Local therapy with CpG motifs in a murine model of allergic airway inflammation in IFN-beta knock-out mice.

abstract：:Small airways disease (SAD) is a cardinal feature of chronic obstructive pulmonary disease (COPD) first recognized in the nineteenth century. The diverse histopathological features associated with SAD underpin the heterogeneous nature of COPD. Our understanding of the key molecular mechanisms which drive the pathologi...

journal_title：Respiratory research

authors： Higham A,Quinn AM,Cançado JED,Singh D

更新日期：2019-03-04 00:00:00

abstract：BACKGROUND:Lung inflammation in COPD is poorly controlled by inhaled corticosteroids (ICS). Strategies to improve ICS efficacy or the search of biomarkers who may select those patients candidates to receive ICS in COPD are needed. Recent data indicate that MUC1 cytoplasmic tail (CT) membrane mucin can mediate corticost...

journal_title：Respiratory research

authors： Milara J,Díaz-Platas L,Contreras S,Ribera P,Roger I,Ballester B,Montero P,Cogolludo Á,Morcillo E,Cortijo J

更新日期：2018-11-20 00:00:00

abstract：BACKGROUND:ATP-regulated potassium channels (KATP) regulate pulmonary vascular tone and are involved in hypoxic pulmonary vasoconstriction (HPV). In patients with inflammation like sepsis or ARDS, HPV is impaired, resulting in a ventilation-perfusion mismatch and hypoxia. Since increase of vascular KATP channel Kir6.1 ...

journal_title：Respiratory research

authors： Turzo M,Vaith J,Lasitschka F,Weigand MA,Busch CJ

更新日期：2018-02-13 00:00:00

abstract：BACKGROUND:Heightened inflammation, including expression of COX-2, is associated with COPD pathogenesis. RelB is an NF-κB family member that attenuates COX-2 in response to cigarette smoke by a mechanism that may involve the miRNA miR-146a. There is no information on the expression of RelB in COPD or if RelB prevents C...

journal_title：Respiratory research

authors： Sheridan JA,Zago M,Nair P,Li PZ,Bourbeau J,Tan WC,Hamid Q,Eidelman DH,Benedetti AL,Baglole CJ

更新日期：2015-05-06 00:00:00

abstract：BACKGROUND:25-hydroxycholesterol (25-HC) is one of the oxysterols, which are oxidized derivatives of cholesterol, and has been reported to be involved in the pathogenesis of atherosclerosis and Alzheimer's disease. In lung, the possible involvement of 25-HC in airway diseases has been revealed. In the present study, we...

journal_title：Respiratory research

authors： Koarai A,Yanagisawa S,Sugiura H,Ichikawa T,Kikuchi T,Furukawa K,Akamatsu K,Hirano T,Nakanishi M,Matsunaga K,Minakata Y,Ichinose M

更新日期：2012-07-31 00:00:00

abstract：BACKGROUND:The investigation of mesenchymal stromal cell (MSC)-conditioned medium or extracellular vesicles (exosomes or microvesicles) as a remedy for acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) has become a fast-growing field in recent years. Our purpose was to conduct a meta-analysis to inv...

journal_title：Respiratory research

authors： Wang F,Fang B,Qiang X,Shao J,Zhou L

更新日期：2020-11-20 00:00:00

abstract：: ...

journal_title：Respiratory research

authors：

更新日期：2018-12-20 00:00:00

abstract：BACKGROUND:Allergic asthma is characterized by airway inflammation in response to antigen exposure, leading to airway remodeling and lung dysfunction. Epithelial-mesenchymal transition (EMT) may play a role in airway remodeling through the acquisition of a mesenchymal phenotype in airway epithelial cells. TGF-β1 is kno...

journal_title：Respiratory research

authors： Johnson JR,Nishioka M,Chakir J,Risse PA,Almaghlouth I,Bazarbashi AN,Plante S,Martin JG,Eidelman D,Hamid Q

