Effect of chemokine receptor CXCR4 on hypoxia-induced pulmonary hypertension and vascular remodeling in rats.

abstract：BACKGROUND:Two randomised, double-blind, placebo-controlled trials have investigated the efficacy of IV alpha-1 antitrypsin (AAT) augmentation therapy on emphysema progression using CT densitometry. METHODS:Data from these similar trials, a 2-center Danish-Dutch study (n = 54) and the 3-center EXAcerbations and CT sca...

journal_title：Respiratory research

authors： Stockley RA,Parr DG,Piitulainen E,Stolk J,Stoel BC,Dirksen A

更新日期：2010-10-05 00:00:00

abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) is characterised by pulmonary and systemic inflammation which flare-up during episodes of acute exacerbation (AECOPD). Given the role of Toll-like receptors (TLRs) in the induction of inflammatory responses we investigated the involvement of TLRs in COPD pathogene...

journal_title：Respiratory research

authors： Pons J,Sauleda J,Regueiro V,Santos C,López M,Ferrer J,Agustí AG,Bengoechea JA

更新日期：2006-04-10 00:00:00

abstract：:The aim was to compare the diagnosis of COPD among smokers according to different international guidelines and to compare the outcome when using slow (SVC) and forced vital capacity (FVC). In order to find current smokers a questionnaire was sent to persons who had been on sick leave for more than two weeks. Those who...

journal_title：Respiratory research

authors： Nathell L,Nathell M,Malmberg P,Larsson K

更新日期：2007-12-04 00:00:00

abstract：BACKGROUND:Legionella pneumophila (LPN) can cause a lethal infectious disease with a marked inflammatory response in humans. However, the mechanism of this severe inflammation remains poorly understood. Since necrosis is known to induce inflammation, we investigated whether LPN induces necrosis in macrophages. We also ...

journal_title：Respiratory research

authors： Morinaga Y,Yanagihara K,Nakamura S,Hasegawa H,Seki M,Izumikawa K,Kakeya H,Yamamoto Y,Yamada Y,Kohno S,Kamihira S

更新日期：2010-11-22 00:00:00

abstract：BACKGROUND:Low body mass index has been associated with increased mortality in severe COPD. The impact of body composition earlier in the disease remains unclear. We studied the impact of body composition on the risk of functional limitation in COPD. METHODS:We used bioelectrical impedance to estimate body composition...

journal_title：Respiratory research

authors： Eisner MD,Blanc PD,Sidney S,Yelin EH,Lathon PV,Katz PP,Tolstykh I,Ackerson L,Iribarren C

更新日期：2007-01-29 00:00:00

abstract：BACKGROUND:This study assessed the cost-effectiveness of indacaterol/glycopyrronium (IND/GLY) versus salmeterol/fluticasone (SFC) in chronic obstructive pulmonary disease (COPD) patients with moderate to very severe airflow limitation and ≥1 exacerbation in the preceding year. METHODS:A previously published and valida...

journal_title：Respiratory research

authors： Bjermer L,van Boven JFM,Costa-Scharplatz M,Keininger DL,Gutzwiller FS,Lisspers K,Mahon R,Olsson P,Roche N

更新日期：2017-12-11 00:00:00

abstract：BACKGROUND:CD14, a receptor for lipopolysaccharides (LPS), is found in both a membrane-bound form (mCD14) and a soluble form (sCD14). It is suggested that sCD14 is mainly released from blood monocytes by serine protease-mediated shedding. Because alpha1-antitrypsin (AAT), an inhibitor of serine proteases, has been show...

journal_title：Respiratory research

authors： Sandström CS,Novoradovskaya N,Cilio CM,Piitulainen E,Sveger T,Janciauskiene S

更新日期：2008-04-21 00:00:00

abstract：:In many model systems, cystic fibrosis (CF) phenotype airway epithelial cells in culture respond to P. aeruginosa with greater interleukin (IL)-8 and IL-6 secretion than matched controls. In order to test whether this excess inflammatory response results from the reported increased adherence of P. aeruginosa to the CF...

