Abstract:
INTRODUCTION:The first birth cohorts of women offered human papillomavirus (HPV) vaccination as girls are now entering cervical screening. However, there is no international consensus on how to screen HPV vaccinated women. These women are better protected against cervical cancer and could therefore be offered less intensive screening. Primary HPV testing is more sensitive than cytology, allowing for a longer screening interval. The aim of Trial23 is to investigate if primary HPV testing with cytology triage of HPV positive samples is a reasonable screening scheme for women offered HPV vaccination as girls. METHODS:Trial23 is a method study embedded in the existing cervical screening programme in four out of five Danish regions. Without affecting the screening programme, women born in 1994 are randomised to present screening with liquid-based cytology every third year (present programme arm) or present screening plus an HPV test (HPV arm). The study started 1 February 2017 and will run over three screening rounds corresponding to 7-8 years. ANALYSES:The primary endpoint is cervical intraepithelial neoplasia grade 3 or above. The trial is undertaken as a non-inferiority study including intention-to-treat and per-protocol analyses. The potential effect of primary HPV screening with a 6-year interval will be calculated from the observed data. ETHICS AND DISSEMINATION:The study protocol has been submitted to the ethical committee and deemed a method study. All women are screened according to routine guidelines. The study will contribute new evidence on the future screening of HPV vaccinated birth cohorts of women. All results will be published in open-access journal. TRIAL REGISTRATION:NCT03049553; Pre-results.
journal_name
BMJ Openjournal_title
BMJ openauthors
Thamsborg LH,Andersen B,Larsen LG,Christensen J,Johansen T,Hariri J,Christiansen S,Rygaard C,Lynge Edoi
10.1136/bmjopen-2017-020294subject
Has Abstractpub_date
2018-05-26 00:00:00pages
e020294issue
5issn
2044-6055pii
bmjopen-2017-020294journal_volume
8pub_type
杂志文章相关文献
BMJ Open文献大全abstract:INTRODUCTION:Monitoring and reduction of aversive tension is a core issue in dialectical behaviour therapy of patients. It has been shown that aversive tension is increased in adult borderline personality disorder and is linked to low emotion labelling ability. However, until now there is no documented evidence that pa...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2013-004703
更新日期:2014-04-23 00:00:00
abstract:INTRODUCTION:Activated protein C (aPC) plays a pivotal role in modulating a severe inflammatory response and is thought to be beneficial for patients with sepsis. However, several meta-analyses of randomised controlled trials (RCTs) show that aPC is not significantly associated with improved survival in critically ill ...
journal_title:BMJ open
pub_type: 杂志文章,评审
doi:10.1136/bmjopen-2014-005622
更新日期:2014-07-31 00:00:00
abstract:INTRODUCTION:Circulating prostaglandin E2 levels are elevated in acutely decompensated cirrhosis and have been shown to contribute to immune suppression. Albumin binds to and inactivates this immune-suppressive lipid mediator. Human albumin solution (HAS) could thus be repurposed as an immune-restorative drug in these ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-023754
更新日期:2018-10-21 00:00:00
abstract:OBJECTIVE:This study aimed to evaluate the factor structure of the Chinese version of the 22-item Zarit Burden Interview (ZBI) among family caregivers of patients with schizophrenia in China. METHODS:Using one-stage cluster-sampling design, 324 primary caregivers of patients with schizophrenia in Ningxiang County, Hun...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-015621
更新日期:2017-09-29 00:00:00
abstract:OBJECTIVE:To assess the cost-effectiveness of a multifaceted quality improvement programme focused on reducing central line-associated bloodstream infections in intensive care units. DESIGN:Cost-effectiveness analysis using a decision tree model to compare programme to non-programme intensive care units. SETTING:USA....
