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Whole blood RNA sequencing reveals a unique transcriptomic profile in patients with ARDS following hematopoietic stem cell transplantation.

Abstract：

BACKGROUND:The acute respiratory distress syndrome (ARDS) is characterized by the acute onset of hypoxemia and bilateral lung infiltrates in response to an inciting event, and is associated with high morbidity and mortality. Patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) are at increased risk for ARDS. We hypothesized that HSCT patients with ARDS would have a unique transcriptomic profile identifiable in peripheral blood compared to those that did not undergo HSCT. METHODS:We isolated RNA from banked peripheral blood samples from a biorepository of critically ill ICU patients. RNA-Seq was performed on 11 patients with ARDS (5 that had undergone HSCT and 6 that had not) and 12 patients with sepsis without ARDS (5 that that had undergone HCST and 7 that had not). RESULTS:We identified 687 differentially expressed genes between ARDS and ARDS-HSCT (adjusted p-value < 0.01), including IFI44L, OAS3, LY6E, and SPATS2L that had increased expression in ARDS vs. ARDS-HSCT; these genes were not differentially expressed in sepsis vs sepsis-HSCT. Gene ontology enrichment analysis revealed that many differentially expressed genes were related to response to type I interferon. CONCLUSIONS:Our findings reveal significant differences in whole blood transcriptomic profiles of patients with non-HSCT ARDS compared to ARDS-HSCT patients and point toward different immune responses underlying ARDS and ARDS-HSCT that contribute to lung injury.

journal_name

Respir Res

journal_title

Respiratory research

authors

Englert JA,Cho MH,Lamb AE,Shumyatcher M,Barragan-Bradford D,Basil MC,Higuera A,Isabelle C,Vera MP,Dieffenbach PB,Fredenburgh LE,Kang JB,Bhatt AS,Antin JH,Ho VT,Soiffer RJ,Howrylak JA,Himes BE,Baron RM

doi

10.1186/s12931-019-0981-6

subject

Has Abstract

pub_date

2019-01-21 00:00:00

pages

15

issue

1

eissn

1465-9921

issn

1465-993X

pii

10.1186/s12931-019-0981-6

journal_volume

20

pub_type

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