journal_title：Respiratory research

authors： Kube DM,Fletcher D,Davis PB

更新日期：2005-07-11 00:00:00

abstract：BACKGROUND:Manual auscultation to detect abnormal breath sounds has poor inter-observer reliability. Digital stethoscopes with artificial intelligence (AI) could improve reliable detection of these sounds. We aimed to independently test the abilities of AI developed for this purpose. METHODS:One hundred and ninety two...

journal_title：Respiratory research

authors： Kevat A,Kalirajah A,Roseby R

更新日期：2020-09-29 00:00:00

abstract：BACKGROUND:Proteomic studies of respiratory disorders have the potential to identify protein biomarkers for diagnosis and disease monitoring. Utilisation of sensitive quantitative proteomic methods creates opportunities to determine individual patient proteomes. The aim of the current study was to determine if quantita...

journal_title：Respiratory research

authors： O'Neil SE,Sitkauskiene B,Babusyte A,Krisiukeniene A,Stravinskaite-Bieksiene K,Sakalauskas R,Sihlbom C,Ekerljung L,Carlsohn E,Lötvall J

更新日期：2011-09-22 00:00:00

abstract：BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is a rapid progressive fibro-proliferative disorder with poor prognosis similar to lung cancer. The pathogenesis of IPF is uncertain, but loss of epithelial cells and fibroblast proliferation are thought to be central processes. Previous reports have shown that BARD1 expre...

journal_title：Respiratory research

authors： André PA,Prêle CM,Vierkotten S,Carnesecchi S,Donati Y,Chambers RC,Pache JC,Crestani B,Barazzone-Argiroffo C,Königshoff M,Laurent GJ,Irminger-Finger I

更新日期：2015-09-29 00:00:00

abstract：BACKGROUND:Recent research has suggested that the Th1 and Th2 chemokine/cytokine axis contributes to the development of chronic hypersensitivity pneumonitis (HP). Acute exacerbations (AE) are significant factors in the prognosis of chronic HP. Little is known, however, about these biomarkers in association with AE in c...

journal_title：Respiratory research

authors： Miyazaki Y,Unoura K,Tateishi T,Akashi T,Takemura T,Tomita M,Inase N,Yoshizawa Y

更新日期：2013-05-25 00:00:00

abstract：BACKGROUND:The role of the microbiota in the pathogenesis of chronic obstructive pulmonary disease (COPD) following exposure to ambient particulate matter (PM) is largely unknown. METHODS:Fifty-four male Sprague-Dawley rats were exposed to clean air, biomass fuel (BMF), or motor vehicle exhaust (MVE) for 4, 12, and 24...

journal_title：Respiratory research

authors： Li N,Yang Z,Liao B,Pan T,Pu J,Hao B,Fu Z,Cao W,Zhou Y,He F,Li B,Ran P

更新日期：2020-10-19 00:00:00

abstract：BACKGROUND:Allergic asthma is characterized by airway inflammation in response to antigen exposure, leading to airway remodeling and lung dysfunction. Epithelial-mesenchymal transition (EMT) may play a role in airway remodeling through the acquisition of a mesenchymal phenotype in airway epithelial cells. TGF-β1 is kno...

journal_title：Respiratory research

authors： Johnson JR,Nishioka M,Chakir J,Risse PA,Almaghlouth I,Bazarbashi AN,Plante S,Martin JG,Eidelman D,Hamid Q

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:IL-10 is a cytokine mainly produced by macrophages that plays key roles in tolerance to inhaled antigens and in lung homeostasis. Its regulation in alveolar macrophages (HAM), the resident lung phagocytes, remains however unknown. METHODS:The present study investigated the role of intracellular signalling a...

