Abstract:
BACKGROUND:The merozoite of the zoonotic Plasmodium knowlesi invades human erythrocytes via the binding of its Duffy binding protein (PkDBPαII) to the Duffy antigen on the eythrocytes. The Duffy antigen has two immunologically distinct forms, Fya and Fyb. In this study, the erythrocyte-binding assay was used to quantitatively determine and compare the binding level of PkDBPαII to Fya+/b+ and Fya+/b- human erythrocytes. RESULTS:In the erythrocyte-binding assay, binding level was determined by scoring the number of rosettes that were formed by erythrocytes surrounding transfected mammalian COS-7 cells which expressed PkDBPαII. The assay result revealed a significant difference in the binding level. The number of rosettes scored for Fya+/b+ was 1.64-fold higher than that of Fya+/b- (155.50 ± 34.32 and 94.75 ± 23.16 rosettes, respectively; t(6) = -2.935, P = 0.026). CONCLUSIONS:The erythrocyte-binding assay provided a simple approach to quantitatively determine the binding level of PkDBPαII to the erythrocyte Duffy antigen. Using this assay, PkDBPαII was found to display higher binding to Fya+/b+ erythrocytes than to Fya+/b- erythrocytes.
journal_name
Parasit Vectorsjournal_title
Parasites & vectorsauthors
Fong MY,Cheong FW,Lau YLdoi
10.1186/s13071-018-3118-8subject
Has Abstractpub_date
2018-09-26 00:00:00pages
527issue
1issn
1756-3305pii
10.1186/s13071-018-3118-8journal_volume
11pub_type
杂志文章abstract:BACKGROUND:The identification of Trypanosoma cruzi and blood-meal sources in synanthropic triatomines is important to assess the potential risk of Chagas disease transmission. We identified T. cruzi infection and blood-meal sources of triatomines caught in and around houses in the state of Bahia, northeastern Brazil, a...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3849-1
更新日期:2019-12-26 00:00:00
abstract:BACKGROUND:Dirofilaria immitis and Dirofilaria repens are transmitted by bloodsucking culicid mosquitoes belonging to Culex, Aedes, Ochlerotatus, Anopheles and Mansonia genera. The detection of filarioids in mosquitoes for assessing distribution of vectors and/or of pathogens in a given area (also known as "xenomonitor...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-5-76
更新日期:2012-04-20 00:00:00
abstract:BACKGROUND:Aedes albopictus is widely distributed across tropical and sub-tropical regions and is associated with the transmission of several arboviruses. Although this species is increasingly relevant to public health due its ability to successfully colonize both urban and rural habitats, favoring the dispersion of vi...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-7-253
更新日期:2014-05-30 00:00:00
abstract:BACKGROUND:Transfer RNA (tRNA)-derived fragments (tRFs) have been widely identified in nature, functioning in diverse biological and pathological situations. Yet, the presence of these small RNAs in Plasmodium spp. remains unknown. Systematic identification and characterization of tRFs is therefore highly needed to und...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3301-6
更新日期:2019-01-15 00:00:00
abstract:BACKGROUND:In Europe, hard ticks of the subgenus Pholeoixodes (Ixodidae: Ixodes) are usually associated with burrow-dwelling mammals and terrestrial birds. Reports of Pholeoixodes spp. from carnivores are frequently contradictory, and their identification is not based on key diagnostic characters. Therefore, the aims o...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2424-x
更新日期:2017-11-03 00:00:00
abstract:BACKGROUND:Eimeria tenella infection leads to acute intestinal disorders responsible for important economic losses in poultry farming worldwide. The life-cycle of E. tenella is monoxenous with the chicken as the exclusive host; infection occurs in caecal epithelial cells. However, in vitro, the complete life-cycle of t...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-2622-1
更新日期:2018-01-18 00:00:00
abstract:BACKGROUND:Babesia motasi is known as an etiological agent of human and ovine babesiosis. Diagnosis of babesiosis is traditionally performed by microscopy, examining Giemsa-stained thin peripheral blood smears. Rapid detection and accurate identification of species are desirable for clinical care and epidemiological st...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-04246-4
更新日期:2020-07-29 00:00:00
abstract:BACKGROUND:Zoonotic onchocerciasis is a vector-borne disease, which involves many animal species, including large ungulates, boars, dogs, and sporadically, humans. So far, 39 cases of zoonotic onchocerciasis have been reported worldwide, 30 of which have been found in the last 20 years. Onchocerca nematodes are transmi...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-3925-6
更新日期:2020-02-12 00:00:00
abstract:BACKGROUND:In this study for the first time, a Dientamoeba fragilis protein profile by MALDI-TOF MS was created in order to identify specific markers for the application of this technology in the laboratory diagnosis of dientamoebiasis. In particular, one D. fragilis reference strain was used to create a reference spec...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2597-3
更新日期:2018-01-04 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-4-149
更新日期:2011-07-27 00:00:00
abstract:BACKGROUND:Mosquito-borne arboviruses, like dengue virus, continue to cause significant global morbidity and mortality, particularly in Southeast Asia. When the infectious mosquitoes probe into human skin for a blood meal, they deposit saliva containing a myriad of pharmacologically active compounds, some of which alte...
