Abstract:
:Polyphenols (PPs) are the naturally occurring bioactive components in fruits and vegetables, and they are the most abundant antioxidant in the human diet. Studies are suggesting that ingestion of PPs might be helpful to ameliorate metabolic syndromes that may contribute in the prevention of several chronic disorders like diabetes, obesity, hypertension, and colon cancer. PPs have structural diversity which impacts their bioavailability as they accumulate in the large intestine and are extensively metabolized through gut microbiota (GM). Intestinal microbiota transforms PPs into their metabolites to make them bioactive. Interestingly, not only GM act on PPs to metabolize them but PPs also modulate the composition of GM. Thus, change in GM from pathogenic to beneficial ones may be helpful to ameliorate gut health and associated diseases. However, to overcome the low bioavailability of PPs, various approaches have been developed to improve their solubility and transportation through the gut. In this review, we present evidence supporting the structural changes that occur after metabolic reactions in PPs (curcumin, quercetin, and catechins) and their effect on GM composition that leads to improving overall gut health and helping to ameliorate metabolic disorders.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Shabbir U,Rubab M,Daliri EB,Chelliah R,Javed A,Oh DHdoi
10.3390/nu13010206subject
Has Abstractpub_date
2021-01-12 00:00:00issue
1issn
2072-6643pii
nu13010206journal_volume
13pub_type
杂志文章,评审相关文献
Nutrients文献大全abstract::Nonalcoholic fatty liver disease (NAFLD) is on the rise worldwide representing a public health issue. Its coexistence with obesity and other metabolic alterations is highly frequent. Therefore, current therapy interventions for NAFLD are mainly focused on progressive weight loss through modulation of overall calorie i...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu12123860
更新日期:2020-12-17 00:00:00
abstract::Obesity is not the same in all individuals and two different phenotypes have been described: metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO). The aim of this study was to identify factors that explain metabolic health status in a rigorously matched Spanish population. Subcutaneous and vis...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu13010119
更新日期:2020-12-31 00:00:00
abstract:BACKGROUND:The influence of diet in pregnant women on the immune tolerance process is intricate. Food-specific immunoglobulin G (IgG) was associated with exposure to particular food antigens. The IgG antibodies can cross the placental barrier and enter into the colostrum, and maternal IgG is amply present in breast mil...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11051096
更新日期:2019-05-17 00:00:00
abstract:BACKGROUND:Diet might influence the risk of allergic diseases. Evidence from developing countries with high prevalence of childhood asthma is scant. METHODS:Information on wheeze, rhinitis, and eczema was collected from 3209 children aged 6-7 years in 2005, who were taking part in the International Study on Asthma and...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu7075098
更新日期:2015-06-25 00:00:00
abstract::Several preventive strategies to reduce dyslipidemia have been suggested, of which dietary modification features as an important one. Dyslipidemia is a major risk factor for coronary heart disease and strategies to manage dyslipidemia have been shown to reduce the incidence of cardiovascular disease (CVD). Although th...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu10040468
更新日期:2018-04-11 00:00:00
abstract::The Brazilian savanna fruit, tucum-do-cerrado (Bactrissetosa Mart.) reduces hepatic hepcidin levels. Therefore, we investigated the effect of tucum-do-cerrado on the TfR/HFE and/or BMP/HJV/SMAD and JAK/STAT pathways, in normal and excess iron conditions. Rats were treated with: control diet (CT); control diet +15% tuc...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12051515
更新日期:2020-05-22 00:00:00
abstract::The American Heart Association (AHA) has advocated that women and men not consume more than 100 and 150 kcal/day, respectively, from added sugars. These levels are currently exceeded by over 90% of the adult population in the United States. Few data exist on longer-term metabolic effects when sucrose and High Fructose...