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Inhaled corticosteroids are the recommended first-line treatment for asthma but adherence to therapy is suboptimal. The objectives of this study were to compare the efficacy and safety of once-daily (OD) evening and twice-daily (BD) regimens of the novel inhaled corticosteroid fluticasone furoate (FF) in ast...

journal_title：Respiratory research

authors： Woodcock A,Bleecker ER,Busse WW,Lötvall J,Snowise NG,Frith L,Jacques L,Haumann B,Bateman ED

更新日期：2011-12-21 00:00:00

abstract：BACKGROUND:Generalized hypoxic pulmonary vasoconstriction (HPV) occurring during exposure to hypoxia is a detrimental process resulting in an increase in lung vascular resistance. Nebulization of sodium nitrite has been shown to inhibit HPV. The aim of this project was to investigate and compare the effects of nebuliza...

journal_title：Respiratory research

authors： Egemnazarov B,Schermuly RT,Dahal BK,Elliott GT,Hoglen NC,Surber MW,Weissmann N,Grimminger F,Seeger W,Ghofrani HA

更新日期：2010-06-21 00:00:00

abstract：BACKGROUND:Possible variation in bronchodilator response (BDR) according to age at the diagnosis of adult-onset asthma is unknown. Our aim was to assess if BDR in FEV1 is related to age at diagnosis of adult-onset asthma and how many subjects fulfill the 400 mL criterion of BDR, the suggested cut-off for asthma-like re...

journal_title：Respiratory research

authors： Tommola M,Won HK,Ilmarinen P,Jung H,Tuomisto LE,Lehtimäki L,Niemelä O,Kim TB,Kankaanranta H

更新日期：2020-07-13 00:00:00

abstract：BACKGROUND:Host-associated microbial communities have important roles in tissue homeostasis and overall health. Severe perturbations can occur within these microbial communities during critical illness due to underlying diseases and clinical interventions, potentially influencing patient outcomes. We sought to profile ...

journal_title：Respiratory research

authors： Lamarche D,Johnstone J,Zytaruk N,Clarke F,Hand L,Loukov D,Szamosi JC,Rossi L,Schenck LP,Verschoor CP,McDonald E,Meade MO,Marshall JC,Bowdish DME,Karachi T,Heels-Ansdell D,Cook DJ,Surette MG,PROSPECT Investigators.,C

更新日期：2018-12-07 00:00:00

abstract：OBJECTIVE:To investigate the differences in the proportions of BMPR2 mutations in familial hereditary pulmonary arterial hypertension (HPAH) and idiopathic pulmonary arterial hypertension (IPAH) between males and females and the relationship between BMPR2 mutation and PAH severity. METHODS:A computer was used to searc...

journal_title：Respiratory research

authors： Ge X,Zhu T,Zhang X,Liu Y,Wang Y,Zhang W

更新日期：2020-02-06 00:00:00

abstract：BACKGROUND:Idiopathic pulmonary arterial hypertension (IPAH) continues to be one of the most serious intractable diseases that might start with activation of several triggers representing the genetic susceptibility of a patient. To elucidate what essentially contributes to the onset and progression of IPAH, we investig...

journal_title：Respiratory research

authors： Shimodaira K,Okubo Y,Ochiai E,Nakayama H,Katano H,Wakayama M,Shinozaki M,Ishiwatari T,Sasai D,Tochigi N,Nemoto T,Saji T,Kamei K,Shibuya K

更新日期：2012-11-17 00:00:00

abstract：BACKGROUND:Patients with severe, uncontrolled asthma, particularly those with a non-eosinophilic phenotype, have a great unmet need for new treatments that act on a broad range of inflammatory pathways in the airway. Tezepelumab is a human monoclonal antibody that blocks the activity of thymic stromal lymphopoietin, an...

journal_title：Respiratory research

authors： Emson C,Diver S,Chachi L,Megally A,Small C,Downie J,Parnes JR,Bowen K,Colice G,Brightling CE