journal_title:Parasites & vectors
pub_type: 临床试验,杂志文章
doi:10.1186/s13071-018-3224-7
更新日期:2018-12-20 00:00:00
abstract:BACKGROUND:Infective larvae of the worldwide occurring zoonotic roundworm T. canis exhibit a marked affinity to the nervous tissues of paratenic hosts. In humans, most cases of neurotoxocarosis are considered to be caused by larvae of T. canis as T. cati larvae have rarely been found in the CNS in previous studies. How...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-7-194
更新日期:2014-04-22 00:00:00
abstract:BACKGROUND:Both falciparum and vivax malaria were historically prevalent in China with high incidence. With the control efforts, the annual incidence in the whole country has reduced to 0.0001% except in some areas in the southern borders after 2000. Despite this, the re-emergence or outbreak of malaria was unavoidable...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-5-136
更新日期:2012-07-09 00:00:00
abstract:BACKGROUND:Anaplasma phagocytophilum is an emerging tick-borne zoonotic pathogen of increased interest worldwide which has been detected in northern Africa. Anaplasma platys is also present in this region and could possibly have a zoonotic potential. However, only one recent article reports on the human esposure to A. ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2148-y
更新日期:2017-04-24 00:00:00
abstract:BACKGROUND:Dengue virus (DENV) is the arbovirus with the highest incidence in New Caledonia and in the South Pacific region. In 2012-2014, a major DENV-1 outbreak occurred in New Caledonia. The only known vector of DENV in New Caledonia is Aedes aegypti but no study has yet evaluated the competence of New Caledonia Ae....
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2319-x
更新日期:2017-08-09 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-1132-7
更新日期:2015-10-22 00:00:00
abstract:BACKGROUND:Surveillance of outdoor resting malaria vector populations is crucial to monitor possible changes in vector resting and feeding behaviour following the widespread use of indoor-based vector control interventions. However, it is seldom included in the routine vector surveillance system in Africa due to lack o...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3535-3
更新日期:2019-05-31 00:00:00
abstract:BACKGROUND:The trypanosome diversity of the Brush-tailed Bettong (Bettongia penicillata), known locally as the woylie, has been further investigated. At a species level, woylies are critically endangered and have declined by 90% since 1999. The predation of individuals made more vulnerable by disease is thought to be t...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-6-121
更新日期:2013-04-26 00:00:00
abstract:BACKGROUND:Human and animal fascioliasis poses serious public health problems in South America. In Venezuela, livestock infection represents an important veterinary problem whereas there appear to be few human cases reported, most of which are passively detected in health centres. However, results of recent surveys sug...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-4-200
更新日期:2011-10-14 00:00:00
abstract:BACKGROUND:The TNF signaling pathway is involved in the regulation of many cellular processes (such as apoptosis and cell proliferation). Previous reports indicated the effect of human TNF-α on metabolism, physiology, gene expression and protein phosphorylation of the human parasite Schistosoma mansoni and suggested th...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-04370-1
更新日期:2020-09-25 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3873-1
更新日期:2020-01-14 00:00:00
abstract:BACKGROUND:Recently the role of gastrointestinal nematodes in modulating the immune responses in inflammatory and immune-mediated conditions such as allergy and autoimmune diseases has been introduced. This is mainly due to the suppressive effects of somatic and excretory secretory (ES) products of nematodes on the imm...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2159-8
更新日期:2017-05-12 00:00:00
abstract:BACKGROUND:Toxoplasma gondii infections and cases of clinical toxoplasmosis have been recorded in zoo animals. Wild felids in human care can serve as definitive hosts that shed oocysts, but also as intermediate hosts for the parasite. Some felid species, such as the Pallas's cat (Otocolobus manul) or sand cat (Felis ma...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3706-2
更新日期:2019-09-11 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-0798-1
更新日期:2015-03-23 00:00:00
abstract:BACKGROUND:As evidence of the infection of domestic animals by Anaplasma phagocytophilum and Anaplasma sp. 'Omatjenne' is presently becoming available, understanding the epidemiological and ecological significance of infection is important to quantify the clinical and socio-economic impact of the diseases they cause. ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-2633-y
更新日期:2018-03-09 00:00:00
abstract:BACKGROUND:Schistosomiasis remains prevalent in Africa, Asia and South America with an estimated burden of 1.9 million disability-adjusted life years in 2016. Targeting snails as a key to success for schistosomiasis control has been widely approved, but the long-term quantitative effects of interventions on snail contr...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-04273-1
更新日期:2020-08-05 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-3105-0
更新日期:2018-09-29 00:00:00
abstract:BACKGROUND:Dirofilaria immitis is a mosquito-borne pathogen that is spreading worldwide, and the associated infection (i.e. dirofilariosis) is becoming a threat to animals and humans living in endemic areas. Little is known about the occurrence and risk of infection of D. immitis in pinnipeds. Here we report dirofilari...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2073-0
更新日期:2017-03-13 00:00:00
abstract:BACKGROUND:Release of gene-drive mutants to suppress Anopheles mosquito reproduction is a promising method of malaria control. However, many scientific, regulatory and ethical questions remain before transgenic mosquitoes can be utilised in the field. At a behavioural level, gene-drive carrying mutants should be at lea...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-04382-x
更新日期:2020-10-07 00:00:00
abstract:BACKGROUND:More than 46 species of mammals can be naturally infected with Schistosoma japonicum in the mainland of China. Mice are permissive and may act as the definitive host of the life cycle. In contrast, rats are less susceptible to S. japonicum infection, and are considered to provide an unsuitable micro-environm...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-4-155
更新日期:2011-08-05 00:00:00