Differences in the risk of mood disorders in patients with asthma-COPD overlap and in patients with COPD alone: a nationwide population-based retrospective cohort study in Korea.


BACKGROUND:Although feelings of anxiety and depression are common in patients with chronic obstructive pulmonary disease (COPD), little is known about the estimates of their incidence in patients with asthma-COPD overlap (ACO), which has been described and acknowledged as a distinct clinical entity. We aimed to estimate the risk of depression and anxiety among patients with ACO and compare it with the risk among those with COPD alone in the general population. METHODS:We conducted a nationwide population-based retrospective cohort study using the Korean National Sample Cohort database between 1 January, 2002, and 31 December, 2013. Patients who were diagnosed with COPD (International Classification of Diseases, 10th revision [ICD-10] codes J42-J44) at least twice and prescribed COPD medications at least once between 2003 and 2011 were classified into two categories: patients who were diagnosed with asthma (ICD-10 codes J45-J46) more than twice and at least once prescribed asthma medications comprised the ACO group, and the remaining COPD patients comprised the COPD alone group. Patients who had been diagnosed with depression or anxiety within a year before the index date were excluded. We defined the outcome as time to first diagnosis with depression and anxiety. Matched Cox regression models were used to compare the risk of depression and anxiety among patients with ACO and patients with COPD alone after propensity score matching with a 1:1 ratio. RESULTS:After propensity score estimation and matching in a 1:1 ratio, the cohort used in the analysis included 15,644 patients. The risk of depression during the entire study period was higher for patients with ACO than for patients with COPD alone (adjusted hazard ratio, 1.10; 95% confidence interval, 1.03-1.18; P value = 0.0039), with an elevated risk in patients aged 40-64 years (1.21; 1.10-1.34; 0.0001) and in women (1.18; 1.07-1.29; 0.0005). The risk of anxiety was higher for patients with ACO than for patients with COPD alone (1.06; 1.01-1.12; 0.0272), with a higher risk in patients aged 40-64 years (1.08; 1.00-1.17; 0.0392); however, the risk was not significant when stratified by sex. CONCLUSIONS:This population-based study revealed a higher incidence of depression and anxiety in patients with ACO than in patients with COPD alone.


Respir Res


Respiratory research


Kang HR,Hong SH,Ha SY,Kim TB,Lee EK




Has Abstract


2019-04-30 00:00:00














  • High frequency chest wall oscillation for asthma and chronic obstructive pulmonary disease exacerbations: a randomized sham-controlled clinical trial.

    abstract:BACKGROUND:High frequency chest wall oscillation (HFCWO) is used for airway mucus clearance. The objective of this study was to evaluate the use of HFCWO early in the treatment of adults hospitalized for acute asthma or chronic obstructive pulmonary disease (COPD). METHODS:Randomized, multi-center, double-masked phase...

    journal_title:Respiratory research

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Mahajan AK,Diette GB,Hatipoğlu U,Bilderback A,Ridge A,Harris VW,Dalapathi V,Badlani S,Lewis S,Charbeneau JT,Naureckas ET,Krishnan JA

    更新日期:2011-09-10 00:00:00

  • Role of SOD3 in silica-related lung fibrosis and pulmonary vascular remodeling.

    abstract:BACKGROUND:Work-place exposure to silica dust may lead to progressive lung inflammation culminating in the development of silicosis, an irreversible condition that can be complicated by onset of pulmonary hypertension (PH). The molecular mechanisms leading to the development of PH and lung fibrosis in response to silic...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Zelko IN,Zhu J,Roman J

    更新日期:2018-11-20 00:00:00

  • Epigenetics dysfunction in morbid obesity with or without obstructive sleep apnoea: the EPIMOOSA study.

    abstract:BACKGROUND:Obstructive sleep apnoea (OSA) and morbid obesity (MO), defined by a body mass index ≥35 kg/m2, are two closely related conditions. Recent studies suggest that circulating microRNA (miRNA) plays a potential role in the physiopathology of both conditions. To date, circulating miRNA expression has been studied...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Lázaro J,Clavería P,Cabrejas C,Fernando J,Daga B,Ordoñez B,Segura S,Sanz-Rubio D,Marín JM

    更新日期:2020-02-04 00:00:00

  • Neurotrophins and neurotrophin receptors in pulmonary sarcoidosis - granulomas as a source of expression.

