Abstract:
OBJECTIVES:To summarise and synthesise the current evidence regarding the effectiveness of drug interventions to prevent sudden cardiac death (SCD) and all-cause mortality in patients with heart failure with reduced ejection fraction (HFrEF). DESIGN:Overview of systematic reviews. DATA SOURCES:MEDLINE, Embase, ISI Web of Science and Cochrane Library from inception to May 2017; manual search of references of included studies for potentially relevant reviews. ELIGIBILITY CRITERIA FOR STUDY SELECTION:We reviewed the effectiveness of drug interventions for SCD and all-cause mortality prevention in patients with HFrEF. We included overviews, systematic reviews and meta-analyses of randomised controlled trials of beta-blockers, angiotensin-converting enzyme inhibitors (ACE-i), angiotensin receptor blockers (ARBs), antialdosterones or mineralocorticoid-receptor antagonists, amiodarone, other antiarrhythmic drugs, combined ARB/neprilysin inhibitors, statins and fish oil supplementation. REVIEW METHODS:Two independent reviewers extracted data and assessed the methodological quality of the reviews and the quality of evidence for the primary studies for each drug intervention, using Assessing the Methodological Quality of Systematic Reviews (AMSTAR) and Grading of Recommendations, Assessment, Development and Evaluation(GRADE), respectively. RESULTS:We identified 41 reviews. Beta-blockers, antialdosterones and combined ARB/neprilysin inhibitors appeared effective to prevent SCD and all-cause mortality. ACE-i significantly reduced all-cause mortality but not SCD events. ARBs and statins were ineffective where antiarrhythmic drugs and omega-3 fatty acids had unclear evidence of effectiveness for prevention of SCD and all-cause mortality. CONCLUSIONS:This comprehensive overview of systematic reviews confirms that beta-blockers, antialdosterone agents and combined ARB/neprilysin inhibitors are effective on SCD prevention but not ACE-i or ARBs. In patients with high risk of SCD, an alternative therapeutic strategy should be explored in future research. SYSTEMATIC REVIEW REGISTRATION:PROSPERO 2017: CRD42017067442.
journal_name
BMJ Openjournal_title
BMJ openauthors
Al-Gobari M,Al-Aqeel S,Gueyffier F,Burnand Bdoi
10.1136/bmjopen-2017-021108subject
Has Abstractpub_date
2018-07-28 00:00:00pages
e021108issue
7issn
2044-6055pii
bmjopen-2017-021108journal_volume
8pub_type
杂志文章,评审相关文献
BMJ Open文献大全abstract:INTRODUCTION:Depressive, anxiety and adjustment disorders are highly prevalent among mental health outpatients. The lack of funding for mental health problems produces inefficient results and a high burden of disease. New cost-effective group interventions aimed at treating these symptoms might be an appropriate soluti...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-029909
更新日期:2019-10-08 00:00:00
abstract:OBJECTIVE:Insomnia is highly prevalent in prisoners and is a risk factor for poor mental well-being, depression, suicidality and aggression, all common concerns in this vulnerable population. Improving sleep management options in prison offers the potential to impact positively on a number of these common risk factors....