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-006065
更新日期:2014-09-25 00:00:00
abstract:OBJECTIVES:Taiwan succeeded in raising the proportion of peritoneal dialysis (PD) usage after the National Health Insurance (NHI) payment scheme introduced financial incentives in 2005. This study aims to compare the economic costs between automated PD (APD) and continuous ambulatory PD (CAPD) modalities from a societa...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-015067
更新日期:2017-03-21 00:00:00
abstract:INTRODUCTION:Repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation approach, might be a promising technique in the management of insomnia. A systematic review of the available literature on this topic is warranted. The systematic review described in this protocol aims to investigate the ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-029206
更新日期:2019-07-16 00:00:00
abstract:OBJECTIVES:The UK ambulance service is expected to now manage more patients in the community and avoid unnecessary transportations to hospital emergency departments (ED). Most people it attends who have experienced seizures have established epilepsy, have experienced uncomplicated seizures and so do not require the ful...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-014022
更新日期:2016-11-09 00:00:00
abstract:OBJECTIVES:To examine the trends in inhospital mortality for England and Scotland over a 17-year period to determine whether and if so to what extent the time trends differ after controlling for differences in the patients treated. DESIGN:Analysis of retrospective administrative hospital data using descriptive aggrega...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究
doi:10.1136/bmjopen-2017-017195
更新日期:2018-02-21 00:00:00
abstract:INTRODUCTION:Robot-assisted laparoscopic prostatectomy (RALP) offers potential cure for localised prostate cancer but is associated with considerable toxicity. Potency and urinary continence are improved when the neurovascular bundles (NVBs) are spared during a nerve spare (NS) RALP. There is reluctance, however, to pe...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-028132
更新日期:2019-06-11 00:00:00
abstract:OBJECTIVES:To evaluate the risk of major congenital anomaly associated with first-trimester exposure to insulin analogues compared with human insulin in offspring of women with pregestational diabetes. DESIGN AND SETTING:A population-based cohort of women with pregestational diabetes (n=1661) who delivered between 199...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究
doi:10.1136/bmjopen-2016-014972
更新日期:2018-02-24 00:00:00
abstract:OBJECTIVE:To measure the experience and perpetration of negative behaviour, including domestic violence and abuse (DVA), and investigate its associations with health conditions and behaviours in men attending general practice. DESIGN:Cross-sectional questionnaire-based study conducted between September 2010 and June 2...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-007141
更新日期:2015-05-19 00:00:00
abstract:OBJECTIVES:To assess the communication potential of three-dimensional (3D) patient-specific models of congenital heart defects and their acceptability in clinical practice for cardiology consultations. DESIGN:This was a questionnaire-based study in which participants were randomised into two groups: the 'model group' ...
journal_title:BMJ open
pub_type: 杂志文章,随机对照试验
doi:10.1136/bmjopen-2014-007165
更新日期:2015-04-30 00:00:00
abstract:OBJECTIVE:To explore how patients who are wait-listed for or who have received a kidney transplant understand the current UK kidney allocation system, and their views on ways to allocate kidneys in the future. DESIGN:Qualitative study using semistructured interviews and thematic analysis based on a pragmatic approach....
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-013896
更新日期:2017-01-27 00:00:00
abstract:INTRODUCTION:Systematic reviews demonstrate that advance care planning (ACP) has many positive effects for residents of aged care facilities, including decreased hospitalisation. The proposed Residential Aged Care Facility (RACF) 'Goals of Patient Care' (GOPC) form incorporates a resident's prior advance care plan into...
journal_title:BMJ open
pub_type: 杂志文章,随机对照试验
doi:10.1136/bmjopen-2016-013909
更新日期:2017-03-10 00:00:00
abstract:OBJECTIVES:To investigate the accuracy, reproducibility and costs of different laboratory assays for the monitoring of unfractionated heparin (UFH) in clinical practice and to study test utilisation in Switzerland. DESIGN:Prospective evaluation study and survey among Swiss hospitals and laboratories. SETTING:Secondar...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-022943
更新日期:2018-06-09 00:00:00
abstract:INTRODUCTION:The role of adjuvant chemotherapy after radical radiotherapy (RT) or chemoradiotherapy (CRT) in cervical cancer awaits further confirmation. Evidences have shown that persistent human papilloma virus (HPV) DNA in exfoliated cell post-RT is a potential biomarker of subclinical residual disease and thus incr...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-028171
更新日期:2019-10-07 00:00:00