    abstract:BACKGROUND:Pulmonary sarcoidosis is an inflammatory disease, characterized by an accumulation of CD4+ lymphocytes and the formation of non-caseating epithelioid cell granulomas in the lungs. The disease either resolves spontaneously or develops into a chronic disease with fibrosis. The neurotrophins nerve growth factor...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Dagnell C,Grunewald J,Kramar M,Haugom-Olsen H,Elmberger GP,Eklund A,Olgart Höglund C

    更新日期:2010-11-08 00:00:00

  • 24-h bronchodilation and inspiratory capacity improvements with glycopyrrolate/formoterol fumarate via co-suspension delivery technology in COPD.

    abstract:BACKGROUND:Symptoms of chronic obstructive pulmonary disease may vary throughout the day and it is important that therapeutic approaches provide 24-h symptom control. We report the results of two phase IIIb crossover studies, PT003011 and PT003012, investigating the 24-h lung function profile of GFF MDI (glycopyrrolate...

    journal_title:Respiratory research

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Reisner C,Gottschlich G,Fakih F,Koser A,Krainson J,Delacruz L,Arora S,Feldman G,Pudi K,Siddiqui S,Orevillo C,Maes A,St Rose E,Martin U

    更新日期:2017-08-18 00:00:00

  • Thank you and farewell after 15 years editing respiratory research.

    abstract:: ...

    journal_title:Respiratory research

    pub_type: 社论


    authors: Lotvall J,Panettieri RA Jr

    更新日期:2018-11-26 00:00:00

  • Fibrocytes are increased in lung and peripheral blood of patients with idiopathic pulmonary fibrosis.

    abstract:BACKGROUND:Fibrocytes are implicated in Idiopathic Pulmonary Fibrosis (IPF) pathogenesis and increased proportions in the circulation are associated with poor prognosis. Upon tissue injury, fibrocytes migrate to the affected organ. In IPF patients, circulating fibrocytes are increased especially during exacerbations, h...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Heukels P,van Hulst JAC,van Nimwegen M,Boorsma CE,Melgert BN,van den Toorn LM,Boomars KAT,Wijsenbeek MS,Hoogsteden H,von der Thüsen JH,Hendriks RW,Kool M,van den Blink B

    更新日期:2018-05-10 00:00:00

  • Inhibition of TNFalpha in vivo prevents hyperoxia-mediated activation of caspase 3 in type II cells.

    abstract:BACKGROUND:The mechanisms during the initial phase of oxygen toxicity leading to pulmonary tissue damage are incompletely known. Increase of tumour necrosis factor alpha (TNFalpha) represents one of the first pulmonary responses to hyperoxia. We hypothesised that, in the initial phase of hyperoxia, TNFalpha activates t...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Guthmann F,Wissel H,Schachtrup C,Tölle A,Rüdiger M,Spener F,Rüstow B

    更新日期:2005-01-21 00:00:00

  • The current position of surgical lung biopsy in the diagnosis of idiopathic pulmonary fibrosis.

    abstract::A new international statement defines usual interstitial pneumonia (UIP) which is a histological and radiological form of idiopathic pulmonary fibrosis (IPF) more precisely than previously. In the diagnosis of IPF, either in high resolution computed tomography (HRCT) a UIP pattern must be present or alternatively spec...

    journal_title:Respiratory research

    pub_type: 杂志文章,评审


    authors: Kaarteenaho R

    更新日期:2013-04-15 00:00:00

  • Rosiglitazone is a superior bronchodilator compared to chloroquine and β-adrenoceptor agonists in mouse lung slices.

    abstract:BACKGROUND:Current therapy for relieving bronchoconstriction may be ineffective in severe asthma, particularly in the small airways. The aim of this study was to further characterise responses to the recently identified novel bronchodilators rosiglitazone (RGZ) and chloroquine (CQ) under conditions where β-adrenoceptor...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Donovan C,Simoons M,Esposito J,Ni Cheong J,Fitzpatrick M,Bourke JE

    更新日期:2014-03-12 00:00:00

  • Sputum and blood transcriptomics characterisation of the inhaled PDE4 inhibitor CHF6001 on top of triple therapy in patients with chronic bronchitis.