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-022406
更新日期:2018-08-29 00:00:00
abstract:INTRODUCTION:Dextro-transposition of the great arteries (d-TGA) is a life-threatening congenital health defect that requires rapid surgery. The most widely used approach is the arterial switch operation (ASO) developed by Jatene in the 1970s. The first set of children who received this intervention are now adults. The ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-005123
更新日期:2014-06-11 00:00:00
abstract:INTRODUCTION:HIV-associated neurocognitive disorder (HAND) may affect 30%-50% of people ageing with HIV. HAND may increase stress and anxiety, and impede coping. Psychosocial group therapy may ameliorate HAND's symptoms, yet the ideal intervention is unclear. This protocol outlines a pilot randomised controlled trial (...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-033183
更新日期:2019-10-31 00:00:00
abstract:OBJECTIVES:To report the distribution and predictors of insulin resistance (IR) in young people presenting to primary care-based mental health services. DESIGN:Cross-sectional. SETTING:Headspace-linked clinics operated by the Brain and Mind Centre of the University of Sydney. PARTICIPANTS:768 young people (66% femal...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-025674
更新日期:2019-05-27 00:00:00
abstract:INTRODUCTION:Emergence delirium (ED) is a common adverse manifestation after general anaesthesia and may result in undesirable consequences. Its causes and mechanisms are diverse and complex, and it is still unavoidable in clinical work. There is a high incidence of ED after otorhinolaryngology surgery, which may resul...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-033803
更新日期:2020-08-26 00:00:00
abstract:OBJECTIVE:In ST elevation myocardial infarction women received less evidence-based medicine and had worse outcome during the fibrinolytic era. With the shift to primary percutaneous coronary intervention (pPCI) as preferred reperfusion strategy, the authors aimed to investigate whether these gender differences has dimi...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2011-000726
更新日期:2012-03-27 00:00:00
abstract:INTRODUCTION:Obesity is a global pandemic that affects all socioeconomic strata, however, the highest figures have been observed in the most disadvantaged social groups. Evidence from the USA and Canada showed that specific urban settings encourage obesogenic behaviour in the population living and/or working there. We ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-018701
更新日期:2018-02-22 00:00:00
abstract:OBJECTIVE:This umbrella review summarises and critically appraises the evidence on the effects of regulated or high-volume perinatal care on outcome among very low birth weight/very preterm infants born in countries with neonatal mortality <5/1000 births. INTERVENTION/EXPOSITION:Perinatal regionalisation, centralisati...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-037135
更新日期:2020-09-25 00:00:00
abstract:OBJECTIVE:Multimorbidity in patients with heart failure (HF) results in poor prognosis and is an increasing public health concern. We aim to examine the effect of multimorbidity focusing on type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD) on all-cause and cardiovascular disease (CVD)-specific mortality ...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究
doi:10.1136/bmjopen-2017-021291
更新日期:2018-05-20 00:00:00
abstract:OBJECTIVE:The Yale Global Tic Severity Scale (YGTSS) is the most commonly used clinician-rated evaluation tool for Tourette syndrome (TS), with established reliability and validity. This study aims to determine whether the YGTSS is a valid parent-reported assessment in the TS population. DESIGN:A prospective cohort st...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-034634
更新日期:2020-08-20 00:00:00
abstract:OBJECTIVES:Chronic hepatitis B virus (HBV) infection is associated with a higher risk of liver diseases. Substantial uncertainty remains, however, about the associations of HBV infection with mortality from extrahepatic causes, especially from subtypes of cardiovascular diseases. We prospectively examined the associati...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-027696
更新日期:2019-04-09 00:00:00
abstract:INTRODUCTION:There is a growing proportion of population aged 65 years and older in low-income and middle-income countries. In Malaysia, this proportion is predicted to increase from 5.1% in 2010 to more than 15.4% by 2050. Cognitive ageing and dementia are global health priorities. However, risk factors and disease as...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-013635
更新日期:2017-01-19 00:00:00
abstract:OBJECTIVES:The aim of this study was to explore the experiences of doctors and nurses caring for patients with delirium in the intensive care unit (ICU) and to describe the process of delirium management. SETTING:This study was performed in 5 ICUs located within 4 hospitals in Madrid (Spain). PARTICIPANTS:Purposeful ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2015-009678
更新日期:2016-01-29 00:00:00
abstract:INTRODUCTION:Inflammation and dysregulated immune responses play a crucial role in atherosclerosis, underlying ischaemic heart disease (IHD) and acute coronary syndromes (ACSs). Immune responses are also major determinants of the postischaemic injury in myocardial infarction. Regulatory T cells (CD4+CD25+FOXP3+; Treg) ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-022452
更新日期:2018-09-17 00:00:00
abstract:OBJECTIVE:Many studies have suggested exposure to secondhand smoke (SHS) is a risk factor for various somatic diseases, but only few studies based on small sample size or specific groups have explored the association between passive smoking and mental distress. We performed this study to examine the relationship betwee...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-011671
更新日期:2016-07-29 00:00:00