更新日期：2020-10-13 00:00:00

abstract：:A new international statement defines usual interstitial pneumonia (UIP) which is a histological and radiological form of idiopathic pulmonary fibrosis (IPF) more precisely than previously. In the diagnosis of IPF, either in high resolution computed tomography (HRCT) a UIP pattern must be present or alternatively spec...

journal_title：Respiratory research

authors： Kaarteenaho R

更新日期：2013-04-15 00:00:00

abstract：BACKGROUND:Azithromycin (Azm) is a macrolide recognized for its disease-modifying effects and reduction in exacerbation of chronic airway diseases. It is not clear whether the beneficial effects of Azm are due to its anti-microbial activity or other pharmacological actions. We have shown that Azm affects the integrity ...

journal_title：Respiratory research

authors： Arason AJ,Joelsson JP,Valdimarsdottir B,Sigurdsson S,Gudjonsson A,Halldorsson S,Johannsson F,Rolfsson O,Lehmann F,Ingthorsson S,Cherek P,Gudmundsson GH,Gardarsson FR,Page CP,Baldursson O,Gudjonsson T,Kricker JA

更新日期：2019-06-24 00:00:00

abstract：BACKGROUND:The mechanisms during the initial phase of oxygen toxicity leading to pulmonary tissue damage are incompletely known. Increase of tumour necrosis factor alpha (TNFalpha) represents one of the first pulmonary responses to hyperoxia. We hypothesised that, in the initial phase of hyperoxia, TNFalpha activates t...

journal_title：Respiratory research

authors： Guthmann F,Wissel H,Schachtrup C,Tölle A,Rüdiger M,Spener F,Rüstow B

更新日期：2005-01-21 00:00:00

abstract：BACKGROUND:The assessment of bronchodilator-induced change in forced vital capacity (FVC) is dependent on forced expiratory time (FET) in subjects with airflow limitation. Limited information is available on the concurrent responses of FVC, forced expiratory volume in six seconds (FEV6), and FET in the bronchodilation ...

journal_title：Respiratory research

authors： Kainu A,Lindqvist A,Sarna S,Lundbäck B,Sovijärvi A

更新日期：2009-07-28 00:00:00

abstract：BACKGROUND:Neonatal mice developed neurological disease and pulmonary dysfunction after an infection with a mouse-adapted human Enterovirus 71 (EV71) strain MP4. However, the hallmark of severe human EV71 infection, pulmonary edema (PE), was not evident. METHODS:To test whether EV71-induced PE required a proinflammato...

journal_title：Respiratory research

authors： Huang SW,Lee YP,Hung YT,Lin CH,Chuang JI,Lei HY,Su IJ,Yu CK

更新日期：2011-11-06 00:00:00

abstract：BACKGROUND:The aim of this study was to develop and validate a model for pulmonary fibrosis, using ex vivo tissue cultures of lungs from bleomycin treated animals, enabling the investigation of fibrosis remodeling using novel biomarkers for the detection of ECM protein fragments. The combination of in vivo and ex vivo ...

journal_title：Respiratory research

authors： Hansen NU,Karsdal MA,Brockbank S,Cruwys S,Rønnow S,Leeming DJ

更新日期：2016-07-05 00:00:00

abstract：BACKGROUND:High frequency chest wall oscillation (HFCWO) is used for airway mucus clearance. The objective of this study was to evaluate the use of HFCWO early in the treatment of adults hospitalized for acute asthma or chronic obstructive pulmonary disease (COPD). METHODS:Randomized, multi-center, double-masked phase...

journal_title：Respiratory research

authors： Mahajan AK,Diette GB,Hatipoğlu U,Bilderback A,Ridge A,Harris VW,Dalapathi V,Badlani S,Lewis S,Charbeneau JT,Naureckas ET,Krishnan JA

更新日期：2011-09-10 00:00:00

abstract：BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive fibrotic lung disease for which there is no cure. Current therapeutics are only able to slow disease progression, therefore there is a need to explore alternative, novel treatment options. There is increasing evidence that the 3', 5' cyclic ade...