journal_title：Respiratory research

authors： Chanteux H,Guisset AC,Pilette C,Sibille Y

更新日期：2007-10-04 00:00:00

abstract：BACKGROUND:A multitude of epidemiological studies have shown that ambient fine particulate matter 2.5 (diameter < 2.5um; PM2.5) was associated with increased morbidity and mortality of chronic obstructive pulmonary disease (COPD). However, the underlying associated mechanisms have not yet been elucidated. We conducted ...

journal_title：Respiratory research

authors： Zhao J,Li M,Wang Z,Chen J,Zhao J,Xu Y,Wei X,Wang J,Xie J

更新日期：2019-06-13 00:00:00

abstract：BACKGROUND:Differences in the expression of regulatory T cells (Tregs) have been suggested to explain why some smokers develop COPD and some do not. Upregulation of Tregs in response to smoking would restrain airway inflammation and thus the development of COPD; while the absense of such upregulation would over time le...

journal_title：Respiratory research

authors： Eriksson Ström J,Pourazar J,Linder R,Blomberg A,Lindberg A,Bucht A,Behndig AF

更新日期：2020-12-14 00:00:00

abstract：BACKGROUND:An imbalance in the generation of pro-inflammatory leukotrienes, and counter-regulatory lipoxins is present in severe asthma. We measured leukotriene B4 (LTB4), and lipoxin A4 (LXA4) production by alveolar macrophages (AMs) and studied the impact of corticosteroids. METHODS:AMs obtained by fiberoptic bronch...

journal_title：Respiratory research

authors： Bhavsar PK,Levy BD,Hew MJ,Pfeffer MA,Kazani S,Israel E,Chung KF

更新日期：2010-06-07 00:00:00

abstract：BACKGROUND:Hypoxia-induced mitogenic factor (HIMF) is developmentally regulated and plays an important role in lung pathogenesis. We initially found that HIMF promotes vascular tubule formation in a matrigel plug model. In this study, we investigated the mechanisms which HIMF enhances expression of vascular endothelial...

journal_title：Respiratory research

authors： Tong Q,Zheng L,Lin L,Li B,Wang D,Huang C,Li D

更新日期：2006-03-02 00:00:00

abstract：RATIONALE:Pulmonary Alveolar Proteinosis (PAP) patients exhibit an acquired deficiency of biologically active granulocyte-macrophage colony stimulating factor (GM-CSF) attributable to GM-CSF specific autoantibodies. PAP alveolar macrophages are foamy, lipid-filled cells with impaired surfactant clearance and markedly r...

journal_title：Respiratory research

authors： Malur A,Kavuru MS,Marshall I,Barna BP,Huizar I,Karnekar R,Thomassen MJ

更新日期：2012-06-14 00:00:00

abstract：BACKGROUND:ExoU, a Pseudomonas aeruginosa cytotoxin with phospholipase A2 activity, was shown to induce vascular hyperpermeability and thrombus formation in a murine model of pneumosepsis. In this study, we investigated the toxin ability to induce alterations in pulmonary fibrinolysis and the contribution of the platel...

journal_title：Respiratory research

authors： Machado GB,de Oliveira AV,Saliba AM,de Lima CD,Suassuna JH,Plotkowski MC

更新日期：2011-08-05 00:00:00

abstract：BACKGROUND:Myofibroblasts play a major role in the synthesis of extracellular matrix (ECM) and the stimulation of these cells is thought to play an important role in the development of silicosis. The present study was undertaken to investigate the anti-fibrotic effects of dibutyryl-cAMP (db-cAMP) on rats induced by sil...

journal_title：Respiratory research

authors： Liu Y,Xu H,Geng Y,Xu D,Zhang L,Yang Y,Wei Z,Zhang B,Li S,Gao X,Wang R,Zhang X,Brann D,Yang F