abstract:OBJECTIVE:Paediatric heart transplantation (PHTX) comprises 12% of all cardiac transplants and many of the children now survive into adulthood. Only a few studies have investigated the long-term psychosocial well-being of young adult patients after PHTX; no studies have investigated developmental tasks of emerging adul...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-022461
更新日期:2018-11-25 00:00:00
abstract:OBJECTIVE:To explore patients' experience of receiving pain relief injection for suspected hip fracture from paramedics at the location of the injury. DESIGN:Qualitative interviews within a feasibility trial about an alternative to routine prehospital pain management for patients with suspected hip fracture. SETTING:...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-033398
更新日期:2019-12-19 00:00:00
abstract:OBJECTIVES:To explore prescribing practitioners' perspectives on prescribed codeine use, their ability to identify dependence and their options for treatment in the UK. DESIGN:Cross-sectional design using a questionnaire containing closed-ended and open-ended items. SETTING:A nationally representative sample of presc...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-011725
更新日期:2016-07-14 00:00:00
abstract:OBJECTIVES:To estimate the prevalence of and associations between anxiety, depression, post-traumatic stress disorder (PTSD), low subjective well-being (SWB), potential traumas and postmigration stress among refugees from Syria resettled in Sweden. DESIGN:A cross-sectional and population-based questionnaire study base...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-018899
更新日期:2017-12-29 00:00:00
abstract:BACKGROUND:Conflicts of interest may bias the findings of systematic reviews. The objective of this methodological survey was to assess the frequency and different types of conflicts of interest that authors of Cochrane and non-Cochrane systematic reviews report. METHODS:We searched for systematic reviews using the Co...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-011997
更新日期:2016-08-10 00:00:00
abstract:OBJECTIVE:To determine ethnic differences in the progression of chronic kidney disease (CKD) and risk of end-stage renal failure (ESRF) and death in adults with type 2 diabetes mellitus (T2DM), and to identify predictors of rapid renal decline. DESIGN:Observational community-based cohort study undertaken from 2006 to ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-020145
更新日期:2018-03-27 00:00:00
abstract:OBJECTIVES:This study was designed to investigate the effect of alcohol intoxication on clinical presentation of hospitalised adult trauma patients at a Level I trauma centre using propensity score matching. DESIGN:Cross-sectional study. SETTING:Taiwan. PARTICIPANTS:Detailed data of 929 hospitalised adult trauma pat...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-013176
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVES:According to a large-scale international survey, Peru has one of the highest prevalences of asthma worldwide; however, data from this survey were limited to participants from urban Lima. The authors sought to characterise the epidemiology of asthma in Peru in two regions with disparate degrees of urbanisatio...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2011-000421
更新日期:2012-02-22 00:00:00
abstract:OBJECTIVES:Assessment of the relations between recorded gonorrhoea rates and clinical testing activity and disposable diagnostic tests. METHODS:In Denmark, two sources of information on the epidemiology of gonorrhoea are available: (1) a mandatory clinical notification system (since 1867) comprising summary informatio...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2015-008013
更新日期:2015-11-30 00:00:00
abstract:OBJECTIVES:To summarise and synthesise the current evidence regarding the effectiveness of drug interventions to prevent sudden cardiac death (SCD) and all-cause mortality in patients with heart failure with reduced ejection fraction (HFrEF). DESIGN:Overview of systematic reviews. DATA SOURCES:MEDLINE, Embase, ISI We...
journal_title:BMJ open
pub_type: 杂志文章,评审
doi:10.1136/bmjopen-2017-021108
更新日期:2018-07-28 00:00:00
abstract:OBJECTIVE:The aim of the present research was to examine associations between poor driving behaviour (DB), driving when fatigued (DF), risk taking (RT) and road traffic accidents (RTAs). DESIGN:The study involved a cross-sectional online survey of clients of an insurance company. The survey measured DB (speeding, dist...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-011461
更新日期:2016-08-18 00:00:00
abstract:OBJECTIVES:(1) To examine the psychometric properties of the Basic Empathy Scale (BES) with Spanish adolescents, comparing a two and a three-dimensional structure;(2) To analyse the relationship between the three-dimensional empathy and social and normative adjustment in school. DESIGN:Transversal and ex post facto re...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-015347
更新日期:2017-09-25 00:00:00
abstract:OBJECTIVES:This study aimed to measure the burden of work-related upper limb amputation in Korea over a 10-year period and assess its trend. DESIGN:Ecological study. SETTING:National level data in Korea between 2004 and 2013. PARTICIPANTS:49 535 subjects who claimed Korea industrial accident compensation insurance d...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-032793
更新日期:2019-11-19 00:00:00