online survey. A NG of 11 members was ...

journal_title：BMJ open

authors： Cui Z,Gao L,Huang QB,Li LH,Qiu BH,Shi GZ,Yu XY,Wang Y,Zhang L,Wang Y,Zhang L,Zhou JX,Working Group from Neuro-Critical Care Committee affiliated to the Chinese Association of Critical Care Physicians and the National Center for H

更新日期：2020-01-06 00:00:00

abstract：OBJECTIVE:Since most biomedical research focuses on a specific disease, evaluation of research output requires disease-specific bibliometric indicators. Currently used methods are insufficient. The aim of this study is to develop a method that enables detailed analysis of worldwide biomedical research output by disease...

journal_title：BMJ open

authors： van de Laar L,de Kruif T,Waltman L,Meijer I,Gupta A,Hagenaars N

更新日期：2018-06-04 00:00:00

abstract：OBJECTIVE:To compare cancer-related systematic reviews (SRs) published in the Cochrane Database of SRs (CDSR) and high-impact journals, with respect to type, content, quality and citation rates. DESIGN:Methodological SR with assessment and comparison of SRs and meta-analyses. Two authors independently assessed methodo...

journal_title：BMJ open

authors： Goldkuhle M,Narayan VM,Weigl A,Dahm P,Skoetz N

更新日期：2018-03-25 00:00:00

abstract：OBJECTIVE:To determine whether kidney transplants performed during a weekend had worse outcomes than those performed during weekdays. DESIGN:Retrospective national database study. SETTING:United Network for Organ Sharing database of the USA. PARTICIPANTS:136,715 adult recipients of deceased donor single organ kidney...

journal_title：BMJ open

authors： Baid-Agrawal S,Martus P,Feldman H,Kramer H

更新日期：2016-04-07 00:00:00

abstract：INTRODUCTION:Chronic lower back pain (CLBP) is a major healthcare problem with wide ranging effects. It is a priority for appropriate management of CLBP to get individuals back to work as early as possible. Interventions that identify biopsychosocial barriers to recovery have been observed to lead to successfully reduc...

journal_title：BMJ open

authors： Dwyer CP,Durand H,MacNeela P,Reynolds B,Hamm RM,Main CJ,O'Connor LL,Conneely S,Taheny D,Slattery BW,O'Neill C,NicGabhainn S,Murphy AW,Kropmans T,McGuire BE

更新日期：2016-05-26 00:00:00

abstract：INTRODUCTION:High-flow nasal oxygen (HFNO) use in adults hospitalised with acute respiratory failure (ARF) is increasing. However, evidence to support widespread use of HFNO compared with non-invasive ventilation (NIV) and conventional oxygen therapy (COT) is unclear. This protocol describes the methods for a systemati...

journal_title：BMJ open

authors： Baldomero AK,Melzer A,Greer N,Majeski BN,Macdonald R,Wilt TJ

更新日期：2020-02-12 00:00:00

abstract：OBJECTIVES:This study aimed to assess the knowledge of risk factors and warning symptoms and attitude towards gastric cancer screening among the general population in China. SETTING:Hunan province, China PARTICIPANTS: Individuals aged older than 18 years were recruited using a cluster sampling method. DESIGN:A cross-...

journal_title：BMJ open

authors： Liu Q,Zeng X,Wang W,Huang RL,Huang YJ,Liu S,Huang YH,Wang YX,Fang QH,He G,Zeng Y

更新日期：2019-07-23 00:00:00

abstract：OBJECTIVES:The field of sport injury prevention has seen a marked increase in published research in recent years, with concomitant proliferation of lay sport safety resources, such as policies, fact sheets and posters. The aim of this study was to catalogue and categorise the number, type and topic focus of sport safet...

journal_title：BMJ open

authors： Bekker S,Finch CF

更新日期：2016-05-06 00:00:00

abstract：OBJECTIVE:To estimate the time spent by the researchers for preparing grant proposals, and to examine whether spending more time increase the chances of success. DESIGN:Observational study. SETTING:The National Health and Medical Research Council (NHMRC) of Australia. PARTICIPANTS:Researchers who submitted one or mo...

journal_title：BMJ open

authors： Herbert DL,Barnett AG,Clarke P,Graves N

更新日期：2013-05-28 00:00:00

abstract：INTRODUCTION:Home-based self-rehabilitation programmes combined with botulinum toxin injections (BTIs) appear to be a relevant approach to increase the recommended intensive rehabilitation of patients with spasticity following a stroke. The literature highlights a lack of evidence of beneficial effects of this adjuvant...

journal_title：BMJ open

authors： Bonnyaud C,Gallien P,Decavel P,Marque P,Aymard C,Pellas F,Isner ME,Boyer FC,Muller F,Daviet JC,Dehail P,Perrouin-Verbe B,Bayle N,Coudeyre E,Perennou D,Laffont I,Ropers J,Domingo-Saidji NY,Bensmail D,Roche N,ADJU-T

更新日期：2018-08-30 00:00:00

abstract：INTRODUCTION:High flow (HF) therapy is an increasingly popular mode of non-invasive respiratory support for preterm infants. While there is now evidence to support the use of HF to reduce extubation failure, there have been no appropriately designed and powered studies to assess the use of HF as primary respiratory sup...

journal_title：BMJ open

authors： Roberts CT,Owen LS,Manley BJ,Donath SM,Davis PG

更新日期：2015-06-24 00:00:00

abstract：INTRODUCTION:Multiple sclerosis (MS) is a severe debilitating disease that affects patients' quality of life. Up to 90% of patients with MS will develop lower urinary tract dysfunction within the first 18 years of the disease. If oral pharmacotherapy with anticholinergics, behavioural modifications and pelvic floor phy...