更新日期：2017-02-21 00:00:00

abstract：BACKGROUND:Dual bronchodilator therapy is recommended for symptomatic patients with chronic obstructive pulmonary disease (COPD). There are limited data on effects of a combination of two long-acting bronchodilators on lung function including body plethysmography. METHODS:This multicentre, randomised, double-blind, si...

journal_title：Respiratory research

authors： Salomon J,Stolz D,Domenighetti G,Frey JG,Turk AJ,Azzola A,Sigrist T,Fitting JW,Schmidt U,Geiser T,Wild C,Kostikas K,Clemens A,Brutsche M

更新日期：2017-01-11 00:00:00

abstract：BACKGROUND:During a lipopolysaccharide-induced lung inflammation, a massive accumulation of neutrophils occurs, which is normally cleared by macrophage phagocytosis following neutrophil apoptosis. However, in cases of extensive apoptosis the normal clearance system may fail, resulting in extensive neutrophil secondary ...

journal_title：Respiratory research

authors： Rydell-Törmänen K,Uller L,Erjefält JS

更新日期：2006-12-14 00:00:00

abstract：BACKGROUND:Airway clearance techniques (ACTs) are an important aspect of the treatment of children with chronic obstructive lung diseases. Unfortunately, a sound evidence base is lacking and airway clearance strategies are largely based on clinical expertise. One of the reasons for the limited evidence is the lack of a...

journal_title：Respiratory research

authors： Lauwers E,Ides K,Van Hoorenbeeck K,Verhulst S

更新日期：2020-08-17 00:00:00

abstract：BACKGROUND:CpG oligodeoxynucleotides (CpG-ODN) are capable of inducing high amounts of type I IFNs with many immunomodulatory properties. Furthermore, type-I IFNs have been proposed to play a key role in mediating effects of CpG-ODN. The precise role of IFN-beta in the immunomodulatory effects of CpG-ODN is not known. ...

journal_title：Respiratory research

authors： Matheu V,Treschow A,Teige I,Navikas V,Issazadeh-Navikas S

更新日期：2005-03-05 00:00:00

abstract：BACKGROUND:Programming a mechanical ventilator with a biologically variable or fractal breathing pattern (an example of 1/f noise) improves gas exchange and respiratory mechanics. Here we show that fractal ventilation increases respiratory sinus arrhythmia (RSA) -- a mechanism known to improve ventilation/perfusion mat...

journal_title：Respiratory research

authors： Mutch WA,Graham MR,Girling LG,Brewster JF

更新日期：2005-05-09 00:00:00

abstract：BACKGROUND:Chitosan, a polymer derived from chitin, has been used for nasal drug delivery because of its biocompatibility, biodegradability and bioadhesiveness. Theophylline is a drug that reduces the inflammatory effects of allergic asthma but is difficult to administer at an appropriate dosage without causing adverse...

journal_title：Respiratory research

authors： Lee DW,Shirley SA,Lockey RF,Mohapatra SS

更新日期：2006-08-24 00:00:00

abstract：BACKGROUND:Aim of this prospective study was to compare clinical and genetic findings in children with idiopathic or heritable pulmonary arterial hypertension (I/HPAH) with children affected with congenital heart defects associated PAH (CHD-APAH). METHODS:Prospectively included were 40 consecutive children with invasi...

journal_title：Respiratory research

authors： Pfarr N,Fischer C,Ehlken N,Becker-Grünig T,López-González V,Gorenflo M,Hager A,Hinderhofer K,Miera O,Nagel C,Schranz D,Grünig E

更新日期：2013-01-09 00:00:00

abstract：BACKGROUND:The assessment of bronchodilator-induced change in forced vital capacity (FVC) is dependent on forced expiratory time (FET) in subjects with airflow limitation. Limited information is available on the concurrent responses of FVC, forced expiratory volume in six seconds (FEV6), and FET in the bronchodilation ...

journal_title：Respiratory research

authors： Kainu A,Lindqvist A,Sarna S,Lundbäck B,Sovijärvi A

更新日期：2009-07-28 00:00:00