Abstract:
BACKGROUND:Transfer RNA (tRNA)-derived fragments (tRFs) have been widely identified in nature, functioning in diverse biological and pathological situations. Yet, the presence of these small RNAs in Plasmodium spp. remains unknown. Systematic identification and characterization of tRFs is therefore highly needed to understand further their roles in Plasmodium parasites, particularly in the virulent Plasmodium falciparum parasite. RESULTS:Genome-wide small RNAs with sizes ranging from 18-30 nucleotides from P. falciparum were deep-sequenced via Illumina HiSeq 2000 technology. In-depth analysis revealed the presence of a vast number of small RNAs originating from tRNA-coding genes, responsible for 22.4% of the total reads as the second predominant group. Three P. falciparum-derived tRF types (ptRFs) were identified as 5'ptRFs, mid-ptRFs and 3'ptRFs. The majority (90%) of ptRFs were derived from tRNAs that coded eight amino acids: Pro, Phe, Asn, Gly, Cys, Gln, His and Ala. Stem-loop reverse transcription polymerase chain reaction further confirmed the presence of tRFs in the blood stages of P. falciparum. Four new motifs with an enriched G/C feature were determined at cleavage sites that might guide the generation of ptRFs. CONCLUSIONS:To our knowledge, this is the first report of a genome-wide investigation of ptRFs from Plasmodium species. The identification of ptRFs reveals a complex small RNA system manipulated by the malaria parasite, and might promote research on the function of tRFs in the pathogenesis of Plasmodium infections.
journal_name
Parasit Vectorsjournal_title
Parasites & vectorsauthors
Wang Z,Wei C,Hao X,Deng W,Zhang L,Wang Z,Wang Hdoi
10.1186/s13071-019-3301-6subject
Has Abstractpub_date
2019-01-15 00:00:00pages
36issue
1issn
1756-3305pii
10.1186/s13071-019-3301-6journal_volume
12pub_type
杂志文章abstract:BACKGROUND:In the last decades, the enormous influx of immigrants to industrialized countries has led to outbreaks of parasitic diseases, with enteric infections being amongst the most frequently encountered. In its strategy to control such infection, Qatar has established the Pre-Employment Certificate (PEC) program w...
journal_title:Parasites & vectors
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abstract:BACKGROUND:Schistosomiasis japonica remains a major public health concern in China. There are many interventions implemented to control the transmission of the disease. The purpose of the present study was to investigate the effects of an integrated control strategy for schistosomiasis control. METHODS:An integrated c...
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journal_title:Parasites & vectors
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journal_title:Parasites & vectors
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journal_title:Parasites & vectors
pub_type: 杂志文章
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更新日期:2012-09-21 00:00:00
abstract::Echinococcus transmission is known to be affected by various environmental factors, which may be modified by human influence or natural events including global warming. Considerable population growth in the last fifty years in Ningxia Hui Autonomous Region (NHAR), the People's Republic of China (PRC), has led to drama...
journal_title:Parasites & vectors
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-0733-5
更新日期:2015-02-24 00:00:00
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journal_title:Parasites & vectors
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journal_title:Parasites & vectors
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journal_title:Parasites & vectors
pub_type: 杂志文章
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2148-y
更新日期:2017-04-24 00:00:00
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journal_title:Parasites & vectors
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-6-274
更新日期:2013-09-21 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-7-41
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-5-121
更新日期:2012-06-18 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
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journal_title:Parasites & vectors
pub_type: 杂志文章
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journal_title:Parasites & vectors
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journal_title:Parasites & vectors
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更新日期:2019-07-29 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
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更新日期:2020-09-29 00:00:00
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更新日期:2019-03-13 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-2791-y
更新日期:2018-03-20 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-3-1
更新日期:2010-01-05 00:00:00
abstract:BACKGROUND:Babesia motasi is known as an etiological agent of human and ovine babesiosis. Diagnosis of babesiosis is traditionally performed by microscopy, examining Giemsa-stained thin peripheral blood smears. Rapid detection and accurate identification of species are desirable for clinical care and epidemiological st...
journal_title:Parasites & vectors
pub_type: 杂志文章
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更新日期:2020-07-29 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-0886-2
更新日期:2015-05-28 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
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更新日期:2018-09-26 00:00:00
abstract:BACKGROUND:Cues that guide gravid Anopheles gambiae sensu lato to oviposition sites can be manipulated to create new strategies for monitoring and controlling malaria vectors. However, progress towards identifying such cues is slow in part due to the lack of appropriate tools for investigating long-range attraction to ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-0916-0
更新日期:2015-06-03 00:00:00