abstract:OBJECTIVES:To simplify our previous risk score for predicting the in-hospital mortality risk in patients with non-ST-segment elevation myocardial infarction (NSTEMI) by dropping laboratory data. DESIGN:Prospective cohort. SETTING:Multicentre, 108 hospitals across three levels in China. PARTICIPANTS:A total of 5775 p...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究
doi:10.1136/bmjopen-2019-030772
更新日期:2019-09-12 00:00:00
abstract:OBJECTIVES:To evaluate trends in premature cancer mortality in Colombia by educational level in three periods: 1998-2002 with low healthcare insurance coverage, 2003-2007 with rapidly increasing coverage and finally 2008-2012 with almost universal coverage (2008-2012). SETTING:Colombian population-based, national seco...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2015-008985
更新日期:2016-04-05 00:00:00
abstract:INTRODUCTION:Α substantial corpus of literature has sought to describe the information-seeking behaviour of patients with cancer. Yet, available evidence comes mainly from cross-sectional studies, which provide 'snapshots' of patients' information needs and information-seeking styles at a single time point. Only a few ...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究
doi:10.1136/bmjopen-2015-008933
更新日期:2015-10-06 00:00:00
abstract:INTRODUCTION:Internal temporomandibular joint (TMJ) disorders are present in approximately 80% of patients with symptomatic temporomandibular disorders. Among the minimally invasive therapies, we find the intra-articular infiltration of substances, such as corticosteroids, hyaluronic acid or platelet-rich plasma accomp...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-034327
更新日期:2020-09-06 00:00:00
abstract:OBJECTIVES:Few studies of tornado injuries have considered differences related to damage levels and Enhanced-Fujita (EF) scale ratings. This study aimed to evaluate the pattern, spectrum and geographical distribution of injuries related to the Yancheng tornado and provide guidelines for effective emergency medical stra...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究
doi:10.1136/bmjopen-2018-021552
更新日期:2018-06-22 00:00:00
abstract:OBJECTIVE:To determine the prevalence, nature and predictors of patients having medication administration omissions in hospitals. METHODS:All medication administration omissions data collected using the standardised methodology of the Medication Safety Thermometer in January 2015 were examined. Hospital inpatients pre...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究
doi:10.1136/bmjopen-2018-028170
更新日期:2019-06-09 00:00:00
abstract:OBJECTIVE:The purpose of this study was to determine the current work distribution of health professionals from a public Ugandan medical school in a period of major donor funding for HIV programmes. We explore the hypothesis that programmes initiated under unprecedented health investments from the US President's Emerge...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2013-002875
更新日期:2013-05-31 00:00:00
abstract:OBJECTIVE:Neisseria meningitidis carriage prevalence has known variation across the lifespan, but it is unclear whether carriage varies among meningococcal capsular groups. Therefore, we aimed to characterise group-specific meningococcal carriage by age group and world region from 2007 to 2016. DESIGN:Systematic revie...
journal_title:BMJ open
pub_type: 杂志文章,meta分析
doi:10.1136/bmjopen-2018-024343
更新日期:2019-04-20 00:00:00
abstract:OBJECTIVE:To evaluate whether hyperthyroidism or hypothyroidism increases the risk of subsequent breast cancer in an Asian population. DESIGN:Nationwide population-based case-control study. SETTING:All healthcare facilities in Taiwan. PARTICIPANTS:A total of 103 466 women (mean age 53.3 years) were enrolled. METHOD...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-020194
更新日期:2018-03-30 00:00:00
abstract:OBJECTIVES:To understand the experiences of parents of infants who required surgery early in life. To identify messages and training needs for the extended clinical teams caring for these families-including paediatric surgeons, neonatologists, nurses, obstetricians, midwives and sonographers. SETTING:UK-wide interview...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-020921
更新日期:2018-06-30 00:00:00
abstract:OBJECTIVE:To explore how patients who are wait-listed for or who have received a kidney transplant understand the current UK kidney allocation system, and their views on ways to allocate kidneys in the future. DESIGN:Qualitative study using semistructured interviews and thematic analysis based on a pragmatic approach....
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-013896
更新日期:2017-01-27 00:00:00
abstract:PURPOSE:We have established a prospective cohort of 1959 patients with chronic Chagas cardiomyopathy to evaluate if a clinical prediction rule based on ECG, brain natriuretic peptide (BNP) levels, and other biomarkers can be useful in clinical practice. This paper outlines the study and baseline characteristics of the ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-011181
更新日期:2016-05-04 00:00:00
abstract:PURPOSE:In response to the need for more advanced and longitudinal data concerning chronic diseases, behavioural risk factors and social support systems in India, the SWADES (Social Well-being and Determinants of Health Study) was established. PARTICIPANTS:At baseline, 997 adults aged 30 years and over, living in the ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-032803
更新日期:2020-03-09 00:00:00
abstract:OBJECTIVES:To describe the demographic characteristics and incidence of unintentional fall-related fractures among older adults treated in the US hospital emergency departments (EDs). DESIGN:Retrospective observational study. SETTINGS:Hospitals' ED participants in the National Electronic Injury Surveillance System Al...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2012-001722
更新日期:2013-01-24 00:00:00