journal_title:Nutrients
pub_type: 杂志文章,随机对照试验
doi:10.3390/nu6031128
更新日期:2014-03-17 00:00:00
abstract::The immunological mechanism underlying Immunoglobuline E (IgE)-mediated cow's milk allergy has been subject to investigations for many years. Identification of the key immune cells (mast cells, B cells) and molecules (IgE) in the allergic process has led to the understanding that avoidance of IgE-crosslinking epitopes...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu11112734
更新日期:2019-11-11 00:00:00
abstract::Dietary supplement use may modify the risk of periodontal disease but effects on wound healing after periodontal procedures are less clear. This study characterized dietary supplement use by male and female patients (n = 376) attending a periodontal clinic-information that is essential for evidence-based intervention ...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu5041110
更新日期:2013-04-02 00:00:00
abstract::Metabolomics provide an unbiased tool for exploring the modulation of the human metabolome in response to food intake. This study applied metabolomics to capture the postprandial metabolic response to breakfast meals corresponding to vegan (VE), lacto ovo-vegetarian (LOV), and omnivore (OM) diets. In a cross over desi...
journal_title:Nutrients
pub_type: 杂志文章,随机对照试验
doi:10.3390/nu10081063
更新日期:2018-08-10 00:00:00
abstract::Preserving the efficacy of probiotic bacteria exhibits paramount challenges that need to be addressed during the development of functional food products. Several factors have been claimed to be responsible for reducing the viability of probiotics including matrix acidity, level of oxygen in products, presence of other...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu11071591
更新日期:2019-07-13 00:00:00
abstract::Dietary n-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are associated with reduction of inflammation, although the mechanisms are poorly understood, especially how the spleen, as a secondary lymphoid organ, is involved. To investigate the effects of EPA and DHA on spleen gene expression, ma...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu9010050
更新日期:2017-01-10 00:00:00
abstract::Few studies have examined the association of a wide range of metabolites with total and subtypes of coffee consumption. The aim of this study was to investigate associations of plasma metabolites with total, caffeinated, and decaffeinated coffee consumption. We also assessed the ability of metabolites to discriminate ...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11051032
更新日期:2019-05-08 00:00:00
abstract:INTRODUCTION:The effects of bariatric surgery on skeletal health raise many concerns. Trabecular bone score (TBS) is obtained through the analysis of lumbar spine dual X-ray absorptiometry (DXA) images and allows an indirect assessment of skeletal microarchitecture (MA). The aim of our study was to evaluate the changes...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu9121314
更新日期:2017-12-02 00:00:00
abstract::The association between elevated body mass index (BMI) and risk of death has been reported in many studies. However, the association between BMI and all-cause mortality for hypertensive Chinese adults remains unclear. We conducted a post-hoc analysis using data from the China Stroke Primary Prevention Trial (CSPPT). C...
journal_title:Nutrients
pub_type: 杂志文章,随机对照试验
doi:10.3390/nu8060384
更新日期:2016-06-22 00:00:00
abstract::Many of the health benefits associated with dietary fiber are attributed to their fermentation by microbiota and production of short chain fatty acids (SCFA). The aim of this study was to investigate the fermentability of the functional fiber PolyGlyopleX® (PGX®) in vitro. A validated dynamic, computer-controlled in v...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu6031115
更新日期:2014-03-14 00:00:00
abstract::Insufficient dietary intake, micronutrient deficiencies, and infection may result in malnutrition. In Zambia, an estimated 14% of women are vitamin A-deficient, ~50% are anemic, 10% are underweight, and 23% are overweight/obese. A cross-sectional survey determined food and nutrient intakes of randomly selected Zambian...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11020288
更新日期:2019-01-29 00:00:00
abstract::Plants belonging to the genus Opuntia spp. are the most abundant of the Cactaceae family, grown throughout America and the Mediterranean central area. Its fruit, known as cactus pear or prickly pear, is an oval berry grouped in different colors. Some studies have shown its antioxidant activities which may help in prev...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu5104145
更新日期:2013-10-18 00:00:00
abstract::The indications for delaying the start of dialysis have revived interest in low-protein diets (LPDs). In this observational prospective study, we enrolled all patients with chronic kidney disease (CKD) who followed a moderately restricted LPD in 2007-2015 in a nephrology unit in Italy: 449 patients, 847 years of obser...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu8120758
更新日期:2016-11-25 00:00:00
abstract::The Mediterranean diet (MD) is linked to decreased risk of chronic disease, such as cardiovascular disease, obesity, hypertension, diabetes mellitus and cognitive disease. Given the health promoting aspects of this diet, we conducted a secondary analysis of data from the National Nutrition and Physical Activity Survey...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12051251
更新日期:2020-04-28 00:00:00
abstract::Coffee is a blend of compounds related to gastrointestinal physiology. Given its popularity and the epidemiology of colorectal cancer, the impact of this beverage on public health could be considerable. Our aim was to provide an updated synthesis of the relationship between coffee consumption and the risk of colorecta...
