Abstract:
INTRODUCTION:Acute pancreatitis (AP) is a life-threatening inflammatory disease of the exocrine pancreas which needs acute hospitalisation. Despite its importance, we have significant lack of knowledge whether the lifestyle factors elevate or decrease the risk of AP or influence the disease outcome. So far, no synthetising study has been carried out examining associations between socioeconomic factors, dietary habits, physical activity, chronic stress, sleep quality and AP. Accordingly, LIFESPAN identifies risk factors of acute pancreatitis and helps to prepare preventive recommendations for lifestyle elements. METHODS AND ANALYSIS:LIFESPAN is an observational, multicentre international case-control study. Participating subjects will create case and control groups. The study protocol was designed according to the SPIRIT guideline. Patients in the case group (n=1700) have suffered from AP (alcohol-induced, n=500; biliary, n=500; hypertriglyceridemiainduced, n=200; other, n=500); the control group subjects have no AP in their medical history. Our study will have three major control groups (n=2200): hospital-based (n=500), population-based (n=500) and aetiology-based (alcohol, n=500; biliary, n=500 and hypertriglyceridemia, n=200). All of them will be matched to the case group individually by gender, age and location of residence. Aggregately, 3900 subjects will be enrolled into the study. The study participants will complete a complex questionnaire with the help of a clinical research administrator/study nurse. Analysis methods include analysis of the continuous and categorical values. ETHICS AND DISSEMINATION:The study has obtained the relevant ethical approval (54175-2/2018/EKU) and also internationally registered (ISRCTN25940508). After obtaining the final conclusions, we will publish the data to the medical community and will also disseminate our results via open access. TRIAL REGISTRATION NUMBER:ISRCTN25940508; Pre-results.
journal_name
BMJ Openjournal_title
BMJ openauthors
Koncz B,Darvasi E,Erdősi D,Szentesi A,Márta K,Erőss B,Pécsi D,Gyöngyi Z,Girán J,Farkas N,Papp M,Fehér E,Vitális Z,Janka T,Vincze Á,Izbéki F,Dunás-Varga V,Gajdán L,Török I,Károly S,Antal J,Zádori N,Lerch MM,Ndoi
10.1136/bmjopen-2019-029660subject
Has Abstractpub_date
2020-01-06 00:00:00pages
e029660issue
1issn
2044-6055pii
bmjopen-2019-029660journal_volume
10pub_type
杂志文章相关文献
BMJ Open文献大全abstract:OBJECTIVES:Determine how general practitioners (GPs) manage patients with cancer symptoms. DESIGN:GPs reviewed 24 video-vignettes and case notes on patients with cancer symptoms and indicated whether they would refer the patient and/or prescribe medication, and/or undertake further investigation. According to availabl...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2015-008525
更新日期:2015-09-14 00:00:00
abstract:INTRODUCTION:It is unclear whether advance care planning (ACP) undertaken with patients living in the community can improve patient care and avoid unwanted interventions and hospital admissions. We have designed a randomised controlled trial (RCT) to examine if ACP undertaken with patients with advanced illnesses atten...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-023107
更新日期:2019-01-24 00:00:00
abstract:OBJECTIVE:To evaluate the evidence on the efficacy of psychosocial interventions for improving pregnancy rates and reducing distress for couples in treatment with assisted reproductive technology (ART). DESIGN:Systematic review and meta-analysis. DATA SOURCES:PsycINFO, PubMed, EMBASE, CINAHL, Web of Science and The C...
