Abstract:
OBJECTIVES:Epidemiological studies evaluating the association between adiponectin levels and endometrial carcinoma risk have produced inconsistent results. Thus, a meta-analysis was conducted to assess the association between them. METHODS:Pertinent studies were identified by a search of PubMed and Web of Knowledge through January of 2015. A random-effects model was used to combine the data for analysis. Dose-response relationship was assessed by restricted cubic spline and variance-weighted least squares regression analysis. RESULTS:Twelve articles (5 prospective studies and 7 case-control studies) involving 1916 endometrial carcinoma cases were included in this meta-analysis. Pooled results suggested that highest adiponectin levels versus lowest levels were significantly associated with the risk of endometrial carcinoma (summary relative risk (RR)=0.525, 95% CI 0.388 to 0.712, I(2)=64.2%). The association was also found in postmenopausal women (summary RR=0.646, 95% CI 0.433 to 0.964), but not in premenopausal women. A linear dose-response relationship was found, with the risk of endometrial carcinoma decreasing by 3% for every 1 μg/mL increase in adiponectin levels (summary RR=0.97, 95% CI 0.96 to 0.98). No publication bias was found. CONCLUSIONS:Our analysis suggested that the higher adiponectin levels might have a protective effect against endometrial carcinoma, especially in postmenopausal women.
journal_name
BMJ Openjournal_title
BMJ openauthors
Lin T,Zhao X,Kong WMdoi
10.1136/bmjopen-2015-008541subject
Has Abstractpub_date
2015-09-03 00:00:00pages
e008541issue
9issn
2044-6055pii
bmjopen-2015-008541journal_volume
5pub_type
杂志文章,meta分析,评审相关文献
BMJ Open文献大全abstract:OBJECTIVE:To assess the seroprevalence of recent/acute and past exposure to rubella virus infection and associated risk factors among pregnant women. DESIGN:A hospital-based cross-sectional study. SETTING:The study was conducted in two public hospitals in Hawassa City, Southern Ethiopia. PARTICIPANTS:A total of 422 ...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究
doi:10.1136/bmjopen-2017-016824
更新日期:2017-10-05 00:00:00
abstract:OBJECTIVES:Our work aimed at exploring the relationship between cold spells and acute exacerbation of chronic obstructive pulmonary disease (AECOPD) hospitalisations in Beijing, China, and assessing the moderating effects of the intensities and the durations of cold spells, as well as identifying the vulnerable. DESIG...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-039745
更新日期:2021-01-06 00:00:00
abstract:OBJECTIVES:To assess the association between blood circulating vitamin D levels and colorectal cancer risk in the Asian population. DESIGN:This is a systematic review and dose-response meta-analysis of observational studies that investigated the relationship between blood circulating vitamin D levels and colorectal ca...
journal_title:BMJ open
pub_type: 杂志文章,meta分析
doi:10.1136/bmjopen-2019-030513
更新日期:2019-12-23 00:00:00
abstract:OBJECTIVES:To analyse the parental understanding of informed consent information in first-line randomised clinical trials (RCTs) including children with malignant solid tumours and to assess parents' needs for decision-making. DESIGN:Observational prospective study. SETTING:3 paediatric oncology centres in the Parisi...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2013-002733
更新日期:2013-05-28 00:00:00
abstract:OBJECTIVES:French authorities are considering the implementation of a simplified nutrition labelling system on food products to help consumers make healthier food choices. One of the most documented candidates (Five-Colour Nutrition Label/Nutri-score) is based on the British Food Standards Agency Nutrient Profiling Sys...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-013718
更新日期:2017-06-08 00:00:00
abstract:OBJECTIVES:The health benefits of professional sport dissipate after retirement unless an active lifestyle is adopted, yet reasons for adopting an active or inactive lifestyle after retirement from sport are poorly understood. Elite cricket is all-encompassing, requiring a high volume of activity and unique physical de...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-017785
更新日期:2017-11-17 00:00:00
abstract:INTRODUCTION:Acute hypoxaemic respiratory failure (AHRF) in children is the most frequent reason for non-elective hospital admission. During the initial phase, AHRF is a clinical syndrome defined for the purpose of this study by an oxygen requirement and caused by pneumonia, lower respiratory tract infections, asthma o...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-030516
更新日期:2019-12-18 00:00:00