journal_title:Nutrients
pub_type: 杂志文章,meta分析
doi:10.3390/nu11030694
更新日期:2019-03-24 00:00:00
abstract::This secondary analysis study addressed a gap of knowledge: whether perceived stress reduction created by a lifestyle intervention might serve as a mediator for reducing fat and fast food intakes in low-income overweight or obese mothers of young children. This analysis included 338 low-income overweight or obese moth...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12123606
更新日期:2020-11-24 00:00:00
abstract::A dynamic human gastrointestinal (GI) model was used to digest cooked tubers from purple-fleshed Amachi and Leona potato cultivars to study anthocyanin biotransformation in the stomach, small intestine and colonic vessels. Colonic Caco-2 cancer cells and non-tumorigenic colonic CCD-112CoN cells were tested for cytotox...
journal_title:Nutrients
pub_type: 临床试验,杂志文章
doi:10.3390/nu9090953
更新日期:2017-08-29 00:00:00
abstract::Zinc (Zn) deficiency is a prevalent micronutrient insufficiency. Although the gut is a vital organ for Zn utilization, and Zn deficiency is associated with impaired intestinal permeability and a global decrease in gastrointestinal health, alterations in the gut microbial ecology of the host under conditions of Zn defi...
journal_title:Nutrients
pub_type: 杂志文章,随机对照试验
doi:10.3390/nu7125497
更新日期:2015-11-27 00:00:00
abstract::Advances in web and mobile technologies have created efficiencies relating to collection, analysis and interpretation of dietary intake data. This study compared the impact of two levels of nutrition support: (1) low personalization, comprising a web-based personalized nutrition feedback report generated using the Aus...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12113334
更新日期:2020-10-29 00:00:00
abstract::Some rural areas of Ecuador, including the Imbabura Province of the Andes Highlands, are experiencing a double burden of malnutrition where micronutrient deficiencies persist at the same time obesity is increasing as many traditional home-grown foods are being replaced with more commercially prepared convenience foods...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12082454
更新日期:2020-08-15 00:00:00
abstract::Ingestion of pure fructose stimulates de novo lipogenesis and gluconeogenesis. This may however not be relevant to typical nutritional situations, where fructose is invariably ingested with glucose. We therefore assessed the metabolic fate of fructose incorporated in a mixed meal without or with glucose in eight healt...
journal_title:Nutrients
pub_type: 杂志文章,随机对照试验
doi:10.3390/nu6072632
更新日期:2014-07-15 00:00:00
abstract::The rising prevalence of overweight and obesity is a global concern, increasing the risk of numerous non-communicable diseases and reducing quality of life. A healthy diet and exercise remain the cornerstone treatments for obesity. However, adherence rates can be low and the effectiveness of these interventions is oft...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu12051398
更新日期:2020-05-13 00:00:00
abstract::Lower vitamin D status at birth and during infancy has been associated with increased incidence of eczema and food allergies. The aim of this study was to investigate the effect of early infancy vitamin D supplementation on allergic disease outcomes in infants at "hereditary risk" of allergic disease, but who had suff...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12061747
更新日期:2020-06-11 00:00:00
abstract::The Eastern Mediterranean region is characterized by one of the highest burdens of paediatric obesity worldwide. This study aims at examining dietary, lifestyle, and socio-economic correlates of overweight, obesity, and abdominal adiposity amongst children and adolescents in Lebanon, a country of the Eastern Mediterra...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu6031038
更新日期:2014-03-10 00:00:00