journal_title:BMJ open
pub_type: 杂志文章,meta分析,评审
doi:10.1136/bmjopen-2014-006592
更新日期:2015-01-28 00:00:00
abstract:OBJECTIVES:(1) To explain general practitioners' (GPs') approaches to prostate-specific antigen (PSA) testing and overdiagnosis; (2) to explain how GPs reason about their PSA testing routines and (3) to explain how these routines influence GPs' personal experience as clinicians. SETTING:Primary care practices in Austr...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-006367
更新日期:2015-03-17 00:00:00
abstract:OBJECTIVE:To assess the validity and reliability of the Sheffield Peer Review Assessment Tool (SPRAT) Japanese version for evaluating doctors' competencies using multisource feedback. METHODS:SPRAT, originally developed in the UK, was translated and validated in three phases: (1) an existing Japanese version of SPRAT ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-007135
更新日期:2015-06-15 00:00:00
abstract:INTRODUCTION:Emergency admission risk prediction models are increasingly used to identify patients, typically with one or more chronic conditions, for proactive management in primary care to avoid admissions, save costs and improve patient experience. AIM:To identify and review the published evidence on the costs, eff...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2015-009653
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVES:To determine the availability of continuous positive airway pressure (CPAP) and to provide an overview of its use in neonatal units in government hospitals across India. SETTING:Cross-sectional cluster survey of a nationally representative sample of government hospitals from across India. PRIMARY OUTCOMES:...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-031128
更新日期:2020-02-28 00:00:00
abstract::Background Although recent genome-wide association studies have identified several genetic variants contributing to the complex aetiology of multiple sclerosis (MS), expression and functional studies are required to further understand its molecular basis. Objectives To identify genes and pathways with differential ex...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2011-000053
更新日期:2011-07-18 00:00:00
abstract:OBJECTIVE:To determine the effects of yoga practice on subclinical cardiovascular measures, risk factors and neuro-endocrine pathways in patients undergoing cardiac rehabilitation (CR) following acute coronary events. DESIGN:3-month, two-arm (yoga +usual care vs usual care alone) parallel randomised mechanistic study....
journal_title:BMJ open
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/bmjopen-2019-030119
更新日期:2019-11-03 00:00:00
abstract:INTRODUCTION:The first birth cohorts of women offered human papillomavirus (HPV) vaccination as girls are now entering cervical screening. However, there is no international consensus on how to screen HPV vaccinated women. These women are better protected against cervical cancer and could therefore be offered less inte...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-020294
更新日期:2018-05-26 00:00:00
abstract:INTRODUCTION:Historically, Kenya has used various distribution models for long-lasting insecticide-treated bed nets (LLINs) with variable results in population coverage. The models presently vary widely in scale, target population and strategy. There is limited information to determine the best combination of distribut...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-012776
更新日期:2016-11-21 00:00:00
abstract:INTRODUCTION:Mortality and morbidity following surgery are pressing public health concerns in the USA. Traditional prediction models for postoperative adverse outcomes demonstrate good discrimination at the population level, but the ability to forecast an individual patient's trajectory in real time remains poor. We pr...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-020124
更新日期:2018-04-10 00:00:00
abstract:OBJECTIVES:Social Autopsy (SA) is an innovative strategy where a trained facilitator leads community groups through a structured, standardised analysis of the physical, environmental, cultural and social factors contributing to a serious, non-fatal health event or death. The discussion stimulated by the formal process ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2015-010490
更新日期:2016-08-23 00:00:00
abstract:OBJECTIVES:The study aimed to understand through qualitative research what patients considered material in their decision to consent to an acute surgical intervention. PARTICIPANTS, SETTING AND INTERVENTION:The patients selected aged between 18 and 90, having been admitted to a major trauma centre to undergo an acute ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-037657
更新日期:2020-10-08 00:00:00
abstract:OBJECTIVES:Hospice care (HC) is seen as a comprehensive approach, that enhances quality of end-of-life (EOL) care, for terminally ill patients. Despite its positive aspects, HC enrolment is disproportionate for rural patients, who are less likely to use HC in comparison to their urban counterparts. The purpose of this ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-035634
更新日期:2020-07-01 00:00:00
abstract:INTRODUCTION:For over a decade, enquiries into adverse perinatal outcomes have led to reports that poor collaboration has been detrimental to the safety and experience of maternity care. Despite efforts to improve collaboration, investigations into maternity care at Morecambe Bay (UK) and Djerriwarrh Health Services (A...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究
doi:10.1136/bmjopen-2016-014262
更新日期:2017-03-07 00:00:00