    abstract:BACKGROUND:Although phosphodiesterase-4 (PDE4) inhibitors have been shown to reduce COPD exacerbation rate, their biological mechanism of action is not completely elucidated at the molecular level. We aimed to characterise the whole genome gene expression profile of the inhaled PDE4-inhibitor CHF6001 on top of triple t...

    journal_title:Respiratory research

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Govoni M,Bassi M,Vezzoli S,Lucci G,Emirova A,Nandeuil MA,Petruzzelli S,Jellema GL,Afolabi EK,Colgan B,Leaker B,Kornmann O,Beeh KM,Watz H,Singh D

    更新日期:2020-03-20 00:00:00

  • The revised ATS/ERS/JRS/ALAT diagnostic criteria for idiopathic pulmonary fibrosis (IPF)--practical implications.

    abstract::Idiopathic pulmonary fibrosis (IPF), the most prevalent idiopathic interstitial pneumonia, is associated with a poor prognosis. An accurate diagnosis of IPF is essential for optimal management. The recent ATS/ERS/JRS/ALAT recommendations on the diagnosis and management of IPF were developed from a systematic review of...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Wells AU

    更新日期:2013-01-01 00:00:00

  • Childhood infections and asthma: at the crossroads of the hygiene and Barker hypotheses.

    abstract::The hygiene hypothesis states that childhood asthma develops as a result of decreased exposure to infectious agents during infancy and early childhood. This results in the persistence of the neonatal T helper lymphocyte 2 immunophenotype, thereby predisposing the child to atopic disease. While multiple studies support...

    journal_title:Respiratory research

    pub_type: 杂志文章,评审


    authors: Tantisira KG,Weiss ST

    更新日期:2001-01-01 00:00:00

  • Clinical outcomes stratified by baseline functional class after initial combination therapy for pulmonary arterial hypertension.

    abstract:BACKGROUND:Initial combination therapy with ambrisentan and tadalafil reduced the risk of clinical failure events for treatment-naïve participants with pulmonary arterial hypertension (PAH) as compared to monotherapy. Previous studies in PAH have demonstrated greater treatment benefits in more symptomatic participants....

    journal_title:Respiratory research

    pub_type: 杂志文章,随机对照试验


    authors: White RJ,Vonk-Noordegraaf A,Rosenkranz S,Oudiz RJ,McLaughlin VV,Hoeper MM,Grünig E,Ghofrani HA,Chakinala MM,Barberà JA,Blair C,Langley J,Frost AE

    更新日期:2019-09-12 00:00:00

  • Serum heat shock protein 47 levels in patients with drug-induced lung disease.

    abstract:BACKGROUND:Heat shock protein (HSP) 47 is a collagen-specific molecular chaperone that is required for molecular maturation of various types of collagens. We recently reported that HSP47 serum levels were markedly higher in patients with acute exacerbations of idiopathic pulmonary fibrosis (IPF) when compared with pati...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Kakugawa T,Yokota S,Ishimatsu Y,Hayashi T,Nakashima S,Hara S,Sakamoto N,Matsuoka Y,Kubota H,Mine M,Mukae H,Nagata K,Kohno S

    更新日期:2013-11-20 00:00:00

  • Profibrotic potential of prominin-1+ epithelial progenitor cells in pulmonary fibrosis.

    abstract:BACKGROUND:In idiopathic pulmonary fibrosis loss of alveolar epithelium induces inflammation of the pulmonary tissue followed by accumulation of pathogenic myofibroblasts leading eventually to respiratory failures. In animal models inflammatory and resident cells have been demonstrated to contribute to pulmonary fibros...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Blyszczuk P,Germano D,Stein S,Moch H,Matter CM,Beck-Schimmer B,Lüscher TF,Eriksson U,Kania G

    更新日期:2011-09-26 00:00:00

  • Legionella pneumophila induces cathepsin B-dependent necrotic cell death with releasing high mobility group box1 in macrophages.

    abstract:BACKGROUND:Legionella pneumophila (LPN) can cause a lethal infectious disease with a marked inflammatory response in humans. However, the mechanism of this severe inflammation remains poorly understood. Since necrosis is known to induce inflammation, we investigated whether LPN induces necrosis in macrophages. We also ...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Morinaga Y,Yanagihara K,Nakamura S,Hasegawa H,Seki M,Izumikawa K,Kakeya H,Yamamoto Y,Yamada Y,Kohno S,Kamihira S

