Abstract:
INTRODUCTION:Chemotherapy may cause infertility in young survivors of breast cancer. Various fertility preservation techniques increase the likelihood of survivors becoming genetic mothers. Disclosure of cancer diagnosis may impact decision making about fertility preservation. This protocol will develop and test the effectiveness of a web-based decision aid for helping women with breast cancer to make well-informed choices about fertility preservation. METHODS AND ANALYSIS:This study will be conducted in three phases using mixed methods. In phase I, the aim is to develop a web-based patient decision aid (PDA) in French with a steering committee and using a focus group of five women already treated for breast cancer. In phase II, the face validity of the decision aid will be assessed using questionnaires. In phase III, the PDA will be assessed by a two-arm randomised controlled trial. This will involve a quantitative evaluation of the PDA in clinical practice comparing the quality of the decision-making process between usual care and the PDA. The primary outcome will be informed choice and its components. The secondary outcomes will be decisional conflict and anxiety. Data will be collected during and after an oncofertility consultation. Phase III is underway. Since September 2018, 52 participants have been enrolled in the study and have completed the survey. We expect to have results by February 2020 for a total of 186 patients. ETHICS AND DISSEMINATION:This study protocol was approved by the Ouest V Research Ethics Board. Results will be spread through peer-reviewed publications, and reported at suitable meetings. TRIAL REGISTRATION NUMBER:The ClinicalTrials.gov registry .(NCT03591848).
journal_name
BMJ Openjournal_title
BMJ openauthors
Benoit A,Grynberg M,Morello R,Sermondade N,Grandazzi G,Moutel Gdoi
10.1136/bmjopen-2019-031739subject
Has Abstractpub_date
2020-02-10 00:00:00pages
e031739issue
2issn
2044-6055pii
bmjopen-2019-031739journal_volume
10pub_type
杂志文章相关文献
BMJ Open文献大全abstract:INTRODUCTION:Amyotrophic lateral sclerosis (ALS) is a representative rare disease characterised by progressive, fatal motor neuron degeneration. Due to the unknown aetiology and variability of the phenotypes, there are no accurate reports concerning the epidemiology or clinical characteristics of the disease. The low p...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-042603
更新日期:2020-12-04 00:00:00
abstract:INTRODUCTION:Selective dorsal rhizotomy (SDR) is a neurosurgical intervention intended to permanently reduce spasticity in the lower limbs and improve mobility in selected children with cerebral palsy (CP). Despite SDR having been performed worldwide for the past 30 years, there is moderate quality of evidence that SDR...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-025093
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVE:To evaluate sex-specific and age-specific associations of active living environments (ALEs) with premature cardiometabolic mortality. DESIGN:Population-based retrospective cohort study. SETTING:Residential neighbourhoods (1000-metre circular buffers from the centroids of dissemination areas) across Canada f...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-035942
更新日期:2020-11-20 00:00:00
abstract:INTRODUCTION:Healthcare systems around the world are looking for solutions to the growing problem of mental disorders. RECOVER is the synonym for an evidence-based, stepped and cross-sectoral coordinated care service model for mental disorders. RECOVER implements a cross-sectoral network with managed care, comprehensiv...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-036021
更新日期:2020-05-04 00:00:00
abstract:BACKGROUND:COVID-19 has posed several medical, psychosocial and economic impacts among the majority of the society. The ambiguity of its transmission, the intense desire of self-protection, family, and friends, the unknown impact of catching the disease itself, unstoppable spread, the panic and outright misinformation ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-043185
更新日期:2021-01-06 00:00:00
abstract:OBJECTIVES:The need for thorough patient information is increasing as maternity care becomes more medicalised. The aim was to assess the quality of written patient information on labour induction. In most Danish hospitals, misoprostol is the first-choice drug for induction in low-risk pregnancies. Misoprostol has been ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-011333
更新日期:2016-05-27 00:00:00
abstract:OBJECTIVES:The objective of this study was to explore whether reducing the material supplied to external experts during peer review and decreasing the burden of response would maintain review quality into prioritising research questions for a major research funder. METHODS AND ANALYSIS:Clinical experts who agreed to r...
