Abstract：
:Diet is major modifiable risk factor for cardiovascular disease that can influence the immune status of the individual and contribute to persistent low-grade inflammation. In recent years, there has been an increased appreciation of the role of polyunsaturated fatty acids (PUFA) in improving immune function and reduction of systemic inflammation via the modulation of pattern recognition receptors (PRR) on immune cells. Extensive research on the use of bioactive lipids such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and their metabolites have illustrated the importance of these pro-resolving lipid mediators in modulating signaling through PRRs. While their mechanism of action, bioavailability in the blood, and their efficacy for clinical use forms an active area of research, they are found widely administered as marine animal-based supplements like fish oil and krill oil to promote health. The focus of this review will be to discuss the effect of these bioactive fatty acids and their metabolites on immune cells and the resulting inflammatory response, with a brief discussion about modern methods for their analysis using mass spectrometry-based methods.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Kumar NG,Contaifer D,Madurantakam P,Carbone S,Price ET,Van Tassell B,Brophy DF,Wijesinghe DSdoi
10.3390/nu11122974subject
Has Abstractpub_date
2019-12-05 00:00:00issue
12issn
2072-6643pii
nu11122974journal_volume
11pub_type
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