journal_title：Respiratory research

authors： Roberts MJ,Broome RE,Kent TC,Charlton SJ,Rosethorne EM

更新日期：2018-04-07 00:00:00

abstract：BACKGROUND:Family history of asthma and other allergic diseases have been linked to the risk of childhood asthma previously, but little is known about their effect on the age-of-onset and persistency of asthma until young adulthood. METHODS:We assessed the effect of the family history of asthma and allergic diseases o...

journal_title：Respiratory research

authors： Paaso EM,Jaakkola MS,Rantala AK,Hugg TT,Jaakkola JJ

更新日期：2014-11-27 00:00:00

abstract：BACKGROUND:Fibrocytes are implicated in Idiopathic Pulmonary Fibrosis (IPF) pathogenesis and increased proportions in the circulation are associated with poor prognosis. Upon tissue injury, fibrocytes migrate to the affected organ. In IPF patients, circulating fibrocytes are increased especially during exacerbations, h...

journal_title：Respiratory research

authors： Heukels P,van Hulst JAC,van Nimwegen M,Boorsma CE,Melgert BN,van den Toorn LM,Boomars KAT,Wijsenbeek MS,Hoogsteden H,von der Thüsen JH,Hendriks RW,Kool M,van den Blink B

更新日期：2018-05-10 00:00:00

abstract：BACKGROUND:Activated fibroblasts, which have previously been obtained from bronchoalveolar lavage fluid (BALF), are proposed to be important cells in the fibrotic processes of asthma and scleroderma (SSc). We have studied the motility for BALF derived fibroblasts in patients with SSc that may explain the presence of th...

journal_title：Respiratory research

authors： Larsen K,Malmström J,Wildt M,Dahlqvist C,Hansson L,Marko-Varga G,Bjermer L,Scheja A,Westergren-Thorsson G

更新日期：2006-01-23 00:00:00

abstract：BACKGROUND:Eosinophilic airway inflammation has successfully been used to tailor anti-inflammatory therapy in chronic obstructive pulmonary disease (COPD). Airway hyperresponsiveness (AHR) by indirect challenges is associated with airway inflammation. We hypothesized that AHR to inhaled mannitol captures eosinophilia i...

journal_title：Respiratory research

authors： de Nijs SB,Fens N,Lutter R,Dijkers E,Krouwels FH,Smids-Dierdorp BS,van Steenwijk RP,Sterk PJ

更新日期：2011-01-18 00:00:00

abstract：BACKGROUND:Studies have shown that epinephrine release is impaired in patients with asthma. The pregnancy of female rats (dams) with asthma promotes in their pups the differentiation of adrenal medulla chromaffin cells (AMCCs) into sympathetic neurons, mediated by nerve growth factor, which leads to a reduction in epin...

journal_title：Respiratory research

authors： Feng JT,Wu XM,Li XZ,Zou YQ,Qin L,Hu CP

更新日期：2012-11-08 00:00:00

abstract：:Pre-bronchodilator lung function including forced vital capacity (FVC), forced expiratory flow in 1 second (FEV1), their ratio (FEV1/FVC), and forced expiratory flow 25-75% (FEF25-75) measured at age 10, 18, and 26 years in the Isle of Wight birth cohort was analyzed for developmental patterns (trajectories). Early li...

journal_title：Respiratory research

authors： Karmaus W,Mukherjee N,Janjanam VD,Chen S,Zhang H,Roberts G,Kurukulaaratchy RJ,Arshad H

更新日期：2019-05-22 00:00:00

abstract：BACKGROUND:Tobacco smoke and genetic susceptibility are risk factors for asthma and wheezing. The aim of this study was to investigate whether there is a combined effect of interleukin-13 gene (IL13) polymorphisms and tobacco smoke on persistent childhood wheezing and asthma. METHODS:In the Isle of Wight birth cohort ...

journal_title：Respiratory research

authors： Sadeghnejad A,Karmaus W,Arshad SH,Kurukulaaratchy R,Huebner M,Ewart S

更新日期：2008-01-10 00:00:00