journal_title:BMJ open
pub_type: 杂志文章,随机对照试验
doi:10.1136/bmjopen-2017-016104
更新日期:2017-08-21 00:00:00
abstract:OBJECTIVES:Epidemiological studies evaluating the association between adiponectin levels and endometrial carcinoma risk have produced inconsistent results. Thus, a meta-analysis was conducted to assess the association between them. METHODS:Pertinent studies were identified by a search of PubMed and Web of Knowledge th...
journal_title:BMJ open
pub_type: 杂志文章,meta分析,评审
doi:10.1136/bmjopen-2015-008541
更新日期:2015-09-03 00:00:00
abstract:OBJECTIVE:To assess serum B12, folate and the associated homocysteine (Hcy) levels among women of childbearing age in the UK and examine their association with dietary intake in relation to the UK Recommended Nutrient Intakes (RNIs) for B12 and folate. DESIGN:Cross-sectional study. SETTING:Data from two publicly avai...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-011247
更新日期:2016-08-12 00:00:00
abstract:BACKGROUND:Implementing venous thromboembolism (VTE) risk assessment guidance on admission to hospital has proved difficult worldwide. In 2010, VTE risk assessment in English hospitals was linked to financial sanctions. This study investigated possible barriers and facilitators for VTE risk assessment in medical patien...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2012-001668
更新日期:2012-11-06 00:00:00
abstract:OBJECTIVE:To examine consumers' confidence in their own, and also in other people's, over-the-counter (OTC) skills and to describe their attitude towards the availability of OTC painkillers. Moreover we examined the association between confidence in OTC skills and attitudes. DESIGN:Cross-sectional survey. Mixed method...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2013-003455
更新日期:2013-09-25 00:00:00
abstract:OBJECTIVE:Control of glycaemic, hypertension and low-density lipoprotein-cholesterol (LDL-C) among patients with type 2 diabetes mellitus (T2DM) is vital for the prevention of cardiovascular diseases. The current study was an audit of glycaemic, hypertension and LDL-C control among ambulant patients with T2DM in Botswa...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-026807
更新日期:2019-07-23 00:00:00
abstract:OBJECTIVE:To assess the effect of the Pregnant+ app on the 2-hour glucose level of the routine postpartum oral glucose tolerance test (OGTT) among women with gestational diabetes mellitus (GDM). The Pregnant+ app was designed to provide information about GDM, and promote physical activity and a healthy diet. DESIGN:A ...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/bmjopen-2019-030884
更新日期:2019-11-11 00:00:00
abstract:INTRODUCTION:Evidence from individual longitudinal studies suggests that anxiety and depression may impact quality of life. However, systematic reviews synthesising current evidence have mainly focused on specific samples. Thus, the aim of this study is to synthesise evidence from longitudinal studies on the associatio...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-027218
更新日期:2019-03-04 00:00:00
abstract:INTRODUCTION:Obese patients with type 2 diabetes undergoing bariatric surgery experience significant and lasting weight loss and improved glycaemic control. However, bariatric surgical procedures such as Roux-en-Y gastric bypass are irreversible and associated with considerable short-term and long-term risks. The EndoB...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2013-003417
更新日期:2013-09-13 00:00:00
abstract:INTRODUCTION:Prescription-drug use in the USA has increased by more than 60% in the last three decades. Prevalence of prescription-drug use among pregnant women is currently estimated around 50%. Prevalence of illicit drug use in the USA is 14.6% among pregnant adolescents, 8.6% among pregnant young adults and 3.2% amo...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究
doi:10.1136/bmjopen-2017-020248
更新日期:2018-02-17 00:00:00
abstract:OBJECTIVES:Current research on the perceptions of overdiagnosis or overdetection of breast cancer has largely been conducted outside of the USA and with women younger than 70 years.Therefore, we explored older women's perceptions about the concept of overdetection of breast cancer and its influence on future screening ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-022138
更新日期:2018-06-14 00:00:00
abstract:INTRODUCTION:The optimal management of patent ductus arteriosus (PDA) remains contentious. The medications used to treat PDA are often non-steroidal anti-inflammatory drugs, which are associated with a number of unwanted adverse effects. Paracetamol is a medication with an excellent safety profile in infants and has be...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-031428
更新日期:2019-10-30 00:00:00