abstract:OBJECTIVE:Risk factors for breast, colorectal, and lung cancer are known to be more common among lesbian, gay, and bisexual (LGB) individuals, suggesting they may be more likely to develop these cancers. Our objective was to determine differences in cancer incidence by sexual orientation, using sexual orientation data ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2013-004461
更新日期:2014-03-26 00:00:00
abstract:INTRODUCTION:Psychosocial factors are increasingly recognised as important determinants of cardiovascular disease risk. The North Texas Heart Study aims to understand the mechanisms responsible for this association with a focus on social vigilance (ie, scanning the environment for social threats). There is also growing...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-017345
更新日期:2017-08-14 00:00:00
abstract:OBJECTIVES:In May 2018, the British Health Secretary announced the 'serious failure' that 450 000 women had missed out on invitations to breast screening in England, leading to extensive media coverage. This study measured public awareness of the story and tested for associated factors (eg, educational level and trust ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-028040
更新日期:2019-09-06 00:00:00
abstract:OBJECTIVES:This article presents the findings from a scoping review which explored the nature of interprofessional online learning in primary healthcare. The review was informed by the following questions: What is the nature of evidence on online postgraduate education for primary healthcare interprofessional teams? Wh...
journal_title:BMJ open
pub_type: 杂志文章,评审
doi:10.1136/bmjopen-2017-016872
更新日期:2017-08-04 00:00:00
abstract:OBJECTIVE:To test agreement of two methods to measure intraocular pressure (IOP): rebound tonometry (RBT) and gold standard Goldmann applanation tonometry (GAT) in children with glaucoma. DESIGN:Observational prospective cohort study. SETTING:Tertiary paediatric glaucoma clinic at a single centre. PARTICIPANTS:102 i...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2012-001788
更新日期:2013-04-02 00:00:00
abstract:OBJECTIVE:This study examined the risk factors associated with failure of enhanced recovery protocol after major hepatobiliary and pancreatic (HBP) surgery. SETTING AND PARTICIPANTS:A retrospective cohort of 194 adult patients undergoing major HBP surgery at a university hospital in Hong Kong was followed up for 30 da...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-005330
更新日期:2014-07-10 00:00:00
abstract:OBJECTIVE:To assess the sociodemographic patterning of changes in glycaemic control of patients with diabetes affected by the 2011 triple disaster in Japan (earthquake, tsunami and nuclear accident). METHODS:A retrospective cohort study was undertaken with 404 patients with diabetes at a public hospital in Minamisoma ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-011455
更新日期:2016-07-07 00:00:00
abstract:OBJECTIVES:There is an increasing trend in the use of electronic health records (EHRs) for clinical research. However, more knowledge is needed on how to assure and improve data quality. This study aimed to explore healthcare professionals' experiences and perceptions of barriers and facilitators of data quality of EHR...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究
doi:10.1136/bmjopen-2019-029314
更新日期:2019-07-02 00:00:00
abstract:INTRODUCTION:Workplace social capital (WSC) has been shown to affect employees' well-being and health, yet it is not clear how public managers can create WSC and which forms of WSC are most important. This study is the first prospective cohort study to examine the relationship between management behaviour, WSC, well-be...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-039027
更新日期:2020-10-27 00:00:00
abstract:OBJECTIVES:To assess variation in antibiotic prescribing practices among village doctors in a rural region of Shandong province, China. DESIGN, SETTING AND PARTICIPANTS:Almost all outpatient encounters at village clinics result in a prescription being issued. Prescriptions were collected over a 2.5-year period from 8 ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-036703
更新日期:2020-06-01 00:00:00
abstract:OBJECTIVES:To study whether self-reported health problems predict sickness absence (SA) from work in employees from different industries. METHODS:The results of a health risk appraisal (HRA) were combined with archival data of SA of 21 608 employees (59% female, 56% clerical). Exposure variables were self-reported hea...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-025967
更新日期:2019-10-31 00:00:00
abstract:OBJECTIVES:Describe the prevalence of substance-related and addictive disorders (SRAD) in adults with intellectual and developmental disabilities (IDD) and compare the sociodemographic and clinical characteristics of adults with IDD and SRAD to those with IDD or SRAD only. DESIGN:Population-based cohort study (the Hea...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-011638