    更新日期:2010-11-22 00:00:00

  • Identifying tuberculous pleural effusion using artificial intelligence machine learning algorithms.

    abstract:BACKGROUND:The differential diagnosis of tuberculous pleural effusion (TPE) is challenging. In recent years, artificial intelligence (AI) machine learning algorithms have started being used to an increasing extent in disease diagnosis due to the high level of efficiency, objectivity, and accuracy that they offer. METH...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Ren Z,Hu Y,Xu L

    更新日期:2019-10-16 00:00:00

  • Tissue fibrocytes in patients with mild asthma: a possible link to thickness of reticular basement membrane?

    abstract:BACKGROUND:Myofibroblasts, proposed as being derived from circulating fibrocytes, are considered to be important cells in thickening of the basement membrane in patients with asthma. We have studied the correlation of tissue fibrocyte levels to basement membrane thickness and the presence of fibrocytes in bronchoalveol...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Nihlberg K,Larsen K,Hultgårdh-Nilsson A,Malmström A,Bjermer L,Westergren-Thorsson G

    更新日期:2006-03-29 00:00:00

  • Metformin attenuates lung fibrosis development via NOX4 suppression.

    abstract:BACKGROUND:Accumulation of profibrotic myofibroblasts in fibroblastic foci (FF) is a crucial process for development of fibrosis during idiopathic pulmonary fibrosis (IPF) pathogenesis, and transforming growth factor (TGF)-β plays a key regulatory role in myofibroblast differentiation. Reactive oxygen species (ROS) has...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Sato N,Takasaka N,Yoshida M,Tsubouchi K,Minagawa S,Araya J,Saito N,Fujita Y,Kurita Y,Kobayashi K,Ito S,Hara H,Kadota T,Yanagisawa H,Hashimoto M,Utsumi H,Wakui H,Kojima J,Numata T,Kaneko Y,Odaka M,Morikawa T,Na

    更新日期:2016-08-30 00:00:00

  • VEGF is upregulated by hypoxia-induced mitogenic factor via the PI-3K/Akt-NF-kappaB signaling pathway.

    abstract:BACKGROUND:Hypoxia-induced mitogenic factor (HIMF) is developmentally regulated and plays an important role in lung pathogenesis. We initially found that HIMF promotes vascular tubule formation in a matrigel plug model. In this study, we investigated the mechanisms which HIMF enhances expression of vascular endothelial...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Tong Q,Zheng L,Lin L,Li B,Wang D,Huang C,Li D

    更新日期:2006-03-02 00:00:00

  • Cigarette smoke alters the ability of human dendritic cells to promote anti-Streptococcus pneumoniae Th17 response.

    abstract:BACKGROUND:Chronic obstructive pulmonary disease (COPD) is associated with chronic inflammation and impaired immune response to pathogens leading to bacteria-induced exacerbation of the disease. A defect in Th17 cytokines in response to Streptococcus pneumoniae, a bacteria associated with COPD exacerbations, has been r...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Le Rouzic O,Koné B,Kluza J,Marchetti P,Hennegrave F,Olivier C,Kervoaze G,Vilain E,Mordacq C,Just N,Perez T,Bautin N,Pichavant M,Gosset P

    更新日期:2016-07-26 00:00:00

  • Low-molecular-weight heparin reduces hyperoxia-augmented ventilator-induced lung injury via serine/threonine kinase-protein kinase B.

    abstract:BACKGROUND:High-tidal-volume mechanical ventilation and hyperoxia used in patients with acute lung injury (ALI) can induce the release of cytokines, including high-mobility group box-1 (HMGB1), oxygen radicals, neutrophil infiltration, and the disruption of epithelial and endothelial barriers. Hyperoxia has been shown ...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Li LF,Yang CT,Huang CC,Liu YY,Kao KC,Lin HC

    更新日期:2011-07-05 00:00:00

  • The clinical features of the overlap between COPD and asthma.

    abstract:BACKGROUND:The coexistence of COPD and asthma is widely recognized but has not been well described. This study characterizes clinical features, spirometry, and chest CT scans of smoking subjects with both COPD and asthma. METHODS:We performed a cross-sectional study comparing subjects with COPD and asthma to subjects ...

    journal_title:Respiratory research

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Hardin M,Silverman EK,Barr RG,Hansel NN,Schroeder JD,Make BJ,Crapo JD,Hersh CP,COPDGene Investigators.

