Abstract:
BACKGROUND:Colombia was the second most affected country during the American Zika virus (ZIKV) epidemic, with over 109,000 reported cases. Despite the scale of the outbreak, limited genomic sequence data were available from Colombia. We sought to sequence additional samples and use genomic epidemiology to describe ZIKV dynamics in Colombia. METHODS:We sequenced ZIKV genomes directly from clinical diagnostic specimens and infected Aedes aegypti samples selected to cover the temporal and geographic breadth of the Colombian outbreak. We performed phylogeographic analysis of these genomes, along with other publicly-available ZIKV genomes from the Americas, to estimate the frequency and timing of ZIKV introductions to Colombia. RESULTS:We attempted PCR amplification on 184 samples; 19 samples amplified sufficiently to perform sequencing. Of these, 8 samples yielded sequences with at least 50% coverage. Our phylogeographic reconstruction indicates two separate introductions of ZIKV to Colombia, one of which was previously unrecognized. We find that ZIKV was first introduced to Colombia in February 2015 (95%CI: Jan 2015 - Apr 2015), corresponding to 5 to 8 months of cryptic ZIKV transmission prior to confirmation in September 2015. Despite the presence of multiple introductions, we find that the majority of Colombian ZIKV diversity descends from a single introduction. We find evidence for movement of ZIKV from Colombia into bordering countries, including Peru, Ecuador, Panama, and Venezuela. CONCLUSIONS:Similarly to genomic epidemiological studies of ZIKV dynamics in other countries, we find that ZIKV circulated cryptically in Colombia. More accurately dating when ZIKV was circulating refines our definition of the population at risk. Additionally, our finding that the majority of ZIKV transmission within Colombia was attributable to transmission between individuals, rather than repeated travel-related importations, indicates that improved detection and control might have succeeded in limiting the scale of the outbreak within Colombia.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Black A,Moncla LH,Laiton-Donato K,Potter B,Pardo L,Rico A,Tovar C,Rojas DP,Longini IM,Halloran ME,Peláez-Carvajal D,Ramírez JD,Mercado-Reyes M,Bedford Tdoi
10.1186/s12879-019-4566-2subject
Has Abstractpub_date
2019-11-12 00:00:00pages
963issue
1issn
1471-2334pii
10.1186/s12879-019-4566-2journal_volume
19pub_type
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journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-018-3076-y
更新日期:2018-04-10 00:00:00
abstract:BACKGROUND:The federal state of Hesse, Germany, introduced a laboratory-based reporting scheme for carbapenem-resistant organisms (CROs). METHOD:The results of the first year of mandated reporting of CROs from April 2012 through March 2013 to the Public Health Authority of Frankfurt/Main, responsible for a population ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-14-446
更新日期:2014-08-19 00:00:00
abstract:BACKGROUND:Human rotavirus A (human RV-A) is the most common cause of viral gastroenteritis in infants. The objective of the study was to characterize the G and P genotypes among clinical rotavirus isolates from children with acute diarrhea admitted to a tertiary care hospital in Riyadh, Saudi Arabia. METHODS:From 201...
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pub_type: 杂志文章
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abstract:BACKGROUND:Elderly people are at increased risk for severe influenza illness and constitute therefore a major target-group for seasonal influenza vaccination in most industrialized countries. The aim of this study was to estimate influenza vaccine effectiveness (VE) among individuals aged 60+ years over three seasons a...
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journal_title:BMC infectious diseases
pub_type: 杂志文章,随机对照试验
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abstract:BACKGROUND:Active tuberculosis (TB) is common among HIV-infected persons living in tuberculosis endemic countries, and screening for tuberculosis (TB) is recommended routinely. We sought to determine the role of chest x-ray and sputum culture in the decision to treat for presumptive TB using active case finding in a la...
journal_title:BMC infectious diseases
pub_type: 杂志文章
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journal_title:BMC infectious diseases
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journal_title:BMC infectious diseases
pub_type: 杂志文章
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更新日期:2009-05-21 00:00:00
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更新日期:2010-09-03 00:00:00
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更新日期:2012-10-25 00:00:00
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