更新日期:2016-09-02 00:00:00
abstract:INTRODUCTION:Hospitals are complex systems and optimising their function is critical to the provision of high quality, cost effective healthcare. Metrics of performance have to date focused on the performance of individual elements rather than the whole system. Manipulation of individual elements of a complex system wi...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-034265
更新日期:2020-02-09 00:00:00
abstract:OBJECTIVES:Chronic hepatitis B virus (HBV) infection is associated with a higher risk of liver diseases. Substantial uncertainty remains, however, about the associations of HBV infection with mortality from extrahepatic causes, especially from subtypes of cardiovascular diseases. We prospectively examined the associati...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-027696
更新日期:2019-04-09 00:00:00
abstract:OBJECTIVES:Creation of linked mental health, social and education records for research to support evidence-based practice for regional mental health services. SETTING:The Clinical Record Interactive Search (CRIS) system was used to extract personal identifiers who accessed psychiatric services between September 2007 a...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-024355
更新日期:2019-01-29 00:00:00
abstract:OBJECTIVE:This umbrella review summarises and critically appraises the evidence on the effects of regulated or high-volume perinatal care on outcome among very low birth weight/very preterm infants born in countries with neonatal mortality <5/1000 births. INTERVENTION/EXPOSITION:Perinatal regionalisation, centralisati...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-037135
更新日期:2020-09-25 00:00:00
abstract:BACKGROUND:COVID-19 has posed several medical, psychosocial and economic impacts among the majority of the society. The ambiguity of its transmission, the intense desire of self-protection, family, and friends, the unknown impact of catching the disease itself, unstoppable spread, the panic and outright misinformation ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-043185
更新日期:2021-01-06 00:00:00
abstract:OBJECTIVE:Prenatal exposure to antiepileptic drugs (AEDs) has been associated with adverse outcomes in the offspring such as congenital malformations and neuropsychiatric disorders. The objective of this study was to investigate whether prenatal exposure to AEDs is also associated with more frequent use of primary heal...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-012836
更新日期:2017-01-05 00:00:00
abstract:BACKGROUND:According to new Norwegian laws, mental healthcare for adults are obligated to assess all patients who are parents and to act on their children's needs. This article describes the study protocol of implementing the interventions Family Assessment and Child Talks for children of patients in the adult psychiat...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2011-000709
更新日期:2012-05-03 00:00:00
abstract:INTRODUCTION:Foot ulceration is a multifactorial complication of diabetes. Therapeutic insoles and footwear are frequently used to reduce elevated tissue pressures associated with risk of foot ulceration. A novel protocol using in-shoe pressure measurement technology to provide an instant optimised insole and house sho...
journal_title:BMJ open
pub_type: 杂志文章,随机对照试验
doi:10.1136/bmjopen-2019-029185
更新日期:2019-03-23 00:00:00
abstract:INTRODUCTION:Subjective tinnitus is very common and has a number of comorbid associations including depression, sleep disturbance and concentration difficulties. Concentration difficulties may be observable in people with tinnitus through poorer behavioural performance in tasks thought to measure specific cognitive dom...
journal_title:BMJ open
pub_type: 杂志文章,meta分析
doi:10.1136/bmjopen-2018-023700
更新日期:2018-08-13 00:00:00
abstract:OBJECTIVE:American Indians (AI) have a high prevalence of electronic nicotine delivery system (ENDS) use. However, little information exists on (ENDS) use, either alone or in combination with cigarettes (dual use), among AI. The objective of this small-scaled study was to examine use behaviours and dependence among exc...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-018469
更新日期:2017-12-19 00:00:00
abstract:OBJECTIVES AND DESIGN:We identified a novel TRIM59 gene, as an early signal transducer in two (SV40Tag and Ras) oncogene pathways in murine prostate cancer (CaP) models. We explore its clinical applications as a multitumour marker detecting early tumorigenesis by immunohistochemistry (IHC). SETTING AND PARTICIPANTS:88...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2012-001410
更新日期:2012-10-08 00:00:00