journal_title：BMJ open

authors： Elizondo RA,Karmonik C,Boone TB,Khavari R

更新日期：2017-02-03 00:00:00

abstract：OBJECTIVES:There is a wide variation between European countries in antibiotic prescribing for patients in primary care with lower respiratory tract infection (LRTI) that is not explained by case mix and clinical factors alone. Variation in antibiotic prescribing that is not warranted by differences in illness and clini...

journal_title：BMJ open

authors： Brookes-Howell L,Hood K,Cooper L,Little P,Verheij T,Coenen S,Godycki-Cwirko M,Melbye H,Borras-Santos A,Worby P,Jakobsen K,Goossens H,Butler CC

更新日期：2012-08-22 00:00:00

abstract：OBJECTIVE:Control of glycaemic, hypertension and low-density lipoprotein-cholesterol (LDL-C) among patients with type 2 diabetes mellitus (T2DM) is vital for the prevention of cardiovascular diseases. The current study was an audit of glycaemic, hypertension and LDL-C control among ambulant patients with T2DM in Botswa...

journal_title：BMJ open

authors： Mwita JC,Francis JM,Omech B,Botsile E,Oyewo A,Mokgwathi M,Molefe-Baikai OJ,Godman B,Tshikuka JG

更新日期：2019-07-23 00:00:00

abstract：OBJECTIVES:While bidirectional relationships exist between body weight and physical activity, direction of causality remains uncertain and previous studies have been limited by self-reported activity or weight and small sample size. We investigated the prospective relationships between weight and physical activity. DE...

journal_title：BMJ open

authors： Preiss D,Thomas LE,Wojdyla DM,Haffner SM,Gill JM,Yates T,Davies MJ,Holman RR,McMurray JJ,Califf RM,Kraus WE,NAVIGATOR Investigators.

更新日期：2015-08-14 00:00:00

abstract：:Objectives Low serum vitamin D levels have been associated with risk for certain malignancies, but studies have not directly analysed levels between community oncology and primary care practices. The purpose of this study was to compare serum vitamin D levels in patients at a community oncology practice with non-cance...

journal_title：BMJ open

authors： Churilla TM,Lesko SL,Brereton HD,Klem M,Donnelly PE,Peters CA

更新日期：2011-12-19 00:00:00

abstract：OBJECTIVE:We report on: (1) the proportion of patients with known atrial fibrillation (AF); and (2) demographic, clinical or radiological differences between patients with known AF (and not treated) and patients with newly diagnosed AF, in a cohort of patients who presented with ischaemic stroke or transient ischaemic ...

journal_title：BMJ open

authors： Wilson D,Ambler G,Shakeshaft C,Banerjee G,Charidimou A,Seiffge D,White M,Cohen H,Yousry T,Salman R,Lip GYH,Muir K,Brown MM,Jäger HR,Werring DJ,CROMIS-2 collaborators.

更新日期：2019-07-24 00:00:00

abstract：OBJECTIVES:Evidence about the relationship between socioeconomic status (SES) and small-for-gestational-age (SGA) infants was insufficient among Chinese primiparae. In addition, factors that may mediate this relationship are poorly understood. The purpose of this study was to investigate the risk of and mediators betwe...

journal_title：BMJ open

authors： Luo X,Liu L,Gu H,Hou F,Xie X,Li X,Meng H,Zhang J,Xu S,Song R

更新日期：2018-06-14 00:00:00

abstract：OBJECTIVES:Contingency management (CM) is a treatment for substance misuse that involves the provision of incentives. This review examines the hypothesis that adding another formal psychotherapy, such as cognitive-behavioural therapy (CBT) or motivational enhancement therapy (MET), to CM improves substance use outcomes...

journal_title：BMJ open

authors： Sheridan Rains L,Steare T,Mason O,Johnson S

更新日期：2020-10-08 00:00:00

abstract：INTRODUCTION:Atrial fibrillation (AF) is one of the leading causes of cerebrovascular mortality and morbidity. Oral anticoagulants (OACs) have been shown to reduce the incidence of cardioembolic stroke in patients with AF, adherence to treatment being an essential element for their effectiveness. Since the release of t...

journal_title：BMJ open

authors： Rodríguez-Bernal CL,García-Sempere A,Hurtado I,Santa-Ana Y,Peiró S,Sanfélix-Gimeno G

更新日期：2018-12-19 00:00:00

abstract：OBJECTIVES:Our aim was to provide nationwide age-standardised rates (ASR) on the usage of endovascular coiling and neurosurgical clipping for unruptured intracranial aneurysm (UIA) treatment in Germany. SETTING:Nationwide observational study using the Diagnosis-Related-Groups (DRG) statistics for the years 2005-2009 (...

journal_title：BMJ open

authors： Walendy V,Stang A

更新日期：2017-01-17 00:00:00

abstract：OBJECTIVE:Few studies have comprehensively examined changes in smoking status and related factors after a disaster. We examined these factors among residents of an evacuation area in Fukushima after the Great East Japan Earthquake. METHODS:The study participants included 58 755 men and women aged ≥20 years who partici...

journal_title：BMJ open

authors： Nakano H,Ohira T,Maeda M,Yabe H,Ohtsuru A,Suzuki Y,Harigane M,Horikoshi N,Nagai M,Zhang W,Takahashi H,Yasumura S,Iso H,Kamiya K,Fukushima Health Management Survey Group.

更新日期：2018-06-30 00:00:00