abstract:INTRODUCTION:Much testing in medicine is aimed at healthy people to facilitate the early detection of health conditions. However, there is growing evidence that early detection is a double-edged sword that may cause harm in the form of overdiagnosis. The media can be seen as a major generator of consumer demand for hea...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-029532
更新日期:2019-08-24 00:00:00
abstract:BACKGROUND:In 2002, the WHO declared interpersonal violence to be a leading public health problem. Previous research demonstrates that urban spaces with a high incidence of violent trauma (hotspots) correlate with features of built environment and social determinants. However, there are few studies that analyse injury ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2013-003642
更新日期:2014-02-20 00:00:00
abstract:OBJECTIVES:To assess whether chronic kidney disease of unknown aetiology (CKDu) is present in India and to identify risk factors for it using population-based data and standardised methods. DESIGN:Secondary data analysis of three population-based cross-sectional studies conducted between 2010 and 2014. SETTING:Urban ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-023353
更新日期:2019-03-07 00:00:00
abstract:INTRODUCTION:The burden of frailty on older people is easily recognisable by increasing mortality and morbidity, longer hospital stays and adverse discharge locations. In the UK, frailty screening has recently become part of the best practice commissioning tariff within National Health Service England, yet there is no ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-038082
更新日期:2020-08-05 00:00:00
abstract:OBJECTIVE:In 2001, Chinese guidelines for the care of acute myocardial infarction (AMI) included a new recommendation against the routine use of magnesium. We studied temporal trends and institutional variation in the use of intravenous magnesium sulfate in nationally representative samples of individuals hospitalised ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-033269
更新日期:2020-03-26 00:00:00
abstract:OBJECTIVE:The aim of this pilot study was to determine risk factors, including Staphylococcus aureus nasal carriage, for dermatitis in submariners during a submarine patrol. PARTICIPANTS AND METHODS:36 submariners undertaking a submerged 6-week patrol participated in the study. Severity of dermatitis and its impact wa...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2015-010975
更新日期:2016-06-02 00:00:00
abstract:OBJECTIVE:Recent studies have suggested that stress in a pregnant mother may affect the future health of the unborn child negatively. An excellent proxy for health problems is the use of healthcare resources. Using nationwide data, we examined whether persons born to mothers who lost a close relative during pregnancy h...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-005657
更新日期:2015-01-08 00:00:00
abstract:OBJECTIVES:Defects in the human thyroid peroxidase (TPO) gene are reported to be one of the causes of congenital hypothyroidism (CH) due to dyshormonogenesis. The aim of this study was to examine the TPO mutation spectrum and prevalence among patients with CH in the Guangxi Zhuang Autonomous Region of China and to defi...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2015-010719
更新日期:2016-05-12 00:00:00
abstract:OBJECTIVE:To assess whether the obesity paradox persists in the long term and to study the effect of optimal medical treatment on this phenomenon. DESIGN:A retrospective cohort study. SETTING:A tertiary care centre in Rotterdam. PARTICIPANTS:From January 2000 to December 2005, 6332 patients undergoing percutaneous c...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2011-000535
更新日期:2012-02-09 00:00:00
abstract:OBJECTIVES:The study examined medical care utilisation by health insurance status changes. SETTING:The Korean Welfare Panel Study (KoWePs) was used. PARTICIPANTS:This study analysed 14,267 participants at baseline (2006). INTERVENTIONS:The individuals were categorised into four health insurance status groups: contin...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2015-009538
更新日期:2016-04-01 00:00:00
abstract:INTRODUCTION:Insomnia is a highly prevalent and costly condition that is associated with increased health risks and healthcare utilisation. Anecdotally, cannabis use is frequently reported by consumers to promote sleep. However, there is limited research on the effects of cannabis on sleep and daytime function in peopl...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-034421
更新日期:2020-05-18 00:00:00
abstract:OBJECTIVES:To establish the prevalence and correlates of continuum beliefs for five mental illnesses in a multiethnic population and to explore its association with stigma. DESIGN:A community-based, cross-sectional study. SETTING:A national study in a multiethnic Asian country. PARTICIPANTS:A comprehensive study of ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-014993
更新日期:2017-04-05 00:00:00