abstract:OBJECTIVES:Creation of linked mental health, social and education records for research to support evidence-based practice for regional mental health services. SETTING:The Clinical Record Interactive Search (CRIS) system was used to extract personal identifiers who accessed psychiatric services between September 2007 a...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-024355
更新日期:2019-01-29 00:00:00
abstract:INTRODUCTION:Cyclooxygenase 2 (COX-2) inhibitors have less upper gastrointestinal toxicity than traditional non-steroidal anti-inflammatory drugs (NSAIDs). However, both COX-2 inhibitors and traditional NSAIDs may be associated with adverse cardiovascular side effects. Data from randomised and observational studies sug...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2012-002295
更新日期:2013-01-29 00:00:00
abstract:OBJECTIVE:Percutaneous pulmonary valve implantation is an alternative to open heart surgery in selected patients with pulmonary outflow tract disorder. The technique may reduce the number of open-chest surgeries in these patients. This study was conducted to understand how the patients and their next-of-kin experienced...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-005102
更新日期:2014-07-29 00:00:00
abstract:OBJECTIVE:The objective is to evaluate efficiency based on data on morbidity and mortality, health-related quality of life and healthcare-related costs after early reversal of temporary ileostomy after rectal resection for cancer compared with the standard procedure (late reversal). BACKGROUND:Reversal of a temporary ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2011-000162
更新日期:2011-07-29 00:00:00
abstract:OBJECTIVES:A significant proportion of cardiovascular disease (CVD) cannot be explained by well-known risk factors such as high cholesterol, hypertension and diabetes. One potential novel risk factor for CVD is asthma. We aimed to investigate the association between asthma and mortality due to CVD. DESIGN:Prospective ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-019992
更新日期:2018-05-31 00:00:00
abstract:OBJECTIVES:Falls are among the major external causes of unintentional injury and injury-related mortality in the elderly. The aim of this study was to compare the patterns of unintentional fall-related mortalities in two countries with different demographic structure: Slovakia and Austria in 2003-2010. METHODS:A study...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2015-008672
更新日期:2015-08-12 00:00:00
abstract:OBJECTIVES:To summarise and synthesise the current evidence regarding the effectiveness of drug interventions to prevent sudden cardiac death (SCD) and all-cause mortality in patients with heart failure with reduced ejection fraction (HFrEF). DESIGN:Overview of systematic reviews. DATA SOURCES:MEDLINE, Embase, ISI We...
journal_title:BMJ open
pub_type: 杂志文章,评审
doi:10.1136/bmjopen-2017-021108
更新日期:2018-07-28 00:00:00
abstract:OBJECTIVES:To determine the prevalence of depression among male and female medical students, its change over time and whether depression persists for affected students. DESIGN:Longitudinal study comprising annual questionnaire surveys which included the depression subscale of the Hospital Anxiety and Depression Scale ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2012-001519
更新日期:2012-08-13 00:00:00
abstract:INTRODUCTION:Despite the strong relationship between smoking and health-related consequences, very few smokers quit. Heavy drinking is a significant risk factor for health consequences, and is implicated in persistent smoking and less success at quitting smoking. Self-efficacy (SE) to abstain from smoking is an importa...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-007046
更新日期:2015-01-06 00:00:00
abstract:OBJECTIVE:To investigate the effects of vitreomacular adhesion (VMA), vitreomacular separation (VMS) and absence of vitreous gel due to vitrectomy on macular thickness measured in the spectral domain optical coherence tomographic (SD-OCT) images. DESIGN:A longitudinal, retrospective, observational study. SETTING:Seco...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究
doi:10.1136/bmjopen-2016-012972
更新日期:2016-09-30 00:00:00
abstract:INTRODUCTION:Type 2 diabetes (T2D) is a leading health priority worldwide. Multimorbidity (MM) is a term describing the co-occurrence of two or more chronic diseases or conditions. The majority of people living with T2D have MM. The relationship between MM and mortality and glycaemia in people with T2D is not clear. M...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-021100
更新日期:2018-04-05 00:00:00
abstract:PURPOSE:Optical coherence tomography (OCT) captures retinal damage in neuromyelitis optica spectrum disorders (NMOSD). Previous studies investigating OCT in NMOSD have been limited by the rareness and heterogeneity of the disease. The goal of this study was to establish an image repository platform, which will facilita...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-035397
更新日期:2020-10-29 00:00:00
abstract:OBJECTIVES:This study aims to identify the sources of funding for investigator-initiated clinical trials (IICTs) in Portugal, and to recommend ways to improve the quality of information collected from clinical trial databases about funding. DESIGN AND METHODS:A systematic search of trial registrations over the last 13...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-023394
更新日期:2019-05-14 00:00:00
abstract:OBJECTIVE:The objective was to compare the results of performance-based and self-assessed measures of health literacy (HL) and to evaluate the contribution of their joint use in assessing some HL antecedents. DESIGN:This was a cross-sectional study. SETTING:The study was conducted on the general population in Florenc...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-035987
更新日期:2020-10-05 00:00:00