    更新日期:2011-09-27 00:00:00

  • Spirometric changes during exacerbations of COPD: a post hoc analysis of the WISDOM trial.

    abstract:BACKGROUND:Exacerbations of chronic obstructive pulmonary disease (COPD) are associated with loss of lung function and poor outcomes for patients. However, there are limited data on the time course of changes in forced expiratory volume in 1 s (FEV1) preceding the first reported symptom and after the start of an exacer...

    journal_title:Respiratory research

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Watz H,Tetzlaff K,Magnussen H,Mueller A,Rodriguez-Roisin R,Wouters EFM,Vogelmeier C,Calverley PMA

    更新日期:2018-12-13 00:00:00

  • The influence of chlorine in indoor swimming pools on the composition of breathing phase of professional swimmers.

    abstract:OBJECTIVES:Swimming is one of the most popular forms of physical activity. Pool water is cleaned with chlorine, which - in combination with compounds contained in water - could form chloramines and trichloromethane in the swimmer's lungs. The aim of the present study was to examine the effect of swimming training in an...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Swinarew AS,Stanula AJ,Gabor J,Raif P,Paluch J,Karpiński J,Kubik K,Okła H,Ostrowski A,Tkacz E,Skoczyński S,Waśkiewicz Z,Rosemann T,Nikolaidis PT,Knechtle B

    更新日期:2020-04-15 00:00:00

  • Apoptosis and the activity of ceramide, Bax and Bcl-2 in the lungs of neonatal rats exposed to limited and prolonged hyperoxia.

    abstract:BACKGROUND:The aim of the study is to examine the effect of limited and prolonged hyperoxia on neonatal rat lung. This is done by examining the morphologic changes of apoptosis, the expression of ceramide, an important mediator of apoptosis, the expression of inflammatory mediators represented by IL-1beta and the expre...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Husari AW,Dbaibo GS,Bitar H,Khayat A,Panjarian S,Nasser M,Bitar FF,El-Sabban M,Zaatari G,Mroueh SM

    更新日期:2006-07-26 00:00:00

  • Sex-specific lung functional changes in adult mice exposed only to second-hand smoke in utero.

    abstract:BACKGROUND:An increasing number of epidemiological and experimental studies have associated exposure to second-hand smoke (SHS) during pregnancy with adverse outcomes in newborns. As we have previously shown in mice, in utero exposure to SHS at critical stages of fetal development, results in altered lung responses and...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Noël A,Xiao R,Perveen Z,Zaman H,Le Donne V,Penn A

    更新日期:2017-06-27 00:00:00

  • Azithromycin induces epidermal differentiation and multivesicular bodies in airway epithelia.

    abstract:BACKGROUND:Azithromycin (Azm) is a macrolide recognized for its disease-modifying effects and reduction in exacerbation of chronic airway diseases. It is not clear whether the beneficial effects of Azm are due to its anti-microbial activity or other pharmacological actions. We have shown that Azm affects the integrity ...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Arason AJ,Joelsson JP,Valdimarsdottir B,Sigurdsson S,Gudjonsson A,Halldorsson S,Johannsson F,Rolfsson O,Lehmann F,Ingthorsson S,Cherek P,Gudmundsson GH,Gardarsson FR,Page CP,Baldursson O,Gudjonsson T,Kricker JA

    更新日期:2019-06-24 00:00:00

  • HIF-1 expression is associated with CCL2 chemokine expression in airway inflammatory cells: implications in allergic airway inflammation.

    abstract:BACKGROUND:The pathogenesis of allergic airway inflammation in asthmatic patients is complex and characterized by cellular infiltrates and activity of many cytokines and chemokines. Both the transcription factor hypoxia inducible factor-1 (HIF-1) and chemokine CCL2 have been shown to play pivotal roles in allergic airw...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Baay-Guzman GJ,Bebenek IG,Zeidler M,Hernandez-Pando R,Vega MI,Garcia-Zepeda EA,Antonio-Andres G,Bonavida B,Riedl M,Kleerup E,Tashkin DP,Hankinson O,Huerta-Yepez S

    更新日期:2012-07-23 00:00:00